Impact of SGLT2 Inhibitors on Cardiovascular Risk Scores, Metabolic Parameters, and Laboratory Profiles in Type 2 Diabetes DOI Creative Commons
Nazif Yalçın, Selman Aktaş, Seyit Uyar

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 722 - 722

Published: April 29, 2025

Background: Cardiovascular disease (CVD) is a leading cause of mortality in Type 2 diabetes mellitus (T2DM). Sodium-glucose co-transporter (SGLT2) inhibitors are known to provide cardioprotective effects, but their influence on validated cardiovascular risk models remains underexplored. This study assessed the impact SGLT2 scores, metabolic parameters, and laboratory profiles over six months. Methods: was conducted 152 T2DM patients initiating inhibitors. evaluated using SCORE2-DM model at baseline after Generalized Estimating Equation (GEE) analysis temporal stratification changes. Metabolic parameters were analyzed repeated-measures ANOVA. Results: scores decreased significantly, i.e., from 21.68 17.43 (p < 0.001). Systolic diastolic blood pressure reduced by 9.21 mmHg 6.16 mmHg, respectively BMI declined 1.27 kg/m2 0.001), HbA1c 1.38% Triglyceride levels dropped 22.91 mg/dL while renal remained stable. The GEE confirmed significant shifts lower categories (β = −0.777, p with comparable efficacy between empagliflozin dapagliflozin 0.922). Conclusions: inhibitor therapy significantly reduces improves patients. These findings highlight importance integrating into comprehensive cardiometabolic management strategies.

Language: Английский

Recent Perspectives on the Pharmacological, Nutraceutical, Functional, and Therapeutic Properties of Moringa oleifera Plant DOI Creative Commons

Muhammad Tayyab Arshad,

Sammra Maqsood, Ali Ikram

et al.

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(4)

Published: April 1, 2025

ABSTRACT The “miracle tree,” Moringa oleifera , has gained so much attention because of its spectacular nutritional profile and potential health benefits, making it one the candidates for functional food product creation. benefits M. are presented here in this review alongside antioxidant conformation, bioactive constituents, macro‐ micronutrient conformation. is rapidly becoming a key effective component formulating healthy foodstuffs outstanding anti‐inflammatory, antimicrobial, antidiabetic, antioxidant, neuroprotective activities. Investigation into usage moringa products foods like dairy substitutes, powders, supplements, drinks, even snacks also part review. Notwithstanding auspicious there contests with development such as issues sensory perception, active ingredient constancy, budget constraints. Maintainable plant‐based demand across sphere pushing novelty industry. To improve current scalability suitability moringa‐based foods, concludes call additional investigation.

Language: Английский

Citations

3
Mechanisms of inflammatory microenvironment formation in cardiometabolic diseases: molecular and cellular perspectives DOI Creative Commons
Menghua Liu, Rumeng Chen,

Zhiwei Zheng

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 14, 2025

Cardiometabolic diseases (CMD) are leading causes of death and disability worldwide, with complex pathophysiological mechanisms in which inflammation plays a crucial role. This review aims to elucidate the molecular cellular within inflammatory microenvironment atherosclerosis, hypertension diabetic cardiomyopathy. In oxidized low-density lipoprotein (ox-LDL) pro-inflammatory cytokines such as Interleukin-6 (IL-6) Tumor Necrosis Factor-alpha (TNF-α) activate immune cells contributing foam cell formation arterial wall thickening. Hypertension involves activation renin-angiotensin system (RAS) alongside oxidative stress-induced endothelial dysfunction local mediated by T cells. cardiomyopathy, high-glucose environment leads accumulation advanced glycation end products (AGEs), activating Receptor for Advanced Glycation Endproducts (RAGE) triggering responses that further damage cardiac microvascular function. summary, different types metabolic cardiovascular diverse; understanding these deeply will aid developing more effective individualized treatment strategies.

Language: Английский

Citations

2
Causal associations between HbA1c and multiple diseases unveiled through a Mendelian randomization phenome-wide association study in East Asian populations DOI Creative Commons
Li Han,

Shuling Xu,

Rumeng Chen

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(11), P. e41861 - e41861

Published: March 14, 2025

Most analyses of hemoglobin A1c (HbA1c) and multiple common diseases have focused on European populations, thus there is a need for Mendelian randomization phenome-wide association study (MR-PheWAS) in East Asian populations. We used MR-PheWAS to investigate the potential causal associations between HbA1c 159 types Biobank Japan dataset, employing inverse variance weighted as primary statistical approach, supplemented by MR-Egger median analyses. Additionally, sensitivity were conducted assess heterogeneity pleiotropy. High levels are associated with an increased risk type 1 diabetes (odds ratio [OR] = 4.07; 95% confidence interval [CI]: 2.34~7.07), 2 (OR 4.76; CI: 3.01~7.55), cataract 1.33; 1.18~1.51), diabetic nephropathy 5.70; 2.24~14.46), peripheral arterial disease 1.62; 1.29~2.04). Conversely, elevated reduced asthma 0.76; 0.67~0.86), breast cancer 0.75; 0.65~0.87), cerebral aneurysm 0.71; 0.57~0.88). The results numerous populations provides insights region’s specialized glycemic control prevention programs, well new preventive treatment options.

Language: Английский

Citations

0
Pharmacological and Computational Investigations of Isosteviol 16-oxime for Attenuating Streptozotocin-induced Diabetic Neuroinflammation utilizing rat as Animal Model DOI

Shumaila Bashir,

Muhammad Faheem, Mariam K. Alamoudi

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114506 - 114506

Published: March 28, 2025

Language: Английский

Citations

0
Risk factors for cognitive decline in type 2 diabetes mellitus adults: a systematic review and meta-analysis DOI
Shennen A. Mao,

Yingmin Wang

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

Language: Английский

Citations

0
Chitosan as a multifunctional polymer in drug delivery systems for diabetic wound management DOI
Huma Hameed, S. Ahmad, Mahtab Ahmad Khan

et al.

Polymer Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Language: Английский

Citations

0
Development of Novel α-Amylase Inhibitors: Synthesis, Molecular Docking, and Biochemical Studies DOI

K. Ramakrishnan,

Reshma Rajan,

Lenin Nachimuthu

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Language: Английский

Citations

0
Exploring the Anti-Diabetic Potential of Bis-Schiff Base Derivatives of Benzimidazole: In-Vitro α-amylase, α-glucosidase Inhibition, Molecular Docking, ADMET and DFT Studies DOI
Hamid Ullah, Aftab Alam, Ahmed A. Elhenawy

et al.

Computational Biology and Chemistry, Journal Year: 2025, Volume and Issue: 118, P. 108497 - 108497

Published: April 30, 2025

Language: Английский

Citations

0
Impact of SGLT2 Inhibitors on Cardiovascular Risk Scores, Metabolic Parameters, and Laboratory Profiles in Type 2 Diabetes DOI Creative Commons
Nazif Yalçın, Selman Aktaş, Seyit Uyar

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 722 - 722

Published: April 29, 2025

Background: Cardiovascular disease (CVD) is a leading cause of mortality in Type 2 diabetes mellitus (T2DM). Sodium-glucose co-transporter (SGLT2) inhibitors are known to provide cardioprotective effects, but their influence on validated cardiovascular risk models remains underexplored. This study assessed the impact SGLT2 scores, metabolic parameters, and laboratory profiles over six months. Methods: was conducted 152 T2DM patients initiating inhibitors. evaluated using SCORE2-DM model at baseline after Generalized Estimating Equation (GEE) analysis temporal stratification changes. Metabolic parameters were analyzed repeated-measures ANOVA. Results: scores decreased significantly, i.e., from 21.68 17.43 (p < 0.001). Systolic diastolic blood pressure reduced by 9.21 mmHg 6.16 mmHg, respectively BMI declined 1.27 kg/m2 0.001), HbA1c 1.38% Triglyceride levels dropped 22.91 mg/dL while renal remained stable. The GEE confirmed significant shifts lower categories (β = −0.777, p with comparable efficacy between empagliflozin dapagliflozin 0.922). Conclusions: inhibitor therapy significantly reduces improves patients. These findings highlight importance integrating into comprehensive cardiometabolic management strategies.

Language: Английский

Citations

0