The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside DOI Creative Commons
Xin Jin,

C. Huang,

Yue Tian

и другие.

Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)

Опубликована: Июль 3, 2024

Despite being characterized by high malignancy, morbidity, and low survival rates, the underlying mechanism of hepatocellular carcinoma (HCC) has not been fully elucidated. Ferroptosis, a non-apoptotic form regulated cell death, possesses distinct morphological, biochemical, genetic characteristics compared to other types death. Dysregulated actions within molecular network that regulates ferroptosis have identified as significant contributors progression HCC. Long non-coding RNAs (lncRNAs) emerged influential diverse cellular processes, regulating gene function expression through multiple mechanistic pathways. An increasing body evidence indicates deregulated lncRNAs are implicated in malignant events such proliferation, growth, invasion, metabolism influencing Therefore, elucidating inherent role modulatory functions on HCC might promote development novel therapeutic interventions for this disease. This review provides succinct overview roles ferroptosis-related treatment, aiming drive promising targets biomarkers patients.

Язык: Английский

The role of competing endogenous RNA network in the development of hepatocellular carcinoma: potential therapeutic targets DOI Creative Commons
Ziwei Tang, Xue Li,

Yanfeng Zheng

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Янв. 31, 2024

The current situation of hepatocellular carcinoma (HCC) management is challenging due to its high incidence, mortality, recurrence and metastasis. Recent advances in gene genetic expression regulation have unveiled the significant role non-coding RNA (ncRNA) various cancers. This led formulation competing endogenous (ceRNA) hypothesis, which posits that both coding ncRNA, containing miRNA response elements (MRE), can share same sequence. results a competitive network between ncRNAs, such as lncRNA mRNA, allowing them regulate each other. Extensive research has highlighted crucial ceRNA HCC development, impacting cellular processes including proliferation, metastasis, cell death, angiogenesis, tumor microenvironment, organismal immunity, chemotherapy resistance. Additionally, network, mediated by or circRNA, offers potential early diagnosis prevention HCC. Consequently, ceRNAs are emerging therapeutic targets for complexity these networks aligns with multi-target approach traditional Chinese medicine (TCM), presenting novel perspective TCM combating Research beginning show compounds prescriptions affect progression through inhibiting proliferation inducing apoptosis. Currently, lncRNAs TUG1, NEAT1, CCAT1, along their associated networks, among most promising ncRNAs research. However, this field still infancy, necessitating advanced technology extensive basic fully understand mechanisms treatment.

Язык: Английский

Процитировано

16
Long Non-Coding RNAs in Humans: Classification, Genomic Organization and Function DOI Creative Commons

Barbara Chodurska,

Tanja Kunej

Non-coding RNA Research, Год журнала: 2025, Номер 11, С. 313 - 327

Опубликована: Янв. 14, 2025

Long non-coding RNAs (lncRNAs) regulate numerous biological functions in animals. Despite recent advances lncRNA research, their structural and functional annotation classification remain an ongoing challenge. This review provides a comprehensive overview of human lncRNAs, highlighting genomic organization, mode action role physiological pathological processes. Subgroups genes are discussed using representative examples visualizations organization. The HUGO Gene Nomenclature Committee (HGNC) categorizes lncRNAs into nine subgroups: (1) microRNA host genes, (2) small nucleolar RNA (3) long intergenic non-protein coding (LINC), (4) antisense RNAs, (5) overlapping transcripts, (6) intronic (7) divergent (8) with non-systematic symbols (9) FAM root systems. Circular (circRNAs) separate class that shares some characteristics divided exonic, intronic-exonic types. LncRNAs act as molecular signals, decoys, scaffolds sponges for microRNAs often function competing endogenous (ceRNAs). involved various processes, such cell differentiation, p53-mediated DNA damage response, glucose metabolism, inflammation immune functions. They associated several diseases, including types neoplasms, Alzheimer's disease autoimmune diseases. A clear system is essential understanding facilitating practical applications biomedical research. Future studies should focus on drug development biomarker discovery. As important regulators represent promising targets innovative therapies.

Язык: Английский

Процитировано

2
The Biological Roles and Molecular Mechanisms of Long Non-Coding RNA MEG3 in the Hallmarks of Cancer DOI Open Access
Lei Zhang, Fuqiang Zhao, Wenfang Li

и другие.

Cancers, Год журнала: 2022, Номер 14(24), С. 6032 - 6032

Опубликована: Дек. 7, 2022

Long non-coding RNAs (lncRNAs) are critical regulators in various biological processes involved the hallmarks of cancer. Maternally expressed gene 3 (MEG3) is lncRNA that regulates target genes through transcription, translation, post-translational modification, and epigenetic regulation. MEG3 has been known as a tumor suppressor, its downregulation could be found cancers. Furthermore, clinical studies revealed impaired expression associated with poor prognosis drug resistance. exerts suppressive effect by suppressing cancer preventing cells from acquiring cancer-specific characteristics; it suppress proliferation, invasion, metastasis, angiogenesis; also promote cell death regulate metabolic reprogramming. Hence, potential prognostic marker, overexpressing might become antitumor therapeutic strategy. Herein, we summarize recent knowledge regarding role regulating well underlying molecular mechanisms. discuss importance MEG3, their strategies.

Язык: Английский

Процитировано

29
Deubiquitinating enzymes: potential regulators of the tumor microenvironment and implications for immune evasion DOI Creative Commons

Sheng‐Kai Hsu,

Chon‐Kit Chou, I‐Ling Lin

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Май 7, 2024

Abstract Ubiquitination and deubiquitination are important forms of posttranslational modification that govern protein homeostasis. Deubiquitinating enzymes (DUBs), a superfamily consisting more than 100 members, deconjugate ubiquitin chains from client proteins to regulate cellular However, the dysregulation DUBs is reportedly associated with several diseases, including cancer. The tumor microenvironment (TME) highly complex entity comprising diverse noncancerous cells (e.g., immune stromal cells) extracellular matrix (ECM). Since TME heterogeneity closely related tumorigenesis evasion, targeting components has recently been considered an attractive therapeutic strategy for restoring antitumor immunity. Emerging studies have revealed involvement in modulation within TME, regulation checkpoints immunocyte infiltration function, which renders promising potent cancer immunotherapy. Nevertheless, roles crosstalk between tumors their surrounding not comprehensively reviewed. In this review, we discuss dynamic interplay tumors, cells, illustrate how dysregulated facilitate evasion promote progression. We also summarize potential small molecules target alleviate immunosuppression suppress tumorigenesis. Finally, prospects challenges regarding immunotherapeutics urgent problems warrant further investigation.

Язык: Английский

Процитировано

6
Profiles and interactions of gut microbiome and intestinal microRNAs in pediatric Crohn’s disease DOI Creative Commons
Yao Lv,

Changjun Zhen,

Ana Liu

и другие.

mSystems, Год журнала: 2024, Номер 9(9)

Опубликована: Авг. 16, 2024

Gut dysbiosis is closely related to dysregulated microRNAs (miRNAs) in the intestinal epithelial cells, which plays an important role pathogenesis of Crohn's disease (CD). We investigated relationship between fecal gut microbiome (GM) and tissue miRNAs different stages pediatric CD. Metagenomic analysis miRNA sequencing were conducted examine GM profiles CD patients before after clinical induction therapy controls. Twenty-seven newly diagnosed, therapy-naïve with active 11 non-inflammatory bowel (IBD) controls recruited this study. Among patients, completed treatment reached remission. Both significantly changed Seven key bacteria identified at species level including

Язык: Английский

Процитировано

5
Function of the Long Noncoding RNAs in Hepatocellular Carcinoma: Classification, Molecular Mechanisms, and Significant Therapeutic Potentials DOI Creative Commons
Ahmad Khan, Xiaobo Zhang

Bioengineering, Год журнала: 2022, Номер 9(8), С. 406 - 406

Опубликована: Авг. 21, 2022

Hepatocellular carcinoma (HCC) is the most common and serious type of primary liver cancer. HCC patients have a high death rate poor prognosis due to lack clear signs inadequate treatment interventions. However, molecular pathways that underpin pathogenesis remain unclear. Long non-coding RNAs (lncRNAs), new RNAs, been found play important roles in HCC. LncRNAs ability influence gene expression protein activity. Dysregulation lncRNAs has linked growing number disorders, including As result, improved understanding could lead insights into etiology, as well approaches for early detection The latest results with respect role controlling multiple were summarized this study. processes by which advancement interacting chromatin, proteins at epigenetic, transcriptional, post-transcriptional levels examined. This critical review also highlights recent breakthroughs lncRNA signaling progression, shedding light on potential applications diagnosis therapy.

Язык: Английский

Процитировано

19
The Role of Non-Coding RNAs in Liver Disease, Injury, and Regeneration DOI Creative Commons

Melissa M. Rowe,

Klaus H. Kaestner

Cells, Год журнала: 2023, Номер 12(3), С. 359 - 359

Опубликована: Янв. 18, 2023

Non-coding RNAs (ncRNAs) have diverse functions in health and pathology many tissues, including the liver. This review highlights important microRNAs (miRs), long non-coding (lncRNAs), circular (circRNAs) liver disease regeneration. Greater attention is given to more prevalent well characterized RNAs, including: miR-122, miR-21, let-7 family of miRs, miR-451a, miR-144, MALAT1.

Язык: Английский

Процитировано

11
The role of lncRNA-mediated ceRNA regulatory networks in liver fibrosis DOI Creative Commons

Jianhao Jiang,

Ilgiz Gareev,

Tatiana Ilyasova

и другие.

Non-coding RNA Research, Год журнала: 2024, Номер 9(2), С. 463 - 470

Опубликована: Янв. 9, 2024

In the dynamic realm of molecular biology and biomedical research, significance long non-coding RNAs (lncRNAs) acting as competing endogenous (ceRNAs) continues to grow, encompassing a broad spectrum both physiological pathological conditions. Particularly noteworthy is their pivotal role in intricate series events leading development hepatic fibrosis, where stellate cells (HSCs) play central role. Recent strides scientific exploration have unveiled involvement lncRNAs ceRNAs orchestrating activation HSCs. This not only deepens our comprehension functioning proteins, DNA, extensive array coding noncoding but also sheds light on interactions among these molecules. Furthermore, well-established ceRNA networks, involving classical between lncRNAs, microRNAs (miRNAs), messenger (mRNAs), are mere bystanders; they actively participate instigating advancing liver fibrosis. underscores pressing need for additional thorough research fully grasp potential ceRNA. The unyielding pursuit knowledge this field remains potent driving force with capacity enhance quality life numerous individuals grappling such diseases. It holds promise ushering new era precision medicine, signifying relentless dedication unraveling intricacies that could pave way transformative advancements diagnosis treatment

Язык: Английский

Процитировано

4
LncRNA SNHG14 silencing attenuates the progression of diabetic nephropathy via the miR‐30e‐5p/SOX4 axis DOI Creative Commons

YunXia Wang,

Jiajia Yang, Chun Wu

и другие.

Journal of Diabetes, Год журнала: 2024, Номер 16(6)

Опубликована: Май 16, 2024

Abstract Background Diabetic nephropathy (DN) is a diabetic complication. LncRNAs are reported to participate in the pathophysiology of DN. Here, function and mechanism lncRNA small nucleolar RNA host gene 14 ( SNHG14 ) DN were explored. Methods Streptozotocin (STZ)‐induced mouse models high glucose (HG)‐treated human mesangial cells (MCs) used detect expression. silencing plasmids applied examine on proliferation fibrosis HG‐treated MCs. Potential targets predicted using bioinformatics tools verified by luciferase reporter, pulldown, northern blotting assays. The functional role vivo was detected injection with adenoviral vector carrying sh‐ into mice. Serum creatinine, blood urea nitrogen, glucose, 24‐h proteinuria, relative kidney weight, renal pathological changes examined Results expression elevated kidneys mice inhibited HG‐stimulated bound miR‐30e‐5p upregulate SOX4 In rescue assays, elevation diminished effects MCs, reversed overexpression. studies, downregulation significantly ameliorated injuries interstitial Conclusions attenuates injury reduces fibrotic phenotype MCs via / axis. image

Язык: Английский

Процитировано

4
Hsa_circ_0010882 facilitates hepatocellular carcinoma progression by modulating M1/M2 macrophage polarization DOI
Ming Yang, Tao Yu, Li Han

и другие.

Journal of Viral Hepatitis, Год журнала: 2024, Номер 31(4), С. 189 - 196

Опубликована: Янв. 18, 2024

Abstract Hepatocellular carcinoma (HCC) is one common malignant tumour with a high immunosuppressive microenvironment and poor outcomes. This study investigated the influence of hsa_circ_0010882 on M1/M2 macrophage polarization in progression HCC. A total 125 paired tissue specimens from HCC patients who underwent hepatectomy were collected. M1 M2 phenotypes macrophages induced using THP‐1. After co‐cultured transfected cells, viability, migration invasion cells detected by cellular experiments. Bioinformatic databases dual‐luciferase reporter assays used to predict validate interaction between circ_0010882 miR‐382. Expression was increased tissues associated shorter overall survival The mRNA expression markers Arg‐1, CD163 CD206 elevated tissues. Interfering M1‐type (TNF‐α iNOS) while decreasing M2‐type (Arg‐1 CD206). Silencing strengthened capacity suppress cell capacities potential reducing ability promote above abilities. MiR‐382 direct target miRNA circ_0010882. prognosis patients. inhibits regulating miR‐382 expression. Circ_0010882 may serve as biomarker provide novel strategies for treatment patient rehabilitation, thereby improving

Язык: Английский

Процитировано

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