Exploring ncRNA-mediated pathways in sepsis-induced pyroptosis
Pathology - Research and Practice,
Год журнала:
2024,
Номер
256, С. 155224 - 155224
Опубликована: Фев. 23, 2024
Язык: Английский
LncRNA SNHG1: A novel biomarker and therapeutic target in hepatocellular carcinoma
Gene,
Год журнала:
2025,
Номер
unknown, С. 149462 - 149462
Опубликована: Апрель 1, 2025
Язык: Английский
Recent advances in the reciprocal regulation of m6A modification with non-coding RNAs and its therapeutic application in acute myeloid leukemia
Pharmacology & Therapeutics,
Год журнала:
2024,
Номер
259, С. 108671 - 108671
Опубликована: Июнь 1, 2024
Язык: Английский
Epigenetic regulation on fungal disease affecting plant-based food: A review from the perspectives of host, pathogen and their interactions
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106633 - 106633
Опубликована: Апрель 1, 2025
Язык: Английский
ZC3H13‐induced the m6A modification of hsa_circ_0081723 promotes cervical cancer progression via AMPK/p53 pathway
Journal of Obstetrics and Gynaecology Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 30, 2024
Abstract
Background
N6‐methyladenosine
(m6A)
modification
and
circular
RNAs
(circRNAs)
have
been
confirmed
to
participate
in
cervical
cancer
(CC)
progression.
However,
the
function
of
a
novel
circRNA,
hsa_circ_0081723,
has
not
yet
explored
CC.
Therefore,
this
study
aimed
investigate
potential
role
hsa_circ_0081723
its
m6A
Methods
The
ZC3H13
expressions
were
examined
by
qRT‐PCR
CC
tissues,
their
prognostic
significance
was
evaluated
via
Kaplan–Meier
Plotter.
progression
checked
loss‐of‐function
assays.
relative
protein
levels
AMPK/p53
pathway
determined
western
blotting.
interactions
verified
MeRIP
RNA
stability
Results
expression
elevated
samples,
higher
indicated
high
histological
grade,
FIGO
stage,
poor
differentiation,
prognosis.
Functionally,
silencing
impaired
malignant
behavior
cells
enhanced
key
molecules
AMPK
signaling
pathway.
Moreover,
also
samples
demonstrated
positive
association
with
hsa_circ_0081723.
enrichment
overexpressed
cells.
Mechanically,
overexpression
partially
reversed
antitumor
effects
caused
knockdown
Conclusions
This
innovatively
demonstrates
that
ZC3H13‐mediated
promotes
modulating
Our
findings
may
contribute
understanding
molecular
mechanisms
underlying
offer
therapeutic
targets
for
clinical
treatment.
Язык: Английский
RNA methylase RBM15 facilitates malignant progression of colorectal cancer through regulating E2F2 in an m6A modification‐dependent manner
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2024,
Номер
38(11)
Опубликована: Окт. 15, 2024
Recently,
RBM15
has
emerged
as
an
oncogenic
factor
in
a
majority
of
tumors.
However,
the
mechanism
is
unclear
that
accounts
for
how
RBM15-induces
colorectal
cancer
(CRC)
progression
and
it
need
further
study.
We
determined
expression
through
UALCAN
database
RT-qPCR.
The
role
inducing
malignant
aggressive
cancerous
phenotype
was
characterized
based
on
results
western
blot,
RT-qPCR,
CCK-8
transwell
assays.
target
genes
were
screened
by
LinkedOmics.
m6A
methylation
kit
applied
to
analyze
levels
mRNA.
SRAMP
website
employed
predict
sites
targeted
RIP,
dual
luciferase
reporter
gene
actinomycin
D
assay
conducted
verify
interactions
between
its
gene,
presence
modification
site
mRNA,
respectively.
confirmed
augmentation
CRC,
which
also
high
clinical
diagnostic
value
CRC.
Functionally,
silencing
clearly
restrained
cellular
processes
CRC
cells.
Mechanistically,
bound
E2F2
increased
binding
stabilized
corresponding
mRNA
formation.
Excessive
largely
restored
repression
tumor
cells
caused
silencing.
regulated
modification-dependent
manner
thereby
boosting
RBM15/E2F2
axis
may
be
novel
therapy.
Язык: Английский
Base on the Cancer Genome Atlas prognostic for grade II and III glioma
Опубликована: Янв. 19, 2024
Abstract:
Our
objective
is
to
establish
a
prognostic
nomogram
model
that
can
assist
clinical
professionals
in
making
precise
predictions
about
the
prognosis
of
glioma.
We
retrieved
data
on
glioma
patients
from
Cancer
Genome
Atlas
(TCGA)
database
and
utilized
Cox
proportional
hazard
analysis
construct
model.
For
validation,
we
bootstrap
resampling
method,
generating
1000
iterations.
The
were
subsequently
divided
into
high-
low-risk
categories
based
median
risk
score.
Kaplan-Meier(K-M)
survival
was
executed
for
both
cohorts,
model's
evaluation
encompassed
concordance
index
(C-index),
receiver
operating
characteristic
(ROC)
curve,
calibration
3-year
5-year
overall
(OS)
rates.
During
multivariate
regression
analysis,
age
group
60-69
years
demonstrated
significant
level
(P
=
0.014),
while
70
above
showed
0.022).
Additionally,
pathological
stage
had
impact
outcome.
K-M
cohorts
indicated
difference
0.00024)
log
rank
test.
confidence
intervals
estimated
at
0.780
(0.678-0.882).
ROC
curve
exhibited
coverage
area
0.746
rates
0.824
In
addition,
model,
conducted
through
samplings,
strong
between
predicted
actual
values.
Gliomas
exhibit
notable
association
stage,
age,
OS.
Individuals
aged
with
high
experience
lower
rate.
Furthermore,
our
developed
not
only
capable
accurately
predicting
but
also
serves
as
valuable
tool
diagnosis
treatment
decisions.
Язык: Английский