Base on the Cancer Genome Atlas prognostic for grade II and III glioma DOI
Yanfeng Li, Hui Xie

Published: Jan. 19, 2024

Abstract: Our objective is to establish a prognostic nomogram model that can assist clinical professionals in making precise predictions about the prognosis of glioma. We retrieved data on glioma patients from Cancer Genome Atlas (TCGA) database and utilized Cox proportional hazard analysis construct model. For validation, we bootstrap resampling method, generating 1000 iterations. The were subsequently divided into high- low-risk categories based median risk score. Kaplan-Meier(K-M) survival was executed for both cohorts, model's evaluation encompassed concordance index (C-index), receiver operating characteristic (ROC) curve, calibration 3-year 5-year overall (OS) rates. During multivariate regression analysis, age group 60-69 years demonstrated significant level (P = 0.014), while 70 above showed 0.022). Additionally, pathological stage had impact outcome. K-M cohorts indicated difference 0.00024) log rank test. confidence intervals estimated at 0.780 (0.678-0.882). ROC curve exhibited coverage area 0.746 rates 0.824 In addition, model, conducted through samplings, strong between predicted actual values. Gliomas exhibit notable association stage, age, OS. Individuals aged with high experience lower rate. Furthermore, our developed not only capable accurately predicting but also serves as valuable tool diagnosis treatment decisions.

Language: Английский

Exploring ncRNA-mediated pathways in sepsis-induced pyroptosis DOI
Asif Ahmad Bhat, Yassine Riadi, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155224 - 155224

Published: Feb. 23, 2024

Language: Английский

Citations

6
LncRNA SNHG1: A novel biomarker and therapeutic target in hepatocellular carcinoma DOI
Zhou Fang, Yong Pan,

Zhengmei Lu

et al.

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149462 - 149462

Published: April 1, 2025

Language: Английский

Citations

0
Epigenetic regulation on fungal disease affecting plant-based food: A review from the perspectives of host, pathogen and their interactions DOI
Yan-Ling Ren,

Linyan Feng,

Xin Xu

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106633 - 106633

Published: April 1, 2025

Language: Английский

Citations

0
Recent advances in the reciprocal regulation of m6A modification with non-coding RNAs and its therapeutic application in acute myeloid leukemia DOI

Jiawang Yang,

Liang Feng, Fenglin Zhang

et al.

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 259, P. 108671 - 108671

Published: June 1, 2024

Language: Английский

Citations

3
RNA methylase RBM15 facilitates malignant progression of colorectal cancer through regulating E2F2 in an m6A modification‐dependent manner DOI Open Access

Huijun Zhang,

Yuan Li, Ying Zhou

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(11)

Published: Oct. 15, 2024

Recently, RBM15 has emerged as an oncogenic factor in a majority of tumors. However, the mechanism is unclear that accounts for how RBM15-induces colorectal cancer (CRC) progression and it need further study. We determined expression through UALCAN database RT-qPCR. The role inducing malignant aggressive cancerous phenotype was characterized based on results western blot, RT-qPCR, CCK-8 transwell assays. target genes were screened by LinkedOmics. m6A methylation kit applied to analyze levels mRNA. SRAMP website employed predict sites targeted RIP, dual luciferase reporter gene actinomycin D assay conducted verify interactions between its gene, presence modification site mRNA, respectively. confirmed augmentation CRC, which also high clinical diagnostic value CRC. Functionally, silencing clearly restrained cellular processes CRC cells. Mechanistically, bound E2F2 increased binding stabilized corresponding mRNA formation. Excessive largely restored repression tumor cells caused silencing. regulated modification-dependent manner thereby boosting RBM15/E2F2 axis may be novel therapy.

Language: Английский

Citations

1
ZC3H13‐induced the m6A modification of hsa_circ_0081723 promotes cervical cancer progression via AMPK/p53 pathway DOI
Qiong Wei, Yi Yang, Chun Li

et al.

Journal of Obstetrics and Gynaecology Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

Abstract Background N6‐methyladenosine (m6A) modification and circular RNAs (circRNAs) have been confirmed to participate in cervical cancer (CC) progression. However, the function of a novel circRNA, hsa_circ_0081723, has not yet explored CC. Therefore, this study aimed investigate potential role hsa_circ_0081723 its m6A Methods The ZC3H13 expressions were examined by qRT‐PCR CC tissues, their prognostic significance was evaluated via Kaplan–Meier Plotter. progression checked loss‐of‐function assays. relative protein levels AMPK/p53 pathway determined western blotting. interactions verified MeRIP RNA stability Results expression elevated samples, higher indicated high histological grade, FIGO stage, poor differentiation, prognosis. Functionally, silencing impaired malignant behavior cells enhanced key molecules AMPK signaling pathway. Moreover, also samples demonstrated positive association with hsa_circ_0081723. enrichment overexpressed cells. Mechanically, overexpression partially reversed antitumor effects caused knockdown Conclusions This innovatively demonstrates that ZC3H13‐mediated promotes modulating Our findings may contribute understanding molecular mechanisms underlying offer therapeutic targets for clinical treatment.

Language: Английский

Citations

1
Base on the Cancer Genome Atlas prognostic for grade II and III glioma DOI
Yanfeng Li, Hui Xie

Published: Jan. 19, 2024

Abstract: Our objective is to establish a prognostic nomogram model that can assist clinical professionals in making precise predictions about the prognosis of glioma. We retrieved data on glioma patients from Cancer Genome Atlas (TCGA) database and utilized Cox proportional hazard analysis construct model. For validation, we bootstrap resampling method, generating 1000 iterations. The were subsequently divided into high- low-risk categories based median risk score. Kaplan-Meier(K-M) survival was executed for both cohorts, model's evaluation encompassed concordance index (C-index), receiver operating characteristic (ROC) curve, calibration 3-year 5-year overall (OS) rates. During multivariate regression analysis, age group 60-69 years demonstrated significant level (P = 0.014), while 70 above showed 0.022). Additionally, pathological stage had impact outcome. K-M cohorts indicated difference 0.00024) log rank test. confidence intervals estimated at 0.780 (0.678-0.882). ROC curve exhibited coverage area 0.746 rates 0.824 In addition, model, conducted through samplings, strong between predicted actual values. Gliomas exhibit notable association stage, age, OS. Individuals aged with high experience lower rate. Furthermore, our developed not only capable accurately predicting but also serves as valuable tool diagnosis treatment decisions.

Language: Английский

Citations

0