Potential Candidate Genes Associated with Litter Size in Goats: A Review
Animals,
Год журнала:
2025,
Номер
15(1), С. 82 - 82
Опубликована: Янв. 2, 2025
This
review
examines
genetic
markers
associated
with
litter
size
in
goats,
a
key
reproductive
trait
impacting
productivity
small
ruminant
farming.
Goats
play
vital
socioeconomic
role
both
low-
and
high-income
regions;
however,
their
remains
limited
due
to
low
efficiency.
Litter
size,
influenced
by
multiple
genes
environmental
factors,
directly
affects
farm
profitability
sustainability
increasing
the
output
per
breeding
cycle.
Recent
advancements
research
have
identified
pathways
traits,
including
gonadotropin-releasing
hormone
(GnRH),
inhibin
(INHAA),
Kit
ligand
(KITLG),
protein
phosphatase
3
catalytic
subunit
alpha
(PPP3CA),
prolactin
receptor
(PRLR),
POU
domain
class
1
transcription
factor
(POU1F1),
anti-Müllerian
(AMH),
bone
morphogenetic
proteins
(BMP),
growth
differentiation
9
(GDF9),
KISS1
suppressor
of
mothers
against
decapentaplegic
(SMAD)
family
genes,
among
others.
These
regulate
crucial
physiological
processes
such
as
folliculogenesis,
synthesis,
ovulation.
Genome-wide
association
studies
(GWASs)
transcriptomic
analyses
pinpointed
specific
linked
increased
highlighting
potential
selective
programs.
By
incorporating
genomic
data,
strategies
can
achieve
higher
selection
accuracy,
accelerate
gains,
improve
emphasizes
importance
optimizing
promoting
sustainable
goat
Язык: Английский
Population Structure and Selection Signal Analysis of Nanyang Cattle Based on Whole-Genome Sequencing Data
Genes,
Год журнала:
2024,
Номер
15(3), С. 351 - 351
Опубликована: Март 11, 2024
With
a
rich
breeding
history,
Nanyang
cattle
(NY
cattle)
have
undergone
extensive
natural
and
artificial
selection,
resulting
in
distinctive
traits
such
as
high
fertility,
excellent
meat
quality,
disease
resistance.
This
makes
them
an
ideal
model
for
studying
the
mechanisms
of
environmental
adaptability.
To
assess
population
structure
genetic
diversity
NY
cattle,
we
performed
whole-genome
resequencing
on
30
individuals.
These
data
were
then
compared
with
published
from
432
globally.
The
results
indicate
that
is
significantly
different
European
commercial
breeds
more
similar
to
North–Central
Chinese
breeds.
Furthermore,
among
all
breeds,
exhibit
highest
lowest
inbreeding
levels.
A
genome-wide
selection
signal
analysis
using
Fst,
θπ-ratio,
θπ
methods
revealed
significant
signals
genes
associated
reproductive
performance
immunity.
Our
functional
annotation
suggests
these
may
be
responsible
reproduction
(MAP2K2,
PGR,
GSE1),
immune
response
(NCOA2,
HSF1,
PAX5),
olfaction
(TAS1R3).
We
provide
comprehensive
overview
sequence
variations
genome,
revealing
insights
into
cattle.
Additionally,
identify
candidate
important
economic
traits,
offering
valuable
references
future
conservation
efforts
Язык: Английский
Differential Expression of lncRNAs in Ovarian Tissue of Meigu Goats During the Sexually Immature and Mature Periods
Current Issues in Molecular Biology,
Год журнала:
2025,
Номер
47(6), С. 395 - 395
Опубликована: Май 26, 2025
The
ovary
is
the
primary
reproductive
organ
in
goats,
and
its
development
significantly
influences
sexual
maturity
capacity
of
individuals.
Long
non-coding
RNAs
(lncRNAs)
are
integral
to
a
wide
array
biological
processes.
However,
regulatory
function
lncRNAs
ovarian
tissue
during
goats
remains
largely
unexplored.
In
this
study,
we
conducted
RNA
sequencing
on
samples
from
Meigu
at
sexually
immature
(3
months,
n
=
3)
mature
periods
(6
3).
We
identified
total
966
across
six
libraries,
with
95
exhibiting
differential
expression.
Additionally,
target
genes
these
DElncRNAs.
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
enrichment
analyses
indicated
that
were
associated
various
processes
pathways
pertinent
development,
including
reproduction,
process,
JAK-STAT
signaling
pathway,
progesterone-mediated
oocyte
maturation,
Wnt
cytokine–cytokine
receptor
interaction.
Furthermore,
lncRNA–mRNA
interaction
network
analysis
suggested
MSTRG.15120.9
MSTRG.15110.2
play
crucial
roles
development.
This
study
provides
valuable
resource
for
elucidating
molecular
mechanisms
period
goats.
Язык: Английский
Pituitary whole transcriptome analysis reveals key genes regulating reproduction in Hy-Line Brown hens and the construction of their ceRNA molecular regulatory network
BMC Genomics,
Год журнала:
2024,
Номер
25(1)
Опубликована: Ноя. 18, 2024
The
development
and
egg-laying
performance
of
hens
are
precisely
regulated
by
hormones
secreted
the
pituitary.
In
this
study,
we
performed
comprehensive
transcriptome
sequencing
pituitary
from
Hy-Line
Brown
at
15,
20,
30
68
W
age.
Through
association
analysis,
identified
key
genes
ceRNA
regulatory
networks
related
to
egg
production.
Based
on
data,
470
differentially
expressed
lncRNAs
(DE-lncRNAs),
38
miRNAs
(DE-miRNAs),
2,449
mRNAs
(DE-mRNAs).
Time-series
analysis
pinpointed
signaling
pathways
that
significantly
influence
hormone
secretion
various
stages.
At
15
W,
high
expression
GHRHR,
NPY1R,
TSHR
in
supports
growth.
20
elevated
GNRHR
sustains
continuous
late
laying
period,
PRL
may
lead
a
decline
Additionally,
enabled
construction
network
involving
non-coding
RNAs
regulate
reproduction
hens.
This
study
elucidated
profiles
gland
during
processes
constructed
associated
molecular
networks.
These
findings
lay
foundation
for
investigating
mechanisms
which
secretion.
Язык: Английский