The Indissociable Triad: Vascular Impairment, Muscle Atrophy, and Cognitive Decline

Опубликована: Авг. 12, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating mass reduction seen in sarcopenia the neuronal functions characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review ana-lyzes interrelated mechanisms contribute to these conditions, with a specific focus on ox-idative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting sar-copenia characterized by atrophy weakness. dysfunction have negative physical function quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing oxidative in-flammation, integrated therapies improving muscular well-being. Better links can refine strategies yield better patient out-comes. study emphasizes complex interplay between dysfunction, de-generation, decline, highlighting necessity for multidisciplinary ap-proaches. Advances domain promise improved diagnostic accuracy, more thera-peutic options, enhanced preventive measures, all contributing higher life elderly population.

Язык: Английский

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Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

Biomedicines, Год журнала: 2024, Номер 12(9), С. 2096 - 2096

Опубликована: Сен. 13, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.

Язык: Английский

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Regulatory Roles of Exosomes in Aging and Aging-Related Diseases

Biogerontology, Год журнала: 2025, Номер 26(2)

Опубликована: Фев. 18, 2025

Язык: Английский

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Causal Relationship Between Circulating Metabolites and Sarcopenia‐Related Traits: A Mendelian Randomization and Experimental Study

Food Science & Nutrition, Год журнала: 2025, Номер 13(1)

Опубликована: Янв. 1, 2025

ABSTRACT Sarcopenia (SP), an age‐associated condition marked by muscle weakness and loss has been strongly connected with metabolic factors according to substantial evidence. Nevertheless, the causal correlation between SP serum metabolites, biological signaling pathways involved, is still not well understood. We performed a bidirectional two‐sample Mendelian randomization (MR) analysis examine relationships 1091 levels 309 ratios of metabolites traits, alongside investigating relevant pathways. Additionally, we explored differential expression plasma potential in animal model SP. When was utilized as outcome, identified 11 robust associations seven metabolite levels/ratios SP‐related traits using Bonferroni's correction (threshold: p < 0.05). verified stable association glycine validation. As for reverse MR analysis, there were strong remaining after multiple contrast correction. pathway showed that metabolism, insulin resistance, cAMP may contribute connection validation various datasets observations metabolomics suggests metabolism Our results indicate biosignaling could serve important circulatory biomarkers screening prevention clinical settings. they represent molecules future exploration mechanisms selection drug targets.

Язык: Английский

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Empowering Physical Functions in Older Women With Sarcopenia Through Aomori Gymnastics: A Prospective, Observational, Nested Case-Control Study in Aomori Prefecture

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Japan faces rapid population aging, resulting in significant health challenges such as sarcopenia and frailty, which affect the independence quality of life older adults. This study evaluated effectiveness Aomori gymnastics, a culturally tailored exercise program, improving physical function women with sarcopenia, over three-month period. prospective observational included 24 divided into three groups based on their living conditions: community-dwelling participants attending preventive care programs (Groups 1 2) residents long-term facility (Group 3). The performed gymnastics daily for months. Physical was assessed at baseline, month, months using Short Performance Battery (SPPB), grip strength, curl-ups, forward bend from long sitting position, one-leg stance, 10-m walk tests. Data were analyzed generalized linear mixed models Mann-Whitney U test. Significant improvements SPPB scores observed between non-sarcopenia baseline one month (p < .05), these differences not Participants showed marked improvement function, approaching level those without after exercise. Adherence higher among than participants, is likely due to severe winter weather Prefecture. an effective low-cost intervention that can significantly improve sarcopenia. Implementing this program communities facilities enhance adults, particularly regions harsh conditions.

Язык: Английский

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miR-34a-5p/MARCHF8/ADAM10 axis in the regulation of vascular endothelial cell dysfunction and senescence

Mechanisms of Ageing and Development, Год журнала: 2025, Номер 225, С. 112060 - 112060

Опубликована: Апрель 11, 2025

Язык: Английский

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Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Abstract Aging is a complex biological process that detrimentally affects the brain and cerebrovascular system, contributing to pathogenesis of age-related diseases like vascular cognitive impairment dementia (VCID) Alzheimer’s disease (AD). While cell-autonomous mechanisms occur within cells, independent external signals from neighboring cells or systemic factors, account for some aspects aging, they cannot explain entire aging process. Non-autonomous, paracrine endocrine, pathways also play crucial role in orchestrating aging. The milieu modulates through pro-geronic anti-geronic circulating factors mediate decline confer rejuvenative effects. This review explores impact on with particular focus findings heterochronic parabiosis, blood exchange, plasma transfer experiments. We discuss how these influence fundamental cellular molecular processes endothelial function, neurovascular coupling mechanisms, blood–brain barrier integrity, neuroinflammation, capillary density, amyloid pathologies, significant consequences function. Additionally, we address translational potential challenges modifying promote health prevent impairment.

Язык: Английский

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Lumican Is Both a Novel Risk Factor and Potential Plasma Biomarker for Vascular Aging, Capable of Promoting Vascular Smooth Cells Senescence Through Interacting With Integrin α2β1

The Journals of Gerontology Series A, Год журнала: 2024, Номер 80(1)

Опубликована: Авг. 27, 2024

Abstract Vascular aging, a common pathogenesis of senile chronic diseases, significantly increases morbidity and mortality in older adults; its intricate cellular molecular mechanisms necessitate further investigation. Lumican (LUM) integrin α2β1 are profibrotic extracellular matrix proteins vital cell regulatory receptors, respectively. However, their roles vascular aging remain unclear. This study sought to elucidate the connection between LUM as well biological mechanism LUM/integrin this process. Using an enzyme-linked immunosorbent assay, we discovered that plasma was elevated individuals positively correlated with brachial-ankle pulse wave velocity. Additionally, immunohistochemical Western blot analyses confirmed upregulation arteries adults aged mice, senescent smooth cells (VSMCs). Wild-type semiknockout (Lum−/+) along primary VSMCs extracted from these were exposed angiotensin II induce stress-induced senescence model. mitigated II-induced arteriosclerosis, hypertension, remodeling mice. Both vitro vivo studies revealed deficiency suppressed p53, p21, collagen 1, 3 synthetic phenotype formation stimulated by II. Treating antagonist reversed aforementioned changes triggered proteins. Briefly, functions potential marker risk factor for promotes pathological affecting VSMCs. introduces novel target early diagnosis treatment age-related diseases.

Язык: Английский

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Causality of multiple serum metabolites on emotional lability: A two-sample Mendelian randomization study

Journal of Affective Disorders, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Causal Associations with Arterial Stiffness and Sarcopenia: A Mendelian Randomization Analysis

Rejuvenation Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

Observational studies and clinical trials indicate a link between arterial stiffness (AS) sarcopenia (SAR), yet the causal relationship these remains unclear. The study aims to investigate connection from AS SAR by Mendelian randomization (MR). We analyzed Genome-Wide Association Studies data for indicators: pulse wave index (PWASI) peak-to-peak time (PPT), low hand grip strength (LHGS), usual walking pace (UWP), moderate-to-vigorous physical activity levels (MVPA), walk or cycle unassisted 10 minutes. inverse variance-weighted, MR-Egger, weighted mode, median were applied MR. There is bidirectional SAR. PWASI has causation with UWP (odds ratio [OR] = 0.97, 95% confidence interval [CI] 0.94-0.99). PPT association MVPA (OR 1.08, CI 1.002-1.144) 1.05, 1.017-1.096). LHGS causally associated 0.95, 0.91-0.98) 0.77, 0.65-0.90) 1.37, 1.17-1.60). increased could reduce motor ability slightly lower upper limb lead higher AS. This of two may offer novel perspectives advancing understanding underlying mechanisms related muscle pathophysiology.

Язык: Английский

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