EBioMedicine, Год журнала: 2022, Номер 84, С. 104286 - 104286
Опубликована: Сен. 27, 2022
Alterations in the gut microbiome have been associated with HIV infection, but relative impact of versus other factors on has difficult to determine cross-sectional studies.
Язык: Английский
Frontiers in Immunology, Год журнала: 2020, Номер 11
Опубликована: Июль 22, 2020
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia or insulin resistance and obesity play key roles in the induction progression of type 2 diabetes mellitus (T2DM). The field immunometabolism implies a bidirectional link between immune system metabolism, which inflammation plays an essential role promotion metabolic (e.g. T2DM), factors, turn, regulate cell functions. Obesity main inducer systemic low-level is susceptibility factor for T2DM. Obesity-related infiltration, increased oxidative stress promote impairments insulin-sensitive tissues finally, resistance, organ failure premature aging occur. Hyperglycemia subsequent are causes micro- macroangiopathies circulatory system. They also gut microbiota dysbiosis, intestinal permeability fatty liver disease. impaired together with imbalance increases patients to several pathogenic agents severe acute respiratory syndrome coronavirus (SARS-CoV-2). Thus, need proper immunization protocol among granted. focus current review explore immunological affecting organs T2DM explain mechanisms, whereby diabetic become more susceptible infectious diseases.
Язык: Английский
Процитировано
440
Nature Medicine, Год журнала: 2022, Номер 28(2), С. 315 - 324
Опубликована: Фев. 1, 2022
Язык: Английский
Процитировано
408
Nature, Год журнала: 2022, Номер 608(7921), С. 168 - 173
Опубликована: Июль 27, 2022
Abstract Multiple studies have established associations between human gut bacteria and host physiology, but determining the molecular mechanisms underlying these has been challenging 1–3 . Akkermansia muciniphila robustly associated with positive systemic effects on metabolism, favourable outcomes to checkpoint blockade in cancer immunotherapy homeostatic immunity 4–7 Here we report identification of a lipid from A. ’s cell membrane that recapitulates immunomodulatory activity cell-based assays 8 The isolated immunogen, diacyl phosphatidylethanolamine two branched chains (a15:0-i15:0 PE), was characterized through both spectroscopic analysis chemical synthesis. immunogenic a15:0-i15:0 PE highly restricted structure–activity relationship, its immune signalling requires an unexpected toll-like receptor TLR2–TLR1 heterodimer 9,10 Certain features phospholipid’s are worth noting: it is significantly less potent than known natural synthetic TLR2 agonists; preferentially induces some inflammatory cytokines not others; and, at low doses (1% EC 50 ) resets activation thresholds responses for signalling. Identifying molecule equipotent analogue, non-canonical pathway, selectivity low-dose immunoregulatory provide mechanism model muciniphila’ s ability set immunological tone varied roles health disease.
Язык: Английский
Процитировано
244
Gut, Год журнала: 2018, Номер 68(3), С. 453 - 464
Опубликована: Июль 31, 2018
Objective The consumption of fruits is strongly associated with better health and higher bacterial diversity in the gut microbiota (GM). Camu camu ( Myrciaria dubia ) an Amazonian fruit a unique phytochemical profile, strong antioxidant potential purported anti-inflammatory potential. Design By using metabolic tests coupled 16S rRNA gene-based taxonomic profiling faecal microbial transplantation (FMT), we have assessed effect crude extract (CC) on obesity immunometabolic disorders high fat/high sucrose (HFHS)-fed mice. Results Treatment HFHS-fed mice CC prevented weight gain, lowered fat accumulation blunted inflammation endotoxaemia. CC-treated displayed improved glucose tolerance insulin sensitivity were also fully protected against hepatic steatosis. These effects linked to increased energy expenditure upregulation uncoupling protein 1 mRNA expression brown adipose tissue (BAT) mice, which correlated membrane bile acid (BA) receptor TGR5. Moreover, showed altered plasma BA pool size composition drastic changes GM (eg, bloom Akkermansia muciniphila reduction Lactobacillus ). Germ-free (GF) reconstituted gained less than GF-mice colonised FM HFHS controls. Conclusion Our results show that prevents visceral liver deposition through BAT activation expenditure, mechanism dependent major composition.
Язык: Английский
Процитировано
241
Pharmacological Research, Год журнала: 2021, Номер 171, С. 105767 - 105767
Опубликована: Июль 14, 2021
Язык: Английский
Процитировано
135
CNS Neuroscience & Therapeutics, Год журнала: 2022, Номер 29(1), С. 140 - 157
Опубликована: Окт. 25, 2022
Abstract Introduction Recent advances have highlighted the relationships between gut dysbiosis and Parkinson's disease (PD). Microbiota transplantation from PD patients to mice can induce increased alpha‐synuclein‐mediated motor deficits. Human studies identified differences in microbiota of compared healthy controls. We undertook a systematic review evaluate available evidence for involvement bacteria etiology PD. Methods The PubMed databank, China National Knowledge Infrastructure Wanfang Data were searched inception until June 2021 identify human case–control that investigated quantified feces. evaluated resulting focusing on bacterial taxa different Results Twenty‐six found which 53 microbial families 98 genera exhibited with by more than two as Bifidobacterium , Alistipes Christensenella Enterococcus Oscillospira Bilophila Desulfovibrio Escherichia/Shigella Akkermansia while Prevotella Blautia Faecalibacterium Fusicatenibacter Haemophilus had three or reports being lower patients. More one report demonstrated Bacteroides Odoribacter Parabacteroides Butyricicoccus Butyrivibrio Clostridium Coprococcus Lachnospira Lactobacillus Megasphaera Phascolarctobacterium Roseburia Ruminococcus Streptococcus Klebsiella altered both directions. Conclusion Our shows microbiome may involve alterations short‐chain fatty acids (SCFAs)‐producing an increase putative pathobionts. SCFAs‐producing vary above below “optimal range,” causing imbalances. Considering are beneficial health, be associated medications, especially COMT inhibitors, high level aging.
Язык: Английский
Процитировано
106
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 3900 - 3900
Опубликована: Фев. 15, 2023
Appreciation of the importance Akkermansia muciniphila is growing, and it becoming increasingly relevant to identify preventive and/or therapeutic solutions targeting gut–liver–brain axes for multiple diseases via muciniphila. In recent years, its components such as outer membrane proteins extracellular vesicles have been known ameliorate host metabolic health intestinal homeostasis. However, impacts on disease are complex, both potentially beneficial adverse effects mediated by derivatives, in some cases, these dependent upon physiology microenvironment forms, genotypes, strain sources Therefore, this review aims summarize current knowledge how interacts with influences homeostasis progression. Details will be discussed including biological genetic characteristics; functions anti-obesity, anti-diabetes, anti-metabolic-syndrome, anti-inflammation, anti-aging, anti-neurodegenerative disease, anti-cancer therapy functions; strategies elevate abundance. Key events referred specific states, should facilitate identification muciniphila-based probiotic axes.
Язык: Английский
Процитировано
86
Microorganisms, Год журнала: 2022, Номер 10(12), С. 2382 - 2382
Опубликована: Ноя. 30, 2022
Probiotics and synbiotics are used to treat chronic illnesses due their roles in immune system modulation anti-inflammatory response. They have been shown reduce inflammation a number of immune-related disorders, including systemic lupus erythematosus (SLE), human immunodeficiency virus (HIV), inflammatory skin conditions such as psoriasis atopic dermatitis (AD). Akkermansia muciniphila (A. muciniphila) Faecalibacterium prausnitzii (F. prausnitzii) two different types bacteria that play significant part this function. It has established abundant normal populations protective benefits on digestive health while also enhancing the system, metabolism, gut barrier host. potential be therapeutic target diseases connected microbiota, immunological disorders cancer immunotherapy. There not review effects Faecalibacterium, particularly diseases. In review, we highlight most recent scientific findings regarding A. F. microbiota for microbiome alterations seek provide cutting-edge insight terms microbiome-targeted therapies promising preventive tools
Язык: Английский
Процитировано
77
Frontiers in Oncology, Год журнала: 2021, Номер 11
Опубликована: Авг. 19, 2021
The influence of microbiota on host health and disease has attracted adequate attention, gut components microbiota-derived metabolites affect immune homeostasis locally systematically. Some studies have found that dysbiosis, disturbance the structure function microbiome, disrupts pulmonary homeostasis, thus leading to increased susceptibility; gut-lung axis is primary cross-talk for this communication. Gut dysbiosis involved in carcinogenesis progression lung cancer through genotoxicity, systemic inflammation, defective immunosurveillance. In addition, microbiome harbors potential be a novel biomarker predicting sensitivity adverse reactions immunotherapy patients with cancer. Probiotics fecal transplantation (FMT) can enhance efficacy depress toxicity checkpoint inhibitors by regulating microbiota. Although current closely participates development cancer, mechanisms require further investigation. Therefore, review aims discuss underlying influencing provide new strategies governing prevention treatment
Язык: Английский
Процитировано
79
Journal of Molecular Endocrinology, Год журнала: 2022, Номер 69(3), С. R81 - R94
Опубликована: Июль 18, 2022
The gut microbiome is considered an endocrine organ that can influence distant organs and associated biological pathways. Recent advances suggest microbial homeostasis essential for reproductive health perturbations in the microbiota lead to pathologies. This review provides updated overview of relationship between female diseases. Specifically, we highlight most recent findings on gynecological pathologies including polycystic ovarian syndrome, endometriosis, endometrial cancer. Most studies revealed associations altered compositions these diseases, though few have suggested cause-effect relationships. Future should focus determining molecular mechanisms underlying Understanding this bidirectional could development novel effective strategies prevent, diagnose, treat organ-related
Язык: Английский
Процитировано
63