Faecalibacterium: a bacterial genus with promising human health applications

FEMS Microbiology Reviews, Год журнала: 2023, Номер 47(4)

Опубликована: Июль 1, 2023

Abstract In humans, many diseases are associated with alterations in gut microbiota, namely increases or decreases the abundance of specific bacterial groups. One example is genus Faecalibacterium. Numerous studies have underscored that low levels Faecalibacterium correlated inflammatory conditions, bowel disease (IBD) forefront. Its representation also diminished case several diseases, including colorectal cancer (CRC), dermatitis, and depression. Additionally, relative presence this considered to reflect, at least part, intestinal health status because frequently present reduced individuals gastrointestinal disorders. review, we first thoroughly describe updates taxonomy Faecalibacterium, which has transformed a single-species taxon multispecies over last decade. We then explore links discovered between various since IBD-focused were published. Next, examine current available strategies for modulating gut. Finally, summarize mechanisms underlying beneficial effects been attributed genus. Together, epidemiological experimental data strongly support use as next-generation probiotic (NGP) live biotherapeutic product (LBP).

Язык: Английский

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Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease

Nutrients, Год журнала: 2023, Номер 15(20), С. 4466 - 4466

Опубликована: Окт. 21, 2023

The gut microbiome is a diverse bacterial community in the human gastrointestinal tract that plays important roles variety of biological processes. Short-chain fatty acids (SCFA) are produced through fermentation dietary fiber. Certain microbes responsible for producing SCFAs such as acetate, propionate and butyrate. An imbalance diversity can lead to metabolic disorders inflammation-related diseases. Changes SCFA levels associated microbiota were observed IBD, suggesting an association between disease. affect reactive oxygen species (ROS) with IBD. Gut closely related it study them further.

Язык: Английский

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The influence of Akkermansia muciniphila on intestinal barrier function

Gut Pathogens, Год журнала: 2024, Номер 16(1)

Опубликована: Авг. 3, 2024

Intestinal barriers play a crucial role in human physiology, both homeostatic and pathological conditions. Disruption of the intestinal barrier is significant factor pathogenesis gastrointestinal inflammatory diseases, such as bowel disease. The profound influence gut microbiota on diseases has sparked considerable interest manipulating it through dietary interventions, probiotics, fecal transplantation potential approaches to enhance integrity barrier. Numerous studies have underscored protective effects specific their associated metabolites. In recent years, an increasing body research demonstrated that Akkermansia muciniphila (A. muciniphila, Am) plays beneficial various including diabetes, obesity, aging, cancer, metabolic syndrome. It gaining popularity regulator influences flora recognized 'new generation probiotics'. Consequently, may represent target promising therapy option for diseases. This article systematically summarizes Am gut. Specifically, we carefully discuss key scientific issues need resolution future regarding bacteria represented by Am, which provide insights application drugs targeting clinical treatment.

Язык: Английский

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Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms

Journal of Advanced Research, Год журнала: 2024, Номер unknown

Опубликована: Март 1, 2024

Population aging has become a primary global public health issue, and the prevention of age-associated diseases prolonging healthy life expectancies are particular importance. Gut microbiota emerged as novel target in various host physiological disorders including aging. Comprehensive understanding on changes gut during aging, characteristics centenarians, can provide us possibility to achieving or intervene pathological through microbiota-directed strategies. This review aims summarize associated with explore potential biomarkers address microbiota-associated mechanisms focusing intestinal barrier immune status. By summarizing existing effective dietary strategies interventions, probability developing diet targeting future is provided. focused three key notions: Firstly, new for regulating status lifespan, its closely related age. Thus, we summarized aging-associated features at levels genus/species important metabolites comparing differences among elderly people younger people. Secondly, exploring discussing using regime/components targeted aging-related promote human lifespan. Thirdly, intervention effectively improve imbalance such probiotics, prebiotics, postbiotics, but their effects vary among.

Язык: Английский

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The Crucial Role of Inflammation and the Immune System in Colorectal Cancer Carcinogenesis: A Comprehensive Perspective

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 6188 - 6188

Опубликована: Июнь 4, 2024

Chronic inflammation drives the growth of colorectal cancer through dysregulation molecular pathways within immune system. Infiltration cells, such as macrophages, into tumoral regions results in release proinflammatory cytokines (IL-6; IL-17; TNF-α), fostering tumor proliferation, survival, and invasion. Tumors employ various mechanisms to evade surveillance, effectively ‘cloaking’ themselves from detection subsequent attack. A comprehensive understanding these intricate interactions is paramount for advancing novel strategies aimed at modulating response against cancer.

Язык: Английский

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Harnessing Gut Microbiota for Biomimetic Innovations in Health and Biotechnology

Biomimetics, Год журнала: 2025, Номер 10(2), С. 73 - 73

Опубликована: Янв. 24, 2025

The gut microbiota is a complex and dynamic ecosystem that plays fundamental role in human health by regulating immunity, metabolism, the gut–brain axis. Beyond its critical physiological functions, it has emerged as rich source of inspiration for biomimetic innovations healthcare biotechnology. This review explores transformative potential microbiota-based biomimetics, focusing on key biological mechanisms such resilience, self-regulation, quorum sensing. These have inspired development innovative applications, including personalized probiotics, synbiotics, artificial microbiomes, bioinspired biosensors, bioremediation systems. Such technologies aim to emulate optimize intricate functions microbial ecosystems, addressing challenges environmental sustainability. integration advanced technologies, intelligence, bioengineering, multi-omics approaches, further accelerated biomimetics. tools enable precision therapies tailored individual profiles, enhance efficacy diagnostic systems, facilitate design environmentally sustainable solutions, waste-to-energy systems platforms. Emerging areas innovation, gut-on-chip models synthetic biology, offer unprecedented opportunities studying applying principles controlled environments. Despite these advancements, remain. replication complexity environments, ethical concerns regarding genetically engineered microorganisms, equitable access are hurdles must be addressed. underscores importance interdisciplinary collaboration public awareness overcoming barriers ensuring responsible solutions. By leveraging biomimetics represents promising frontier approach revolutionize therapeutic strategies, redefine tools, address global challenges, paving way more personalized, efficient, future medicine

Язык: Английский

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Probiotics for Neurodegenerative Diseases: A Systemic Review

Microorganisms, Год журнала: 2023, Номер 11(4), С. 1083 - 1083

Опубликована: Апрель 20, 2023

Neurodegenerative disorders (ND) are a group of conditions that affect the neurons in brain and spinal cord, leading to their degeneration eventually causing loss function affected areas. These can be caused by range factors, including genetics, environmental lifestyle choices. Major pathological signs these diseases protein misfolding, proteosomal dysfunction, aggregation, inadequate degradation, oxidative stress, free radical formation, mitochondrial dysfunctions, impaired bioenergetics, DNA damage, fragmentation Golgi apparatus neurons, disruption axonal transport, dysfunction neurotrophins (NTFs), neuroinflammatory or neuroimmune processes, neurohumoral symptoms. According recent studies, defects imbalances gut microbiota directly lead neurological through gut-brain axis. Probiotics ND recommended prevent cognitive which is major symptom diseases. Many vivo clinical trials have revealed probiotics (Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus casei, etc.) effective candidates against progression ND. It has been proven inflammatory process stress modulated modifying with help probiotics. As result, this study provides an overview available data, bacterial variety, axis defects, probiotics’ mode action averting A literature search on particular sites, PubMed, Nature, Springer Link, identified articles might pertinent subject. The contains following few groups terms: (1) OR (2) disorders. outcomes aid elucidating relationship between effects different neurodegenerative This systematic review will assist discovering new treatments future, as generally safe cause mild side some cases human body.

Язык: Английский

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Strain-level screening of human gut microbes identifies Blautia producta as a new anti-hyperlipidemic probiotic

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Июль 5, 2023

Compelling evidence has tightly linked gut microbiota with host metabolism homeostasis and inspired novel therapeutic potentials against metabolic diseases (e.g., hyperlipidemia). However, the regulatory profile of individual bacterial species strain on lipid remains largely unknown. Herein, we performed a large-scale screening 2250 human strains (186 species) for lipid-decreasing activity. Different in same usually displayed distinct lipid-modulatory actions, showing evident strain-specificity. Among tested strains, Blautia producta exhibited most potency to suppress cellular accumulation effectively ameliorated hyperlipidemia high fat diet (HFD)-feeding mice. Taking joint comparative approach pharmacology, genomics metabolomics, identified an anteiso-fatty acid, 12-methylmyristic acid (12-MMA), as key active metabolite Bl. Producta. In vivo experiment confirmed that 12-MMA could exert potent hyperlipidemia-ameliorating efficacy improve glucose via activating G protein-coupled receptor 120 (GPR120). Altogether, our work reveals previously unreported microbes at level, emphasizes strain-specific function bacteria, provides possibility develop microbial therapeutics based its metabolite.

Язык: Английский

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Diabetes and gut microbiome

Frontiers in Microbiology, Год журнала: 2025, Номер 15

Опубликована: Янв. 7, 2025

Diabetes mellitus represents a significant global health problem. The number of people suffering from this metabolic disease is constantly rising and although the incidence heterogeneous depending on region, country, economic situation, lifestyle, diet level medical care, it increasing worldwide, especially among youths children, mainly due to lifestyle environmental changes. pathogenesis two most common subtypes diabetes mellitus, type 1 (T1DM) 2 (T2DM), substantially different, so each form characterized by different causation, etiology, pathophysiology, presentation, treatment. Research in recent decades increasingly indicates potential role gut microbiome initiation, development, progression disease. Intestinal microbes their fermentation products have an important impact host metabolism, immune system, nutrient digestion absorption, barrier integrity protection against pathogens. This review summarizes current evidence changes microbial populations both types mellitus. Attention focused abundance specific bacterial groups at taxonomic levels humans, shift also assessed relation geographic location, age, antidiabetic drug. causal relationship between bacteria still unclear, future studies applying new methodological approaches broader range microorganisms inhabiting digestive tract are urgently needed. would not only provide better understanding disease, but use beneficial species probiotics for treatment diabetes.

Язык: Английский

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Akkermansia muciniphila: A potential target and pending issues for oncotherapy

Pharmacological Research, Год журнала: 2023, Номер 196, С. 106916 - 106916

Опубликована: Сен. 9, 2023

In the wake of development metagenomic, metabolomic, and metatranscriptomic approaches, intricate interactions between host various microbes are now being progressively understood. Numerous studies have demonstrated evident changes in gut microbiota during process a variety diseases, such as diabetes, obesity, aging, cancers. Notably, is viewed potential source novel therapeutics. Currently, Next-generation probiotics (NGPs) gaining popularity therapeutic agents that alter affect cancer development. Akkermansia muciniphila (A. muciniphila), representative commensal bacterium, has received substantial attention over past decade promising NGP. The components metabolites A. can directly or indirectly tumorigenesis, particular through its effects on antitumor immunosurveillance, including stimulation pattern recognition receptors (PRRs), which also leads to better outcomes situations, prevention curation this article, we systematically summarize role tumorigenesis (involving gastrointestinal non-gastrointestinal cancers) tumor therapy. particular, carefully discuss some critical scientific issues need be solved for future using beneficial bacterium treatment, might provide bright clues assistance application drugs targeting clinical oncotherapy.

Язык: Английский

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