World Journal of Psychiatry,
Год журнала:
2021,
Номер
11(10), С. 821 - 829
Опубликована: Окт. 15, 2021
In
December
2019,
a
novel
coronavirus
disease
2019
(COVID-19)
caused
by
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2)
was
initially
reported
in
Wuhan,
China.Previous
epidemics
including
SARS
and
middle
east
raises
concern
that
COVID-19
infection
may
pose
significant
threat
to
the
mental
health
of
affected
individuals.Studies
reviews
have
shown
psychiatric
manifestations
patients,
although
long
term
sequelae
are
predicted,
there
only
few
review
studies
about
psychiatry
outcome
survivors.Clinically
posttraumatic
stress
disorder,
anxiety,
and/or
depression
among
survivors
during
14-90
d
were
observed
following
diagnosis.Risk
anxiety
or
higher
patients
with
more
illness
at
6
mo
follow-up,
early
convalescence,
1
follow-up.Diagnosis
Led
first
diagnoses
relapses
after
diagnosis.The
possible
underlying
mechanisms
neurotropism,
immune
response
SARS-CoV-2,
hypothalamo-pituitary-adrenal
axis
hyperactivity,
disrupted
neuronal
circuits
several
brain
regions,
increased
levels,
neuroinflammation,
death.This
study
will
previous
pandemics,
current
studies,
risk
factors,
thorough
explanation
on
pathophysiology
sequalae
survivors.
Emerging Microbes & Infections,
Год журнала:
2020,
Номер
9(1), С. 386 - 389
Опубликована: Янв. 1, 2020
In
December
2019,
a
novel
coronavirus
(2019-nCoV)
caused
an
outbreak
in
Wuhan,
China,
and
soon
spread
to
other
parts
of
the
world.
It
was
believed
that
2019-nCoV
transmitted
through
respiratory
tract
then
induced
pneumonia,
thus
molecular
diagnosis
based
on
oral
swabs
used
for
confirmation
this
disease.
Likewise,
patient
will
be
released
upon
two
times
negative
detection
from
swabs.
However,
many
coronaviruses
can
also
oral–fecal
route
by
infecting
intestines.
Whether
infected
patients
carry
virus
organs
like
intestine
need
tested.
We
conducted
investigation
local
hospital
who
were
with
virus.
found
presence
anal
blood
as
well,
more
swab
positives
than
later
stage
infection,
suggesting
shedding
thereby
route.
showed
serology
test
improve
positive
rate
should
future
epidemiology.
Our
report
provides
cautionary
warning
may
shed
multiple
routes.
General Psychiatry,
Год журнала:
2021,
Номер
34(1), С. e100424 - e100424
Опубликована: Фев. 1, 2021
The
COVID-19
pandemic
has
posed
a
serious
threat
to
global
mental
health.
Multiple
lines
of
evidence
suggest
that
there
is
varying
yet
considerable
increase
in
health
issues
among
the
general
population
and
vulnerable
groups.1
2
aftermath
obscure
speculative
from
social,
economic,
individual
public
perspective.
Recently
published
studies
support
existence
an
emotional
epidemic
curve,
describing
high
probability
burden
postpandemic
era.3
4
Furthermore,
previous
major
emergencies
showed
more
than
half
developed
problems
required
intervention.4
5
There
is,
therefore,
urgent
need
reorganise
existing
services
address
current
unmet
needs
for
prepare
future
challenges
era
terms
prevention
management.
literature
related
epidemics
may
arise
after
peak
pandemic,
with
increased
prevalence
people
risk
factors
(box
1).4
surge
remain
untreated
or
undiagnosed
due
interrupted
other
post-COVID-19
era.
Box
1
###
Mental
issues,
1.
:
including
grief
reactions,
substance
use
disorders,
anxiety,
sleep
depression,
suicides,
post-traumatic
stress
panic
disorders.4,25,26
Journal of Clinical Medicine,
Год журнала:
2021,
Номер
10(18), С. 4142 - 4142
Опубликована: Сен. 14, 2021
The
COVID-19
pandemic
is
spreading
around
the
world
and
187
million
people
have
already
been
affected.
One
of
its
after-effects
post-COVID
depression,
which,
according
to
latest
data,
affects
up
40%
who
had
SARS-CoV-2
infection.
A
very
important
issue
for
mental
health
general
population
look
causes
this
complication
biomarkers.
This
will
help
in
faster
diagnosis
effective
treatment
affected
patients.
In
our
work,
we
focused
on
search
major
depressive
disorder
(MDD)
biomarkers,
which
are
also
present
patients
may
influence
development
depression.
For
purpose,
searched
PubMed,
Scopus
Google
Scholar
scientific
literature
databases
using
keywords
such
as
'COVID-19',
'SARS-CoV-2',
'depression',
'post-COVID',
'biomarkers'
others.
Among
biomarkers
found,
most
that
were
frequently
described
increased
levels
interleukin
6
(IL-6),
soluble
receptor
(sIL-6R),
1
β
(IL-1β),
tumor
necrosis
factor
α
(TNF-α),
interferon
gamma
(IFN-γ),
10
(IL-10),
2
(IL-2),
(sIL-2R),
C-reactive
protein
(CRP),
Monocyte
Chemoattractant
Protein-1
(MCP-1),
serum
amyloid
a
(SAA1)
metabolites
kynurenine
pathway,
well
decreased
brain
derived
neurotrophic
(BDNF)
tryptophan
(TRP).
identified
by
us
indicate
etiopathogenesis
depression
analogous
leading
inflammatory
hypothesis
MDD.
Molecular Neurobiology,
Год журнала:
2020,
Номер
57(12), С. 5263 - 5275
Опубликована: Сен. 1, 2020
Similar
to
its
predecessors,
coronavirus
disease
2019
(COVID-19)
exhibits
neurotrophic
properties,
which
lead
progression
of
neurologic
sequelae.
Besides
direct
viral
invasion
the
central
nervous
system
(CNS),
indirect
CNS
involvement
through
viral-mediated
immune
response
is
plausible.
Aberrant
pathways
such
as
extreme
release
cytokines
(cytokine
storm),
autoimmunity
mediated
by
cross-reactivity
between
components
and
particles,
microglial
activation
propagate
damage
in
these
patients.
Here,
we
review
currently
available
evidence
discuss
plausible
immunologic
that
may
contribute
development
COVID-19
neurological
complications,
namely
Alzheimer's
disease,
Parkinson's
stroke,
multiple
sclerosis,
Guillain-Barre
syndrome,
seizure,
brainstem
involvement.
Healthcare,
Год журнала:
2020,
Номер
8(3), С. 336 - 336
Опубликована: Сен. 12, 2020
The
raging
COVID-19
pandemic
has
been
a
great
source
of
anxiety,
distress,
and
stress
among
the
population.
Along
with
mandates
for
social
distancing
infection
control
measures,
growing
importance
managing
cultivating
good
mental
well-being
practices
cannot
be
disregarded.
purpose
this
commentary
is
to
outline
discuss
some
research-proven
positive
reduction
strategies
instill
healthy
coping
mechanisms
individuals
community
members.
authors
anticipate
that
usage
these
at
individual
level
should
greatly
benefit
not
only
in
current
but
also
any
future
epidemics
national
level.
