Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 207, С. 115239 - 115239

Опубликована: Март 3, 2024

Язык: Английский

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Aldehyde dehydrogenase in solid tumors and other diseases: Potential biomarkers and therapeutic targets

MedComm, Год журнала: 2023, Номер 4(1)

Опубликована: Янв. 16, 2023

The family of aldehyde dehydrogenases (ALDHs) contains 19 isozymes and is involved in the oxidation endogenous exogenous aldehydes to carboxylic acids, which contributes cellular tissue homeostasis. ALDHs play essential parts detoxification, biosynthesis, antioxidants, are important value for cell proliferation, differentiation, survival normal body tissues. However, frequently dysregulated associated with various diseases like Alzheimer's disease, Parkinson's especially solid tumors. Notably, involvement tumor progression responsible maintenance stem-cell-like phenotype, triggering rapid aggressive clinical progressions. have captured increasing attention as biomarkers disease diagnosis prognosis. Nevertheless, these require further longitudinal studies large populations broad application. This review summarizes our current knowledge regarding potential tumors several non-tumor diseases, well recent advances understanding functions underlying molecular mechanisms development. Finally, we discuss therapeutic therapy an emphasis on their implications.

Язык: Английский

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NR5A2 gene affects the overall survival of LUAD patients by regulating the activity of CSCs through SNP pathway by OCLR algorithm and immune score

Heliyon, Год журнала: 2024, Номер 10(7), С. e28282 - e28282

Опубликована: Март 28, 2024

Differentially expressed genes (DEGs) in lung adenocarcinoma (LUAD) tumor stem cells were screened, and the biological characteristics of

Язык: Английский

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Single-cell profiling transcriptomic reveals cellular heterogeneity and cellular crosstalk in breast cancer lymphatic node, bone, and brain metastases

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 17, 2025

Breast cancer is the most common malignant tumor in world, and its metastasis main cause of death breast patients. However, differences between primary tissue lymphatic node, bone, brain metastases at single-cell level are not fully understood. We analyzed microenvironment heterogeneity samples (n = 4), node 3), bone 2) using sequencing data from GEO database. The epithelial cells were characterized by InferCNV algorithm. cell-cell communication was CellChat package. biological function cell subpopulations gene set variation analysis. expression STMN1 immunohistochemical staining. proportion pCAFs explored multispectral identified seven clusters metastatic (Lymphatic brain, metastases) analyzing transcriptomic profiles. T-NK B dominated with metastasis, whereas fibroblasts prevalent cancer. five T (T memory, CD8 + cells, regulatory natural killer CD4 cells), three (naïve memory plasma cancer-associated (CAFs) (Smooth muscle (SMC), pericyte, antigen-presenting CAFs (apCAFs), proliferative (pCAFs), matrix (mCAFs)). Notably. metastasis. Furthermore, we four subpopulations: G0, G1, G2, G3. G2 population exhibited strong invasion ability, it can differentiate into G3 ability proliferation-related G1 after Cell-cell demonstrated an interaction metastasis-associated cells. Finally, discovered that advanced cancer, pCAF increased associated a poor prognosis This study elucidated potential cellular origins drivers to nodes, utilizing prognosis.

Язык: Английский

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Differences and similarities between cancer and somatic stem cells: therapeutic implications

Stem Cell Research & Therapy, Год журнала: 2020, Номер 11(1)

Опубликована: Ноя. 18, 2020

Abstract Over the last decades, cancer survival rate has increased due to personalized therapies, discovery of targeted therapeutics and novel biological agents, application palliative treatments. Despite these advances, tumor resistance chemotherapy radiation rapid progression metastatic disease are still seen in many patients. Evidence shown that stem cells (CSCs), a sub-population share common characteristics with somatic (SSCs), contribute this therapeutic failure. The most critical properties CSCs their self-renewal ability capacity for differentiation into heterogeneous populations cells. Although only constitute low percentage total mass, can regrow mass on own. Initially identified leukemia, have subsequently been found cancers breast, colon, pancreas, brain. Common genetic phenotypic features both SSCs CSCs, including upregulated signaling pathways such as Notch, Wnt, Hedgehog, TGF-β. These play fundamental roles development well control cell fate relevant targeting CSCs. differences expression membrane proteins exosome-delivered microRNAs between also important specifically target cancer. Further research efforts should be directed toward elucidation improve existing therapies generate new clinically

Язык: Английский

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Ferroptosis: Cancer Stem Cells Rely on Iron until “to Die for” It

Cells, Год журнала: 2021, Номер 10(11), С. 2981 - 2981

Опубликована: Ноя. 2, 2021

Cancer stem cells (CSCs) are a distinct subpopulation of tumor with cell-like features. Able to initiate and sustain growth mostly resistant anti-cancer therapies, they thought responsible for recurrence metastasis. Recent accumulated evidence supports that iron metabolism the recent discovery ferroptosis constitutes promising new lead in field anti-CSC therapeutic strategies. Indeed, uptake, efflux, storage regulation pathways all over-engaged microenvironment suggesting reprogramming is crucial occurrence cell survival. In particular, studies have highlighted importance maintenance CSCs. Furthermore, high concentration found CSCs, as compared non-CSCs, underlines their addiction. line this, if an essential macronutrient nevertheless highly reactive, it represents Achilles’ heel by inducing death therefore providing opportunities target this review, we first summarize our current understanding its Then, provide overview knowledge discuss role autophagy (regulation of) ferroptotic pathways. Finally, potential strategies could be used CSCs treat cancer.

Язык: Английский

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The Fight against Cancer by Microgravity: The Multicellular Spheroid as a Metastasis Model

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(6), С. 3073 - 3073

Опубликована: Март 12, 2022

Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the organism. It heavy, worldwide burden for mankind with high morbidity mortality. Therefore, groundbreaking research innovations are necessary. Research in space under microgravity (µg) conditions novel approach potential fight cancer develop future therapies. Space travel accompanied by adverse effects on our health, there need counteract these health problems. On cellular level, studies have shown that real (r-) simulated (s-) µg impact survival, apoptosis, proliferation, migration, adhesion as well cytoskeleton, extracellular matrix, focal adhesion, factors cells. Moreover, µg-environment induces vitro 3D tumor models (multicellular spheroids organoids) preclinical drug targeting, development, studying processes progression metastasis molecular level. This review focuses r- s-µg different types cells deriving from thyroid, breast, lung, skin, prostate cancer, tumors gastrointestinal tract. In addition, we summarize current knowledge cancerous stem The information demonstrates has become an important new technology increasing biology.

Язык: Английский

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Long non-coding RNAs (lncRNAs) signaling in cancer chemoresistance: From prediction to druggability

Drug Resistance Updates, Год журнала: 2022, Номер 65, С. 100866 - 100866

Опубликована: Сен. 20, 2022

Язык: Английский

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Machine learning to construct sphingolipid metabolism genes signature to characterize the immune landscape and prognosis of patients with uveal melanoma

Frontiers in Endocrinology, Год журнала: 2022, Номер 13

Опубликована: Дек. 8, 2022

Background Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults and highly metastatic, resulting a poor patient prognosis. Sphingolipid metabolism plays an important role tumor development, diagnosis, This study aimed to establish reliable signature based on sphingolipid genes (SMGs), thus providing new perspective for assessing immunotherapy response prognosis patients with UVM. Methods In this study, SMGs were used classify UVM from TCGA-UVM GEO cohorts. Genes significantly associated screened using univariate cox regression analysis. The characterized obtained by machine learning, 4-SMGs was constructed stepwise multifactorial cox. External validation performed GSE84976 cohort. level of immune infiltration high- low-risk analyzed platforms such as CIBERSORT. prediction checkpoint blockade (ICB) assessed ImmuCellAI TIP portals. Results considered be strongly good predictors Multivariate analysis found that model independent predictor UVM, group having higher overall survival than those high-risk group. nomogram clinical characteristics risk scores had prognostic power. showed better results when receiving immunotherapy. Conclusions excellent predictive performance provided pre-immune efficacy, which will facilitate future precision immuno-oncology studies.

Язык: Английский

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Biomarkers of Cancer Stem Cells for Experimental Research and Clinical Application

Journal of Personalized Medicine, Год журнала: 2022, Номер 12(5), С. 715 - 715

Опубликована: Апрель 29, 2022

The use of biomarkers in cancer diagnosis, therapy, and prognosis has been highly effective over several decades. Studies patients pre- post-treatment during progression have helped identify stem cells (CSCs) their related microenvironments. These analyses are critical for the therapeutic application drugs efficient targeting prevention progression, as well investigation mechanism development. Biomarkers that characterize CSCs thus identified correlated to prognosis. However, demonstrate elevated levels plasticity, which alters functional phenotype appearance by interacting with microenvironments, response chemotherapy radiotherapeutics. In turn, these changes induce different metabolic adaptations CSCs. This article provides a review most frequently used cell markers.

Язык: Английский

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