Towards precision medicine: Omics approach for COVID-19 DOI Creative Commons
Xiaoping Cen,

Feng-ao Wang,

Xinhe Huang

и другие.

Biosafety and Health, Год журнала: 2023, Номер 5(2), С. 78 - 88

Опубликована: Янв. 18, 2023

The coronavirus disease 2019 (COVID-19) pandemic had a devastating impact on human society. Beginning with genome surveillance of severe acute respiratory syndrome 2 (SARS-CoV-2), the development omics technologies brought clearer understanding complex SARS-CoV-2 and COVID-19. Here, we reviewed how omics, including genomics, proteomics, single-cell multi-omics, clinical phenomics, play roles in answering biological questions about Large-scale sequencing advanced analysis methods facilitate COVID-19 discovery from virus evolution severity risk prediction to potential treatment identification. Omics would indicate precise globalized prevention medicine for under utilization big data capability phenotypes refinement. Furthermore, decoding rule by deep learning models is promising forecast new variants achieve more predict future pandemics prevent them time.

Язык: Английский

Systematic review and meta-analysis of human genetic variants contributing to COVID-19 susceptibility and severity DOI

Kajal Gupta,

Gaganpreet Kaur,

Tejal Pathak

и другие.

Gene, Год журнала: 2022, Номер 844, С. 146790 - 146790

Опубликована: Авг. 17, 2022

Язык: Английский

Процитировано

54
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients DOI Creative Commons
Hongsheng Zhang,

Lin Shao,

Zhihao Lin

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Авг. 1, 2022

Abstract Apolipoprotein E (APOE) plays a pivotal role in lipid including cholesterol metabolism. The APOE ε4 (APOE4) allele is major genetic risk factor for Alzheimer’s and cardiovascular diseases. Although has recently been associated with increased susceptibility to infections of several viruses, whether how its isoforms affect SARS-CoV-2 infection remains unclear. Here, we show that serum concentrations correlate inversely levels cytokine/chemokine 73 COVID-19 patients. Utilizing multiple protein interaction assays, demonstrate APOE3 APOE4 interact the receptor ACE2; APOE/ACE2 interactions require zinc metallopeptidase domain ACE2, key docking site Spike protein. In addition, immuno-imaging assays using confocal, super-resolution, transmission electron microscopies reveal both reduce ACE2/Spike-mediated viral entry into cells. Interestingly, while having comparable binding affinity inhibits lesser extent compared APOE3, which likely due APOE4’s more compact structure smaller spatial obstacle compete against ACE2. Furthermore, carriers clinically elevated inflammatory factors 142 patients assessed. Our study suggests regulatory mechanism underlying through may explain part disease severity carriers.

Язык: Английский

Процитировано

46
Demographic and social determinants of cognitive dysfunction following hospitalization for COVID-19 DOI Open Access
Eduard Valdes, Benjamin Fuchs,

Chris Morrison

и другие.

Journal of the Neurological Sciences, Год журнала: 2022, Номер 438, С. 120146 - 120146

Опубликована: Янв. 7, 2022

Язык: Английский

Процитировано

38
The Complex Association between COPD and COVID-19 DOI Open Access
Nikhil T Awatade, Peter Wark, Andrew S. L. Chan

и другие.

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(11), С. 3791 - 3791

Опубликована: Май 31, 2023

Chronic obstructive pulmonary disease (COPD) is significant cause of morbidity and mortality worldwide. There mounting evidence suggesting that COPD patients are at increased risk severe COVID-19 outcomes; however, it remains unclear whether they more susceptible to acquiring SARS-CoV-2 infection. In this comprehensive review, we aim provide an up-to-date perspective the intricate relationship between COVID-19. We conducted a thorough review literature examine regarding susceptibility infection severity their outcomes. While most studies have found pre-existing associated with worse outcomes, some yielded conflicting results. also discuss confounding factors such as cigarette smoking, inhaled corticosteroids, socioeconomic genetic may influence association. Furthermore, acute management, treatment, rehabilitation, recovery in how public health measures impact care. conclusion, while association complex requires further investigation, highlights need for careful management during pandemic minimize

Язык: Английский

Процитировано

25
Serum troponin, D‐dimer, and CRP level in severe coronavirus (COVID‐19) patients DOI Creative Commons
Ayad M. Ali,

Hassan M. Rostam,

Mohammed Hassan Fatah

и другие.

Immunity Inflammation and Disease, Год журнала: 2021, Номер 10(3)

Опубликована: Дек. 22, 2021

Abstract Background Abnormal inflammation coagulation biomarker levels of troponin, C‐reactive protein (CRP), and D‐dimer in serum have been demonstrated to be associated involved the disease progression coronavirus 2019 (COVID‐19). Methods First: study aimed investigate correlation CRP, d ‐dimer, white blood cell (WBC) polymerase chain reaction–cycle threshold (PCR‐Ct) within COVID‐19 survivors (143 patients; 79 males, 64 females) deceased (30 12 18 group. Also, assessing any differences between both groups studied parameters. Second: a parameters' level has conducted families (41 23 males [seven deaths] females [eight deaths]) that lost more than one member due severity disease. these family control group (132 69 63 parameters assessed. Results In first week hospitalization, there were significant D‐dimer, CRP troponin survived patient groups. second admission, had all parameters; I, WBCs. WBC positively correlated male ( r = 0.75, p < 0.0001), patients 0.74, 0.007). The admission was critical who person, when with Conclusion Troponin, WBCs significantly higher died survivors. High levels, considerably member, compared unrelated control.

Язык: Английский

Процитировано

47
Potential Genes Associated with COVID-19 and Comorbidity DOI Creative Commons
Shanshan Feng,

Fu-Qiang Song,

Wenqiong Guo

и другие.

International Journal of Medical Sciences, Год журнала: 2022, Номер 19(2), С. 402 - 415

Опубликована: Янв. 1, 2022

Hypertension, diabetes mellitus, and coronary artery disease are common comorbidities dangerous factors for infection serious COVID-19.Polymorphisms in genes associated with may help observe susceptibility severity variation.However, specific genetic the extent to which they can explain variation of unclear.Therefore, we evaluated candidate COVID-19 hypertension, disease.In particular, performed searches against OMIM, NCBI, other databases, protein-protein interaction network construction, GO KEGG pathway enrichment analyses.Results showed that overlapping were TLR4, NLRP3, MBL2, IL6, IL1RN, IL1B, CX3CR1, CCR5, AGT, ACE, F2.GO analyses yielded 302 terms (q < 0.05) 29 signaling pathways 0.05), respectively, mainly including coronavirus disease-COVID-19 cytokine-cytokine receptor interaction.IL6 AGT central PPI, 8 5 connections, respectively.In this study, identified 11 both three contribute severity.The key IL6 involved regulating immune response, cytokine activity, viral infection.Therefore, RAAS inhibitors, antisense nucleotides, vitamin D, fenofibrate, vaccines non-immune could be potential strategies prevent cure COVID-19.The study provides a basis further investigation predictive value risk prognosis guide drug vaccine development improve treatment efficacy personalised treatments, especially individuals comorbidities.

Язык: Английский

Процитировано

37
Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19 DOI Open Access
Cristine Dieter, Letícia de Almeida Brondani, Natália Emerim Lemos

и другие.

Genes, Год журнала: 2022, Номер 14(1), С. 29 - 29

Опубликована: Дек. 22, 2022

Although advanced age, male sex, and some comorbidities impact the clinical course of COVID-19, these factors only partially explain inter-individual variability in disease severity. Some studies have shown that genetic polymorphisms contribute to COVID-19 severity; however, results are inconclusive. Thus, we investigated association between ACE1, ACE2, DPP9, IFIH1, IFNAR2, IFNL4, TLR3, TMPRSS2, TYK2 COVID-19. A total 694 patients with were categorized as: (1) ward inpatients (moderate symptoms) or admitted at intensive care unit (ICU; severe symptoms); (2) survivors non-survivors. In females, rs1990760/IFIH1 T/T genotype was associated risk ICU admission death. Moreover, rs1799752/ACE1 Ins rs12329760/TMPRSS2 T alleles admission. non-white patients, rs2236757/IFNAR2 A/A admission, while Ins/Ins genotype, allele analyzed interact worse outcomes. conclusion, this study shows an rs1799752/ACE1, rs1990760/IFIH1, rs2236757/IFNAR2, rs12329760/TMPRSS2, rs2304256/TYK2 outcomes, especially among female patients.

Язык: Английский

Процитировано

34
The Complexity of SARS-CoV-2 Infection and the COVID-19 Pandemic DOI Creative Commons
Maria Karoliny da Silva Torres,

Carlos David Araújo Bichara,

Maria de Nazaré do Socorro de Almeida

и другие.

Frontiers in Microbiology, Год журнала: 2022, Номер 13

Опубликована: Фев. 10, 2022

The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to death of millions people worldwide and thousands more infected individuals developed sequelae due disease new 2019 (COVID-19). development several studies has contributed knowledge about evolution SARS-CoV2 infection forms. Despite this information being debated in scientific literature, many mechanisms still need be better understood order control spread virus treat clinical cases COVID-19. In article, we carried out an extensive literature review bring together, a single biological, social, genetic, diagnostic, therapeutic, immunization, even socioeconomic aspects that impact SAR-CoV-2 pandemic. This gathered article will enable broad consistent reading main related current

Язык: Английский

Процитировано

30
HLA-C*04:01 Affects HLA Class I Heterozygosity and Predicted Affinity to SARS-CoV-2 Peptides, and in Combination With Age and Sex of Armenian Patients Contributes to COVID-19 Severity DOI Creative Commons
Anahit Hovhannisyan,

Vergine Madelian,

Sevak Avagyan

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Фев. 3, 2022

The novel SARS-CoV-2 coronavirus infection has become a global health concern, causing the COVID-19 pandemic. disease symptoms and outcomes depend on host immunity, in which human leukocyte antigen (HLA) molecules play distinct role. HLA alleles have an inter-population variability, understanding their link to ethnically population may contribute personalized medicine. present study aimed at detecting associations between common susceptibility severity Armenians. In 299 patients (75 asymptomatic, 102 mild/moderate, 122 severe), association classic HLA-I II loci was examined. We found that advanced age, male sex of patients, age interaction significantly contributed disease. observed age-dependent effect HLA-B*51:01 carriage [odds ratio (OR)=0.48 (0.28-0.80), P

Язык: Английский

Процитировано

29
HLA alleles associated with COVID-19 susceptibility and severity in different populations: a systematic review DOI Creative Commons
Meryem Fakhkhari, Hayat Caidi, Khalid Sadki

и другие.

Egyptian Journal of Medical Human Genetics, Год журнала: 2023, Номер 24(1)

Опубликована: Янв. 22, 2023

COVID-19 is a respiratory disease caused by novel coronavirus called as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Detected for the first time in December 2019 Wuhan and it has quickly spread all over world couple of months becoming pandemic. Symptoms clinical outcomes are very different infected people. These differences highlight paramount need to study understand human genetic variation that occurring viral infections. Human leukocyte antigen (HLA) an important component presentation pathway, plays essential role conferring differential susceptibility severity diseases. HLA alleles have been involved immune response diseases such SARS-CoV-2.

Язык: Английский

Процитировано

18