Nano‐biotechnology in tumour and cancerous disease: A perspective review

Journal of Cellular and Molecular Medicine, Год журнала: 2023, Номер 27(6), С. 737 - 762

Опубликована: Фев. 24, 2023

Abstract In recent years, drug manufacturers and researchers have begun to consider the nanobiotechnology approach improve delivery system for tumour cancer diseases. this article, we review current strategies delivery, which mainly focuses on sustaining biocompatibility, biodistribution, active targeting. The conventional therapy using cornerstone drugs such as fludarabine, cisplatin etoposide, paclitaxel has its own challenges especially not being able discriminate between versus normal cells eventually led toxicity side effects in patients. contrast approach, nanoparticle‐based provides target‐specific controlled release of drug, a better therapeutic window treatment options by focusing eradication diseased via targeting sparing passive Additionally, tumours associated with brain is hampered impermeability blood–brain barriers drugs, poor survival Nanoparticle‐based offers superior target breaching barriers. Herein, provide an overview properties nanoparticles that are crucial nanotechnology applications. We address potential future applications specific or desired areas. particular, use nanomaterials, biostructures, methods targeted explored.

Язык: Английский

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Dioscin: A review on pharmacological properties and therapeutic values

BioFactors, Год журнала: 2021, Номер 48(1), С. 22 - 55

Опубликована: Дек. 16, 2021

Abstract Dioscin has gained immense popularity as a natural, bioactive steroid saponin, which offers numerous medical benefits. The growing global incidence of disease‐associated morbidity and mortality continues to compromise human health, facilitating an increasingly urgent need for nontoxic, noninvasive, efficient treatment alternatives. Natural compounds can contribute vastly this field. Over recent years, studies have demonstrated the remarkable protective actions dioscin against variety malignancies, metabolic disorders, organ injuries, viral/fungal infections. successful usage phytocompound been widely seen in procedures under traditional Chinese medicine, it is becoming progressively prevalent worldwide. This review provides insight into wide spectrum pharmacological activities dioscin, reported compiled literature. various novel approaches applications also verify advantages exhibited by plant extracts commercially available drugs, highlighting potential phytochemical agents like be further incorporated clinical practice.

Язык: Английский

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Cuban Abdala vaccine: Effectiveness in preventing severe disease and death from COVID-19 in Havana, Cuba; A cohort study

The Lancet Regional Health - Americas, Год журнала: 2022, Номер 16, С. 100366 - 100366

Опубликована: Сен. 24, 2022

COVID-19 vaccines have proven safe and efficacious in reducing severe illness death. Cuban protein subunit vaccine Abdala has shown safety, tolerability efficacy (92·3% [95% CI: 85·7‒95·8]) against SARS-CoV-2 clinical trials. This study aimed to estimate Abdala's real-world effectiveness (VE).This retrospective cohort Havana analyzed Ministry of Public Health databases (May 12-August 31, 2021) assess VE preventing death from (primary outcomes). Cox models accounting for time-varying vaccination status adjusting by demographics were used hazard ratios. A subgroup analysis age group a sensitivity including tested persons (qRT-PCR) conducted. Daily cases deaths modelled different VE.The included 1 355 638 (Mean age: 49·5 years [SD: 18·2]; 704 932 female [52·0%]; ethnicity data unavailable): 324 vaccinated (partially/fully) 31 433 unvaccinated. Estimated was 93·3% (95% 92·1-94·3) partially- 98·2% 97·9-98·5) fully-vaccinated 94·1% 92·5-95·4) partially-vaccinated 98·7% 98·3-99·0) fully-vaccinated. exceeded 92·0% all groups. during the period corresponded above 90%, as predicted models.The highly effective under real-life conditions.Cuban Health. Genetic Engineering Biotechnology Centre.

Язык: Английский

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Environmental challenges of COVID-19 pandemic: resilience and sustainability – A review

Environmental Research, Год журнала: 2022, Номер 216, С. 114496 - 114496

Опубликована: Окт. 17, 2022

Язык: Английский

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Designing a Novel Peptide-Based Multi-Epitope Vaccine to Evoke a Robust Immune Response against Pathogenic Multidrug-Resistant Providencia heimbachae

Vaccines, Год журнала: 2022, Номер 10(8), С. 1300 - 1300

Опубликована: Авг. 11, 2022

Providencia heimbachae, a Gram -ve, rod-shaped, and opportunistic bacteria isolated from the urine, feces, skin of humans engage in wide range infectious diseases such as urinary tract infection (UTI), gastroenteritis, bacteremia. This bacterium belongs to Enterobacteriaceae family can resist antibiotics known multidrug-resistant (MDR), be life-threatening humans. After retrieving whole proteomic sequence P. heimbachae ATCC 35613, total 6 non-homologous pathogenic proteins were separated. These shortlisted further analyzed for epitope prediction found highly non-toxic, non-allergenic, antigenic. From these sequences, T-cell B-cell (major histocompatibility complex class 1 2) epitopes extracted that provided vaccine constructs, which then population coverage find its reliability worldwide. The MHC-1 MHC-2 was 98.29% 81.81%, respectively. Structural confirmed by validation through physiochemical molecular immunological characteristics design stable effective could give positive results when injected into body organism. Due this approach, computational vaccines an alternative against microbe since they cover large with results. In end, given findings may help experimental vaccinologists develop very potent peptide-based vaccine.

Язык: Английский

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The role of social influence on COVID-19 vaccination hesitancy and acceptance in Tanzania

Journal of Public Health in Africa, Год журнала: 2025, Номер 16(3)

Опубликована: Апрель 15, 2025

COVID-19 vaccination hesitancy and acceptance remain critical public health concerns, influenced by socio-cultural factors globally. Social influence - particularly conformity, compliance obedience intentions, decisions behaviours based on the information circulated people already vaccinated. Understanding these dynamics is essential for promotion vaccine uptake through reassuring hesitant about safety effectiveness of vaccine. We explored social in Tanzania. Our study was conducted eight regions Mainland Tanzania: Arusha, Morogoro, Mtwara, Njombe, Mbeya, Tabora, Singida Shinyanga, to represent zones adopted a mixed-methods research approach, collect data from 3098 respondents quantitative part, 336 key informants as well 376 participants focus group discussions. Data analysis involved both descriptive inferential statistics thematic qualitative data. There regional variation rates, with Mtwara showing high at 50% 49.7%, respectively, while Morogoro (22.5%) Mbeya (26.2%) showed lower rates. influence, especially friends, family, community discussions, trust government reliable source regarding were key. Changes Tanzanian government's political will also contributed positive attitudes acceptance. Tanzania, requiring tailored strategies involving government, trusted figures considering ties interaction boost offers insights role acceptance; hence, necessity context-specific participatory interventions quest reduce improve context.

Язык: Английский

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Antimicrobial Resistance in the COVID-19 Landscape: Is There an Opportunity for Anti-Infective Antibodies and Antimicrobial Peptides?

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июнь 2, 2022

Although COVID-19 has captured most of the public health attention, antimicrobial resistance (AMR) not disappeared. To prevent escape resistant microorganisms in animals or environmental reservoirs a “one approach” is desirable. In this context COVID-19, AMR probably been affected by inappropriate over-use antibiotics. The increased use antimicrobials and biocides for disinfection may have enhanced prevalence AMR. Antibiotics used empirically patients with to avoid bacterial coinfection superinfections. On other hand, measures transmission could reduced risk emergence multidrug-resistant microorganisms. Since we do currently sterilizing vaccine against SARS-CoV-2, virus still multiply organism new mutations occur. As consequence, there appearance variants. Nature-derived anti-infective agents, such as antibodies peptides (AMPs), are very promising fight infectious diseases, because they less likely develop resistance, even though further investigation required.

Язык: Английский

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Quinones as Promising Compounds against Respiratory Viruses: A Review

Molecules, Год журнала: 2023, Номер 28(4), С. 1981 - 1981

Опубликована: Фев. 20, 2023

Respiratory viruses represent a world public health problem, giving rise to annual seasonal epidemics and several pandemics caused by some of these viruses, including the COVID-19 pandemic novel SARS-CoV-2, which continues date. Some antiviral drugs have been licensed for treatment influenza, but they cause side effects lead resistant viral strains. Likewise, aerosolized ribavirin is only drug approved therapy infections respiratory syncytial virus, it possesses various limitations. On other hand, no specific are treat diseases. In this sense, natural products their derivatives appeared as promising alternatives in searching new compounds with activity. Besides chemical properties, quinones demonstrated interesting biological activities, activity against viruses. This review summarizes molecular targets different types (both synthetic). Thus, present work offers general overview importance an option future pharmacological infections, subject additional studies that support effectiveness safety.

Язык: Английский

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The spread of the omicron variant: Identification of knowledge gaps, virus diffusion modelling, and future research needs

Environmental Research, Год журнала: 2023, Номер 225, С. 115612 - 115612

Опубликована: Март 5, 2023

The World Health Organization (WHO) recognised variant B.1.1.529 of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as a concern, termed "Omicron", on November 26, 2021. Its diffusion was attributed to its several mutations, which allow promoting ability diffuse worldwide and capability in immune evasion. As consequence, some additional serious threats public health posed risk undermine global efforts made last two years control pandemic. In past, works were devoted discussing possible contribution air pollution SARS-CoV-2 spread. However, best authors' knowledge, there are still no dealing with Omicron mechanisms. This work represents snapshot what we know right now, frame an analysis paper proposes use single indicator, commercial trade data, model virus It is proposed surrogate interactions occurring between humans (the transmission mechanism due human-to-human contacts) could be considered for other diseases. allows also explain unexpected increase infection cases China, detected at beginning 2023. quality data analyzed evaluate first time role particulate matter (PM) carrier diffusion. Due emerging concerns associated viruses (such smallpox-like Europe America), approach seems promising spreading.

Язык: Английский

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COVID-19 Vaccination Acceptance Among Chinese Population and Its Implications for the Pandemic: A National Cross-Sectional Study

Frontiers in Public Health, Год журнала: 2022, Номер 10

Опубликована: Фев. 8, 2022

Objective To examine the COVID-19 vaccination rate among a representative sample of adults from 31 provinces on Chinese mainland and identify its influencing factors. Methods We gathered sociodemographic information, data people's awareness behavior regarding vaccine, accessibility services, community environmental factors vaccination, information about skepticism trust in doctors as well vaccine developers through an online nationwide cross-sectional survey (18 years older). The odds ratios (OR) 95% confidence intervals (CI) for statistical associations were estimated using logistic regression models. Results A total 29,925 participants (51.4% females 48.6% males) responded. 89.4% had already received vaccination. After adjusting demographic characteristics, pandemic/ factors, general vaccinations, we discovered that having no religious affiliation, same occupational status result coronavirus epidemic, being non-smoker, always engaging physical activity, lower social status, perceiving to be easily curable, easier access are all associated with high (all P <0.05). Conclusions China currently have relatively further increase must remove barriers context improve services. In addition, taking proactive effective measures address reasons non-vaccination will aid epidemic prevention control.

Язык: Английский

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