Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Июль 18, 2024
The
gut-brain
axis
(GBA)
plays
a
dominant
role
in
maintaining
homeostasis
as
well
contributes
to
mental
health
maintenance.
pathways
that
underpin
the
expand
from
macroscopic
interactions
with
nervous
system,
molecular
signals
include
microbial
metabolites,
tight
junction
protein
expression,
or
cytokines
released
during
inflammation.
dysfunctional
GBA
has
been
repeatedly
linked
occurrence
of
anxiety-
and
depressive-like
behaviors
development.
importance
inflammatory
aspects
altered
recently
highlighted
literature.
Here
we
summarize
current
reports
on
signaling
which
involves
immune
response
within
intestinal
blood-brain
barrier
(BBB).
We
also
emphasize
effect
stress
altering
barriers'
permeability,
therapeutic
potential
microbiota
restoration
by
probiotic
administration
transplantation,
based
latest
animal
studies.
Most
research
performed
various
models
showed
an
association
between
behaviors,
dysbiosis
gut
microbiota,
disruption
permeability
simultaneous
changes
BBB
integrity.
It
could
be
postulated
under
conditions
impaired
communication
across
may
therefore
represent
significant
mechanism
allowing
affect
brain
functions.
International Journal of Environmental Research and Public Health,
Год журнала:
2021,
Номер
18(23), С. 12836 - 12836
Опубликована: Дек. 6, 2021
The
intestinal
mucosa
provides
a
selective
permeable
barrier
for
nutrient
absorption
and
protection
from
external
factors.
It
consists
of
epithelial
cells,
immune
cells
their
secretions.
gut
microbiota
participates
in
regulating
the
integrity
function
homeostatic
balance.
Pathogens,
xenobiotics
food
can
disrupt
barrier,
promoting
systemic
inflammation
tissue
damage.
Genetic
factors
predispose
individuals
to
dysfunction,
changes
composition
are
central
this
process.
progressive
identification
these
has
led
development
concept
‘leaky
syndrome’
‘gut
dysbiosis’,
which
underlie
relationship
between
impairment,
metabolic
diseases
autoimmunity.
Understanding
mechanisms
underlying
process
is
an
intriguing
subject
research
diagnosis
treatment
various
extraintestinal
diseases.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
164, С. 114985 - 114985
Опубликована: Июнь 11, 2023
The
gut
microbiota
is
indispensable
for
maintaining
host
health
by
enhancing
the
host's
digestive
capacity,
safeguarding
intestinal
epithelial
barrier,
and
preventing
pathogen
invasion.
Additionally,
exhibits
a
bidirectional
interaction
with
immune
system
promotes
of
to
mature.
Dysbiosis
microbiota,
primarily
caused
factors
such
as
genetic
susceptibility,
age,
BMI,
diet,
drug
abuse,
significant
contributor
inflammatory
diseases.
However,
mechanisms
underlying
diseases
resulting
from
dysbiosis
lack
systematic
categorization.
In
this
study,
we
summarize
normal
physiological
functions
symbiotic
in
healthy
state
demonstrate
that
when
occurs
due
various
external
factors,
are
lost,
leading
pathological
damage
lining,
metabolic
disorders,
barrier
damage.
This,
turn,
triggers
disorders
eventually
causes
systems.
These
discoveries
provide
fresh
perspectives
on
how
diagnose
treat
unrecognized
variables
might
affect
link
between
illnesses
need
further
studies
extensive
basic
clinical
research
will
still
be
required
investigate
relationship
future.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 8, 2022
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disease
that
primarily
affects
the
joints.
Microbial
infection
considered
crucial
inducer
of
RA.
Alterations
in
composition
intestinal
bacteria
individuals
with
preclinical
and
established
RA
suggest
vital
role
gut
microbiota
immune
dysfunction
characteristic
However,
mechanisms
by
which
dysbiosis
contributes
to
are
not
fully
understood.
Furthermore,
multiple
therapies
commonly
used
treat
may
alter
diversity,
suggesting
modulating
help
prevent
or
Hence,
better
understanding
changes
accompany
should
aid
development
novel
therapeutic
approaches.
This
mini-review
discusses
impact
pathogenesis
RA,
selection
microbiota-related
biomarkers
for
diagnosing
provides
examples
cross-modulation
between
some
drugs
Some
suggestions
outlooks
also
raised,
guide
future
research
efforts.
Frontiers in Physiology,
Год журнала:
2023,
Номер
14
Опубликована: Апрель 25, 2023
Mitochondria
play
a
key
role
in
both
health
and
disease.
Their
function
is
not
limited
to
energy
production
but
serves
multiple
mechanisms
varying
from
iron
calcium
homeostasis
the
of
hormones
neurotransmitters,
such
as
melatonin.
They
enable
influence
communication
at
all
physical
levels
through
interaction
with
other
organelles,
nucleus,
outside
environment.
The
literature
suggests
crosstalk
between
mitochondria
circadian
clocks,
gut
microbiota,
immune
system.
might
even
be
hub
supporting
integrating
activity
across
these
domains.
Hence,
they
(missing)
link
Mitochondrial
dysfunction
related
metabolic
syndrome,
neuronal
diseases,
cancer,
cardiovascular
infectious
inflammatory
disorders.
In
this
regard,
diseases
Alzheimer’s,
Parkinson’s,
amyotrophic
lateral
sclerosis
(ALS),
chronic
fatigue
syndrome
(CFS),
pain
are
discussed.
This
review
focuses
on
understanding
mitochondrial
action
that
allow
for
maintenance
pathways
toward
dysregulated
mechanisms.
Although
have
allowed
us
adapt
changes
over
course
evolution,
turn,
evolution
has
shaped
mitochondria.
Each
evolution-based
intervention
influences
its
own
way.
use
physiological
stress
triggers
tolerance
stressor,
achieving
adaptability
resistance.
describes
strategies
could
recover
functioning
providing
comprehensive,
root-cause-focused,
integrative
approach
recovering
treating
people
suffering
diseases.
Pharmacological Research,
Год журнала:
2023,
Номер
189, С. 106687 - 106687
Опубликована: Фев. 4, 2023
Accumulating
evidence
indicates
gut
microbiota
contributes
to
aging-related
disorders.
However,
the
exact
mechanism
underlying
dysbiosis-related
pathophysiological
changes
during
aging
remains
largely
unclear.
In
current
study,
we
first
performed
remodeling
on
old
mice
by
fecal
transplantation
(FMT)
from
young
mice,
and
then
characterized
bacteria
signature
that
was
specifically
altered
FMT.
Our
results
revealed
FMT
significantly
improved
natural
systemic
disorders,
particularly
exerted
hepatoprotective
effects,
glucose
sensitivity,
hepatosplenomegaly,
inflammaging,
antioxidative
capacity
intestinal
barrier.
Moreover,
increased
abundance
of
A.muciniphila,
which
almost
nondetectable
in
mice.
Interestingly,
A.muciniphila
supplementation
also
similar
benefits
with
Notably,
targeted
metabolomics
short
chain
fatty
acids
(SCFAs)
only
acetic
acid
consistently
reversed
Then,
intervention
beneficial
actions
both
Caenorhabditis
elegans
conclusion,
our
study
demonstrated
disorders
through
its
derived
acid,
suggesting
interventions
potent
stimulative
A.
muciniphila
growth
production
alternative
effective
way
maintain
healthy
aging.
The
data
RNAseq
16
S
rRNA
gene
sequencing
can
be
accessed
NCBI
accession
number
PRJNA848996
PRJNA849355.
Molecular Psychiatry,
Год журнала:
2023,
Номер
28(7), С. 2645 - 2673
Опубликована: Янв. 27, 2023
Abstract
Bipolar
disorders
(BD)
represent
a
severe
leading
disabling
mental
condition
worldwide
characterized
by
episodic
and
often
progressive
mood
fluctuations
with
manic
depressive
stages.
The
biological
mechanisms
underlying
the
pathophysiology
of
BD
remain
incompletely
understood,
but
it
seems
that
there
is
complex
picture
genetic
environmental
factors
implicated.
Nowadays,
gut
microbiota
in
spotlight
new
research
related
to
this
kind
psychiatric
disorder,
as
can
be
consistently
several
pathophysiological
events
observed
BD.
In
context
so-called
microbiota–gut–brain
(MGB)
axis,
shown
have
strong
influence
on
host
neuromodulation
endocrine
functions
(i.e.,
controlling
synthesis
neurotransmitters
like
serotonin
or
mediating
activation
hypothalamic–pituitary–adrenal
axis),
well
modulation
immune
responses,
critically
regulating
intestinal,
systemic
brain
inflammation
(neuroinflammation).
present
review
aims
elucidate
derived
from
MGB
axis
disruption
possible
therapeutic
approaches
mainly
focusing
network
Understanding
its
bidirectional
communication
other
systems
shed
light
discovery
therapies
for
improving
clinical
management
these
patients.
Besides,
effect
drugs
currently
used
patients,
together
therapeutical
targeting
ecosystem
(dietary
patterns,
probiotics,
prebiotics,
novelties)
will
also
contemplated.
L-arginine
(L-arg)
is
a
versatile
amino
acid
and
central
intestinal
metabolite
in
mammalian
microbial
organisms.
Thus,
L-arg
participates
as
precursor
of
multiple
metabolic
pathways
the
regulation
cell
division
growth.
It
also
serves
source
carbon,
nitrogen,
energy
or
substrate
for
protein
synthesis.
Consequently,
can
simultaneously
modify
immune
functions,
intraluminal
metabolism,
microbiota,
pathogenesis.
While
dietary
intake,
turnover
de
novo
synthesis
usually
supply
sufficient
amounts,
expression
several
key
enzymes
metabolism
change
rapidly
dramatically
following
inflammation,
sepsis,
injury.
availability
be
restricted
due
to
increased
catabolism,
transforming
into
an
essential
acid.
Here,
we
review
enzymatic
cells
their
role
function,
colonization
resistance,
pathogenesis
gut.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Май 3, 2024
Accumulating
studies
have
indicated
that
the
gut
microbiota
plays
a
pivotal
role
in
onset
of
autoimmune
diseases
by
engaging
complex
interactions
with
host.
This
review
aims
to
provide
comprehensive
overview
existing
literatures
concerning
relationship
between
and
diseases,
shedding
light
on
interplay
microbiota,
host
immune
system.
Furthermore,
we
aim
summarize
impacts
potential
mechanisms
underlie
primarily
focusing
systemic
lupus
erythematosus,
rheumatoid
arthritis,
Sjögren’s
syndrome,
type
1
diabetes
mellitus,
ulcerative
colitis
psoriasis.
The
present
will
emphasize
clinical
significance
applications
interventions
based
as
innovative
adjunctive
therapies
for
diseases.
