Nutrients,
Год журнала:
2023,
Номер
15(14), С. 3258 - 3258
Опубликована: Июль 23, 2023
The
number
of
individuals
experiencing
mental
disorders
(e.g.,
anxiety
and
depression)
has
significantly
risen
in
recent
years.
Therefore,
it
is
essential
to
seek
prevention
treatment
strategies
for
disorders.
Several
gut
microbiota,
especially
Firmicutes
Bacteroidetes,
are
demonstrated
affect
health
through
microbiota-gut-brain
axis,
the
microbiota
dysbiosis
can
be
related
disorders,
such
as
anxiety,
depression,
other
On
hand,
dietary
components,
including
probiotics
Lactobacillus
Bifidobacterium),
prebiotics
fiber
alpha-lactalbumin),
synbiotics,
postbiotics
short-chain
fatty
acids),
dairy
products,
spices
Zanthoxylum
bungeanum,
curcumin,
capsaicin),
fruits,
vegetables,
medicinal
herbs,
so
on,
could
exert
protective
effects
against
by
enhancing
beneficial
while
suppressing
harmful
ones.
In
this
paper,
disorder-associated
summarized.
addition,
components
on
targeting
discussed.
This
paper
helpful
develop
some
natural
products
into
pharmaceuticals
functional
foods
prevent
treat
Molecular Psychiatry,
Год журнала:
2023,
Номер
28(9), С. 3625 - 3637
Опубликована: Сен. 1, 2023
Abstract
The
human
body
harbors
a
diverse
ecosystem
of
microorganisms,
including
bacteria,
viruses,
and
fungi,
collectively
known
as
the
microbiota.
Current
research
is
increasingly
focusing
on
potential
association
between
microbiota
various
neuropsychiatric
disorders.
resides
in
parts
body,
such
oral
cavity,
nasal
passages,
lungs,
gut,
skin,
bladder,
vagina.
gut
gastrointestinal
tract
has
received
particular
attention
due
to
its
high
abundance
role
psychiatric
neurodegenerative
However,
presents
other
tissues,
though
less
abundant,
also
plays
crucial
immune
system
homeostasis,
thus
influencing
development
progression
For
example,
imbalance
associated
periodontitis
might
increase
risk
for
Additionally,
studies
using
postmortem
brain
samples
have
detected
widespread
presence
bacteria
brains
patients
with
Alzheimer’s
disease.
This
article
provides
an
overview
emerging
host
disorders
discusses
future
directions,
underlying
biological
mechanisms,
reliable
biomarkers
microbiota,
microbiota-targeted
interventions,
this
field.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 14, 2024
Recent
studies
have
indicated
that
gut
microbiota-mediated
oxidative
stress
is
significantly
associated
with
intestinal
diseases
such
as
colorectal
cancer,
ulcerative
colitis,
and
Crohn’s
disease.
The
level
of
reactive
oxygen
species
(ROS)
has
been
reported
to
increase
when
the
microbiota
dysregulated,
especially
several
bacterial
metabolites
are
present.
Although
healthy
plays
a
vital
role
in
defending
against
excessive
stress,
disease
influenced
by
ROS,
this
process
controlled
immunological
responses,
DNA
damage,
inflammation.
In
review,
we
discuss
relationship
between
from
an
perspective.
addition,
also
provide
summary
most
recent
therapeutic
approaches
for
preventing
or
treating
modifying
microbiota.
Nutrition Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 14, 2024
Abstract
Context
High
adherence
to
the
Mediterranean
diet
(MD)
has
been
associated
with
a
reduced
risk
of
depression
in
prospective
cohort
studies,
but
whether
MD
interventions
are
effective
among
adults
is
uncertain.
Objective
This
study
aimed
synthesize
findings
on
effects
severity
depressive
symptoms
depression.
Data
Sources
PubMed,
Cochrane
CENTRAL,
PsycINFO,
Scopus,
and
Web
Science
were
systematically
searched
from
database
inception
March
2023.
The
Preferred
Reporting
Items
for
Systematic
Review
Meta-Analyses
guidelines
recommendations
followed.
We
included
randomized
controlled
trials
(RCTs)
comparing
outcomes
after
control
conditions
disorders
or
symptoms.
Extraction
Two
authors
extracted
data
independently.
Sidik-Jonkman
estimator,
I2
metric,
prediction
interval
used
estimate
between-study
heterogeneity.
To
determine
bias
certainty
evidence
RCTs,
we
Collaboration’s
Risk
Bias
2
Grades
Recommendation,
Assessment,
Development,
Evaluation
tools,
respectively.
Analysis
In
total,
1507
participants
(mean
age
range:
22.0
years–53.3
years)
initially
5
RCTs
this
review.
Compared
conditions,
significantly
young
middle-aged
major
mild
moderate
(standardized
mean
difference:
–0.53;
95%
confidence
interval:
–0.90
–0.16;
=
87.1%).
ranged
–1.86
0.81.
overall
was
within
range
“some
concerns”
“high,”
while
low.
Conclusion
appear
have
substantial
potential
alleviating
people
experiencing
However,
establish
robust
recommendations,
there
remains
need
high-quality,
large-scale,
long-term
RCTs.
Registration
PROSPERO
registration
no.
CRD42022341895.
Journal of Gastroenterology and Hepatology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
ABSTRACT
Endogenous
ethanol
production,
or
auto‐brewery
syndrome
(ABS),
is
a
rare
condition
of
the
human
alimentary
canal
that
results
in
intoxication
without
alcohol
consumption.
Despite
its
clinical
significance,
ABS
remains
largely
undiagnosed
because
lack
awareness
among
clinicians.
Published
cases
have
reported
extensive
biopsychosocial
comorbidities
accompanying
delayed
diagnosis
and
incomplete
management;
these
include
social
rejection
family
separation,
court‐ordered
rehabilitation
psychiatric
admission,
legal
employment
ramifications,
deteriorating
mental
health
suicidality.
In
this
mini
review,
we
aim
to
educate
enlighten
clinicians
by
discussing
literature
findings
pertaining
pathophysiological
mechanisms
gut
dysbiosis
due
overgrowth
Saccharomyces
cerevisiae
,
E.
coli
Klebsiella
impaired
intestinal
barrier
function,
dysregulation
hypothalamic–pituitary–adrenal
axis.
Furthermore,
discuss
recently
discovered
associations
with
sleep
quality
mood
disorders
explore
medical
sequelae
metabolic
dysfunction‐associated
fatty
liver
disease
steatohepatitis.
Drawing
on
data,
propose
protocols
for
initial
care
emergency
room,
subsequent
critical
care,
diagnostic
testing
glucose
challenge
testing,
definitive
microbiological
during
acute
phase
illness.
We
also
present
an
empirical
treatment
outline
while
awaiting
confirmation
causative
organisms
sensitivities.
Military Medical Research,
Год журнала:
2023,
Номер
10(1)
Опубликована: Июнь 9, 2023
Abstract
Spinal
cord
injury
(SCI)
is
a
devastating
and
disabling
medical
condition
generally
caused
by
traumatic
event
(primary
injury).
This
initial
trauma
accompanied
set
of
biological
mechanisms
directed
to
ameliorate
neural
damage
but
also
exacerbate
(secondary
The
alterations
that
occur
in
the
spinal
have
not
only
local
systemic
consequences
virtually
all
organs
tissues
body
incur
important
changes
after
SCI,
explaining
progression
detrimental
related
this
condition.
Psychoneuroimmunoendocrinology
(PNIE)
growing
area
research
aiming
integrate
explore
interactions
among
different
systems
compose
human
organism,
considering
mind
as
whole.
consequent
neurological
disruption
trigger
immune,
endocrine,
multisystem
dysfunction,
which
turn
affect
patient’s
psyche
well-being.
In
present
review,
we
will
most
SCI
from
PNIE
perspective,
defining
occurring
each
system
how
these
are
interconnected.
Finally,
potential
clinical
approaches
derived
knowledge
be
collectively
presented
with
aim
develop
integrative
therapies
maximize
management
patients.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 21, 2024
The
bidirectional
communication
between
the
gut
and
brain
or
gut-brain
axis
is
regulated
by
several
microbes
microbial
derived
metabolites,
such
as
short-chain
fatty
acids,
trimethylamine
N-oxide,
lipopolysaccharides.
Gut
microbiota
(GM)
produce
neuroactives,
specifically
neurotransmitters
that
modulates
local
central
neuronal
functions.
An
imbalance
intestinal
commensals
pathobionts
leads
to
a
disruption
in
dysbiosis,
which
affects
barrier
integrity
gut-immune
neuroimmune
systems.
Currently,
fecal
transplantation
(FMT)
recommended
for
treatment
of
recurrent
Nutrients,
Год журнала:
2024,
Номер
16(10), С. 1500 - 1500
Опубликована: Май 16, 2024
As
the
population
ages,
incidence
of
age-related
neurodegenerative
diseases
is
rapidly
increasing,
and
novel
approaches
to
mitigate
this
soaring
prevalence
are
sorely
needed.
Recent
studies
have
highlighted
importance
gut
microbial
homeostasis
its
impact
on
brain
functions,
commonly
referred
as
gut–brain
axis,
in
maintaining
overall
health
wellbeing.
Nonetheless,
mechanisms
by
which
system
acts
remains
poorly
defined.
In
review,
we
will
explore
how
(poly)phenols,
a
class
natural
compounds
found
many
plant-based
foods
beverages,
can
modulate
thereby
promote
neural
health.
While
evidence
indicates
beneficial
role
(poly)phenol
consumption
part
balanced
diet,
human
scarce
mechanistic
insight
still
lacking.
regard,
make
case
that
dietary
(poly)phenols
should
be
further
explored
establish
their
therapeutic
efficacy
through
modulation
with
much
greater
emphasis
carefully
designed
interventions.
Brain Behavior & Immunity - Health,
Год журнала:
2024,
Номер
36, С. 100729 - 100729
Опубликована: Янв. 23, 2024
Communication
among
the
brain,
gut
and
microbiota
in
is
known
to
affect
susceptibility
stress,
but
mechanisms
involved
are
unclear.
Here
we
demonstrated
that
stress
resistance
mice
was
associated
with
more
abundant
