Although
the
concept
of
declined
immune
function
associated
with
cancer
has
been
accepted
extensively,
real-world
clinical
studies
focusing
on
analysis
peripheral
blood
changes
underlying
ageing,
immunity
and
are
scarce.In
this
case-control
study,
we
retrospectively
analysed
1375
patients
enrolled
275
age
gender
matched
healthy
individuals.
Flow
cytometry
was
conducted
to
assess
changes.
Further
examined
by
SPSS
17.0
GraphPad
Prism
9
software.Cancer
showed
obviously
decreased
CD3+
T,
CD3+CD4+
Th,
CD3+CD8+
CTL,
CD19+
B,
CD16+CD56+
NK
cell
counts
lower
percentage
PD-1
(programmed
death
protein-1,
PD-1)
positive
cells
than
control
(P
<
0.0001).
For
patients,
reference
range
circulating
PD-1+CD45+
cells,
PD-1+CD3+
T
PD-1+CD3+CD4+
Th
PD-1+CD3+CD8+
CTL
(Cytotoxic
Lymphocyte,
CTL)
were
11.2%
(95%
CI
10.8%-11.6%),
15.5%
14.7%-16.0%),
15.4%
14.9%-16.0%)
14.5%
14.0%-15.5%),
respectively.
Moreover,
reduction
B
accompanied
stage
advancing
0.05).
stage,
but
elevated
in
aged
male
Additionally,
varied
across
types,
raised
stage.
Head
neck,
pancreatic,
gynaecological
lung
demonstrated
a
higher
level
melanoma,
prostate,
breast
0.05).This
study
provides
blood,
confirms
series
accompanying
cancer,
expands
our
real
world
evidence
better
understand
interactions
immunity.
shows
similar
tumor
type
distribution
mutational
burden
(TMB),
supports
that
it
maybe
potential
predictive
biomarker
for
checkpoint
inhibitor
therapy.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Авг. 2, 2022
Aging
induces
a
series
of
immune
related
changes,
which
is
called
immunosenescence,
playing
important
roles
in
many
age-related
diseases,
especially
neurodegenerative
tumors,
cardiovascular
autoimmune
diseases
and
coronavirus
disease
2019(COVID-19).
However,
the
mechanism
association
with
aging
successful
aging,
effects
on
are
not
revealed
obviously.
In
order
to
provide
theoretical
basis
for
preventing
or
controlling
effectively
achieve
we
conducted
review
found
that
changes
aging-related
phenotypes,
deterioration
organ
function
alterations
cell
subsets
participated
process
had
great
occurrence
development
diseases.
Microorganisms,
Год журнала:
2024,
Номер
12(4), С. 775 - 775
Опубликована: Апрель 11, 2024
Immune
system
aging
is
becoming
a
field
of
increasing
public
health
interest
because
prolonged
life
expectancy,
which
not
paralleled
by
an
increase
in
expectancy.
As
age
progresses,
innate
and
adaptive
immune
systems
undergo
changes,
are
defined,
respectively,
as
inflammaging
senescence.
A
wealth
available
data
demonstrates
that
these
two
conditions
closely
linked,
leading
to
greater
vulnerability
elderly
subjects
viral,
bacterial,
opportunistic
infections
well
lower
post-vaccination
protection.
To
face
this
novel
scenario,
in-depth
assessment
the
players
involved
changing
epidemiology
demanded
regarding
individual
concerted
involvement
cells
mediators
within
endogenous
exogenous
factors
co-morbidities.
This
review
provides
overall
updated
description
changes
affecting
system,
may
be
help
understanding
underlying
mechanisms
associated
with
main
age-associated
infectious
diseases.
Frontiers in Neurology,
Год журнала:
2023,
Номер
14
Опубликована: Июль 7, 2023
With
a
rapidly
aging
global
population
and
improvement
of
outcomes
with
newer
multiple
sclerosis
(MS)-specific
disease-modifying
therapies
(DMTs),
the
epidemiology
MS
has
shifted
to
an
older
than
previously
described
population,
peak
prevalence
disease
seen
in
55–65
years
age
group.
Changes
pathophysiology
appear
be
age-dependent.
Several
studies
have
identified
consistent
phase
disability
worsening
around
fifth
decade
life.
The
latter
appears
independent
prior
duration
inflammatory
activity
concomitant
pathological
changes
from
acute
focal
active
demyelination
chronic
smoldering
plaques,
slow-expanding
lesions,
compartmentalized
inflammation
within
central
nervous
system
(CNS).
On
other
hand,
decreased
CNS
tissue
reserve
poorer
remyelinating
capacity
lead
loss
relapse
recovery
potential.
Aging
may
imply
longer
exposure
DMTs,
although
treatment
efficacy
patients
>55
not
been
evaluated
pivotal
randomized
controlled
trials
decrease
age.
Older
individuals
are
more
prone
adverse
effects
important
aspect
individualization.
also
implies
higher
burden
comorbid
illnesses
that
contribute
overall
impairments
represent
crucial
confounder
interpreting
clinical
worsening.
Discontinuation
DMTs
after
55,
when
no
evidence
or
radiological
is
detected,
currently
under
spotlight.
In
this
review,
we
will
discuss
impact
on
pathobiology,
effect
comorbidities
confounders
worsening,
focus
current
therapeutic
considerations
Archives of Gerontology and Geriatrics Plus,
Год журнала:
2023,
Номер
1(1), С. 100003 - 100003
Опубликована: Дек. 25, 2023
Aging
is
a
complex
journey
shaped
by
interactions
among
mechanisms,
biochemistry,
physiology,
and
social
habits.
This
review
explores
aging's
core
facets
uncovering
the
mechanisms
driving
cellular
senescence,
oxidative
stress,
telomere
shortening,
mitochondrial
dysfunction.
The
also
delves
into
biochemistry
physiology
of
aging,
shedding
light
on
hormonal
shifts,
genetic
influences,
immune
system
modifications
that
contribute
to
aging
process.
It
navigates
terrain
habits
linked
considering
profound
impact
dietary
choices,
physical
activity,
engagement,
stress
management.
These
elements
intricately
intertwine,
emphasizing
holistic
nature
aging.
interplay
between
underscores
need
for
comprehensive
understanding
transcends
single
disciplines.
Deciphering
these
factors
significance
personalized
approaches
healthy
Tailoring
interventions
individual
genetics,
lifestyles,
health
needs
emerges
as
critical
strategy
optimizing
well-being
in
later
life.
In
conclusion,
this
illuminates
multifaceted
urging
embrace
complexity
interdependence.
By
fostering
holistic,
approach,
individuals
can
navigate
with
grace,
vitality,
resilience.
Abstract
Ageing
as
a
natural
irreversible
process
inherently
results
in
the
functional
deterioration
of
numerous
organ
systems
and
tissues,
including
skeletal
immune
systems.
Recent
studies
have
elucidated
intricate
bidirectional
interactions
between
these
two
In
this
review,
we
provide
comprehensive
synthesis
molecular
mechanisms
cell
ageing.
We
further
discuss
how
age-related
changes
influence
system
consequent
impact
alterations
on
system.
Finally,
highlight
clinical
implications
findings
propose
potential
strategies
to
promote
healthy
ageing
reduce
pathologic
both
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Март 22, 2024
Abstract
The
B
cell
response
in
the
germinal
centre
(GC)
reaction
requires
a
unique
bioenergetic
supply.
Although
mitochondria
are
remodelled
upon
antigen-mediated
receptor
stimulation,
mitochondrial
function
cells
is
still
poorly
understood.
To
gain
better
understanding
of
role
function,
here
we
generate
mice
with
cell-specific
deficiency
Tfam,
transcription
factor
necessary
for
biogenesis.
Tfam
conditional
knock-out
(KO)
display
blockage
GC
and
bias
differentiation
towards
memory
aged-related
cells,
hallmarks
an
aged
immune
response.
Unexpectedly,
blocked
KO
not
caused
by
defects
supply
but
associated
defect
remodelling
lysosomal
compartment
cells.
Our
results
may
thus
describe
lysosome
regulation
downstream
antigen
presentation
during
reaction,
dysruption
which
manifested
as
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
24(1), С. 380 - 380
Опубликована: Дек. 26, 2022
Aging
is
associated
with
a
low-grade,
systemic
inflammatory
state
defined
as
“inflammaging”,
ruled
by
the
loss
of
proper
regulation
immune
system
leading
to
accumulation
pro-inflammatory
mediators.
Such
condition
closely
connected
an
increased
risk
developing
chronic
diseases.
A
number
studies
demonstrate
that
olive
oil
phenolic
compound
oleuropein
and
its
derivative
hydroxytyrosol
contribute
modulating
tissue
inflammation
oxidative
stress,
thus
becoming
attractive
potential
candidates
be
used
in
context
nutraceutical
interventions,
order
ameliorate
aging
subjects.
In
this
review,
we
aim
summarize
available
data
about
anti-inflammatory
properties
hydroxytyrosol,
discussing
them
light
molecular
pathways
involved
synthesis
release
mediators
inflammaging.
