Abstract
The
prevalence
of
centenarians,
people
who
lived
100
years
and
longer,
is
steadily
growing
in
the
last
decades.
This
exceptional
longevity
based
on
multifaceted
processes
influenced
by
a
combination
intrinsic
extrinsic
factors
such
as
sex,
(epi-)genetic
factors,
gut
microbiota,
cellular
metabolism,
exposure
to
oxidative
stress,
immune
status,
cardiovascular
risk
environmental
lifestyle
behavior.
Epidemiologically,
incidence
rate
diseases
reduced
healthy
centenarians
along
with
late
onset
age-related
compared
general
aged
population.
Understanding
mechanisms
that
affect
vascular
ageing
underlying
could
offer
valuable
insights
for
developing
strategies
improve
overall
life
span
elderly.
review
discusses
these
key
influencing
how
their
modulation
foster
longevity.
Microorganisms,
Год журнала:
2024,
Номер
12(10), С. 1978 - 1978
Опубликована: Сен. 30, 2024
Antibiotic
resistance
presents
a
critical
challenge
in
healthcare,
particularly
among
the
elderly,
where
multidrug-resistant
organisms
(MDROs)
contribute
to
increased
morbidity,
mortality,
and
healthcare
costs.
This
review
focuses
on
mechanisms
underlying
key
bacterial
pathogens
highlights
how
aging-related
factors
like
immunosenescence,
frailty,
multimorbidity
increase
burden
of
infections
from
MDROs
this
population.
Novel
strategies
mitigate
include
development
next-generation
antibiotics
teixobactin
cefiderocol,
innovative
therapies
such
as
bacteriophage
therapy
antivirulence
treatments,
implementation
antimicrobial
stewardship
programs
optimize
antibiotic
use.
Furthermore,
advanced
molecular
diagnostic
techniques,
including
nucleic
acid
amplification
tests
sequencing,
allow
for
faster
more
precise
identification
resistant
pathogens.
Vaccine
development,
through
approaches
multi-epitope
vaccines
nanoparticle-based
platforms,
holds
promise
preventing
MDRO
elderly.
The
role
machine
learning
(ML)
predicting
patterns
aiding
vaccine
is
also
explored,
offering
promising
solutions
personalized
treatment
prevention
By
integrating
cutting-edge
diagnostics,
therapeutic
innovations,
ML-based
approaches,
underscores
importance
multidisciplinary
efforts
address
global
aging
populations.
Diseases,
Год журнала:
2025,
Номер
13(2), С. 42 - 42
Опубликована: Фев. 1, 2025
Obesity,
chronic
pain,
and
aging
are
prevalent
global
challenges
with
profound
implications
for
health
well-being.
Central
to
these
processes
adrenal
hormones,
particularly
cortisol
dehydroepiandrosterone
(DHEA),
along
its
sulfated
form
(DHEAS).
Cortisol,
essential
stress
adaptation,
can
have
adverse
effects
on
pain
perception
when
dysregulated,
while
DHEA/S
possess
properties
that
may
mitigate
effects.
This
review
explores
the
roles
of
in
contexts
obesity,
acute
aging,
age-related
diseases.
We
examine
hormonal
balance,
specifically
cortisol-to-DHEA
ratio
(CDR),
as
a
key
marker
system
functionality
impact
sensitivity,
neurodegeneration,
physical
decline.
Elevated
CDR
decreased
levels
associated
worsened
outcomes,
including
increased
frailty,
immune
dysfunction,
progression
conditions
such
osteoporosis
Alzheimer’s
disease.
synthesizes
current
literature
highlight
complex
interplay
between
hormones
their
broader
health.
It
aims
provide
insights
into
potential
future
therapies
improve
management
promote
healthy
weight
aging.
By
investigating
mechanisms,
this
work
contributes
deeper
understanding
physiological
intersections
endocrine
system.
South of Russia ecology development,
Год журнала:
2025,
Номер
19(4), С. 28 - 40
Опубликована: Янв. 21, 2025
Aim.
To
analyze
existing
data
on
the
impact
of
mutations
in
human
genome
pathogenesis
respiratory
viral
infections
and
to
discuss
their
relevance
clinical
practice.
The
primary
objectives
include
describing
mechanisms
genetic
mutations,
reviewing
examples
genes
that
affect
susceptibility
disease
severity
evaluating
prospects
for
testing
personalized
medicine.Research
factors
influencing
demonstrates
significant
progression
outcomes.
For
instance,
IFITM3
gene,
which
plays
a
crucial
role
limiting
influenza
virus
replication,
along
with
its
rs12252‐C
polymorphism,
is
linked
severe
cases
influenza.
Similarly,
TLR7
gene
are
associated
manifestations
COVID‐19,
particularly
males.
These
findings
underscore
importance
identify
individuals
at
heightened
risk
emphasize
potential
medicine
enhance
patient
Additionally,
it
essential
consider
interplay
between
environmental
as
well
social
determinants
health.This
review
examines
influence
progression.
It
can
significantly
course
these
infections.
integrating
into
practice
efficiency
diagnosis,
prognosis
treatment
emphasized.
Tropical Medicine & International Health,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
Strongyloides
stercoralis
is
a
neglected
soil-transmitted
helminth
endemic
in
tropical
and
subtropical
regions.
This
study
aimed
to
determine
the
prevalence,
risk
factors,
spatial
distribution
of
S.
infection
rural
villages
Khon
Kaen
Province,
Northeastern
Thailand.
A
cross-sectional
survey
was
conducted
among
260
participants
from
201
households
across
five
randomly
selected
villages.
Stool
samples
were
analysed
using
agar
plate
culture
formalin-ethyl
acetate
concentration
techniques,
soil
assessed
for
DNA
by
PCR
physicochemical
properties
including
pH,
porosity,
bulk
density,
moisture,
organic
matter,
nitrate.
The
prevalence
16.15%,
with
detecting
41
cases
(15.77%)
compared
12
(4.62%)
techniques.
highest
observed
Norng
Thungmon
village
(31.80%).
Risk
factors
included
male
gender,
older
age,
being
head
household,
living
homes
earthen
floors,
walking
barefoot,
proximity
water
sources.
Soil
169
revealed
an
detection
rate
8.3%
via
PCR.
Positive
predominantly
Huachang
Don
Du
Spatial
analysis
identified
significant
clustering
infections
within
high-risk
areas.
properties,
measured,
though
no
correlations
found
rates.
In
conclusion,
remains
health
concern
but
Kaen,
identifiable
human
environmental
factors.
Enhanced
education,
improved
sanitation,
targeted
interventions
are
essential
reducing
transmission
Biomolecules,
Год журнала:
2025,
Номер
15(3), С. 404 - 404
Опубликована: Март 12, 2025
Aging
is
a
complex,
progressive,
and
irreversible
biological
process
that
entails
numerous
structural
functional
changes
in
the
organism.
These
affect
all
bodily
systems,
reducing
their
ability
to
respond
adapt
environment.
Chronic
inflammation
one
of
key
factors
driving
development
age-related
diseases,
ultimately
causing
substantial
decline
abilities
older
individuals.
This
persistent
inflammatory
state
(commonly
known
as
“inflammaging”)
characterized
by
elevated
levels
pro-inflammatory
cytokines,
an
increase
oxidative
stress,
perturbation
immune
homeostasis.
Several
factors,
including
cellular
senescence,
contribute
this
milieu,
thereby
amplifying
conditions
such
cardiovascular
disease,
neurodegeneration,
metabolic
disorders.
Exploring
mechanisms
chronic
aging
essential
for
developing
targeted
interventions
aimed
at
promoting
healthy
aging.
review
explains
strong
connection
between
inflammation,
highlighting
potential
therapeutic
approaches
like
pharmacological
treatments,
dietary
strategies,
lifestyle
changes.
