Antioxidants and Redox Signaling,
Год журнала:
2023,
Номер
unknown
Опубликована: Фев. 2, 2023
Significance:
As
a
redox-sensitive
protein,
high-mobility
group
box
1
(HMGB1)
is
implicated
in
regulating
stress
responses
to
oxidative
damage
and
cell
death,
which
are
closely
related
the
pathology
of
inflammatory
diseases,
including
cancer.
Recent
advances:
HMGB1
non-histone
nuclear
protein
that
acts
as
DNA
chaperone
control
chromosomal
structure
function.
can
also
be
released
into
extracellular
space
function
damage-associated
molecular
pattern
during
apoptosis,
necrosis,
necroptosis,
pyroptosis,
ferroptosis,
alkaliptosis,
cuproptosis.
Once
released,
binds
membrane
receptors
shape
immune
metabolic
responses.
In
addition
subcellular
localization,
activity
depends
on
its
redox
state
posttranslational
modifications.
Abnormal
plays
dual
role
tumorigenesis
anticancer
therapy
(e.g.,
chemotherapy,
radiation
therapy,
immunotherapy)
depending
tumor
types
stages.
Critical
issues:
A
comprehensive
understanding
cellular
homeostasis
important
for
deciphering
normal
functions
pathological
manifestations.
this
review,
we
discuss
compartmental-defined
roles
death
Understanding
these
advances
may
help
us
develop
potential
HMGB1-targeting
drugs
or
approaches
treat
stress-related
diseases
conditions.
Future
directions:
Further
studies
required
dissect
mechanism
by
maintains
under
different
multidisciplinary
effort
evaluate
applications
precisely
targeting
pathway
human
health
disease.
Journal of Neuroinflammation,
Год журнала:
2022,
Номер
19(1)
Опубликована: Июль 14, 2022
Pyroptosis
is
a
programmed
cell
death
characterized
by
swift
plasma
membrane
disruption
and
subsequent
release
of
cellular
contents
pro-inflammatory
mediators
(cytokines),
including
IL-1β
IL-18.
It
differs
from
other
types
such
as
apoptosis,
autophagy,
necroptosis,
ferroptosis,
NETosis
in
terms
its
morphology
mechanism.
As
recently
discovered
form
death,
pyroptosis
has
been
demonstrated
to
be
involved
the
progression
multiple
diseases.
Recent
studies
have
also
suggested
that
linked
various
ocular
In
this
review,
we
systematically
summarized
discussed
recent
scientific
discoveries
involvement
common
diseases,
diabetic
retinopathy,
age-related
macular
degeneration,
AIDS-related
human
cytomegalovirus
retinitis,
glaucoma,
dry
eye
disease,
keratitis,
uveitis,
cataract.
We
organized
new
emerging
evidence
suggesting
signaling
pathways
may
potential
therapeutic
targets
hoping
provide
summary
overall
intervention
strategies
relevant
multi-dimensional
evaluations
for
well
offer
valuable
ideas
further
research
development
perspective
pyroptosis.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 30, 2022
Pyroptosis
is
a
relatively
newly
discovered
programmed
cell
death
accompanied
by
an
inflammatory
response.
In
the
classical
view,
pyroptosis
mediated
caspases-1,-4,-5,-11
and
executed
GSDMD,
however,
recently
it
was
demonstrated
that
caspase-3
and-8
also
participate
in
process
of
pyroptosis,
cleaving
GSDMD/E
GSDMD
respectively.
Different
from
autophagy
apoptosis,
many
pores
are
formed
on
membrane
during
which
makes
lose
its
integrity,
eventually
leading
to
release
cytokines
interleukin(IL)-1β
IL-18.
When
body
infected
with
pathogens
or
exposed
some
stimulations,
could
play
immune
defense
role.
It
found
exists
widely
infectious
respiratory
diseases
such
as
acute
lung
injury,
bronchial
dysplasia,
chronic
obstructive
pulmonary
disease,
asthma.
Excessive
may
accompany
airway
inflammation,
tissue
damage,
induce
reaction,
more
serious
damage
poor
prognosis
diseases.
This
review
summarizes
relationship
between
related
Autophagy,
Год журнала:
2023,
Номер
20(3), С. 469 - 488
Опубликована: Сен. 28, 2023
Triglycerides,
phospholipids,
and
cholesterol
are
prominent
lipid
types
that
serve
diverse
biological
functions.
These
lipids
act
as
vital
structural
components
of
cell
membranes,
provide
energy
for
the
body,
signaling
molecules
regulate
physiological
pathological
processes,
including
regulated
death
(RCD).
While
initiation
signals,
biochemical
pathways,
effector
may
differ,
increased
membrane
permeabilization
from
plasma
membranes
or
organelles
is
a
shared
characteristic
RCD.
This
process
involves
alterations
in
species
functions,
along
with
autophagic
degradation.
Thus,
hypothesis
presents
novel
perspective
complements
other
theories
elucidating
features
survival
death.
In
this
review,
we
present
comprehensive
summary
latest
findings
on
role
potential
mechanisms
influencing
RCD
encompassing
apoptosis,
necroptosis,
pyroptosis,
ferroptosis,
autophagy.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 18, 2024
The
gasdermin
(GSDM)
protein
family
plays
a
pivotal
role
in
pyroptosis,
process
critical
to
the
body’s
immune
response,
particularly
combatting
bacterial
infections,
impeding
tumor
invasion,
and
contributing
pathogenesis
of
various
inflammatory
diseases.
These
proteins
are
adept
at
activating
inflammasome
signaling
pathways,
recruiting
effector
cells,
creating
an
microenvironment,
initiating
pyroptosis.
This
article
serves
as
introduction
GSDM
protein-mediated
pyroptosis
providing
overview
GSDMs’
involvement
immunity.
Additionally,
we
explore
potential
applications
GSDMs
both
innovative
established
antitumor
strategies.
Frontiers in Cell and Developmental Biology,
Год журнала:
2022,
Номер
10
Опубликована: Апрель 20, 2022
The
inflammasomes
are
critical
regulators
of
innate
immunity,
inflammation
and
cell
death
have
emerged
as
important
cancer
development
control.
Inflammasomes
assembled
by
pattern
recognition
receptors
(PRR)
following
the
sensing
microbial-
or
danger-associated
molecular
patterns
(MAMPs/DAMPs)
elicit
through
oligomerization
activation
inflammatory
caspases.
These
cysteinyl-aspartate
proteases
cleave
proinflammatory
cytokines
IL-1β
IL-18
into
their
biologically
active
mature
form.
roles
associated
pro-inflammatory
vary
greatly
depending
on
type.
Here
we
discuss
recent
studies
highlighting
contrasting
inflammasome
pathway
in
curbing
versus
promoting
tumorigenesis.
On
one
hand,
participate
stimulating
anti-tumor
but
they
also
been
shown
to
contribute
immunosuppression
directly
promote
tumor
survival,
proliferation,
metastasis.
A
better
understanding
functions
different
cancers
is
thus
for
design
novel
immunotherapies.
