Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Сен. 27, 2024
The
human
genome
harbors
many
endogenous
retroviral
elements,
known
as
retroviruses
(HERVs),
which
have
been
integrated
into
the
during
evolution
due
to
infections
by
exogenous
retroviruses.
Accounting
for
up
8%
of
genome,
HERVs
are
tightly
regulated
host
and
implicated
in
various
physiological
pathological
processes.
Aberrant
expression
has
observed
numerous
studies
on
viral
infections.
In
this
review,
we
focus
elucidating
potential
roles
further
discuss
their
implications
antiviral
immunity.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Фев. 10, 2022
The
role
for
human
herpesvirus
(HHV)-6A
or
HHV-6B
in
multiple
sclerosis
(MS)
pathogenesis
has
been
controversial.
Possibly
because
the
damage
of
virus
infection
may
occur
before
onset
clinical
symptoms
and
it
difficult
to
detect
active
separate
serological
responses
HHV-6A
6B.
Recent
studies
report
that
MS
patients
response
against
is
increased
whereas
decreased
HHV-6B.
This
effect
seems
be
even
more
pronounced
prior
diagnosis
supports
previous
postulating
a
predomination
disease
suggests
important
at
early
stages
disease.
Furthermore,
interacts
with
other
factors
suspected
modulating
susceptibility
progression
such
as
Epstein-Barr
(EBV)
Cytomegalovirus
(CMV),
tobacco
smoking,
HLA
alleles,
UV
irradiation
vitamin
D
levels.
multifactorial
nature
pathophysiological
inflammation
autoimmunity
are
discussed.
JMIRx Med,
Год журнала:
2024,
Номер
6, С. e50712 - e50712
Опубликована: Ноя. 20, 2024
The
causes
of
breast
cancer
are
poorly
understood.
A
potential
risk
factor
is
Epstein-Barr
virus
(EBV),
a
lifelong
infection
nearly
everyone
acquires.
EBV-transformed
human
mammary
cells
accelerate
when
transplanted
into
immunosuppressed
mice,
but
the
can
disappear
as
malignant
reproduce.
If
this
model
applies
to
cancers,
then
they
should
have
genome
damage
characteristic
EBV
infection.
This
study
tests
hypothesis
that
predisposes
one
by
causing
permanent
compromises
safeguards.
Publicly
available
data
from
approximately
2100
cancers
and
25
ovarian
were
compared
with
proven
associations
EBV,
including
70
nasopharyngeal
90
Burkitt
lymphomas,
88
diffuse
large
B-cell
34
gastric
cancers.
Calculation
algorithms
make
these
comparisons
developed.
Chromosome
breakpoints
in
clustered
around
EBV-associated
Breakpoint
distributions
on
some
chromosomes
not
confidently
distinguished
(P>.05),
differed
controls
unrelated
Viral
breakpoint
clusters
occurred
high-risk,
sporadic,
other
subgroups.
disrupted
gene
functions
essential
for
protection,
which
remain
compromised
even
if
disappears.
As
CRISPR
(clustered
regularly
interspaced
short
palindromic
repeats)-like
reminders
past
during
evolution,
fragments
found
between
Piwi-interacting
RNA
(piRNA)
genes
chromosome
6.
Both
had
inactivated
guard
piRNA
defenses
major
histocompatibility
complex
(MHC)
locus.
Breast
variations
converged
highly
polymorphic
MHC.
Not
develops
because
MHC
differences
produce
differing
responses
shattering
mutation
hot
spots
preferentially
at
incorporated
viral
sequences.
On
17,
those
EBV-mediated
linked
estrogen
effects.
Other
breaks
affected
sites
where
inhibits
JAK-STAT
SWI-SNF
signaling
pathways.
EBV-cancer
deletion
shifts
metabolism
favor
tumors
was
also
These
changes
push
metastasis
survival
metastatic
cells.
metastasis,
Identifying
pathogenic
may
improve
screening,
treatment,
prevention.
Immunizing
children
against
protect
breast,
ovarian,
potentially
chronic
unexplained
diseases.
Autoimmunity Reviews,
Год журнала:
2023,
Номер
22(11), С. 103449 - 103449
Опубликована: Сен. 21, 2023
Multiple
sclerosis
(MS)
is
an
autoimmune-mediated
degenerative
disease
of
the
central
nervous
system,
characterized
by
inflammatory
demyelination.
It
primarily
found
in
women
childbearing
age,
making
pregnancy
a
significant
concern
for
both
patients
with
MS
and
clinicians.
To
assist
these
achieving
their
desire
pregnancy,
reducing
relapses
during
all
stages
preventing
progression
MS,
mitigating
impact
treatment
on
course
outcome
thorough
understanding
relationship
between
as
well
specific
management
application
relevant
medications
at
each
stage
are
essential.
This
article
provides
update
pregnancy-related
issues
including
general
recommendations
pregnancy.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Сен. 27, 2024
The
human
genome
harbors
many
endogenous
retroviral
elements,
known
as
retroviruses
(HERVs),
which
have
been
integrated
into
the
during
evolution
due
to
infections
by
exogenous
retroviruses.
Accounting
for
up
8%
of
genome,
HERVs
are
tightly
regulated
host
and
implicated
in
various
physiological
pathological
processes.
Aberrant
expression
has
observed
numerous
studies
on
viral
infections.
In
this
review,
we
focus
elucidating
potential
roles
further
discuss
their
implications
antiviral
immunity.
