International Journal Of Pharmaceutical Research And Allied Sciences,
Год журнала:
2024,
Номер
13(1), С. 62 - 73
Опубликована: Янв. 1, 2024
This
review
provides
a
comprehensive
overview
of
genetic
variations
influencing
the
effectiveness
and
side
effects
methotrexate
(MTX)
treatment
in
rheumatoid
arthritis
(RA)
patients.
It
synthesizes
findings
on
associations
between
polymorphisms
MTX
therapy
outcomes,
aiming
to
identify
potential
markers
for
enhancing
personalized
strategies
RA.
The
highlights
associated
with
effects.
Variants
genes
involved
tr
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 8, 2022
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disease
that
primarily
affects
the
joints.
Microbial
infection
considered
crucial
inducer
of
RA.
Alterations
in
composition
intestinal
bacteria
individuals
with
preclinical
and
established
RA
suggest
vital
role
gut
microbiota
immune
dysfunction
characteristic
However,
mechanisms
by
which
dysbiosis
contributes
to
are
not
fully
understood.
Furthermore,
multiple
therapies
commonly
used
treat
may
alter
diversity,
suggesting
modulating
help
prevent
or
Hence,
better
understanding
changes
accompany
should
aid
development
novel
therapeutic
approaches.
This
mini-review
discusses
impact
pathogenesis
RA,
selection
microbiota-related
biomarkers
for
diagnosing
provides
examples
cross-modulation
between
some
drugs
Some
suggestions
outlooks
also
raised,
guide
future
research
efforts.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Март 22, 2023
Objective
To
evaluate
safety
and
efficacy
of
dietary
polyphenols
in
the
treatment
rheumatoid
arthritis
(RA).
Methods
CNKI,
Pubmed,
Cochrane
library,
Embase
were
searched
to
collect
randomized
controlled
trials
(RCTs)
RA.
The
databases
from
time
their
establishment
November
8nd,
2022.
After
2
reviewers
independently
screened
literature,
extracted
data,
assessed
risk
bias
included
studies,
Meta-analysis
was
performed
using
RevMan5.4
software.
Results
A
total
49
records
(47
RCTs)
finally
included,
involving
3852
participants
15
types
(Cinnamon
extract,
Cranberry
Crocus
sativus
L.
Curcumin,
Garlic
Ginger
Hesperidin,
Olive
oil,
Pomegranate
Puerarin,
Quercetin,
Resveratrol,
Sesamin,
Tea
polyphenols,
Total
glucosides
paeony).
Cinnamon
Sesamin
only
involve
1
RCT.
RCTs.
paeony
Curcumin
more
than
3
These
RCTs
showed
that
these
could
improve
disease
activity
score
for
28
joints
(DAS28),
inflammation
levels
or
oxidative
stress
addition
did
not
increase
adverse
events.
Conclusion
Dietary
may
DAS28,
reduce
C-reactive
protein
(CRP)
erythrocyte
sedimentation
rate
(ESR),
stress,
etc.
However,
are
needed
verify
modify
polyphenols.
Systematic
review
registration
https://www.crd.york.ac.uk/prospero/
,
identifier
CRD42022315645.
Molecular Medicine,
Год журнала:
2024,
Номер
30(1)
Опубликована: Окт. 10, 2024
Rheumatoid
arthritis,
a
chronic
autoimmune
disease,
is
characterized
by
synovial
hyperplasia
and
cartilage
erosion.
Here,
we
investigated
the
potential
mechanism
of
action
quercetin,
main
component
flavonoids,
in
treating
rheumatoid
arthritis.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 9, 2024
Abstract
The
intestinal
microbiome
plays
an
important
role
in
mammalian
health,
disease,
and
immune
function.
In
light
of
this
function,
recent
studies
have
aimed
to
characterize
the
microbiomes
various
bat
species,
which
are
noteworthy
for
their
roles
as
reservoir
hosts
several
viruses
known
be
highly
pathogenic
other
mammals.
Despite
ongoing
research,
its
function
especially
effects
changes
on
host
remains
nebulous.
Here,
we
describe
a
novel
methodology
investigate
captive
Jamaican
fruit
bats
(
Artibeus
jamaicensis
).
We
observed
high
degree
individual
variation
addition
sex-
cohort-linked
differences.
was
correlated
with
metabolite
composition,
possibly
contributing
differences
status.
This
work
provides
basis
future
infection
field
examine
detail
antiviral
immunity.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10255 - 10255
Опубликована: Сен. 24, 2024
Hematologic
malignancies
(HMs),
including
leukemia,
lymphoma,
and
multiple
myeloma,
involve
the
uncontrolled
proliferation
of
abnormal
blood
cells,
posing
significant
clinical
challenges
due
to
their
heterogeneity
varied
treatment
responses.
Despite
recent
advancements
in
therapies
that
have
improved
survival
rates,
particularly
chronic
lymphocytic
leukemia
acute
lymphoblastic
treatments
like
chemotherapy
stem
cell
transplantation
often
disrupt
gut
microbiota,
which
can
negatively
impact
outcomes
increase
infection
risks.
This
review
explores
complex,
bidirectional
interactions
between
microbiota
cancer
patients
with
HMs.
Gut
influence
drug
metabolism
through
mechanisms
such
as
production
enzymes
bacterial
β-glucuronidases,
alter
efficacy
toxicity.
Moreover,
microbial
metabolites
short-chain
fatty
acids
modulate
host
immune
response,
enhancing
effectiveness.
However,
therapy
reduces
diversity
beneficial
bacteria,
Bifidobacterium
Faecalibacterium,
while
increasing
pathogenic
bacteria
Enterococcus
Escherichia
coli.
These
findings
highlight
critical
need
preserve
during
treatment.
Future
research
should
focus
on
personalized
microbiome-based
therapies,
probiotics,
prebiotics,
fecal
transplantation,
improve
quality
life
for
hematologic
malignancies.
Heliyon,
Год журнала:
2025,
Номер
11(1), С. e41672 - e41672
Опубликована: Янв. 1, 2025
The
last
decennia
have
witnessed
spectacular
advances
in
our
knowledge
about
the
influence
of
gut
microbiome
on
development
a
wide
swathe
diseases
that
extend
beyond
digestive
tract,
including
skin
like
psoriasis,
atopic
dermatitis,
acne
vulgaris,
rosacea,
alopecia
areata,
and
hidradenitis
suppurativa.
novel
concept
gut-skin
axis
delves
into
how
interact
through
inflammatory
mediators,
metabolites,
intestinal
barrier.
Elucidating
effects
health
could
provide
new
opportunities
for
developing
innovative
treatments
dermatological
diseases.
Psoriasis
is
complex
disease
with
multiple
factors
contributing
to
its
development,
such
as
diet,
lifestyle,
genetic
predisposition,
microbiome.
This
paper
has
dual
purpose.
First,
we
outline
current
unique
microbiota
patterns
implicated
pathogenesis
psoriasis.
Second,
equal
importance,
briefly
discuss
reciprocal
impact
psoriasis
treatment
In
addition,
this
review
explores
potential
therapeutic
targets
based
microbial
interventions,
which
hold
promise
providing
options
Frontiers in Cardiovascular Medicine,
Год журнала:
2023,
Номер
10
Опубликована: Июнь 2, 2023
Cancer
survivors
undergone
treatment
face
an
increased
risk
of
developing
atherosclerotic
cardiovascular
disease
(CVD),
yet
the
underlying
mechanisms
remain
elusive.
Recent
studies
have
revealed
that
chemotherapy
can
drive
senescent
cancer
cells
to
acquire
a
proliferative
phenotype
known
as
senescence-associated
stemness
(SAS).
These
SAS
exhibit
enhanced
growth
and
resistance
treatment,
thereby
contributing
progression.
Endothelial
cell
(EC)
senescence
has
been
implicated
in
atherosclerosis
cancer,
including
among
survivors.
Treatment
modalities
for
induce
EC
senescence,
leading
development
subsequent
Consequently,
targeting
ECs
displaying
hold
promise
therapeutic
approach
managing
CVD
this
population.
This
review
aims
provide
mechanistic
understanding
induction
its
contribution
We
delve
into
response
disturbed
flow
ionizing
radiation,
which
play
pivotal
role
cancer.
Key
pathways,
p90RSK/TERF2IP,
TGFβR1/SMAD,
BH4
signaling
are
explored
potential
targets
treatment.
By
comprehending
similarities
distinctions
between
different
types
associated
we
pave
way
targeted
interventions
aim
at
enhancing
health
vulnerable
The
insights
gained
from
may
facilitate
novel
strategies
