Emerging roles of lactate in acute and chronic inflammation

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Май 16, 2024

Abstract Traditionally, lactate has been considered a ‘waste product’ of cellular metabolism. Recent findings have shown that is substance plays an indispensable role in various physiological functions and contributes to energy metabolism signal transduction during immune inflammatory responses. The discovery lactylation further revealed the regulating processes. In this review, we comprehensively summarize paradoxical characteristics microenvironment highlight pivotal roles homeostasis, shuttle, (‘lactate clock’) acute chronic responses from molecular perspective. We especially focused on receptors with either proinflammatory or anti-inflammatory effects complex biological signalling pathways investigated dynamic changes cells lactate-related microenvironment. Moreover, reviewed progress use as therapeutic target for response, which may provide new perspective treating inflammation-related diseases.

Язык: Английский

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Examining Chronic Inflammation, Immune Metabolism, and T Cell Dysfunction in HIV Infection

Viruses, Год журнала: 2024, Номер 16(2), С. 219 - 219

Опубликована: Янв. 31, 2024

Chronic Human Immunodeficiency Virus (HIV) infection remains a significant challenge to global public health. Despite advances in antiretroviral therapy (ART), which has transformed HIV from fatal disease into manageable chronic condition, definitive cure elusive. One of the key features is immune activation and inflammation, are strongly associated with, predictive of, progression, even patients successfully treated with suppressive ART. inflammation characterized by persistent cell metabolic dysregulation, cellular exhaustion dysfunction. This review aims summarize current knowledge interplay between metabolism, T dysfunction infection, also discusses use humanized mice models study pathogenesis develop novel therapeutic strategies.

Язык: Английский

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The relationship between CD4+ T cell glycolysis and their functions

Trends in Endocrinology and Metabolism, Год журнала: 2023, Номер 34(6), С. 345 - 360

Опубликована: Апрель 14, 2023

CD4+ T cells are effector (Teffs) produced by the differentiation of initial in peripheral lymphoid tissue after being attacked antigens, and have an indispensable role development activation B CD8+ to regulate assist immunity. In this review, we provide a new perspective on relationship between cell glycolysis its function. We summarize effects changes level their activation, differentiation, proliferation, survival. addition, emphasize that regulation inflammatory phenotypes The study immune metabolism has received more attention recently, but work is needed answer many open questions.

Язык: Английский

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Tumor Microenvironment and Cancer Metastasis

IntechOpen eBooks, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

The tumor microenvironment is a complex ecosystem composed of diverse cell types, extracellular matrix components, growth factors, and cytokines. dynamic interactions within this not only facilitate but also contribute to the establishment metastatic niches in distant organs. Furthermore, presence specific TME components can either promote or inhibit cancer migration, underscoring importance targeting these elements therapeutic strategies. This review seeks elucidate critical influence on metastasis examines potential targeted approaches. By integrating recent research insights, offers thorough understanding interplay between metastasis, serving as valuable reference for future investigations.

Язык: Английский

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Atrazine promotes breast cancer development by suppressing immune function and upregulating MMP expression

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 253, С. 114691 - 114691

Опубликована: Март 1, 2023

There is evidence that the triazine herbicide atrazine, which used extensively, present in both surface water and groundwater, its interfering effect on immune systems, endocrine tumours has been reported by laboratory epidemiological studies. This study explored how atrazine affected 4T1 breast cancer cell development vitro vivo. The obtained results showed after exposure to proliferation tumour volume were significantly increased expression of MMP2, MMP7, MMP9 was upregulated. thymus spleen indices, CD4 + CD3 lymphocyte percentages from inguinal lymph nodes, /CD8 ratio noticeably lower than they control group. Importantly, tumour-infiltrating lymphocytes such as , CD8 NK cells decreased while Treg increased. Moreover, IL-4 IFN-γ TNF-α serum microenvironment. These suggested can suppress systemic well local function upregulate MMPs promote development.

Язык: Английский

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Glutaminolysis of CD4+ T Cells: A Potential Therapeutic Target in Viral Diseases

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 603 - 616

Опубликована: Фев. 1, 2024

Abstract: CD4 + T cells play a critical role in the pathogenesis of viral diseases, which are activated by internal metabolic pathways encountering with antigens. Glutaminolysis converts glutamine into tricarboxylic acid (TCA) circulating metabolites α-ketoglutaric acid, is essential for proliferation and differentiation plays central providing energy structural components needed replication after virus hijacks host cell. Changes glutaminolysis accompanied changes status cell due to competition between immune cells. More recently, attempts have been made treat tumours, autoimmune diseases altering breakdown In this review, we will discuss current knowledge subsets from not only increasing our understanding immunometabolism but also new perspective therapeutic target diseases. Keywords: cells, glutamine, glutaminolysis, response

Язык: Английский

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Metabolism of NK cells during viral infections

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Янв. 18, 2023

Cellular metabolism is essential for the correct function of immune system cells, including Natural Killer cells (NK). These depend on energy to carry out their effector functions, especially in early stages viral infection. NK participate innate response against viruses and tumors. Their main functions are cytotoxicity cytokine production. Metabolic changes can impact intracellular signals, molecule production, secretion, cell activation which as first line defense. variations different a tumor or pathogen infection have been described; however, little known about context This review summarizes activation-specific metabolic immunometabolism during early, late, chronic antiviral responses, alterations SARS-CoV2 The modulation points these routes also discussed explore potential new immunotherapies infections.

Язык: Английский

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Bidirectional crosstalk between the epithelial-mesenchymal transition and immunotherapy: A bibliometric study

Human Vaccines & Immunotherapeutics, Год журнала: 2024, Номер 20(1)

Опубликована: Март 19, 2024

Immunotherapy has recently attracted considerable attention. However, currently, a thorough analysis of the trends associated with epithelial-mesenchymal transition (EMT) and immunotherapy is lacking. In this study, we used bibliometric tools to provide comprehensive overview progress in EMT-immunotherapy research. A total 1,302 articles related EMT were retrieved from Web Science Core Collection (WOSCC). The indicated that terms volume research, China was most productive country (49.07%, 639), followed by United States (16.89%, 220) Italy (3.6%, 47). influential according frequency citations citation burstiness. results also suggested Frontiers can be considered as journal respect number impact factors. "Immune infiltration," "bioinformatics analysis," "traditional Chinese medicine," "gene signature," "ferroptosis" found emerging keywords These findings point potential new directions deepen our understanding mechanisms underlying combined effects help develop strategies for improving immunotherapy.

Язык: Английский

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Role of Inflammation in the Development of COVID-19 to Parkinson’s Disease

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 3259 - 3282

Опубликована: Май 1, 2024

The coronavirus disease 2019 (COVID-19) can lead to neurological symptoms such as headaches, confusion, seizures, hearing loss, and loss of smell. link between COVID-19 Parkinson's (PD) is being investigated, but more research needed for a definitive connection.

Язык: Английский

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Crucial Roles of RSAD2/viperin in Immunomodulation, Mitochondrial Metabolism and Autoimmune Diseases

Inflammation, Год журнала: 2024, Номер unknown

Опубликована: Июнь 23, 2024

Autoimmune diseases are typically characterized by aberrant activation of immune system that leads to excessive inflammatory reactions and tissue damage. Nevertheless, precise targeted efficient therapies limited. Thus, studies into novel therapeutic targets for the management autoimmune urgently needed. Radical S-adenosyl methionine domain-containing 2 (RSAD2) is an interferon-stimulated gene (ISG) renowned antiviral properties protein it encodes, named viperin. An increasing number have underscored new roles RSAD2/viperin in immunomodulation mitochondrial metabolism. Previous shown there a complex interplay between RSAD2/vipeirn mitochondria binding iron-sulfur (Fe-S) cluster necessary involvement viperin Viperin influences proliferation development cells as well inflammation via different signaling pathways. However, function varies comprehensive overview this emerging theme lacking. This review will describe characteristics RSAD2/viperin, decipher its immunometabolic processes, clarify crosstalk mitochondria. Furthermore, we emphasize crucial RSAD2 potential application value.

Язык: Английский

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