Regulatory Mechanisms in Biosystems,
Год журнала:
2023,
Номер
14(2), С. 213 - 219
Опубликована: Апрель 15, 2023
The
human
organism
is
home
to
trillions
of
bacteria,
viruses
and
fungi.
In
order
survive,
they
have
adapt
the
living
environment
a
host.
has
adapted
mutual
functioning
by
benefiting
from
microbiota
in
certain
way
or
removing
its
negative
effects.
gut
microorganisms
influence
all
systems,
including
synthesis
heat-shock
proteins.
Their
species
composition
functional
condition
undergo
changes
depending
on
physical
activity
host
organism.
While
moderate
loading
no
doubt
positive
for
diversity
intestinal
barrier,
mechanism
exercises
biodiversity,
coadaptation
yet
be
identified.
Lactobacillus
acidophilus
bacteria
were
found
dominate
long-distance-track
athletes
who
train
endurance,
while
Bacteroidescoccae
dominated
sprinter
runners.
Marathon
runners
many
representatives
conventionally
pathogenic
Veillonella
genus.
They
convert
lactate
into
propionate
acetate
–
substrates
ATF
formation.
Bacteria
generate
an
additional
energy
increase
endurance
athlete.
At
same
time,
cause
inflammatory
process
host’s
gut.
A
temperature-increase
effect
what
adaptation
mechanisms
exercise
bacterial
common.
Rise
temperature
threshold
value
initiates
increased
proteins,
which
regulate
function
barrier
controlling
high-density
are
released
damaged
stressed
cells
act
as
local
“danger
signals”.
Detecting
molecular
interaction
between
subject
can
valuable
identifying
safe
volumes
thresholds
training
load
maintaining
health.
Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2502 - 2502
Опубликована: Ноя. 1, 2024
The
endogenous
ecto-enzyme
and
exogenously
administered
alkaline
phosphatase
(ALP)
have
been
evidenced
to
significantly
attenuate
inflammatory
conditions,
including
Toll-like
receptor
4
(TLR4)-related
signaling
cytokine
overexpression,
barrier
tissue
dysfunction
oxidative
stress,
metabolic
syndrome
insulin
resistance,
in
experimental
models
of
colitis,
liver
failure,
renal
cardiac
ischemia-reperfusion
injury.
This
suggests
multiple
mechanisms
ALP
anti-inflammatory
action
that
remain
be
fully
elucidated.
Journal of Agricultural and Food Chemistry,
Год журнала:
2023,
Номер
72(1), С. 27 - 45
Опубликована: Ноя. 15, 2023
The
intestinal
barrier
is
critical
for
maintaining
homeostasis,
and
its
dysfunction
associated
with
various
diseases.
Recent
findings
have
revealed
the
multifunctional
role
of
alkaline
phosphatase
(IAP)
in
diverse
biological
processes,
including
gut
health
maintenance
function.
This
review
summarizes
protective
effects
IAP
on
integrity,
encompassing
physical,
chemical,
microbial,
immune
barriers.
We
discuss
results
insights
from
vitro,
animal
model,
clinical
studies
as
well
available
evidence
regarding
impact
diet
activity
expression.
can
also
be
used
an
indicator
to
assess
intestinal-barrier-related
Further
research
into
mechanisms
action
long-term
overall
essential
future
use
a
dietary
supplement
or
functional
component
medical
foods.
Comprehensive Reviews in Food Science and Food Safety,
Год журнала:
2023,
Номер
23(1)
Опубликована: Дек. 13, 2023
Abstract
Breastmilk
is
seen
as
the
gold
standard
for
infant
nutrition
it
provides
nutrients
and
compounds
that
stimulate
gut
barrier,
immune,
brain
development
to
infant.
However,
there
are
many
instances
where
not
possible
an
be
fed
with
breastmilk,
especially
full
6
months
recommended
by
World
Health
Organization.
In
such
instances,
formula
next
best
approach.
formulas
do
contain
human
milk
oligosaccharides
(hMOs),
which
uniquely
present
in
third
most
abundant
solid
component.
hMOs
have
been
linked
health
benefits,
of
microbiome,
immune
system,
intestinal
a
healthy
brain.
This
paper
reviews
effects
specific
applied
on
including
not‐often‐recognized
alkaline
phosphatase
system
prevents
inflammation.
Additionally,
impact
immunity
current
proof
neurocognitive
function
corresponding
mechanisms
discussed.
Recent
studies
suggest
can
alter
microbiota,
modulate
barrier
function,
promote
function.
The
2′‐fucosyllactose
lacto‐
N
‐neotetraose
found
positive
infants
deemed
safe
use
formula.
their
has
limited
due
cost
complexity
synthesis.
Thus,
although
benefits
described,
complex
combinations
other
approach
prevention
disease.
Abstract
Radiation
enteritis
is
a
frequently
encountered
issue
for
patients
receiving
radiotherapy
and
has
significant
impact
on
cancer
patients'
quality
of
life.
The
gut
microbiota
plays
pivotal
role
in
intestinal
function,
yet
the
irradiation
microorganisms
not
fully
understood.
This
study
explores
gastroprotective
effect
microbiome-modulating
potential
ubiquinol
(Ubq),
reduced
form
powerful
antioxidant
CoQ-10.
For
this
purpose,
male
albino
rats
were
randomly
assigned
to
four
groups:
Control,
IRR
(acute
7
Gy
γ-radiation),
Ubq_Post
(Ubq
days
post-irradiation),
Ubq_Pre/Post
pre
post-irradiation).
fecal
microbiomes
all
groups
profiled
by
16S
rRNA
amplicon
sequencing
followed
bioinformatics
statistical
analysis.
Histopathological
examination
tissue
indicated
severe
damage
irradiated
group,
which
was
mitigated
with
enhanced
regeneration,
goblet
cells,
alkaline
phosphatase
expression.
Compared
Ubq-treated
had
recovery
interleukin-1β,
caspase-3,
nitric
oxide
metabolites,
thio-barbituric
reactive
substances
near-healthy
levels.
group
displayed
elevated
peroxisome
proliferator-activated
receptor
(PPAR-γ)
level,
suggesting
heightened
benefits.
Serum
insulin
reduction
improved
post-Ubq
treatment,
possible
anti-inflammatory
pancreatic
tissue.
Fecal
profiling
revealed
dysbiosis
state
bacterial
diversity
post-irradiation,
re-modulated
Ubq
treated
profiles
that
are
indistinguishable
from
control
group.
These
findings
underscore
Ubq's
effects
against
radiation-induced
its
restoring
microbiota’s
balance.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 26, 2023
Chito-oligosaccharides
(COS)
and
β-glucan
are
gradually
being
applied
in
aquaculture
as
antioxidants
immunomodulators.
However,
this
study
examined
the
effects
of
dietary
supplementation
COS
on
water
quality,
gut
microbiota,
intestinal
morphology,
non-specific
immunity,
meat
quality
Chinese
soft-shell
turtle.
To
investigate
possible
mechanisms,
3-year-old
turtles
were
fed
basal
diet
(CK
group)
0.1%,
0.5%,
1%
or
supplemented
for
4
weeks.
Colon,
liver,
blood
muscle
tissues,
colon
contents,
sediment
paddy
field
samples
collected
analyzed
after
feeding
2
The
results
indicated
that
altered
microbial
community
composition
diversity
turtles.
relative
abundance
Cellulosilyticum,
Helicobacter
Solibacillus
increased
COS,
while
Romboutsia,
Akkermansia
Paraclostridium
β-glucan,
whereas
Cetobacterium,
Vibrio
Edwardsiella
enriched
control
group.
Furthermore,
morphology
analysis
revealed
improved
length
number
villi,
effect
0.5%
was
more
obvious.
Both
significantly
liver
serum
lysozyme
activity
antibacterial
capacity.
total
antioxidant
capacity
liver.
Further,
0.1%
hepatic
alkaline
phosphatase,
which
closely
related
to
bacteria
involved
lipid
metabolism.
Moreover,
with
enhanced
content
amino
acids,
especially
umami
tissue,
exerting
a
stronger
than
COS.
Additionally,
these
two
prebiotics
promoted
culture
fields
reshaped
bacterial
environment.
All
phenotypic
changes
associated
microbes
regulated
by
prebiotics.
In
summary,
findings
suggest
Pelodiscus
sinensis
could
modulate
improve
enhance
immunity
serum,
increase
This
provides
new
insights
comprehensive
understanding
positive
sinensis.
The Journals of Gerontology Series A,
Год журнала:
2024,
Номер
79(11)
Опубликована: Окт. 22, 2024
Abstract
Aging
triggers
physiological
changes
in
organisms
that
are
tightly
linked
to
metabolic
changes.
Senolytics
targeting
many
fundamental
aging
processes
currently
being
developed.
However,
the
host
response
natural
senescence
and
molecular
mechanism
underlying
antiaging
benefits
of
senolytics
remain
poorly
understood.
In
this
study,
we
investigated
during
based
on
Caenorhabditis
elegans
model
pinpointed
potential
biomarkers
senolytics.
These
results
suggest
age-dependent
occur
C
elegans.
Betaine
was
identified
as
a
crucial
metabolite
process.
We
explored
effects
interventions
by
administering
3
drugs—metformin,
quercetin,
minocycline—to
nematodes.
Notably,
betaine
expression
significantly
increased
under
drug
treatments.
Our
findings
demonstrated
supplementation
extends
lifespan,
primarily
through
pathways
associated
with
forkhead
box
transcription
factor
(FoxO)
signaling
pathway,
p38-mitogen-activated
protein
kinase
(MAPK)
autophagy,
longevity
regulating
target
rapamycin
(mTOR)
pathway.
addition,
autophagy
free
radicals
altered
betaine-treated
Overall,
found
is
critical
extend
lifespan
nematodes
increasing
levels
promoting
antioxidant
activity.
This
finding
suggests
could
be
novel
therapeutic
for
longevity.
Heliyon,
Год журнала:
2023,
Номер
9(11), С. e21838 - e21838
Опубликована: Ноя. 1, 2023
Heatstroke
(HS)
is
a
severe
acute
disease
related
to
gastrointestinal
barrier
dysfunction,
systemic
inflammation
and
multiple
organ
injury.
Many
of
the
functions
Intestinal
alkaline
phosphatase
(IAP)
have
been
linked
gut
homeostasis,
function
inflammation.
However,
protective
effect
IAP
on
heatstroke
not
fully
elucidated.
This
study
aims
explore
by
maintaining
intestinal
improving
permeability.Male
C57BL/6
mice
were
placed
in
controlled
climate
chamber
(ambient
temperature:
40.0
±
0.5
°C;
humidity:
60
5
%)
until
maximum
core
temperature
(Tc,
max)
reached
42.7
°C
(the
received
criterion
HS).
Then
heat
exposed
(n
=
195)
divided
into
three
groups:
0.2
mL
0.9
%
physiological
saline
or
vehicle
(HS
+
Vehicle)
300
IU
IAP)
gavage
at
0,
24,
48
h
after
onset.
Control
group
(Con)
65)
gavaged
with
same
volume
time.IAP
treatment
significantly
reduced
levels
endotoxin,
FD4,
D-lactate
blood
mice,
permeability
maintained
integrity
increasing
expression
tight
junction
proteins.
Meanwhile,
alleviated
liver
kidney
damage
caused
heatstroke,
serum
inflammatory
cytokines,
thus
improved
survival
rate
heatstroke.This
indicates
that
can
improve
junctions,
reduce
injury
heatstroke.
Therefore,
we
consider
may
be
added
enteral
nutrition
formulas
as
potential
means
for
diseases
characterized
disorders,
including
