Frontiers in Pharmacology, Год журнала: 2024, Номер 14
Опубликована: Янв. 12, 2024
Hepatocellular carcinoma (HCC) is responsible for approximately 90% of liver malignancies and the third most common cause cancer-related mortality worldwide. However, role anoikis, a programmed cell death mechanism crucial maintaining tissue equilibrium, not yet fully understood in context HCC.
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2023, Номер 13
Опубликована: Янв. 16, 2023
Cutaneous melanoma (CM) is a highly aggressive malignancy with dimal prognosis and limited treatment options. Anoikis believed to involve in the regeneration, migration, metastasis of tumor. The exact role anoikis-related genes (ARGs) development progression cutaneous melanoma, however, remains elusive. Four ARGs (SNAI2, TFDP1, IKBKG, MCL1) significant differential expression were selected through Cox regression LASSO analyses. Data for internal external cohorts validated accuracy clinical utility prognostic risk model based on ARGs. Kaplan-Meier curve indicated much better overall survival rate low-risk patients. Notably, we also found that action CM was mediated by immune-related signaling pathways. Consensus clustering TIME landscape analysis score patients have excellent immune status. Moreover, results immunotherapy response drug sensitivity confirmed potential implications informing individualized therapeutic strategies CM. Collectively, predictive constructed provides an accurate prediction tool This present research rationale joint application targeted therapy treatment. approach could great value make contribution personalized medicine therapy.
Язык: Английский
Процитировано
8
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Март 28, 2023
Background Despite progression in its treatment, the clinical outcome of patients with clear cell renal carcinoma (ccRCC) remains not ideal. Anoikis is a unique form programmed apoptosis, owing to insufficient cell-matrix interactions. plays crucial role tumor migration and invasion, cells could protect themselves through capacity anoikis resistance. Methods Anoikis-related genes (ARGs) were obtained from Genecards Harmonizome portals. The ARGs related ccRCC prognosis identified univariate Cox regression analysis, then we utilized these construct novel prognostic model for patients. Moreover, explored expression profile using Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) database. We also conducted Real-Time Polymerase Chain Reaction (RT-PCR) probe risk score. Finally, performed correlation analysis between immune microenvironment. Results 17 associated survival, which 7 chosen model. was verified as an independent indicator. most higher samples. These closely correlated infiltration checkpoint members, had value respectively. Functional enrichment demonstrated that significantly multiple types malignances. Conclusion signature be highly efficient predicting prognosis,
Язык: Английский
Процитировано
8
Frontiers in Endocrinology, Год журнала: 2023, Номер 14
Опубликована: Июнь 13, 2023
Background Ovarian cancer (OC) is a highly lethal and aggressive gynecologic cancer, with an overall survival rate that has shown little improvement over the decades. Robust models are urgently needed to distinguish high-risk cases predict reliable treatment options for OC. Although anoikis-related genes (ARGs) have been reported contribute tumor growth metastasis, their prognostic value in OC remains unknown. The purpose of this study was construct ARG pair (ARGP)-based signature patients elucidate potential mechanism underlying involvement ARGs progression. Methods RNA-sequencing clinical information data were obtained from Center Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. A novel algorithm based on pairwise comparison utilized select ARGPs, followed by Least Absolute Shrinkage Selection Operator Cox analysis signature. predictive ability model validated using external dataset, receiver operating characteristic curve, stratification analysis. immune microenvironment proportion cells analyzed high- low-risk seven algorithms. set enrichment weighted gene co-expression network performed investigate mechanisms occurrence prognosis. Results 19-ARGP identified as important predictor 1-, 2-, 3-year function showed group characterized infiltration immunosuppressive adherence-related signaling pathway, suggesting involved progression mediating escape metastasis. Conclusion We constructed ARGP OC, our findings suggested exerted vital interplay therapeutic response. These insights provided valuable regarding molecular disease targeted therapies.
Язык: Английский
Процитировано
7
Frontiers in Oncology, Год журнала: 2023, Номер 13
Опубликована: Июль 4, 2023
Background Tumor heterogeneity is widely recognized as a crucial factor impacting the prognosis of breast cancer (BC) patients. However, there remains an insufficient understanding underlying impact anoikis on BC Methods The researchers utilized TCGA-BRCA dataset to screen and analyze differentially expressed genes anoikis-related (ARGs) in normal tissue. Prognostic gene signatures were established through univariate, LASSO, multivariate Cox regression analyses. These evaluated using Kaplan-Meier curve receiver operating characteristic (ROC) analyses, resulting development index (ACI). training was TCGA-BRCA, while METABRIC GSE96058 used for external validation. Additionally, nomograms developed by combining risk scores clinical parameters, enabling set enrichment analysis (GSEA) tumor immunoassay. Furthermore, exploration small molecule compounds conducted identify potential therapeutic benefits. Results A six-gene signature constructed, which divided patients into high- low-ACI groups based median ACI scores. accurately predicted acted independent prognostic Patients high-ACI group exhibited poorer overall survival (OS) across all cohorts showed more severe manifestations compared group. study also explored impacts immune cells infiltrating tumors, checkpoints, growth factors, cytokine levels. implications immunotherapy discussed, along with highlighting that could offer Conclusions Anoikis found hold significant value cancer, providing novel approach managing different prognoses implementing precise strategies.
Язык: Английский
Процитировано
7
Frontiers in Pharmacology, Год журнала: 2024, Номер 14
Опубликована: Янв. 12, 2024
Hepatocellular carcinoma (HCC) is responsible for approximately 90% of liver malignancies and the third most common cause cancer-related mortality worldwide. However, role anoikis, a programmed cell death mechanism crucial maintaining tissue equilibrium, not yet fully understood in context HCC.
Язык: Английский
Процитировано
2