Inflammopharmacology, Год журнала: 2024, Номер 32(5), С. 2961 - 2986
Опубликована: Авг. 10, 2024
Язык: Английский
Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102665 - 102665
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
13
Animal Models and Experimental Medicine, Год журнала: 2025, Номер unknown
Опубликована: Янв. 22, 2025
Neurodegenerative diseases (NDs), including Alzheimer's disease, Parkinson's and Huntington's are complex challenging due to their intricate pathophysiology limited treatment options. This review systematically sourced articles related neurodegenerative diseases, neurodegeneration, quercetin, clinical studies from primary medical databases, Scopus, PubMed, Web of Science. Recent have included quercetin impact the cellular molecular pathways involved in neurodegeneration. Quercetin, a flavonoid abundant vegetables fruits, is gaining attention for its antioxidant, anti-inflammatory, antiapoptotic properties. It regulates signaling such as nuclear factor-κB (NF-κB), sirtuins, phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt). These essential survival, inflammation regulation, apoptosis. Preclinical shown that improves symptoms pathology models, indicating promising outcomes. The study explores potential incorporating laboratory research into practical treatment, focusing on quercetin's neuroprotective effects NDs optimal dosage.
Язык: Английский
Процитировано
3
Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 11, 2025
Mycotoxin contamination is a universal agricultural problem and critical health issue. Fumonisin B1 (FB1) one of the most toxic extensive fumonisins that exist in various agro-products foods. Lycopene (LYC), as natural carotenoid, becoming increasingly favored owing to its oxidation resistance. Here, we aim explore mechanism FB1-induced hepatotoxicity antagonism LYC. In this study, our findings indicated FB1 induced mitochondrial structure damage loss function chicken hepatocytes. Furthermore, upregulated expression PANoptosis-related signal molecules. also reduced levels SIRT1 Ac-FOXO1 protein expression, which then inhibited mitophagy. However, LYC relieved these alterations. Most importantly, knockdown protective effects PANoptosis. Our study provides evidence for role mycotoxin-induced hepatocyte injury points potential target liver protection.
Язык: Английский
Процитировано
3
International Journal of Biological Sciences, Год журнала: 2022, Номер 19(2), С. 484 - 501
Опубликована: Дек. 19, 2022
Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent deacetylase, is cellular that has received extensive attention in recent years and regarded as sensor of energy metabolism. The accumulated evidence suggests SIRT1 involved the development endocrine metabolic diseases. In variety organisms, regulates gene expression through deacetylation histone, transcription factors, lysine residues other modified proteins including several signal thereby enhancing therapeutic effects These evidences indicate targeting promising applications treatment This review focuses on role First, we describe background structure SIRT1. Then, outline diseases such hyperuricemia, diabetes, hypertension, hyperlipidemia, osteoporosis, polycystic ovarian syndrome. Subsequently, agonists inhibitors above are summarized future research directions proposed. Overall, presents here may highlight potential biomarker target for
Язык: Английский
Процитировано
67
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 165, С. 115071 - 115071
Опубликована: Июнь 28, 2023
SIRT5 is a mitochondrial NAD+ -dependent lysine deacylase. Downregulation of has been linked to several primary cancers and DNA damage. In clinical therapy for non-small cell lung cancer (NSCLC), the Feiyiliu Mixture (FYLM) an experience effective Chinese herb prescription. And we found that quercetin important ingredient in FYLM. However, whether regulates damage repair (DDR) induces apoptosis through NSCLC remains unknown. The present study revealed directly binds inhibits phosphorylation PI3K/AKT interaction between PI3K, thus inhibiting process homologous recombination (HR) non-homologous end-joining (NHEJ) NSCLC, which raise mitotic catastrophe apoptosis. Our provided novel mechanism action treatment NSCLC.
Язык: Английский
Процитировано
43
Cell Death Discovery, Год журнала: 2023, Номер 9(1)
Опубликована: Июль 26, 2023
Abstract Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment. Unexpectedly, its cardiotoxic side effects have proven to be formidable obstacle. Numerous studies are currently devoted elucidating the pathological mechanisms underlying doxorubicin-induced cardiotoxicity. Nrf2 has always played crucial role in oxidative stress, but numerous demonstrated that it also plays vital part like cell death and inflammation. on associated with cardiotoxicity demonstrate this. Several drugs, natural synthetic compounds, as well small molecule RNAs been prevent by activating Nrf2. Consequently, this study emphasizes introduction of Nrf2, discusses cardiotoxicity, concludes summary therapeutic modalities targeting ameliorate highlighting potential value
Язык: Английский
Процитировано
43
International Journal of Molecular Medicine, Год журнала: 2023, Номер 52(6)
Опубликована: Окт. 20, 2023
Acute lung injury (ALI) causes high morbidity and mortality rates in critically ill patients, there are currently no effective therapeutic drugs. Ferroptosis is a newly discovered mode of regulated cell death that contributes to the progression ALI. Quercetin possesses anti‑inflammatory antioxidant properties. However, whether quercetin can protect against lipopolysaccharide (LPS)‑induced ALI by inhibiting ferroptosis its underlying mechanisms remains unclear. The present study evaluated protective effects molecular LPS‑induced establishing an mouse model alveolar epithelial via treatment mice or cells with LPS. Mouse was assessed evaluating histological score, bronchoalveolar lavage fluid count inflammatory cytokine levels; Cell counting kit‑8, lactate dehydrogenase EDU assays; detecting changes levels malondialdehyde, glutathione, iron, glutathione peroxidase 4 (Gpx4) 4‑hydroxynonenal in vivo vitro. indicated effectively ameliorated reducing histopathological changes, proinflammatory release reactive oxygen species generation ferroptosis. significantly decreased improved proliferative ability LPS‑treated cells. Additionally, it demonstrated markedly enhanced barrier, as evidenced upregulation tight junction protein expression both vitro. Mechanistically, activated sirtuin 1 (Sirt1)/nuclear factor erythroid 2‑related 2 (Nrf2)/Gpx4 signaling pathway, targeted inhibition vitro knockdown Sirt1 reduced anti‑ferroptotic functions quercetin. In conclusion, results exerts activation Sirt1/Nrf2/Gpx4 pathway.
Язык: Английский
Процитировано
35
Phytotherapy Research, Год журнала: 2023, Номер 37(11), С. 4999 - 5016
Опубликована: Июль 25, 2023
Abstract Numerous pharmacological effects of quercetin have been illustrated, including antiinflammation, antioxidation, and anticancer properties. In recent years, the antioxidant activity has extensively reported, in particular, its impacts on glutathione, enzyme activity, signaling transduction pathways, reactive oxygen species (ROS). Quercetin also demonstrated to exert a striking antiinflammatory effect mainly by inhibiting production cytokines, reducing expression cyclooxygenase lipoxygenase, preserving integrity mast cells. By regulating oxidative stress inflammation, which are regarded as two critical processes involved defense regular physiological operation biological systems, validated be effective treating variety disorders. Symptoms these reactions linked degenerative metabolic disorders, syndrome, cardiovascular, neurodegeneration, cancer, nonalcoholic fatty liver disease. Despite that evidence demonstrates antioxidants employed prevent excessive inflammatory processes, there still concerns regarding expense, accessibility, side agents. Notably, natural products, especially those derived from plants, widely accessible, affordable, generally safe. this review, abilities active ingredient application stress‐related disorders outlined detail.
Язык: Английский
Процитировано
32
Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 256, С. 114872 - 114872
Опубликована: Апрель 5, 2023
Manganese (Mn), as one of the environmental risk factors for Parkinson's disease (PD), has been widely studied. Though autophagy dysfunction and neuroinflammation mainly are responsible causative issue Mn neurotoxicity, molecular mechanism parkinsonism caused by not explored clearly. The results in vivo vitro experiments showed that overexposure to impairment dysfunction, accompanied increase IL-1β, IL-6, TNF-α mRNA expression, nerve cell apoptosis, microglia activation, NF-κB poor neurobehavior performance. This is due Mn-induced downregulation SIRT1. Upregulation SIRT1 could alleviate neuroinflammation, yet these beneficial effects were abolished following 3-MA administration. Furthermore, we found interfered with acetylation FOXO3 BV2 cells, leading a decrease nuclear translocation FOXO3, its binding LC3B promoter transcription activity. be antagonized upregulation Finally, it proved SIRT1/FOXO3-LC3B signaling involves impairment.
Язык: Английский
Процитировано
29
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 161, С. 114474 - 114474
Опубликована: Март 4, 2023
Alzheimer's disease (AD) is a neurodegenerative mainly characterized by progressive cognitive dysfunction and memory impairment. Recent studies have shown that regulating silent information regulator 1 (SIRT1) expression has significant neuroprotective effect, SIRT1 may become new therapeutic target for AD. Natural molecules are an important source of drug development use in AD therapy regulate wide range biological events as well other SIRT1-mediated signaling pathways. This review aims to summarize the correlation between identify vivo vitro investigating anti-AD properties natural modulators A literature search was conducted published January 2000 October 2022 using various databases, including Web Science, PubMed, Google Scholar, Science Direct, EMBASE. molecules, such resveratrol, quercetin, icariin, bisdemethoxycurcumin, dihydromyricetin, salidroside, patchouli, sesamin, rhein, ligustilide, tetramethoxyflavanone, 1-theanine, schisandrin, curcumin, betaine, pterostilbene, ampelopsin, schisanhenol, eriodictyol, potential modulate pathways, thereby combating The modulating discussed this provide potentially novel multi-mechanistic strategy However, future clinical trials need be further investigate their beneficial determine safety efficacy activators against
Язык: Английский
Процитировано
28