Contemporary insights and prospects on ferroptosis in rheumatoid arthritis management

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Сен. 24, 2024

Rheumatoid arthritis (RA) is a common autoimmune disease characterized primarily by persistent synovial inflammation and joint destruction. In recent years, ferroptosis, as novel form of cell death, has garnered widespread attention due to its critical role in various diseases. This review explores the potential mechanisms ferroptosis RA relationship with pathogenesis RA, systematically analyzing regulatory cells, chondrocytes, immune cells. We emphasize evaluation ferroptosis-related pathways their therapeutic targets, including development application inhibitors activators. Although shows some promise treatment, dual safety issues clinical still require in-depth study. Future research should focus on elucidating specific pathology developing more effective safer strategies provide new treatment options for patients.

Язык: Английский

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Molecular Mechanisms of Immunoinflammatory Infiltration and Ferroptosis in Arthritis Revealed by a Combination of Bioinformatics and Single-Cell Analysis

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 2409 - 2432

Опубликована: Фев. 1, 2025

Osteoarthritis (OA) is a widespread chronic inflammatory disease in orthopedics, and its molecular mechanisms are still poorly understood. The purpose of this work was to detect the immunological infiltration OA manner cell death utilizing bioinformatics single-cell analysis order provide guidelines for clinical therapy medicine. Ferroptosis -associated genes were sourced from ferroptosis Database, bioinformatic expression profiles chosen Gene Expression Comprehensive gene information taken GeneCards. To ascertain categorization status cells, conducted. Protein-protein interaction networks established by SRING analysis, functional enrichment examined Kyoto Encyclopedia Genes Genomes (KEGG) Ontology (GO) databases. important proteins immune-ferroptosis elucidated through co-analysis. Last but not least, network pharmacology docking support mechanism which resveratrol controls OA. development found be tightly related chondrocytes immune particularly T macrophage according profile. In patients with OA, also revealed notable B NK monocytes, macrophages. hub shown enriched responses, chemokine-mediated signaling pathways, analysis. main pathways included autophagy, ferroptosis, HIF-1 pathway, PI3K-Akt FoxO pathway. significant that contributes advancement osteoarthritis. lessened regulation GPX4, TFRC, SLC7A11. Various infiltrates, especially cells macrophages, play an role progression ameliorates modulating chondrocyte ferroptosis.

Язык: Английский

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Iron metabolism and ferroptosis in health and diseases: the crucial role of mitochondria in meta-bolically active tissues

The Journal of Nutritional Biochemistry, Год журнала: 2025, Номер unknown, С. 109888 - 109888

Опубликована: Март 1, 2025

Iron is essential in various physiological processes, but its accumulation leads to oxidative stress and cell damage, thus iron homeostasis has be tightly regulated. Ferroptosis an iron-dependent non-apoptotic regulated death characterized by overload ROS accumulation. Mitochondria are organelles playing a crucial role metabolism involved ferroptosis. MitoNEET, protein of mitochondrial outer membrane, key element this process. Ferroptosis, altering levels several metabolically active organs, linked non-communicable diseases. For example, the liver hepatic fibrosis cirrhosis, accelerating NAFLD progression, muscle cells contributes damage leading sarcopenia, brain associated neurodegeneration. The aim review investigate intricate balance regulation focusing on mitochondria stress, analyzing ferroptosis implications health disease.

Язык: Английский

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Therapeutic prospects and potential mechanisms of Prdx6: as a novel target in musculoskeletal disorders

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Апрель 17, 2025

With the global population aging, musculoskeletal disorders (MSDs) have posed significant physical and psychological health challenges for patients as well a substantial economic burden on society. The advancements in conservative surgical interventions MSDs been remarkable recent years; however, current treatment modalities still fall short of meeting optimal requirements patients. Recently, peroxiredoxin 6 (Prdx6) has gained considerable attention from researchers due to its antioxidative, anti-inflammatory, anti-apoptotic properties. It found that Prdx6 is involved multiple system diseases, including MSDs; exact role lacking. This study aimed summarize structure, regulatory mechanism, potential function Prdx6. These findings may demonstrate novel target inhibiting advancement MSDs.

Язык: Английский

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Environmentally relevant levels of Cd and Mo coexposure induces ferroptosis and excess ferritinophagy through AMPK/mTOR axis in duck myocardium

Environmental Toxicology, Год журнала: 2024, Номер 39(8), С. 4196 - 4206

Опубликована: Май 8, 2024

Abstract Cadmium (Cd) and excess molybdenum (Mo) are multiorgan toxic, but the detrimental impacts of Cd and/or Mo on poultry have not been fully clarified. Thence, a 16‐week sub‐chronic toxic experiment was executed with ducks to assess toxicity Mo. Our data substantiated that coexposure evidently reduced GSH‐Px, GSH, T‐SOD, CAT activities elevated H 2 O MDA concentrations in myocardium. What is more, study suggested united exposure synergistically Fe 2+ content myocardium activated AMPK/mTOR axis, then induced ferroptosis by obviously upregulating ACSL4, PTGS2, TFRC expression levels downregulating SLC7A11, GPX4, FPN1, FTL1, FTH1 levels. Additionally, further caused excessive ferritinophagy observably increasing autophagosomes, colocalization endogenous LC3, ATG5, ATG7, LC3II/LC3I, NCOA4, In brief, this for first time finally augmenting injure ducks, which will offer an additional view between two heavy metals poultry.

Язык: Английский

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Mesenchymal Stem Cell-Derived Exosomal Noncoding RNAs as Alternative Treatments for Myocardial Ischemia-Reperfusion Injury: Current Status and Future Perspectives

Journal of Cardiovascular Translational Research, Год журнала: 2023, Номер 16(5), С. 1085 - 1098

Опубликована: Июнь 7, 2023

Язык: Английский

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Prevention and treatment of osteoporosis with natural products: Regulatory mechanism based on cell ferroptosis

Journal of Orthopaedic Surgery and Research, Год журнала: 2023, Номер 18(1)

Опубликована: Дек. 11, 2023

Abstract Context With the development of society, number patients with osteoporosis is increasing. The prevention and control has become a serious urgent issue. continuous progress biomedical research, ferroptosis attracted increased attention. However, pathophysiology mechanisms still need further study. Natural products are widely used in East Asian countries for treatment. Objective In this paper, we will discuss basic ferroptosis, relationship between osteoclasts osteoblasts, vitro vivo studies natural to prevent by interfering ferroptosis. Methods This article takes products, osteoporosis, osteoblasts osteoclast as key words. Retrieve literature from 2012 2023 indexed databases such PubMed Central, PubMed, Web Science, Scopus ISI. Results Ferroptosis many regulatory mechanisms, including system XC -/GSH/GPX4, p62/Keap1/Nrf2, FSP1/NAD (P) H/CoQ10, P53/SAT1/ALOX15 axes etc. Interestingly, found that Artemisinin, Biochanin A Quercetin, can play role treating promoting inhibiting osteoblasts. Conclusions have great potential regulate OBs OCs mediating treat it worthwhile explore discover more osteoporosis.

Язык: Английский

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The role of extracellular vesicles in iron homeostasis and ferroptosis: Focus on musculoskeletal diseases

Traffic, Год журнала: 2023, Номер 24(9), С. 384 - 396

Опубликована: Июнь 21, 2023

Abstract Iron homeostasis is crucial for maintaining proper cellular function, and its disruption considered one of the pathogenic mechanisms underlying musculoskeletal diseases. Under conditions oxidative stress, accumulation iron overload lipid peroxidation can lead to ferroptosis. Extracellular vesicles (EVs), serving as mediators in cell‐to‐cell communication, play an important role regulating outcome cell Growing evidence has proven that EV biogenesis secretion are tightly associated with export. Furthermore, different sources EVs deliver diverse cargoes bring about phenotypic changes recipient cells, either activating or inhibiting Thus, delivering therapies targeting ferroptosis through may hold significant potential treating This review aims summarize current knowledge on ferroptosis, well their therapeutic applications diseases, thereby provide valuable insights both research clinical practice.

Язык: Английский

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Ferroptosis-related genes LPCAT3 and PGD are potential diagnostic biomarkers for osteoarthritis

Journal of Orthopaedic Surgery and Research, Год журнала: 2023, Номер 18(1)

Опубликована: Сен. 19, 2023

Osteoarthritis (OA) is the most common chronic joint disease and how ferroptosis contributes to OA has garnered much attention recently. Bioinformatics promoted discovery of ferroptosis-related biomarkers for OA. But since a whole-joint disease, sensitive are still limited. We herein focused on subchondral bone, component often-ignored by existing bioinformatic reports, identify diagnostic OA.Microarray datasets GSE51588 GSE55457 were downloaded from Gene Expression Omnibus database. Ferroptosis-related differential expression genes (Ferr-DEGs) between normal samples identified their functional enrichment was analyzed. Common diagnosis selected Ferr-DEGs using combination SVM-RFE, LASSO regression, RandomForest machine learning algorithms. genes' value verified receiver operating characteristic (ROC) curve association with immune infiltration analyzed CIBERSORT. Finally, candidate gene's in chondrocytes patients an vitro IL-1β-induced model, RT-PCR.Two genes, LPCAT3 PGD, as confirmed ROC test. The PGD several types cells identified. decreased both condition.We potential OA, which may offer insight into role provides useful information treatment

Язык: Английский

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Nrf2 as a potential target for improving wound healing in the elderly

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 69 - 88

Опубликована: Янв. 1, 2024

Язык: Английский

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