Association between systemic immune-inflammation index and metabolic syndrome and its components: results from the National Health and Nutrition Examination Survey 2011–2016

Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)

Опубликована: Окт. 4, 2023

Abstract Background Metabolic syndrome (MetS), a worldwide public health problem, affects human and quality of life in dramatic manner. A growing evidence base suggests that MetS is strongly associated with levels systemic immune inflammation. The present study aimed to investigate the possible relationship between immune-inflammation index (SII), novel inflammatory marker, provide data support for effective prevention by reducing response. Methods We included adult participants complete SII information from 2011–2016 National Health Nutrition Examination Survey (NHANES). was defined as using criteria developed Adult Treatment Program III Cholesterol Education Program. formula follows: = platelet counts × neutrophil counts/ lymphocyte counts. Weighted linear regression used assess differences variables across quartile groups after score divided into 4 quartiles. independent interaction investigated weighted multivariate logistic analysis subgroup analysis, 5 particular items further explored depth. Results total 12,402 participants, 3,489 whom were diagnosed MetS, this study. After correcting covariates, results multistage complex sampling revealed higher scores had chance developing (odds ratio (OR) 1.33, 95% confidence interval (CI): 1.14–1.55) could be an risk factor predict likelihood onset. In Q1–Q4 group, 1.33 times Q4 which highest level inflammation than Q1 group. adjusting all confounding factors, found have negative correlation high-density lipoprotein cholesterol (OR 1.29; CI, 0.99–1.67, P 0.056) significant positive waist circumference 2.17; 1.65–2.87, < 0.001) blood pressure (BP) 1.65; 1.20–2.27, 0.003). Gender, age, smoking status shown alter association analyses tests ( p 0.05). Additionally, we demonstrated nonlinear MetS. findings restricted cubic spline indicated there inverted U-shaped Conclusions Our imply increased are related may simple cost-effective method identify individuals Therefore, protective measures such early investigation anti-inflammatory interventions necessary reduce overall incidence

Язык: Английский

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The Associations of Two Novel Inflammation Biomarkers, SIRI and SII, with Mortality Risk in Patients with Chronic Heart Failure

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 1255 - 1264

Опубликована: Фев. 1, 2024

Background: The associations of two novel inflammation biomarkers, systemic response index (SIRI) and immune (SII), with mortality risk in patients chronic heart failure (CHF) are not well-characterized. Methods: This retrospective cohort study included CHF medical centers Chinese People's Liberation Army General Hospital, Beijing, China. outcomes this in-hospital long-term mortality. Associations SIRI SII were assessed using multivariable regressions receiver operating characteristic (ROC) analyses. Results: A total 6232 the present study. We documented 97 cases 1738 during an average 5.01-year follow-up. Compared lowest quartile SIRI, those highest exhibited 134% higher (adjusted odds ratio, 2.34; 95% confidence interval [CI], 1.16– 4.72) 45% hazard 1.45; CI, 1.25– 1.67). SII, 27% 1.27; 1.11– 1.46). In ROC analyses, showed better prognostic discrimination than C-reactive protein (area under curve: 69.39 vs 60.91, P = 0.01, for mortality; 61.82 58.67, 0.03, 3-year mortality), whereas similar value protein. Conclusion: significantly associated CHF. may provide Keywords: inflammation, index, failure,

Язык: Английский

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Association between the systemic immunity-inflammation index and stroke: a population-based study from NHANES (2015–2020)

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 2, 2025

Background The systemic immunity-inflammation index(SII) is a new indicator of composite inflammatory response. Inflammatory response an important pathological process in stroke. Therefore, this study sought to investigate the association between SII and Methods We collected data on participants with stroke from 2015–2020 cycle National Health Nutrition Examination Survey (NHANES) for cross-sectional investigation. Multivariate linear regression models were used test Fitted smoothing curves threshold effect analysis applied describe nonlinear relationship. Results A total 13,287 included our study, including 611 (4.598%) In multivariate analysis, we found significant positive stroke, odds ratio (OR) [95% CI] associating prevalence was [1.02 (1.01, 1.04)] (P < 0.01). subgroup interaction experiments, that relationship not significantly correlated among different population settings such as age, gender, race, education level, smoking status, high blood pressure, diabetes coronary heart disease trend > 0.05). Moreover, inflection point 740 (1,000 cells /µl) by using two-segment model. Conclusions This implies increased levels are linked To confirm findings, more large-scale prospective investigations needed.

Язык: Английский

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Composite dietary antioxidant index is inversely and nonlinearly associated with cardiovascular disease, atherosclerotic cardiovascular disease, and cardiovascular mortality in people with dyslipidemia: evidence from NHANES 2001–2018

Frontiers in Nutrition, Год журнала: 2025, Номер 11

Опубликована: Янв. 7, 2025

Dyslipidemia is a major risk factor for cardiovascular disease (CVD) and atherosclerotic CVD (ASCVD). The composite dietary antioxidant index (CDAI), an emerging measure of combined exposure, may provide insights into the relationship between diet CVD/ASCVD outcomes. We aimed to explore association CDAI prevalence CVD/ASCVD, as well mortality in individuals with dyslipidemia. was assessed by integrating vitamins A, C, E, zinc, selenium, carotenoids. diagnosed according widely established criteria. Data on were obtained through self-reports, while prospective matching participant records National Death Index database. Multivariate logistic regression analysis Cox proportional hazards used these associations calculate odds ratios [OR], hazard [HR], 95% confidence intervals [CI], respectively. A total 23,126 participants dyslipidemia from NHANES 2001-2018 included. After adjusting potential confounders, inversely associated both ASCVD populations (OR CI 0.979 (0.964, 0.995) 0.977 (0.961, 0.993), respectively). Similar observed specific types CVD. also (HR = 0.957, 0.939-0.976, p < 0.0001). Restricted cubic spline threshold effects analyses indicated that nonlinearly significant occurring only when CDAI≤0; however, > -2. Furthermore, age, sex, drinking found modify body mass influenced mortality. events dyslipidemic populations. These findings highlight patterns alleviate burden underscore importance personalized strategies.

Язык: Английский

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Association of systemic immune-inflammation index with all-cause and cardiovascular mortality among adults with depression: evidence from NHANES 2005–2018

BMC Psychiatry, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 8, 2025

The relationship between the systemic immune-inflammatory index (SII) and mortality of adults with depression is uncertain. This study included who were surveyed in National Health Nutrition Examination Survey (NHANES) from 2005 to 2018. Cox proportional hazards regression models compute hazard ratios (HR) 95% confidence intervals (CI) for mortality.The restricted cubic spline(RCS), Kaplan-Meier curve analysis, time-dependent ROC subgroup sensitivity analyses also used. A total 2442 final analysis(average age: 46.51 ± 0.44 years). During a median follow-up 89 months, there 302 all-cause deaths 74 cardiovascular deaths. fully adjusted model showed that an increment 100 unit SII corresponded increased HR 1.05(95% CI,1.02,1.08, p = 0.003) 1.06(95% CI,1.02,1.10, 0.004) mortality, respectively. RCS analysis indicated J-shape positive linear association exhibited excellent efficacy predicting at 1, 3, 5 10 years. Higher levels associated risk depression. Not applicable.

Язык: Английский

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The relationship between dietary index for gut microbiota and diabetes

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 20, 2025

This study aims to explore the relationship between Dietary Index for Gut Microbiota (DI-GM) and diabetes. In recent years, there has been increasing attention role of gut microbiome in regulating host metabolism. However, DI-GM risk diabetes not sufficiently studied. utilized relevant data from National Health Nutrition Examination Survey (NHANES) 2007-2018. Multiple logistic regression analysis was conducted The dose-response observed using restricted cubic splines (RCS). Threshold effect performed based on RCS results. Subgroup analyses were used conduct a sensitivity results multiple indicated significant negative correlation (OR, 0.954, 95%CI, 0.918-0.991). also showed nonlinear (P < 0.001, P = 0.010). threshold revealed that when below 6.191, 0.921, 95% CI, 0.876-0.969). exceeded no longer significant. remained Whites, participants with poverty-income ratio > 3.5, body mass index 24, current drinkers, never or smokers, those without chronic kidney disease 0.05). demonstrates Maintaining above 6.191 may help prevent

Язык: Английский

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System inflammation response index: a novel inflammatory indicator to predict all-cause and cardiovascular disease mortality in the obese population

Diabetology & Metabolic Syndrome, Год журнала: 2023, Номер 15(1)

Опубликована: Окт. 11, 2023

This study aims to investigate the relationship between two novel inflammatory markers, namely, Systemic Inflammatory Response Index (SIRI) and Immune (SII), as well all-cause cardiovascular disease (CVD) mortality in obese population.

Язык: Английский

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Association between oxidative balance score, systemic inflammatory response index, and cardiovascular disease risk: a cross-sectional analysis based on NHANES 2007–2018 data

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Июнь 5, 2024

There is limited research on the relationship between Systemic Oxidative Stress (SOS) status and inflammatory indices. Adding onto existing literature, this study aimed to examine association dietary Balance Score (OBS) lifestyle OBS (which make up overall OBS), Cardiovascular Disease (CVD) prevalence at different Immune Inflammation Index (SII) Inflammatory Response (SIRI) levels. This involved 9,451 subjects selected from National Health Nutrition Examination Survey (NHANES) 2007-2018. The comprised 20 factors. Statistical methods included Weighted Linear Regression Analysis (WLRA), Logistic (LRA), Sensitivity (SA), Restricted Cubic Spline (RCS) analysis. multivariate WLRA revealed that was significantly negatively correlated with both SII (β = -5.36, p < 0.001) SIRI -0.013, In SA, removing any single component had no significant effect results of SIRI. Further subgroup analyses more impactful in lowering women than men. Additionally, low-age group high-age group. Moreover, RCS analysis confirmed linear relationship. Compared OBS, exerted a Coronary Artery (CAD) (OR: 0.794, 0.002), hypertension 0.738, 0.001), Congestive Heart Failure (CHF) 0.736, 0.005), Myocardial Infarction (MI) 0.785, stroke 0.807, 0.029) prevalence. Furthermore, exhibited interaction CHF (P for 0.001). On other hand, MI 0.05). including were associated Higher reduced risks CAD, hypertension, CHF, MI, stroke.

Язык: Английский

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Low-grade Chronic Inflammation: A Shared Mechanism for Chronic Diseases

Physiology, Год журнала: 2024, Номер 40(1), С. 000 - 000

Опубликована: Июль 30, 2024

Inflammation is an important physiological response of the organism to restore homeostasis upon pathogenic or damaging stimuli. However, persistence harmful trigger a deficient resolution process can evolve into state low-grade, chronic inflammation. This condition strongly associated with development several increasingly prevalent and serious conditions, such as obesity, cancer, cardiovascular diseases, elevating overall morbidity mortality worldwide. The current pandemic diseases underscores need address inflammation, its mechanisms, potential preventive measures limit widespread impact. present review discusses knowledge research gaps regarding association between low-grade inflammation focusing on digestive cancer. We examine art in selected aspects topic propose future directions approaches for field.

Язык: Английский

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Prognostic nutritional index as a predictor of cardiovascular and all-cause mortality in American adults with hypertension: results from the NHANES database

Frontiers in Cardiovascular Medicine, Год журнала: 2025, Номер 11

Опубликована: Янв. 6, 2025

Few studies have examined the relationship between nutritional status, as assessed by Prognostic Nutrition Index (PNI), and incident cardiovascular mortality all-cause mortality, particularly in hypertensive patients. This study aimed to examine association PNI Americans with hypertension. Data from this retrospective cohort were obtained National Health Examination (NHANES) 1999-2016. Using data of The NHANES Public-Use Linked Mortality Files assess (ACM) (CVM). After excluding participants younger than 18 years, without hypertension, missing follow-up data, a total 18,189 cases included study. Persons hypertension divided into 4 groups: Q1 (PNI < 49.0), Q2 (PNI: 49.0-52.5), Q3 52.5-55.5), Q4 > 55.5). We used Cox proportional hazard regression model explore predictive role on ACM CVM American adults Restricted cubic spline (RCS) curves investigate existence dose-response linear them. During median period 89 months, 1,444 (7.94%) deaths occurred 5,171 (28.43%) occurred. Multifactorial COX analysis showed [hazard ratio (HR): 0.584, 95% CI: 0.523-0.652, p 0.001] (HR: 0.435, 0.349-0.541, 0.001) associated group risk malnutrition compared group. RCS nonlinear (both non-linear 0.001). Lower levels are patients may be predictor

Язык: Английский

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