Epigenetic and Genetic Keys to Fight HPV-Related Cancers DOI Open Access
Veronica Folliero, Federica Dell’Annunziata, Annalisa Chianese

и другие.

Cancers, Год журнала: 2023, Номер 15(23), С. 5583 - 5583

Опубликована: Ноя. 25, 2023

Cervical cancer ranks as the fourth most prevalent among women globally, with approximately 600,000 new cases being diagnosed each year. The principal driver of cervical is human papillomavirus (HPV), where viral oncoproteins E6 and E7 undertake role driving its carcinogenic potential. Despite extensive investigative efforts, numerous facets concerning HPV infection, replication, pathogenesis remain shrouded in uncertainty. virus operates through a variety epigenetic mechanisms, signature HPV-related tumors major bottleneck our understanding disease. Recent investigations have unveiled capacity to influence changes within tumors, conversely, these exert an on surrounding landscape. Given escalating occurrence HPV-triggered deficiency efficacious treatments, substantial challenges emerge. A promising avenue address this challenge lies modulators. This review aggregates dissects potential modulators capable combatting HPV-associated infections diseases. By delving into modulators, novel avenues for therapeutic interventions against HPV-linked cancers come fore.

Язык: Английский

Cervicovaginal microbiome, high-risk HPV infection and cervical cancer: Mechanisms and therapeutic potential DOI Creative Commons

Roujie Huang,

Zimo Liu,

Tianshu Sun

и другие.

Microbiological Research, Год журнала: 2024, Номер 287, С. 127857 - 127857

Опубликована: Июль 26, 2024

The microbiota in the female genital tract is an intricate assembly of diverse aerobic, anaerobic, and microaerophilic microorganisms, which share space within reproductive engage complex interactions. Microbiome dysbiosis may disrupt symbiotic relationship between host microorganisms play a pivotal role pathogenesis various diseases, including its involvement establishment human papillomavirus (HPV)-associated cervical cancer (CC). Interventions to restore homeostasis (e.g., probiotics) bacterial-vector HPV therapeutic vaccines have been reported be potentially effective clearing infection ameliorating cytological abnormalities. In this review, we place emphasis on elucidating alterations cervical-vaginal as well intratumoral context high-risk (HR-HPV) subsequent progression intraepithelial neoplasia/CC. Furthermore, explore mechanisms by these microbial communities exert potential pathogenic or protective effects, modulating inflammation immune responses, affecting HR-HPV oncogene expression oncoprotein production, regulating oxidative stress deoxyribonucleic acid (DNA) damage, inducing metabolic rewiring. Lastly, summarize latest evidence trials regarding efficacy probiotics, prebiotics probiotic-vector vaccines. This review aims foster deeper understanding infection-related cervix development, further provide theoretical basis for development preventive strategies based modulation.

Язык: Английский

Процитировано

8
Impact of HIV on HPV-related cancers in men who have sex with men: a review DOI Creative Commons
Zixuan Zhang,

Yuying Xing,

Tao Gong

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 14

Опубликована: Янв. 20, 2025

Co-infection with human immunodeficiency virus (HIV) significantly increases the incidence of papillomavirus (HPV) infection and HPV-related cancers among men who have sex (MSM). Conversely, HPV can also influence HIV acquisition rates. HIV-induced immune suppression may affect chromosomal stability, gene expression, protein function other molecular components in MSM cancers. Additionally, alters cellular mechanisms by compromising responses epithelial integrity. In this review, we reviewed on specific MSM, including oropharyngeal squamous cell carcinoma, penile cancer, anal cancer. We integrated epidemiological data from past five years discussed diagnosis treatment strategies. Overall, our review offers crucial insights into underlying these co-infection patients. Our aims to assist future research developing effective strategies for HIV/HPV co-infection.

Язык: Английский

Процитировано

1
Relationship Between Human Papilloma Virus and Upper Gastrointestinal Cancers DOI Creative Commons
Ömer Vefik Özozan, Hikmet Pehlevan Özel, Veli Vural

и другие.

Viruses, Год журнала: 2025, Номер 17(3), С. 367 - 367

Опубликована: Март 4, 2025

The human papillomavirus (HPV) is an oncogenic DNA virus that the most commonly transmitted sexually virus. There substantial evidence HPV associated with different types of cancer. While majority studies have concentrated on urogenital system cancers and head neck cancers, relationship between gastrointestinal particularly esophageal has also been subject investigation. Given a disease can be prevented through vaccination treated antiviral agents, identifying pathogen may inform treatment these cancers. This comprehensive review examines upper tract, highlighting mechanisms its reported prevalence. A deeper understanding HPV’s association cancer relevant to further development therapies.

Язык: Английский

Процитировано

1
Human malignancies associated with persistent HPV infection DOI Creative Commons
Alison A. McBride

The Oncologist, Год журнала: 2024, Номер 29(6), С. 457 - 464

Опубликована: Апрель 17, 2024

Abstract Human papillomavirus (HPV)-associated malignancies account for ~5% of human cancers worldwide. Thirteen, or more, HPV types are oncogenic, but infection with these viruses is common and usually cleared within 2 years. Only infections that become persistent associated the development cancer, often occurring several decades later. These mostly arise in 6 different anatomical regions: 5 anogenital (anus, cervix, penis, vagina, vulva) sixth oropharynx. Oncogenic HPVs promote cellular proliferation genomic instability, niche target tissue also plays an important role cancer. Cells reside transitional regions between epithelia, such as anus, oropharynx, particularly vulnerable to oncogenesis.

Язык: Английский

Процитировано

7
Benzoyl peroxide for acne treatment is not associated with an increased risk of malignancy: A retrospective cohort study DOI
David Gárate, Christopher J Thang, Jenny Lai

и другие.

Journal of the American Academy of Dermatology, Год журнала: 2024, Номер 91(5), С. 966 - 968

Опубликована: Июль 14, 2024

Язык: Английский

Процитировано

6
Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives DOI Open Access
Alan Soo Beng Khoo, Michael Boyer, Zuhayr Jafri

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2798 - 2798

Опубликована: Фев. 28, 2024

Oropharyngeal squamous cell carcinoma (OPSCC), a subset of head and neck (HNSCC), involves the palatine tonsils, soft palate, base tongue, uvula, with ability to spread adjacent subsites. Personalized treatment strategies for Human Papillomavirus-associated oropharynx (HPV+OPSCC) are yet be established. In this article, we summarise our current understanding pathogenesis HPV+OPSCC, intrinsic role immune system, ICI clinical trials, potential small molecule immunotherapy in HPV+OPSCC.

Язык: Английский

Процитировано

5
Cellular Transformation by Human Cytomegalovirus DOI Open Access
Georges Herbein

Cancers, Год журнала: 2024, Номер 16(11), С. 1970 - 1970

Опубликована: Май 22, 2024

Epstein–Barr virus (EBV), Kaposi sarcoma human (KSHV), papillomavirus (HPV), hepatitis B and C viruses (HBV, HCV), T-lymphotropic virus-1 (HTLV-1), Merkel cell polyomavirus (MCPyV) are the seven oncoviruses reported so far. While traditionally viewed as a benign causing mild symptoms in healthy individuals, cytomegalovirus (HCMV) has been recently implicated pathogenesis of various cancers, spanning wide range tissue types malignancies. This perspective article defines biological criteria that characterize oncogenic role HCMV based on new findings underlines critical for cellular transformation modeling tumor microenvironment already other oncoviruses.

Язык: Английский

Процитировано

5
Cancer risk in people living with HIV and solid organ transplant recipients: a systematic review and meta-analysis DOI Creative Commons
Fengyi Jin, Claire M. Vajdic, I. Mary Poynten

и другие.

The Lancet Oncology, Год журнала: 2024, Номер 25(7), С. 933 - 944

Опубликована: Июнь 24, 2024

Язык: Английский

Процитировано

5
Impact of Hormonal Contraceptives on HPV Dynamics in Adolescent Girls and Young Women: Insights from a Randomized Controlled Sub-Study in South Africa DOI Creative Commons
Ramla F. Tanko, Ongeziwe Taku, Zizipho Z. A. Mbulawa

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

ABSTRACT Objectives Human papillomavirus (HPV) is the leading cause of cervical cancer, with adolescent girls and young women (AGYW) in sub-Saharan Africa carrying a disproportionately high burden infection. Hormonal contraceptives may influence HPV acquisition, persistence, clearance, but evidence remains inconclusive. This sub-study aimed to evaluate impact different hormonal on prevalence genotype distribution AGYW. Methods Ninety-eight HIV-seronegative AGYW aged 15–19 years from South were randomized receive one three contraceptive methods: norethisterone enanthate (Net-EN) injectable, combined oral pills (COCPs), or etonorgesterol/ethinyl estradiol vaginal ring (CCVR). Cervical DNA samples collected at baseline after 16 weeks for genotyping using Direct Flow Chip test. prevalence, acquisition analyzed across methods. Results At baseline, was (94.9%), no differences among arms. After weeks, remained (89.5%) groups. No significant observed overall by method. Longitudinal analysis revealed that Net-EN tended have higher cumulative number high-risk (HR-HPV) genotypes cleared whereas those CCVR acquired more HR-HPV types had greater persistence compared other Conclusions study highlights African However, methods did not significantly dynamics.

Язык: Английский

Процитировано

0
Post-transplant Malignancy: An Overview and Review of Literatures DOI Open Access

Jebur Wael Lateef

Journal of Clinical Nephrology, Год журнала: 2025, Номер 9(1), С. 001 - 008

Опубликована: Янв. 7, 2025

Post-transplant malignancy is one of the contentious and feared consequences Solid Organ Transplantation (SOT), which might detrimentally alter outcome transplantation. Risk factors are manifold, principally related to a suppressed immune system with intercurrent immunosuppressant medications commonly used in context SOT. Opportunistic viral infections encountered SOT crucial promoters mitogenic proliferation several common tumors. Lastly, suppressant therapy trigger changes directly.

Язык: Английский

Процитировано

0