Human Cytomegalovirus Infection and Breast Cancer: A Literature Review of Clinical and Experimental Data

Biology, Год журнала: 2025, Номер 14(2), С. 174 - 174

Опубликована: Фев. 8, 2025

Breast cancer (BC) remains a significant global health challenge, highlighting the need for continued research into novel risk factors, diagnostic approaches, and personalized treatments. Among emerging viral infections have been implicated as potential contributors to breast carcinogenesis BC progression. Recent evidence suggests that specific oncogenic strains of human cytomegalovirus (HCMV) may capacity transform mammary epithelial cells. This review assesses clinical data regarding HCMV presence in both tumor non-tumor tissues, examining role oncoproteins development Current findings indicate higher prevalence infection carcinomas compared associated with an elevated BC. Additionally, HCMV-driven model proposed here activate multiple pathways, fostering cell proliferation, survival, development. A deeper understanding could enhance stratification support creation targeted therapeutic strategies.

Язык: Английский

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Molecular Insights into HR-HPV and HCMV Co-Presence in Cervical Cancer Development

Cancers, Год журнала: 2025, Номер 17(4), С. 582 - 582

Опубликована: Фев. 8, 2025

Cervical cancer remains a significant health concern worldwide and the primary cause of cancerous cervical lesions is infection with high-risk human papillomavirus (HR-HPV). However, emerging evidence suggests that HR-HPV alone insufficient for development, other co-factors may contribute to carcinogenesis. Human cytomegalovirus (HCMV), common herpesvirus frequently detected in samples, has demonstrated oncogenic potential. This review aims explore molecular interactions between HCMV promoting progression. A comprehensive search was conducted PubMed Google Scholar, focusing on articles examining role tissues and/or cells, selected based relevance significance. The reviewed literature indicates share several mechanisms could drive cell transformation. Both viruses synergistically promote epithelial transformation tumor progression multiple ways. facilitate entry by increasing host receptors essential viral attachment. Additionally, cooperatively disrupt cellular processes, enhancing also modulate local immune environment, enabling evasion lesion persistence. further vitro vivo studies are required validate these hypotheses.

Язык: Английский

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Is the vIL-10 Protein from Cytomegalovirus Associated with the Potential Development of Acute Lymphoblastic Leukemia?

Viruses, Год журнала: 2025, Номер 17(3), С. 435 - 435

Опубликована: Март 18, 2025

Leukemia is a hematologic malignancy; acute lymphoblastic leukemia (ALL) the most prevalent subtype among children rather than in adults. Orthoherpesviridae family members produce proteins during latent infection phases that may contribute to cancer development. One such protein, viral interleukin-10 (vIL-10), closely resembles human (IL-10) structure. Research has explored involvement of cytomegalovirus (hCMV) pathogenesis ALL. However, limited characterization its latent-phase restricts full understanding relationship between hCMV and progression. Studies have shown induces an inflammatory response infection, marked by release cytokines chemokines. Inflammation may, therefore, play role how contributes oncogenesis pediatric ALL, possibly mediated proteins. The classification virus as oncogenic based on alignment with cancer’s established hallmarks. Viruses can manipulate host cellular mechanisms, causing dysregulated cell proliferation, evasion apoptosis, genomic instability. These processes lead mutations, chromosomal abnormalities, chronic inflammation, all which are vital for carcinogenesis. This study aims investigate vIL-10 phase potential factor

Язык: Английский

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HPV and HCMV in Cervical Cancer: A Review of Their Co-Occurrence in Premalignant and Malignant Lesions

Viruses, Год журнала: 2024, Номер 16(11), С. 1699 - 1699

Опубликована: Окт. 30, 2024

Cervical cancer remains a significant global health concern, particularly in low- and middle-income countries. While persistent infection with high-risk human papillomavirus (HR-HPV) is essential for cervical development, it not sufficient on its own, suggesting the involvement of additional cofactors. The cytomegalovirus (HCMV) widespread β-herpesvirus known ability to establish lifelong latency reactivate under certain conditions, often contributing chronic inflammation immune modulation. Emerging evidence suggests that HCMV may play role various cancers, including cancer, through potential influence oncogenic pathways disrupt host responses. This review explores clinical regarding co-presence HR-HPV premalignant lesions cancer. literature reviewed indicates frequently detected lesions, those co-infected HPV, synergistic interaction could enhance HPV's effects, thereby facilitating progression from low-grade squamous intraepithelial (LSIL) high-grade (HSIL) invasive Although precise molecular mechanisms were thoroughly investigated this review, importance considering alongside HPV management lesions. A better understanding between lead improved diagnostic, therapeutic, preventive strategies

Язык: Английский

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Clinical implications of cytomegalovirus in glioblastoma progression and therapy

npj Precision Oncology, Год журнала: 2024, Номер 8(1)

Опубликована: Сен. 29, 2024

Язык: Английский

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