Arabian Journal of Chemistry,
Год журнала:
2023,
Номер
16(11), С. 105200 - 105200
Опубликована: Авг. 15, 2023
Rheumatoid
arthritis
(RA)
is
a
chronic
immunocompromised
disorder
that
primarily
affects
joints
thereby
leading
to
synovial
inflammation,
pain,
stiffness,
stress,
and
affecting
the
quality
of
life.
The
present
study
aimed
determine
identify
bioactive
compounds
can
be
developed
as
potential
inhibitors
target
human
TNF-α
IL-6
proteins
associated
with
RA.
also
physiochemical
properties
toxicity
by
ADMET,
binding
pockets
via
CASTp
server,
stereochemical
protein
PROCHECK,
MMGB/SA
analysis
fastDRH
molecular
dynamics
(WebGro).
findings
revealed
staurosporine
was
most
effective
compound
against
highest
affinity
-10.8
kcal/mol.
Similarly,
withanoside
L
showed
-8.2
kcal/mol
when
docked
IL-6.
In
study,
rutin,
II,
IV
did
not
follow
Lipinski's
rule
five
whereas
staurosporine,
somnifericin,
withanolide
followed
RO5.
top
pocket
had
area
(SA)
2743.25
Å2
volume
4514.06
Å3
63.54Å2
38.58
respectively.
this
Ramachandran
plot
90.2%
95.2%
residues
for
occupied
favored
region.
rutin
complex
PB1
score
13.69
12.30
WebGro
server
estimated
dynamic
(RMSD,
Rg,
SASA,
RMSF
hydrogen
bonds)
proteins.
Bio2Byte
tools
predicted
biophysical
behaviour
could
TNF-
α
IL-6,
however
further
in-vitro
in-vivo
studies
are
required
validate
these
results.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(11), С. 6099 - 6099
Опубликована: Июнь 1, 2024
Michael
acceptors
represent
a
class
of
compounds
with
potential
anti-cancer
properties.
They
act
by
binding
to
nucleophilic
sites
in
biological
molecules,
thereby
disrupting
cancer
cell
function
and
inducing
death.
This
mode
action,
as
well
their
ability
be
modified
targeted,
makes
them
promising
avenue
for
advancing
therapy.
We
are
investigating
the
molecular
mechanisms
underlying
interactions
cells,
particular
interfere
cellular
processes
induce
apoptosis.
The
properties
not
accidental
but
due
chemical
structure
reactivity.
electrophilic
nature
these
allows
selectively
target
residues
on
disease-associated
proteins,
resulting
significant
therapeutic
benefits
minimal
toxicity
various
diseases.
opens
up
new
perspectives
development
more
effective
precise
drugs.
Nevertheless,
further
studies
essential
fully
understand
impact
our
discoveries
translate
into
clinical
practice.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 28, 2024
Rheumatoid
arthritis
(RA)
is
a
systemic
autoimmune
disease
characterized
by
synovial
inflammation,
cartilage
destruction,
pannus
formation
and
bone
erosion.
Various
immune
cells,
including
macrophages,
are
involved
in
RA
pathogenesis.
The
heterogeneity
plasticity
of
macrophages
render
them
pivotal
regulators
both
the
induction
resolution
inflammatory
response.
Predominantly,
two
different
phenotypes
have
been
identified:
classically
activated
M1
exacerbate
inflammation
via
production
cytokines,
chemokines
other
mediators,
while
alternatively
M2
inhibit
facilitate
tissue
repair.
An
imbalance
M1/M2
macrophage
ratio
critical
during
initiation
progression
RA.
Macrophage
polarization
modulated
various
transcription
factors,
epigenetic
elements
metabolic
reprogramming.
Curcumin,
an
active
component
turmeric,
exhibits
potent
immunomodulatory
effects
administered
treatment
multiple
diseases,
regulation
subsequent
cytokine
as
well
migration
mechanisms
underlying
therapeutic
effect
curcumin
on
In
this
review,
we
summarize
which
modulates
function
context
to
provide
evidence
for
clinical
application
treatment.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 855 - 855
Опубликована: Янв. 20, 2025
Curcumin,
a
compound
known
for
its
antioxidant
and
neuroprotective
properties,
faces
challenges
due
to
low
water
solubility,
which
can
limit
effectiveness.
One
effective
method
address
this
issue
is
through
amorphization.
Incorporating
curcumin
into
polymeric
matrix
form
amorphous
solid
dispersions
common
approach.
Another
strategy
involves
co-amorphous
systems,
where
low-molecular-weight
components
act
as
co-formers.
A
recent
innovative
approach
combines
these
strategies.
This
study
used
tryptophan
co-former
prepared
systems
using
supercritical
fluid
technology.
The
nature
of
two
was
confirmed
X-ray
powder
diffraction:
one
with
10%
polymer,
another
curcumin,
tryptophan.
Fourier-transform
infrared
analysis
demonstrated
molecular
interactions
among
all
in
the
systems.
Scanning
electron
microscopy
revealed
that
amorphization
process
significantly
modified
morphology
particles.
ternary
system
notably
increased
solubility
by
over
300-fold.
both
exhibited
higher
dissolution
rates
compared
crystalline
form.
showed
more
than
threefold
improvement
permeability
according
PAMPA
test.
enhanced
led
sixfold
increase
activity
25-fold
inhibition
enzyme
butyrylcholinesterase.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3521 - 3521
Опубликована: Март 20, 2024
The
phrase
“Let
food
be
thy
medicine…”
means
that
can
a
form
of
medicine
and
food;
in
other
words,
the
diet
we
eat
have
significant
impact
on
our
health
well-being.
Today,
this
is
gaining
prominence
as
more
scientific
evidence
suggests
one’s
help
prevent
treat
disease.
A
rich
fruits,
vegetables,
whole
grains,
lean
protein
reduce
risk
heart
disease,
cancer,
diabetes,
problems
and,
hand,
processed
foods,
added
sugars,
saturated
fats
increase
same
diseases.
Electrophilic
compounds
health,
they
are
molecules
covalently
modify
cysteine
residues
present
thiol-rich
Keap1
protein.
These
bind
to
activate
NRF2,
which
promotes
its
translocation
nucleus
binding
DNA
ARE
region,
triggering
antioxidant
response
protecting
against
oxidative
stress.
include
polyphenols
flavonoids
nucleophilic
but
converted
electrophilic
quinones
by
metabolic
enzymes
such
polyphenol
oxidases
(PPOs)
sulfur
foods
Brassica
genus
(broccoli,
cauliflower,
cabbage,
Brussel
sprouts,
etc.)
garlic.
This
review
summarizes
current
knowledge
subject.
Antioxidants,
Год журнала:
2024,
Номер
13(7), С. 775 - 775
Опубликована: Июнь 27, 2024
Rheumatoid
arthritis
(RA)
is
a
persistent
autoimmune
disorder
that
characterized
by
joint
inflammation,
discomfort,
and
impairment.
Despite
the
existence
of
several
therapeutic
approaches,
their
effectiveness
often
restricted
may
be
linked
to
unfavorable
side
effects.
Consequently,
there
has
been
growing
interest
in
investigating
naturally
derived
compounds
as
plausible
agents
for
RA
disease.
The
objective
this
review
summarize
existing
preclinical
clinical
evidence
regarding
efficacy
extracted
plant
extracts
treatment
RA,
focusing
on
anti-inflammatory,
anti-oxidative,
immunomodulatory
properties.
Some
problems
with
using
natural
chemicals
are
uneven
quality
commercially
available
preparations
poor
bioavailability
these
compounds.
Future
investigations
should
focus
improving
formulations,
conducting
thorough
trials,
exploring
different
techniques
fully
utilize
intrinsic
potential
treating
RA.
International Immunopharmacology,
Год журнала:
2024,
Номер
142, С. 112953 - 112953
Опубликована: Сен. 2, 2024
Rheumatoid
arthritis
(RA)
is
a
chronic,
progressive,
systemic
autoimmune
disease.
While
triptolide
(TPL)
and
curcumin
(CUR)
are
known
to
have
multiple
beneficial
effects
on
RA,
the
combined
effect
of
TPL
CUR
remains
unexplored.
This
study
aimed
investigate
their
synergistic
cell
proliferation
apoptosis
via
IL-17/NF-κB
signaling
pathway.
The
collagen-induced
(CIA)
rat
model
was
established,
showing
severe
joint
synovial
damage
compared
normal
rats.
Treatment
with
reduced
severity
RA
in
CIA
alleviated
serum
inflammatory
cytokines,
such
as
rheumatoid
factor,
IL-17,
TNF-α,
IL-1β,
IL-6.
elevated
levels
IL-17
NF-κB
rats
were
also
inhibited,
resistant
aggravated
by
CUR.
In
vitro,
improvement
induction
observed
LPS-stimulated
MH7A
cells
treated
CUR,
associated
inhibition
Taken
together,
may
involve
relieving
symptoms,
improving
excessive
proliferation,
inducing
resistance,
inhibiting
Abstract
Curcumin,
the
active
compound
in
turmeric,
is
renowned
for
its
anti‐inflammatory,
antioxidant,
and
antimicrobial
properties,
making
it
beneficial
treating
conditions
like
arthritis,
neurodegenerative
diseases,
various
cancers.
Despite
promising
therapeutic
potential,
curcumin's
poor
bioavailability—due
to
rapid
metabolism
low
solubility—limits
clinical
efficacy.
To
address
this,
recent
research
has
focused
on
enhancing
curcumin
delivery
using
nanoparticles,
liposomes,
novel
nanomaterials.
Among
these,
laponite,
a
synthetic
nanoclay,
shown
promise
improving
due
unique
including
large
surface
area,
dual
charge,
stability
solution.
This
study
explores
use
of
curcumin–laponite
nanoparticles
as
carrier
vehicles
controlled
vitro
model
membranes.
Utilizing
advanced
techniques
such
neutron
reflectometry,
atomic
force
microscopy,
quartz
crystal
microbalance
with
dissipation,
infrared
spectroscopy,
interaction
between
solid‐supported
lipid
bilayers
monitored,
revealing
enhanced
release
across
membrane.
These
findings
pave
way
development
curcumin‐based
therapies
targeting
cardiovascular,
neurological,
oncological
leveraging
synergistic
effects
biological
activity
laponite's
capabilities.
Arabian Journal of Chemistry,
Год журнала:
2024,
Номер
17(6), С. 105766 - 105766
Опубликована: Апрель 2, 2024
This
research
aimed
to
fabricate
a
natural
hybrid
biomaterial
and
assess
its
physicochemical/biological
properties
study
the
role
of
therapeutic
in
growth
human
monocytes,
synoviocytes,
chondrocytes,
expression
type-I/II
collagen,
osteogenic
differentiation
for
bone
tissue
engineering
applications,
as
well
effects
bio-ointment
derived
from
this
on
relief
musculoskeletal
pains.
Hence,
an
oily
formula
[turmeric:ginger:chili
pepper:rose
oils
(1:1:1:1w/w)]
was
mixed
with
base
oil
[sesame:black
seed:olive
(1:0.4:0.6w/w)]
3
wt
ratios
1:6(H1),
1.5:5.5(H2),
2:5(H3).
Accordingly,
H2
indicated
better
performance
cell
decrease
inflammatory
mediators
led
highest
osteoblastic
genes
RUNX2,
OCN,
OPN,
collagen
I
II
(COL1A1,COL2A)
respectively
1.3-fold,
1.7-fold,
1.4-fold,
%87
%
∼
60
higher
than
H1,
2-fold,
2.1-fold,
3.4-fold,
19
16
H3.
A
clinical
also
performed
50
patients
H2-based
could
relieve
pain
less
10
min
40
after
30
use
35
%.
Moreover,
analgesia
period
36
lasted
longer
h
between
2
h,
respectively.
76
stated
that
possesses
stronger
other
treatments
along
moderate
warming
functions.
Finally,
although
6
reported
mild
effectiveness
relief,
92
users
method
has
resulted
more
their
damaged
organ
recovery.
Cells,
Год журнала:
2024,
Номер
13(11), С. 915 - 915
Опубликована: Май 25, 2024
Rheumatoid
arthritis
(RA)
is
a
chronic
inflammatory
joint
disease
characterised
by
the
formation
of
hyperplastic
pannus,
as
well
cartilage
and
bone
damage.
The
pathogenesis
RA
complex
involves
broad
interactions
between
various
cells
present
in
inflamed
synovium,
including
fibroblast-like
synoviocytes
(FLSs),
macrophages,
T
cells,
among
others.
Under
conditions,
these
are
activated,
further
enhancing
responses
angiogenesis
promoting
degradation.
Novel
treatment
methods
for
greatly
needed,
mesenchymal
stromal
(MSCs)
have
been
suggested
promising
new
regenerative
immunomodulatory
treatment.
In
this
paper,
we
MSCs
RA-FLSs,
macrophages
summarise
studies
examining
use
preclinical
clinical
studies.