Chitosan-based self-healing thermosensitive hydrogel loaded with siHMGB1 for treatment of rheumatoid arthritis via macrophage repolarization

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 137102 - 137102

Опубликована: Окт. 31, 2024

Язык: Английский

---

Use of medicinal plants in treating arthritis

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 187 - 202

Опубликована: Янв. 1, 2025

Язык: Английский

---

In situ forming gels as subcutaneous delivery systems of curcumin and piperine

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 24, 2025

In this study an in situ forming gel for curcumin and piperine delivery is investigated as a long-lasting strategy the local treatment of inflammatory degenerative joint disease, such osteoarthritis rheumatoid arthritis. Particularly glyceryl monooleate, association with phosphatidylcholine ethanol, were employed. Different ratios between excipients tested, aim to obtain liquid form suitable subcutaneous injection, gaining semisolid consistency contact biological fluids. A formulative was conducted assess composition impact on structural properties formulations, particularly focusing injectability phase transition. Curcumin loaded, singularly or jointly, selected gels. Structural characterization, performed by X-ray scattering, revealed disordered reverse micellar phases, undergoing transition hexagonal cubic Pn3m upon hydration. vitro dialysis release demonstrated sustained both drugs over 96 h, faster case jointly loaded drugs. Mechanistic analysis water uptake studies indicated drug governed diffusion swelling/erosion lipid supramolecular structure. Furthermore, ex vivo using human skin explants suggested formulation suitability indicating that presence formed allowed double respect simple gel.

Язык: Английский

---

Multiomics analysis of human serum and animal experiments reveals the protective mechanism of Qingre Huoxue Decoction against rheumatoid arthritis

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 7, 2025

Qingre Huoxue Decoction (QRHXD) is a traditional Chinese herbal prescription widely used in clinical practice with significant therapeutic effects on RA; however, its mechanism of action remains unclear. This study aimed to investigate the efficacy and underlying mechanisms QRHXD treating RA through research, multiomics approaches, animal experiments. We conducted 24-week which was primary treatment, collecting serum samples from patients before after treatment for integrated proteomic metabolomic analysis identify potential targets. Bioinformatics differentially expressed proteins (DEPs) differential metabolites (DMs) performed using hierarchical clustering, volcano plots, heat maps, Gene Ontology (GO), Kyoto Encyclopaedia Genes Genomes (KEGG) analysis. To validate identified targets, we constructed collagen-induced arthritis (CIA) mouse model. Clinical research has shown that can improve symptoms relevant indicators patients, including disease activity score-28 (DAS28), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), tender joint count (TJC), swollen (SJC), visual analogue scale (VAS), patient-reported outcome (PRO), health assessment questionnaire (HAQ). Proteomics metabolomics 83 DEPs 54 DMs, 46 upregulated 37 downregulated proteins, as well 11 43 metabolites. KEGG enrichment revealed are primarily associated fatty acid degradation, ferroptosis, glycerolipid metabolism, related pathways. The DMs AMPK signalling pathway, FoxO glycolysis/gluconeogenesis, MTOR so on. GO indicated were mainly apoptotic mitochondrial changes, modification processes, fatty-acyl-CoA binding, Integrated proteomics analyses increase fructose-1,6-biphosphatase 1 (FBP1) levels reduction AMP-activated kinase (AMPK) RA. inhibited FBP1 activated signalling. Animal experiments validated findings analyses, demonstrating could also delay bone destruction reduce inflammatory factor CIA mice. may RA, attenuate response, by inhibiting activating pathway.

Язык: Английский

---

Pharmacological modes of plant-derived compounds for targeting inflammation in rheumatoid arthritis: A comprehensive review on immunomodulatory perspective

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Язык: Английский

---

CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis

Inflammation Research, Год журнала: 2025, Номер 74(1)

Опубликована: Март 14, 2025

Язык: Английский

---

Understanding the role of Ethosomes in Rheumatoid Arthritis: Innovative Solutions to Challenges in Transdermal Delivery of Synthetic Drugs and Phytoconstituents

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 27

Опубликована: Март 20, 2025

Rheumatoid Arthritis (RA), an autoimmune disease, is a chronic inflammatory disorder affecting the joints leading to severe damage and cartilage destruction. Current therapies for RA such as DMARDs, NSAIDs, glucocorticoids, phytoconstituents often face challenges related solubility transdermal permeability. Considering barriers posed by stratum corneum in drug delivery, ethosomes have shown promising results overcoming these hurdles. The presence of ethanol imparts flexibility disrupts skin's lipid bilayer, allowing penetration. Researchers explored potential ethosomal delivery systems loaded with various synthetic drugs management RA. Despite preclinical findings, yet transition from bench bedside, there lack comprehensive review papers highlighting treatment. commercial scaling up nano systems, this aims analyse current state art advancements formulations agents phytoconstituents. Further, it explores impact excipients processing parameters, on preparation their efficacy skin barriers, enhance permeability therapeutic agents.

Язык: Английский

---

The Inflammation‐Initiating and Resolving Mechanisms and Oxidation: Could Periodontal Therapy and Nutritional Strategy Improve the Systemic Health? A Narrative Review

Food Science & Nutrition, Год журнала: 2025, Номер 13(3)

Опубликована: Март 1, 2025

ABSTRACT Periodontitis (PDS) is one of the most common and crippling systemic diseases. It a chronic inflammatory condition that leads to loss periodontal attachment, resulting in tooth loss. In addition its effects on oral health nutrition, PDS closely linked other conditions such as diabetes mellitus (DM), cardiovascular diseases (CVD), rheumatoid arthritis (RA). The active role inflammation oxidation health, well their relationship with therapy, has been investigated. This review explores evidence how therapy dietary lifestyle can help reduce inflammation, limit oxidation, prevent related pathologies. Nonsurgical (NSPT) nutrition have extensively discussed potential contributors positive clinical outcomes by resolving pathogenic pathways. NSPT, foods, supplements represent therapeutic strategies address underlying mechanisms at various stages. A key finding from this treatment, conjunction nutritional counseling, improve PDS, DM, CVD, RA. However, for composition be effective, they should integrated into sustainable, long‐term lifestyle.

Язык: Английский

---

Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 24, 2025

Introduction Inflammatory Bowel Disease (IBD), encompassing Crohn disease (CD) and ulcerative colitis (UC), presents complex challenges in management due to dysregulated immune responses genetic predispositions. This study explored the potential of curcumin as an adjunctive therapy IBD, assessing its efficacy safety through a systematic review clinical trials enhance treatment strategies outcomes. Methods To identify placebo-controlled randomized on databases such Medline/PubMed, Scopus, Embase, Web Knowledge, Google Scholar were searched till May 2024. Inclusion criteria focused RCTs comparing with placebo IBD patients, data extraction analysis conducted using established methodologies tools for comprehensive synthesis assessment findings. Results In this meta-analysis, 13 included after screening 362 records conducting full-text review. Most UC patients published post-2010, utilizing oral varying dosages durations. The showed curcumin’s significant achieving remission response heterogeneity observed. Adverse events withdrawal rates did not significantly differ between groups. CD show superiority over endoscopic remission. Conclusion findings highlight but indicate inconclusive results CD, emphasizing need further research. multifaceted mechanisms involve anti-inflammatory, antioxidant, microbiota modulatory, immune-regulating properties. Further research is warranted understanding efficacy. Systematic registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42024567247 .

Язык: Английский

---

Antioxidant Therapies as Emerging Adjuncts in Rheumatoid Arthritis: Targeting Oxidative Stress to Enhance Treatment Outcomes

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2873 - 2873

Опубликована: Март 21, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent inflammation and progressive joint destruction. Recent data underscore oxidative stress as primary factor in the pathophysiology of rheumatoid arthritis, intensifying inflammatory processes tissue damage via overproduction reactive oxygen species (ROS) compromised antioxidant defenses. Current therapies, including disease-modifying antirheumatic drugs (DMARDs), primarily target immune dysregulation but fail to address stress, necessitating novel adjunctive treatment strategies. This review explores potential antioxidant-based therapies complementary approaches RA management. Natural compounds such curcumin, resveratrol, sulforaphane, propolis exhibit strong anti-inflammatory antioxidative properties modulating redox-sensitive pathways, nuclear kappa-light-chain-enhancer activated B cells (NF-κB) erythroid 2-related 2(Nrf2)/heme oxygenase (HO-1). N-acetylcysteine (NAC) replenishes intracellular glutathione, enhancing cellular resilience against stress. Additionally, molecular hydrogen (H2) selectively neutralizes harmful ROS, reducing inflammation. The role vitamin supplementation (D, B12, C, K) regulating responses protecting structures also discussed. aims evaluate efficacy clinical applications RA, emphasizing their mitigating improving outcomes. While preliminary findings are promising, further trials needed establish standardized dosing, long-term safety, integration into current protocols.

Язык: Английский

---