Pharmacological modes of plant-derived compounds for targeting inflammation in rheumatoid arthritis: A comprehensive review on immunomodulatory perspective

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Language: Английский

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Understanding the role of Ethosomes in Rheumatoid Arthritis: Innovative Solutions to Challenges in Transdermal Delivery of Synthetic Drugs and Phytoconstituents

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27

Published: March 20, 2025

Rheumatoid Arthritis (RA), an autoimmune disease, is a chronic inflammatory disorder affecting the joints leading to severe damage and cartilage destruction. Current therapies for RA such as DMARDs, NSAIDs, glucocorticoids, phytoconstituents often face challenges related solubility transdermal permeability. Considering barriers posed by stratum corneum in drug delivery, ethosomes have shown promising results overcoming these hurdles. The presence of ethanol imparts flexibility disrupts skin's lipid bilayer, allowing penetration. Researchers explored potential ethosomal delivery systems loaded with various synthetic drugs management RA. Despite preclinical findings, yet transition from bench bedside, there lack comprehensive review papers highlighting treatment. commercial scaling up nano systems, this aims analyse current state art advancements formulations agents phytoconstituents. Further, it explores impact excipients processing parameters, on preparation their efficacy skin barriers, enhance permeability therapeutic agents.

Language: Английский

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The Inflammation‐Initiating and Resolving Mechanisms and Oxidation: Could Periodontal Therapy and Nutritional Strategy Improve the Systemic Health? A Narrative Review

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

ABSTRACT Periodontitis (PDS) is one of the most common and crippling systemic diseases. It a chronic inflammatory condition that leads to loss periodontal attachment, resulting in tooth loss. In addition its effects on oral health nutrition, PDS closely linked other conditions such as diabetes mellitus (DM), cardiovascular diseases (CVD), rheumatoid arthritis (RA). The active role inflammation oxidation health, well their relationship with therapy, has been investigated. This review explores evidence how therapy dietary lifestyle can help reduce inflammation, limit oxidation, prevent related pathologies. Nonsurgical (NSPT) nutrition have extensively discussed potential contributors positive clinical outcomes by resolving pathogenic pathways. NSPT, foods, supplements represent therapeutic strategies address underlying mechanisms at various stages. A key finding from this treatment, conjunction nutritional counseling, improve PDS, DM, CVD, RA. However, for composition be effective, they should integrated into sustainable, long‐term lifestyle.

Language: Английский

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Fabrication and evaluation of polylactic acid-curcumin containing carbon nanotubes (CNTs) wound dressing using electrospinning method with experimental and computational approaches

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 18, 2025

The development of advanced wound dressings has seen a significant leap with the integration biodegradable nanofibers. This study introduces an innovative approach by designing polylactic acid (PLA)-curcumin nanofiber enhanced carbon nanotubes (CNTs). Using electrospinning method, various formulations were crafted, incorporating diverse weight percentages curcumin and CNTs. Comprehensive analyses, including FT-IR SEM, confirmed structural physical integrity nanofibers, while tensile testing revealed notable enhancement in mechanical strength addition Drug release evaluations highlighted controlled predictable pattern across all samples. Water absorption tests demonstrated ability PLA nanofibers to absorb up 364%, PLA-Cur-0.03%CNT samples absorbing 163%, showcasing their adaptability exudates. Importantly, cytotoxicity assessments biocompatibility samples, high cell viability observed after 3 7 days. Antibacterial underscored efficacy CNT-incorporated PLA-Cur-0.05%CNT achieving highest antibacterial activity at 78.95%. Additionally, using Density Functional Theory (DFT) calculations, transition state, HOMO-LUMO energy, equilibrium constant explored, revealing higher constants for keto-enol transformations compared enol-keto solvents. Tautomeric conversion is easier polar solvents due stability charged species. energy analysis chemical comprehensive research not only mechanical, antibacterial, drug delivery capabilities dressing but also provided optimizing pharmaceutical compounds under challenging environments through modeling computational techniques.

Language: Английский

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The design of natural hybrid biomaterial to promote osteogenic differentiation, collagen i and II expression and relief of musculoskeletal pains: Bone tissue-engineering applications (in-vitro and clinical studies)

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(6), P. 105766 - 105766

Published: April 2, 2024

This research aimed to fabricate a natural hybrid biomaterial and assess its physicochemical/biological properties study the role of therapeutic in growth human monocytes, synoviocytes, chondrocytes, expression type-I/II collagen, osteogenic differentiation for bone tissue engineering applications, as well effects bio-ointment derived from this on relief musculoskeletal pains. Hence, an oily formula [turmeric:ginger:chili pepper:rose oils (1:1:1:1w/w)] was mixed with base oil [sesame:black seed:olive (1:0.4:0.6w/w)] 3 wt ratios 1:6(H1), 1.5:5.5(H2), 2:5(H3). Accordingly, H2 indicated better performance cell decrease inflammatory mediators led highest osteoblastic genes RUNX2, OCN, OPN, collagen I II (COL1A1,COL2A) respectively 1.3-fold, 1.7-fold, 1.4-fold, %87 % ∼ 60 higher than H1, 2-fold, 2.1-fold, 3.4-fold, 19 16 H3. A clinical also performed 50 patients H2-based could relieve pain less 10 min 40 after 30 use 35 %. Moreover, analgesia period 36 lasted longer h between 2 h, respectively. 76 stated that possesses stronger other treatments along moderate warming functions. Finally, although 6 reported mild effectiveness relief, 92 users method has resulted more their damaged organ recovery.

Language: Английский

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CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: March 14, 2025

Language: Английский

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Curcumin for the clinical treatment of inflammatory bowel diseases: a systematic review and meta-analysis of placebo-controlled randomized clinical trials

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 24, 2025

Introduction Inflammatory Bowel Disease (IBD), encompassing Crohn disease (CD) and ulcerative colitis (UC), presents complex challenges in management due to dysregulated immune responses genetic predispositions. This study explored the potential of curcumin as an adjunctive therapy IBD, assessing its efficacy safety through a systematic review clinical trials enhance treatment strategies outcomes. Methods To identify placebo-controlled randomized on databases such Medline/PubMed, Scopus, Embase, Web Knowledge, Google Scholar were searched till May 2024. Inclusion criteria focused RCTs comparing with placebo IBD patients, data extraction analysis conducted using established methodologies tools for comprehensive synthesis assessment findings. Results In this meta-analysis, 13 included after screening 362 records conducting full-text review. Most UC patients published post-2010, utilizing oral varying dosages durations. The showed curcumin’s significant achieving remission response heterogeneity observed. Adverse events withdrawal rates did not significantly differ between groups. CD show superiority over endoscopic remission. Conclusion findings highlight but indicate inconclusive results CD, emphasizing need further research. multifaceted mechanisms involve anti-inflammatory, antioxidant, microbiota modulatory, immune-regulating properties. Further research is warranted understanding efficacy. Systematic registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42024567247 .

Language: Английский

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Antioxidant Therapies as Emerging Adjuncts in Rheumatoid Arthritis: Targeting Oxidative Stress to Enhance Treatment Outcomes

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2873 - 2873

Published: March 21, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent inflammation and progressive joint destruction. Recent data underscore oxidative stress as primary factor in the pathophysiology of rheumatoid arthritis, intensifying inflammatory processes tissue damage via overproduction reactive oxygen species (ROS) compromised antioxidant defenses. Current therapies, including disease-modifying antirheumatic drugs (DMARDs), primarily target immune dysregulation but fail to address stress, necessitating novel adjunctive treatment strategies. This review explores potential antioxidant-based therapies complementary approaches RA management. Natural compounds such curcumin, resveratrol, sulforaphane, propolis exhibit strong anti-inflammatory antioxidative properties modulating redox-sensitive pathways, nuclear kappa-light-chain-enhancer activated B cells (NF-κB) erythroid 2-related 2(Nrf2)/heme oxygenase (HO-1). N-acetylcysteine (NAC) replenishes intracellular glutathione, enhancing cellular resilience against stress. Additionally, molecular hydrogen (H2) selectively neutralizes harmful ROS, reducing inflammation. The role vitamin supplementation (D, B12, C, K) regulating responses protecting structures also discussed. aims evaluate efficacy clinical applications RA, emphasizing their mitigating improving outcomes. While preliminary findings are promising, further trials needed establish standardized dosing, long-term safety, integration into current protocols.

Language: Английский

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Environmental factors and rheumatic diseases

Best Practice & Research Clinical Rheumatology, Journal Year: 2025, Volume and Issue: unknown, P. 102053 - 102053

Published: March 1, 2025

Language: Английский

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Insights on in-silico approaches for identifying potential bioactive inhibitors for TNF-α and IL-6 proteins associated with rheumatoid arthritis

Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 16(11), P. 105200 - 105200

Published: Aug. 15, 2023

Rheumatoid arthritis (RA) is a chronic immunocompromised disorder that primarily affects joints thereby leading to synovial inflammation, pain, stiffness, stress, and affecting the quality of life. The present study aimed determine identify bioactive compounds can be developed as potential inhibitors target human TNF-α IL-6 proteins associated with RA. also physiochemical properties toxicity by ADMET, binding pockets via CASTp server, stereochemical protein PROCHECK, MMGB/SA analysis fastDRH molecular dynamics (WebGro). findings revealed staurosporine was most effective compound against highest affinity -10.8 kcal/mol. Similarly, withanoside L showed -8.2 kcal/mol when docked IL-6. In study, rutin, II, IV did not follow Lipinski's rule five whereas staurosporine, somnifericin, withanolide followed RO5. top pocket had area (SA) 2743.25 Å2 volume 4514.06 Å3 63.54Å2 38.58 respectively. this Ramachandran plot 90.2% 95.2% residues for occupied favored region. rutin complex PB1 score 13.69 12.30 WebGro server estimated dynamic (RMSD, Rg, SASA, RMSF hydrogen bonds) proteins. Bio2Byte tools predicted biophysical behaviour could TNF- α IL-6, however further in-vitro in-vivo studies are required validate these results.

Language: Английский

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