Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 27, 2025
Sjögren's
syndrome
(SS)
is
a
systemic
autoimmune
disease,
with
major
symptoms
including
dry
mouth
and
eyes,
for
which
there
no
effective
treatment.
Recent
studies
have
demonstrated
that
mesenchymal
stem
cells
(MSCs)
are
in
the
treatment
of
SS,
but
efficacy
allogeneic
MSCs
affected
by
variability
among
different
cell
donors,
they
easily
cleared
immune
system
recipient.
Autologous
one
ideal
options
SS;
however,
their
function
decreases
age.
Regenerative
fibroblast
(rFib)
type
new
MSC
obtained
through
chemical
reprogramming
technology
from
skin
fibroblasts.
In
this
study,
we
report
safety
intravenous
infusion
autologous
rFib
volunteer
SS.
March
2021,
was
diagnosed
SS
due
to
positive
anti-SSB
antibodies,
lymphocyte
infiltration
lip
gland,
large
area
purpura
both
lower
limbs.
From
May
2021
November
2022,
she
received
Umbilical
cord
(UCMSC)
therapy
(5.0
×
107
UCMSCs
per
time,
totaling
10
infusions),
her
condition
did
not
improve.
2023,
prepared,
meeting
quality
standard
T/CSCB0003-2021
Human
Mesenchymal
Stem
Cells.
Between
October
2023
June
2024,
total
12
transfusions
rFib.
After
treatments,
experienced
recurrence
Symptoms
mouth,
fatigue
were
relieved.
ESR,
B
lymphocytes,
rheumatoid
factor
IgM,
IgA
declined,
while
proportion
NK
increased,
most
cytokines
returned
normal
levels.
vitro
experiments
showed
could
significantly
inhibit
proliferation
T
lymphocytes
after
PHA
stimulation.
No
adverse
effects
associated
use
during
clinical
trial.
The
results
trial
indicate
injections
safe
treating
may
be
more
suitable
diseases
than
MSCs.
Type
I
interferon
(IFN-I)
plays
crucial
roles
in
the
regulation
of
inflammation
and
it
is
associated
with
various
inflammatory
diseases
including
systemic
lupus
erythematosus
(SLE),
rheumatoid
arthritis
(RA),
periodontitis,
impacting
people's
health
quality
life.
It
well-established
that
IFN-Is
affect
immune
responses
factors
by
regulating
some
signaling.
However,
currently,
there
no
comprehensive
overview
regulatory
role
IFN-I
distinctive
pathways
as
well
diseases.
This
review
aims
to
provide
a
narrative
involvement
different
signaling
pathways,
mainly
mediating
related
key
specific
targets
cascades
influence
progression
As
such,
we
suggested
induce
through
stimulation
certain
which
displays
possible
efficient
treatment
methods
provides
reference
for
precise
control
Cells,
Год журнала:
2023,
Номер
12(13), С. 1766 - 1766
Опубликована: Июль 3, 2023
Inflammasome
complexes
and
their
integral
receptor
proteins
have
essential
roles
in
regulating
the
innate
immune
response
inflammation
at
post-translational
level.
Yet
despite
protective
role,
aberrant
activation
of
inflammasome
gain
function
mutations
component
genes
seem
to
contribute
development
progression
human
autoimmune
autoinflammatory
diseases.
In
past
decade,
our
understanding
biology
mechanisms
has
greatly
progressed.
We
therefore
provide
an
up-to-date
overview
various
inflammasomes
known
action.
addition,
we
highlight
involvement
pathogenic
common
autoinflammatory,
neurodegenerative
diseases,
including
atherosclerosis,
rheumatoid
arthritis,
systemic
lupus
erythematosus,
inflammatory
bowel
disease,
Alzheimer’s
Parkinson’s
multiple
sclerosis.
conclude
by
speculating
on
future
avenues
research
needed
better
understand
health
disease.
Revista Eletrônica Acervo Saúde,
Год журнала:
2023,
Номер
23(5), С. e12774 - e12774
Опубликована: Май 22, 2023
Objetivo:
Analisar
as
características
da
Síndrome
de
Sjögren
(SS).
Revisão
bibliográfica:
A
síndrome
é
uma
doença
autoimune
crônica
do
tecido
conjuntivo,
que
envolve
glândulas
exócrinas
e
pode
ser
dividida
em
primária
secundária.
tríade
sintomas
clínicos
inclui
secura,
fadiga
dor.
Como
sistêmica,
a
SS
envolver
praticamente
qualquer
sistema
orgânico,
levando
manifestações
clínicas
extremamente
pleomórficas.
taxa
incidência
6,92
por
100.000
pessoas
ano.
Em
relação
ao
impacto
na
qualidade
vida,
afeta
negativamente
atividade
diária
paciente
devido
à
alta
prevalência
fadiga,
depressão,
ansiedade
diminuição
desempenho
físico.
Considerações
finais:
cujo
os
principais
são:
ceratoconjuntivite
seca
xerostomia.
Além
disso,
ter
múltiplos
acometimentos
nível
sistêmico.
Não
existe
um
único
teste
para
o
seu
diagnóstico
esta
deve
suspeitada
pacientes
com
persistentes
aumento
glândula
parótida
além
inexplicável
cáries
dentárias.
O
tratamento
feito
sintomáticos
nos
casos
sem
envolvimento
sistêmico
naqueles
afetados
sistêmicamente
são
tratados
imunossupressão.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Сен. 10, 2024
Abstract
Sex
characteristics
exhibit
significant
disparities
in
various
human
diseases,
including
prevalent
cardiovascular
cancers,
metabolic
disorders,
autoimmune
and
neurodegenerative
diseases.
Risk
profiles
pathological
manifestations
of
these
diseases
notable
variations
between
sexes.
The
underlying
reasons
for
sex
encompass
multifactorial
elements,
such
as
physiology,
genetics,
environment.
Recent
studies
have
shown
that
body
systems
demonstrate
sex-specific
gene
expression
during
critical
developmental
stages
editing
processes.
These
genes,
differentially
expressed
based
on
different
sex,
may
be
regulated
by
androgen
or
estrogen-responsive
thereby
influencing
the
incidence
presentation
cardiovascular,
oncological,
metabolic,
immune,
neurological
across
However,
despite
existence
differences
patients
with
treatment
guidelines
predominantly
rely
male
data
due
to
underrepresentation
women
clinical
trials.
At
present,
there
exists
a
substantial
knowledge
gap
concerning
mechanisms
treatments
diverse
Therefore,
this
review
aims
elucidate
advances
examining
epidemiological
factors,
pathogenesis,
innovative
progress
accordance
distinctive
risk
each
disease
provide
new
theoretical
practical
basis
further
optimizing
individualized
improving
patient
prognosis.
Cell Death and Disease,
Год журнала:
2024,
Номер
15(7)
Опубликована: Июль 4, 2024
Abstract
Autoimmune
diseases
commonly
affect
various
systems,
but
their
etiology
and
pathogenesis
remain
unclear.
Currently,
increasing
research
has
highlighted
the
role
of
ferroptosis
in
immune
regulation,
with
cells
being
a
crucial
component
body’s
system.
This
review
provides
an
overview
discusses
relationship
between
ferroptosis,
programmed
cell
death
cells,
autoimmune
diseases.
Additionally,
it
summarizes
key
targets
such
as
GPX4
TFR,
responses.
Furthermore,
release
multiple
molecules,
including
damage-associated
molecular
patterns
(DAMPs),
following
by
is
examined,
these
molecules
further
influence
differentiation
function
thereby
affecting
occurrence
progression
Moreover,
secrete
factors
or
metabolites,
which
also
impact
target
organs
tissues
involved
Iron
chelators,
chloroquine
its
derivatives,
antioxidants,
calreticulin
have
been
demonstrated
to
be
effective
animal
studies
for
certain
diseases,
exerting
anti-inflammatory
immunomodulatory
effects.
Finally,
brief
summary
future
perspectives
on
are
provided,
aiming
guide
disease
treatment
strategies.
