Identification of Epigenetic Alteration of the IFI44L Gene in B Cells of Sjogren’s Syndrome as a Clinical Biomarker and Molecular Significance DOI Creative Commons
Kaiyuan Zhang, Ziyue Luo, Xinyi Yao

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 2499 - 2512

Published: Feb. 1, 2025

Type 1 interferon (IFN-I)-related genes play a critical role in Sjögren's syndrome (SS). However, study on its and impact peripheral blood B cells of SS is limited. This investigated gene expression epigenetic changes IFI44L, analyzing correlation with disease activity clinical indicators. Differentially expressed (DEGs) were identified from the GSE199868 dataset, while IFN-I-related collected GeneCards. Intersection analysis revealed DEGs SS. ClueGO, Kyoto Encyclopedia Genes Genomes (KEGG) enrichment, PPI network construction, hub identification conducted, validated GSE135809. Following this, we recruited 30 patients as group 11 healthy individuals control group. Clinical information samples all participants. After isolating blood, used quantitative real-time polymerase chain reaction (RT-qPCR) pyrosequencing to examine mRNA DNA methylation status IFI44L gene. Further analyses conducted conjunction 125 upregulated 16 downregulated DEGs. Among 2794 GeneCards, 26 overlapped, enriched viral genome replication IFN-I pathways. 14 identified, 7 confirmed GSE135809: ISG15, IFIT1, OASL, IFI6, RSAD2, USP18. was significantly higher (P < 0.05), lower 0.05). correlated positively ESSDAI, ESSPRI, IgG levels, negatively ESSDAI ESSPRI ROC that had high diagnostic value (AUC = 0.8515). The highlights relevance hypomethylation SS, underscoring potential biomarker for progression.

Language: Английский

Update on the pathophysiology and treatment of primary Sjögren syndrome DOI
Chiara Baldini, Giovanni Fulvio, Gaetano La Rocca

et al.

Nature Reviews Rheumatology, Journal Year: 2024, Volume and Issue: 20(8), P. 473 - 491

Published: July 9, 2024

Language: Английский

Citations

31
The crucial regulatory role of type I interferon in inflammatory diseases DOI Creative Commons
Ling Ji, Tianle Li,

Huimin Chen

et al.

Cell & Bioscience, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 20, 2023

Type I interferon (IFN-I) plays crucial roles in the regulation of inflammation and it is associated with various inflammatory diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), periodontitis, impacting people's health quality life. It well-established that IFN-Is affect immune responses factors by regulating some signaling. However, currently, there no comprehensive overview regulatory role IFN-I distinctive pathways as well diseases. This review aims to provide a narrative involvement different signaling pathways, mainly mediating related key specific targets cascades influence progression As such, we suggested induce through stimulation certain which displays possible efficient treatment methods provides reference for precise control

Language: Английский

Citations

33
Inflammasomes: Mechanisms of Action and Involvement in Human Diseases DOI Creative Commons
Dimitri Bulté, Chiara Rigamonti, Alessandro Pecego Martins Romano

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(13), P. 1766 - 1766

Published: July 3, 2023

Inflammasome complexes and their integral receptor proteins have essential roles in regulating the innate immune response inflammation at post-translational level. Yet despite protective role, aberrant activation of inflammasome gain function mutations component genes seem to contribute development progression human autoimmune autoinflammatory diseases. In past decade, our understanding biology mechanisms has greatly progressed. We therefore provide an up-to-date overview various inflammasomes known action. addition, we highlight involvement pathogenic common autoinflammatory, neurodegenerative diseases, including atherosclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, Alzheimer’s Parkinson’s multiple sclerosis. conclude by speculating on future avenues research needed better understand health disease.

Language: Английский

Citations

32
Abordagem dos aspectos da Síndrome de Sjögren DOI Open Access

Natasha Tanus Cury,

Maria Clara do Vale Flora,

Giovanna de Azevedo Chagas Bracci

et al.

Revista Eletrônica Acervo Saúde, Journal Year: 2023, Volume and Issue: 23(5), P. e12774 - e12774

Published: May 22, 2023

Objetivo: Analisar as características da Síndrome de Sjögren (SS). Revisão bibliográfica: A síndrome é uma doença autoimune crônica do tecido conjuntivo, que envolve glândulas exócrinas e pode ser dividida em primária secundária. tríade sintomas clínicos inclui secura, fadiga dor. Como sistêmica, a SS envolver praticamente qualquer sistema orgânico, levando manifestações clínicas extremamente pleomórficas. taxa incidência 6,92 por 100.000 pessoas ano. Em relação ao impacto na qualidade vida, afeta negativamente atividade diária paciente devido à alta prevalência fadiga, depressão, ansiedade diminuição desempenho físico. Considerações finais: cujo os principais são: ceratoconjuntivite seca xerostomia. Além disso, ter múltiplos acometimentos nível sistêmico. Não existe um único teste para o seu diagnóstico esta deve suspeitada pacientes com persistentes aumento glândula parótida além inexplicável cáries dentárias. O tratamento feito sintomáticos nos casos sem envolvimento sistêmico naqueles afetados sistêmicamente são tratados imunossupressão.

Citations

30
Sex difference in human diseases: mechanistic insights and clinical implications DOI Creative Commons

Yuncong Shi,

Jianshuai Ma,

Sijin Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 10, 2024

Abstract Sex characteristics exhibit significant disparities in various human diseases, including prevalent cardiovascular cancers, metabolic disorders, autoimmune and neurodegenerative diseases. Risk profiles pathological manifestations of these diseases notable variations between sexes. The underlying reasons for sex encompass multifactorial elements, such as physiology, genetics, environment. Recent studies have shown that body systems demonstrate sex-specific gene expression during critical developmental stages editing processes. These genes, differentially expressed based on different sex, may be regulated by androgen or estrogen-responsive thereby influencing the incidence presentation cardiovascular, oncological, metabolic, immune, neurological across However, despite existence differences patients with treatment guidelines predominantly rely male data due to underrepresentation women clinical trials. At present, there exists a substantial knowledge gap concerning mechanisms treatments diverse Therefore, this review aims elucidate advances examining epidemiological factors, pathogenesis, innovative progress accordance distinctive risk each disease provide new theoretical practical basis further optimizing individualized improving patient prognosis.

Language: Английский

Citations

13
Human umbilical cord mesenchymal stem cells improve disease characterization of Sjogren's syndrome in NOD mice through regulation of gut microbiota and Treg/Th17 cellular immunity DOI Creative Commons

Yao Zou,

Wei Xiao,

Dongzhou Liu

et al.

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(1)

Published: Jan. 1, 2024

Abstract Background For the unclear pathogenesis of Sjogren's syndrome (SS), further exploration is necessary. Mesenchymal stem cells (MSCs) and derived exosomes (MSCs‐exo) have exhibited promising results in treating SS. Object This study aimed to investigate effect mechanism human umbilical cord MSCs (UC‐MSCs) on Methods Nonobese Diabetic (NOD) mouse splenic T were co‐cultured with UC‐MSCs UC‐MSCs‐exo, interferon‐gamma (IFN‐γ), interleukin (IL)‐6, IL‐10, prostaglandin E2 (PGE2), transforming growth factor‐β1 (TGF‐β1) levels supernatant assessed by quantitative real‐time polymerase chain reaction enzyme‐linked immunosorbent assay. Co‐cultured injected into NOD mice via tail vein. The inflammatory cell infiltration intestine submandibular gland was characterized hematoxylin‐eosin staining. Treg/Th17 homeostasis within spleen determined flow cytometry. Gut microbiota detected 16S rRNA sequencing, relationship between differential cytokines analyzed Pearson correlation coefficient. Results UC‐MSCs, successfully cultured identified. After both IFN‐γ IL‐6 decreased while PGE2, TGF‐β1 increased transcriptional translational levels. UC‐MSCs‐exo partially restored salivary secretion function, reduced Ro/SSA antibody α‐Fodrin immunoglobulin A levels, gland, raised proportion Treg cells, IFN‐γ, IL‐6, IL‐2, IL‐17, lipopolysaccharide, tumor necrosis factor‐alpha Foxp3, affecting cells. intervention improved intestinal increasing diversity richness. Additionally, significantly associated cytokine Conclusion Human disease characterization SS through regulation gut cellular immunity.

Language: Английский

Citations

11
CD4 T cell-secreted IFN-γ in Sjögren's syndrome induces salivary gland epithelial cell ferroptosis DOI Creative Commons

Jiannan Zhou,

Janak L. Pathak,

Tingting Cao

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2024, Volume and Issue: 1870(4), P. 167121 - 167121

Published: March 11, 2024

Language: Английский

Citations

11
Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases DOI Creative Commons

Liuting Zeng,

Kailin Yang,

Ganpeng Yu

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(7)

Published: July 4, 2024

Abstract Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis remain unclear. Currently, increasing research has highlighted the role of ferroptosis in immune regulation, with cells being a crucial component body’s system. This review provides an overview discusses relationship between ferroptosis, programmed cell death cells, autoimmune diseases. Additionally, it summarizes key targets such as GPX4 TFR, responses. Furthermore, release multiple molecules, including damage-associated molecular patterns (DAMPs), following by is examined, these molecules further influence differentiation function thereby affecting occurrence progression Moreover, secrete factors or metabolites, which also impact target organs tissues involved Iron chelators, chloroquine its derivatives, antioxidants, calreticulin have been demonstrated to be effective animal studies for certain diseases, exerting anti-inflammatory immunomodulatory effects. Finally, brief summary future perspectives on are provided, aiming guide disease treatment strategies.

Language: Английский

Citations

10
Genetic insight into dissecting the immunophenotypes and inflammatory profiles in the pathogenesis of Sjogren syndrome DOI Creative Commons
Jingyi Xu, Shucheng Si,

Yijun Han

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 13, 2025

Sjogren syndrome (SS) is a chronic systemic autoimmune disease and its pathogenesis often involves the participation of numerous immune cells inflammatory factors. Despite increased researches studies recently focusing on this area, it remains to be fully elucidated. We decide incorporate genetic insight into investigation causal link between various cells, factors (SS). Our study leveraged variants multi-omics statistics extracted from genome-wide association (GWAS), University Bristol FinnGen study. performed bidirectional Mendelian randomization mediation based randomly allocated instrumental variables infer causality, followed by external validation with UK Biobank data Bayesian colocalization. demonstrated that an elevated level CD27 IgD + CD24 B cell, subset expressing both CD24, was associated higher risk SS (OR = 1.119, 95% CI: 1.061–1.179, P < 0.001), while CD3 CD45RA CD4 Treg protective factor 0.917, 95%CI: 0.877–0.959, 0.001). Results meta-analysis colocalization further supported significant results identified in primary analysis. A total 4 cytokines 7 circulating proteins exhibited potential relationships despite no result achieved after FDR correction. Finally, analysis indicated CD40L receptor levels had mediating effects (β 0.0314, 0.0004–0.0624, 0.0471) at proportion 28% (95% 0.364%-55.6%) relationship cell SS. By providing novel unveiling roles autoimmunity inflammation syndrome, our findings may potentially lead identifying new clinical biomarkers for monitoring therapeutic targets offer more effective alternatives treating condition. Therefore, provide valuable evidence future intervention targeted immunotherapy.

Language: Английский

Citations

1
Telitacicept: A novel horizon in targeting autoimmunity and rheumatic diseases DOI

Liuting Zeng,

Kailin Yang,

Yang Wu

et al.

Journal of Autoimmunity, Journal Year: 2024, Volume and Issue: 148, P. 103291 - 103291

Published: Aug. 14, 2024

Language: Английский

Citations

8