BMC Pulmonary Medicine,
Год журнала:
2024,
Номер
24(1)
Опубликована: Июль 27, 2024
Abstract
The
lung
is
a
highly
mechanical
organ
as
it
exposed
to
approximately
10
9
strain
cycles,
(where
the
length
change
of
tissue
structure
per
unit
initial
length),
with
an
4%
amplitude
during
quiet
tidal
breathing
or
7
cycles
at
25%
heavy
exercises,
sighs,
and
deep
inspirations.
These
indices
have
been
reported
become
aberrant
in
diseases
such
acute
respiratory
distress
syndrome
(ARDS),
pulmonary
hypertension,
bronchopulmonary
dysplasia
(BPD),
idiopathic
fibrosis
(IPF),
asthma.
Through
recent
innovations,
various
vitro
systems/bioreactors
used
mimic
lung’s
developed.
Among
these,
Flexcell
tension
system
which
composed
bioreactors
that
utilize
variety
programs
apply
static
cyclic
on
different
cell-types
established
2D
monolayer
cultures
cell-embedded
3D
hydrogel
models,
has
enabled
assessment
response
cells
fibroblasts
health
disease.
Fibroblasts
are
main
effector
responsible
for
production
extracellular
matrix
(ECM)
proteins
repair
maintain
homeostasis
implicated
excessive
deposition
leads
fibrosis.
In
this
review,
we
summarise,
studies
bioreactor
assess
effects
structure,
function,
phenotype
homeostatic
conditions
abnormal
environments
associated
injury
We
show
these
revealed
regulate
fibroblast
proliferation,
ECM
protein
production,
inflammation
normal
diseased
lung.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 11, 2024
Introduction:
Asthma
is
a
condition
of
airflow
limitation,
common
throughout
the
world,
with
high
mortality
rates,
especially
as
it
still
faces
some
obstacles
in
its
management.
As
constitutes
public
health
challenge,
this
study
aimed
to
investigate
effect
copaiba
oil
(e.g.,
Copaifera
langsdorffii
),
treatment
resource,
at
doses
50
and
100
mg/kg
on
certain
mediators
acute
lung
inflammation
(IL-33,
GATA3,
FOXP3,
STAT3,
TBET)
early
mechanisms
remodeling
(degradation
elastic
fiber
tissues,
collagen
deposition,
goblet
cell
hyperplasia).
Methods:
Using
an
ovalbumin-induced
allergic
asthma
model
BALB/c
mice,
we
analyzed
inflammatory
through
immunohistochemistry
histopathology,
employing
orcein,
Masson’s
trichrome,
periodic
acid-Schiff
staining.
Results:
Copaiba
(CO)
reduced
IL-33
increased
FOXP3
by
stimulating
FOXP3/GATA3
FOXP3/STAT3
pathways.
Additionally,
upregulated
TBET,
suggesting
additional
role
controlling
GATA3
activity.
In
respiratory
epithelium,
CO
decreased
fragmentation
fibers
while
increasing
deposition
fibers,
favoring
epithelial
restructuring.
Simultaneously,
hyperplasia.
Discussion:
Although
research
warranted,
demonstrated
anti-inflammatory
re-epithelializing
action
makes
viable
option
exploring
new
treatments
for
asthma.
Environmental Science Processes & Impacts,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
In
recent
decades,
several
cell-based
and
acellular
methods
have
been
developed
to
evaluate
ambient
particulate
matter
(PM)
toxicity.
Although
provide
a
more
comprehensive
assessment
of
PM
toxicity,
their
results
are
difficult
comprehend
due
the
diversity
in
cellular
endpoints,
cell
types,
assays
interference
chemical
components
with
some
assays'
techniques.
this
review,
we
attempt
clarify
these
issues.
We
first
discuss
morphological
immunological
differences
among
various
macrophage
epithelial
cells,
belonging
respiratory
systems
human
murine
species,
used
Diagnostics,
Год журнала:
2024,
Номер
14(21), С. 2448 - 2448
Опубликована: Окт. 31, 2024
Asthma
is
a
chronic
inflammatory
process
that
leads
to
airway
narrowing,
causing
breath
loss
followed
by
spasms,
wheezing,
and
shortness
of
breath.
Within
the
asthmatic
lungs,
interaction
among
various
immune
cells
structural
plays
significant
role
in
orchestrating
an
response
which
eosinophils
hold
central
importance.
In
these
settings,
allergens
or
other
environmental
exposures
commonly
drive
recruit
airways.
The
appearance
airways
indicates
dynamic
interplay
cell
types
within
lung
tissue
does
not
represent
passive
effect
inflammation.
cellular
cross-talk
causes
persistence
eosinophilic
inflammation,
if
left
untreated,
it
results
long-term
damage
structure
function.
Further
exacerbation
condition
occurs
because
this.
We
discuss
how
this
complex
eosinophils,
immune,
microenvironment
distinct
pathophysiological
features
asthma,
variability
disease
severity,
biological
treatments.
Wiadomości Lekarskie,
Год журнала:
2024,
Номер
77(4), С. 821 - 827
Опубликована: Янв. 1, 2024
Aim:
To
analyse
laboratory
and
biochemical
features
of
the
severe
persistent
course
asthma
in
patients
with
undifferentiated
connective
tissue
dysplasia
(UCTD)
syndrome,
their
phenotypic
visceral
stigmas
dysembryogenesis.
Materials
Methods:
We
enrolled
60
male
asthma,
aged
from
23
to
62
years
(mean
age
(46.83
±0.85)
years):
30
background
UCTD,
-
without
UCTD.
analysed
clinical,
somatometric,
surveying
(original
questionnaire
based
on
map
Glesby),
instrumental
(spirography,
echocardiography,
endoscopy,
esophagofibrogastroduodenoscopy)
(including
eosinophilic
granulocytes
aldosterone
levels)
data.
Results:
Correlations
were
found
men
UCTD
between
number
markers
rate
earlobe
diagonal
fold
(r=+0.75;
р<0.05),
asthenic
constitution
(r=+0.72;
easy
bruising
(r=+0.7;
p<0.05)
straight
abdominal
line
hernia
(r=+0.52;
p<0.05).
Average
serum
level
(176,10
±11,22)
was
significantly
higher
than
those
(142,77
±±
9,43),
(p<0.05),
as
well
average
eosinophils
levels
(1.3
±0.25
vs.
0.57
±0.12,
In
absolute
majority
(93.3%)
onset
confirmed
after
pneumonia,
manifestation
(37.2
±1.21)
(21.4
±1.13).
Also,
there
a
high
exacerbations
during
last
year
(2.7
±0.12
per
year)
doses
combined
inhaled
glucocorticosteroids
use.
Conclusions:
Identified
“phenotypic
profile”,
clinical
which
determine
early
formation
complications,
will
further
accelerate
diagnosis
this
phenotype
improve
approaches
selection
treatment
regimens
for
these
patients.
BMC Pulmonary Medicine,
Год журнала:
2024,
Номер
24(1)
Опубликована: Июль 27, 2024
Abstract
The
lung
is
a
highly
mechanical
organ
as
it
exposed
to
approximately
10
9
strain
cycles,
(where
the
length
change
of
tissue
structure
per
unit
initial
length),
with
an
4%
amplitude
during
quiet
tidal
breathing
or
7
cycles
at
25%
heavy
exercises,
sighs,
and
deep
inspirations.
These
indices
have
been
reported
become
aberrant
in
diseases
such
acute
respiratory
distress
syndrome
(ARDS),
pulmonary
hypertension,
bronchopulmonary
dysplasia
(BPD),
idiopathic
fibrosis
(IPF),
asthma.
Through
recent
innovations,
various
vitro
systems/bioreactors
used
mimic
lung’s
developed.
Among
these,
Flexcell
tension
system
which
composed
bioreactors
that
utilize
variety
programs
apply
static
cyclic
on
different
cell-types
established
2D
monolayer
cultures
cell-embedded
3D
hydrogel
models,
has
enabled
assessment
response
cells
fibroblasts
health
disease.
Fibroblasts
are
main
effector
responsible
for
production
extracellular
matrix
(ECM)
proteins
repair
maintain
homeostasis
implicated
excessive
deposition
leads
fibrosis.
In
this
review,
we
summarise,
studies
bioreactor
assess
effects
structure,
function,
phenotype
homeostatic
conditions
abnormal
environments
associated
injury
We
show
these
revealed
regulate
fibroblast
proliferation,
ECM
protein
production,
inflammation
normal
diseased
lung.
