Antioxidants,
Год журнала:
2024,
Номер
unknown, С. 219 - 255
Опубликована: Ноя. 17, 2024
Respiratory
diseases
exert
a
substantial
impact
and
an
indelible
imprint
on
the
quality
of
life
significant
portion
global
populace.
Diseases
such
as
Asthma,
Chronic
obstructive
pulmonary
disease,
Idiopathic
fibrosis,
etc.,
have
major
association
with
reactive
oxygen
species
oxidative
stress
in
their
underlying
fundamental
pathogenesis.
Antioxidants
are
substances
that
elucidate
action
by
slowing
down
or
blocking
oxidation
other
chemicals
been
found
to
protective
for
management
oxidant
stress.
This
book
chapter
aims
excavate
into
domain
antioxidants
how
they
useful
mitigation
these
respiratory
diseases.
A
plethora
antioxidant
compounds,
along
mechanistic
role
classification
also
discussed
comprehensively.
gives
insight
various
drug
delivery
systems
employed
help
reach
site
action.
Lastly,
future
perspectives
pertaining
holistically
explored
lay
out
possibilities
amalgamation
innovative
novel
concepts
personalized
medicine,
3D
printing
improve
therapeutic
efficacy
antioxidants.
Egyptian Liver Journal,
Год журнала:
2024,
Номер
14(1)
Опубликована: Янв. 2, 2024
Abstract
Background
Hepatocellular
carcinoma
(HCC)
is
a
common
type
of
liver
cancer,
with
high
mortality
rate.
cancer
that
can
be
effectively
managed
through
early
detection
and
accurate
diagnosis,
followed
by
personalized
treatment
plan
may
include
surgical
resection,
transplantation,
minimally-invasive
techniques,
immunotherapy,
or
targeted
therapy
depending
on
the
stage
severity
cancer.
Main
body
abstract
This
paper
discusses
recent
advances
in
detection,
management,
prevention
HCC.
The
use
newer
imaging
such
as
Magnetic
resonance
(MRI)
contrast-enhanced
ultrasound,
along
image
segmentation
technology
deep
learning
models,
have
greatly
enhanced
accuracy
HCC
diagnosis.
Minimally-invasive
thermal
ablation
radiofrequency
ablation,
allowed
for
more
precise
destruction
tumors,
while
Nanoparticles,
immunotherapy
shown
promise
management
advanced
Artificial
intelligence
(AI)
machine
has
revolutionized
research,
aiding
identification
high-risk
patients
predicting
outcomes.
Lifestyle
modifications,
weight
alcohol
avoidance,
hepatitis
B
vaccinations,
play
critical
role
preventing
development.
Short
conclusion
Recent
improving
patient
therapy,
AI
research
lifestyle
modifications
prevention.
However,
further
required
to
fully
understand
potential
benefits
nanoparticles,
traditional
Chinese
medicine
herbal
medicines
treatment.
Graphical
Cancer Communications,
Год журнала:
2024,
Номер
44(11), С. 1316 - 1336
Опубликована: Сен. 21, 2024
Abstract
Glycosylation,
a
key
mode
of
protein
modification
in
living
organisms,
is
critical
regulating
various
biological
functions
by
influencing
folding,
transportation,
and
localization.
Changes
glycosylation
patterns
are
significant
feature
cancer,
associated
with
range
pathological
activities
cancer‐related
processes,
serve
as
biomarkers
providing
new
targets
for
cancer
diagnosis
treatment.
Glycoproteins
like
human
epidermal
growth
factor
receptor
2
(HER2)
breast
alpha‐fetoprotein
(AFP)
liver
carcinoembryonic
antigen
(CEA)
colon
prostate‐specific
(PSA)
prostate
all
tumor
approved
clinical
use.
Here,
we
introduce
the
diversity
structures
newly
discovered
substrate—glycosylated
RNA
(glycoRNA).
This
article
focuses
primarily
on
metastasis,
immune
evasion,
metabolic
reprogramming,
aberrant
ferroptosis
responses,
cellular
senescence
to
illustrate
role
cancer.
Additionally,
summarize
applications
diagnostics,
treatment,
multidrug
resistance.
We
envision
promising
future
glycosylation.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Март 14, 2024
Metabolic
changes
are
coupled
with
alteration
in
protein
glycosylation.
In
this
review,
we
will
focus
on
macrophages
that
pivotal
the
pathogenesis
of
pulmonary
fibrosis
and
sarcoidosis
thanks
to
their
adaptable
metabolism
an
attractive
therapeutic
target.
Examples
presented
review
demonstrate
glycosylation
regulates
metabolism-driven
immune
responses
macrophages,
implications
for
fibrotic
processes
granuloma
formation.
Targeting
proteins
regulate
glycosylation,
such
as
fucosyltransferases,
neuraminidase
1
chitinase
could
effectively
block
immunometabolic
driving
inflammation
fibrosis,
providing
novel
avenues
interventions.
Biomolecules,
Год журнала:
2024,
Номер
14(5), С. 513 - 513
Опубликована: Апрель 24, 2024
Asthma
has
reached
epidemic
levels,
yet
progress
in
developing
specific
therapies
is
slow.
One
of
the
main
reasons
for
this
fact
that
asthma
an
umbrella
term
various
distinct
subsets.
Due
to
its
high
heterogeneity,
it
difficult
establish
biomarkers
each
subset
and
propose
endotype-specific
treatments.
This
review
focuses
on
protein
glycosylation
as
a
process
activated
ways
utilize
develop
novel
We
discuss
known
relevant
glycoproteins
whose
functions
control
disease
development.
The
key
role
processes
integral
asthma,
such
inflammation,
tissue
remodeling,
repair,
justifies
our
interest
research
field
glycobiology.
Altering
states
proteins
contributing
can
change
pathological
we
previously
failed
inhibit.
Special
emphasis
placed
chitotriosidase
1
(CHIT1),
enzyme
capable
modifying
LacNAc-
LacdiNAc-containing
glycans.
expression
activity
CHIT1
are
induced
human
diseased
lungs,
been
demonstrated
by
both
genetic
pharmacological
approaches.
studying
pattern
enzymes
involved
help
patient
stratification
personalized
treatment.
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
The
role
of
peripheral
blood
platelets
as
indicators
cancer
progression
is
increasingly
recognized,
and
the
significance
abnormal
glycosylation
in
platelet
function
related
disorders
gaining
attention.
However,
potential
a
source
protein
site-specific
for
diagnosis
remains
underexplored.
In
this
study,
we
proposed
general
pipeline
that
integrates
quantitative
proteomics
with
glycoproteomics,
allowing
an
in-depth
investigation
glycoproteome.
With
pipeline,
generated
data
set
comprising
3,466
proteins
qualitative
information,
3,199
3,419
glycans
information
3,377
from
hepatocellular
carcinoma
(HCC)
patients,
metastatic
liver
(mLC)
healthy
controls.
integrated
analysis
revealed
significant
changes
N-glycosylation
patients.
Further
systems
biology
lectin
pull-down-coupled
ELISA
assays
independent
clinical
samples
confirmed
two
N-glycoproteins
specific
glycan
types,
complement
C3
(C3)
oligomannose
modification
integrin
β-3
(ITGB3)
sialylation,
biomarkers
distinguishing
patients
individuals,
without
differentiating
between
HCC
mLC
patient
group.
These
findings
highlight
biomarkers.
International Journal of COPD,
Год журнала:
2025,
Номер
Volume 20, С. 511 - 532
Опубликована: Март 1, 2025
COPD
is
a
multifactorial
illness
characterized
by
long-term
restriction
of
airflow
and
an
inflammatory
reaction
in
the
lungs.
The
associated
emphysema
leads
to
breakdown
alveolar
proteins
abnormal
expansion
lung
air
spaces.
Chronic
bronchitis
caused
same
disease
can
result
increased
deposition
structural
proteins,
narrowing
airways,
excessive
mucus
secretion
leading
acute
exacerbation
(AECOPD).
most
commonly
prescribed
medications
for
it,
such
as
glucocorticoids
bronchodilators,
provide
important
therapeutic
benefits,
but
they
also
have
negative
side
effects,
including
immunosuppression
infection.
Therefore,
it
necessary
develop
treatment
that
specifically
target
immune
system
molecular
components.
This
review
focuses
on
non-eosinophilic
aspects
immunological
modulation
management.
Since,
existing
literature
extensively
covers
eosinophilic
inflammation,
this
aims
fill
gap
examining
alternative
pathways
their
implications.
findings
suggest
targeting
specific
responses
may
enhance
efficacy
while
minimizing
adverse
effects
with
traditional
therapies.
In
summary,
emphasizes
importance
advancing
research
into
mechanisms
COPD,
prescribing
development
novel
therapies
more
effectively
manage
disease.
