The triple exposure nexus of microplastic particles, plastic-associated chemicals, and environmental pollutants from a human health perspective

Environment International, Год журнала: 2024, Номер 188, С. 108736 - 108736

Опубликована: Май 10, 2024

The presence of microplastics (MPs) is increasing at a dramatic rate globally, posing risks for exposure and subsequent potential adverse effects on human health. Apart from being physical objects, MP particles contain thousands plastic-associated chemicals (i.e., monomers, chemical additives, non-intentionally added substances) captured within the polymer matrix. These are often migrating MPs can be found in various environmental matrices food chains; health effects. In addition to attributes MPs, plastic surfaces effectively bind exogenous chemicals, including pollutants (e.g., heavy metals, persistent organic pollutants). Therefore, act as vectors pollution across air, drinking water, food, further amplifying posed by exposure. Critically, fragmentation plastics environment increases risk interactions with cells, available leach adsorb transfer pollutants. This review proposes so-called triple nexus approach comprehensively map existing knowledge interconnected particles, Based data, there large gap regard cumulative nexus. Each component known induce genotoxicity, inflammation, endocrine disruption, but about long-term inter-individual lacking. Furthermore, not readily excreted organisms after ingestion they have been accumulated blood, cardiac tissue, placenta, etc. Even though number studies MPs-associated impacts rapidly, this underscores that pressing necessity achieve an integrated assessment MPs' order address future gaps.

Язык: Английский

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Immune-mediated disease caused by climate change-associated environmental hazards: mitigation and adaptation

Frontiers in Science, Год журнала: 2024, Номер 2

Опубликована: Апрель 4, 2024

Global warming and climate change have increased the pollen burden frequency intensity of wildfires, sand dust storms, thunderstorms, heatwaves—with concomitant increases in air pollution, heat stress, flooding. These environmental stressors alter human exposome trigger complex immune responses. In parallel, pollutants, allergens, other factors increase risks skin mucosal barrier disruption microbial dysbiosis, while a loss biodiversity reduced exposure to diversity impairs tolerogenic development. The resulting dysregulation is contributing an immune-mediated diseases such as asthma allergic diseases, autoimmune cancer. It now abundantly clear that multisectoral, multidisciplinary, transborder efforts based on Planetary Health One approaches (which consider dependence health environment natural ecosystems) are urgently needed adapt mitigate effects change. Key actions include reducing emissions improving quality (through fossil fuel use), providing safe housing (e.g., weatherization), diets (i.e., diversity) agricultural practices, increasing green spaces. There also pressing need for collaborative, multidisciplinary research better understand pathophysiology context New data science techniques, biomarkers, economic models should be used measure impact disease, inform mitigation adaptation efforts, evaluate their effectiveness. Justice, equity, diversity, inclusion (JEDI) considerations integral these address disparities

Язык: Английский

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Adverse effects of microplastics and nanoplastics on the reproductive system: A comprehensive review of fertility and potential harmful interactions

The Science of The Total Environment, Год журнала: 2023, Номер 903, С. 166258 - 166258

Опубликована: Авг. 12, 2023

In recent years, microplastics (MPs) and nanoplastics (NPs) have caused ubiquitous environmental pollution raised widespread concern about their potential toxicity to human health, especially in the reproductive system. Moreover, infertility affects >15 % of couples worldwide, birth rate is decreasing. Environmental factors are some most important causes infertility. However, little known effects MPs NPs on testes ovaries. These particles can enter body primarily via ingestion, inhalation, skin contact, target system a size-dependent manner disturb germ cell other somatic development. Our study systematically reviewed adverse plastic function offers valuable insights into different stages cells mechanisms. synergistic these carried contaminants was summarized. Given limited research scale, shift toward innovative technologies adoption multiple omics recommended for advancing related studies. Further needed explore based size, polymer type, shape, toxins, establish effective protective measures, develop precision medicine targeted damage.

Язык: Английский

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Immunotoxic, genotoxic, and endocrine disrupting impacts of polyamide microplastic particles and chemicals

Environment International, Год журнала: 2023, Номер 183, С. 108412 - 108412

Опубликована: Дек. 29, 2023

Due to their exceptional properties and cost effectiveness, polyamides or nylons have emerged as widely used materials, revolutionizing diverse industries, including industrial 3D printing additive manufacturing (AM). Powder-based AM technologies employ tonnes of polyamide microplastics produce complex components every year. However, the lack comprehensive toxicity assessment particulate polyamide-associated chemicals, especially in light global crisis, calls for urgent action. This study investigated physicochemical polyamide-12 AM, assessed a number endpoints focusing on inflammation, immunometabolism, genotoxicity, aryl hydrocarbon receptor (AhR) activation, endocrine disruption, cell morphology. Specifically, examination by means field emission scanning electron microscopy revealed that work flow reuse material created fraction smaller particles with an average size 1-5 µm, range readily available uptake human cells. Moreover, chemical analysis gas chromatography high-resolution mass spectrometry detected several chemicals starting material, plasticizer, thermal stabilizer/antioxidant, migrating slip additive. Even if did not induce acute inflammatory response, repeated prolonged exposure primary macrophages disclosed steady increase levels proinflammatory chemokine Interleukin-8 (IL-8/CXCL-8). targeted metabolomics modulated kynurenine pathway some its key metabolites. The p53-responsive luciferase reporter gene assay showed per se were able activate p53, being indicative genotoxic stress. Polyamide-associated triggered moderate activation AhR elicited anti-androgenic activity. Finally, high-throughput non-targeted morphological profiling Cell Painting outlined major sites bioactivity indicated putative mechanisms These findings reveal increasing use may pose potential health risk exposed individuals, it merits more attention.

Язык: Английский

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Journey of micronanoplastics with blood components

RSC Advances, Год журнала: 2023, Номер 13(45), С. 31435 - 31459

Опубликована: Янв. 1, 2023

Micronanoplastics (MNPs) interact with blood components, resulting in anemia, cardiovascular diseases, etc. Research gaps include toxic impacts of real-world MNPs, monomers, co-pollutants complex, and so on, emphasizing the need for more research.

Язык: Английский

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Nano-sized microplastics exposure induces skin cell senescence via triggering the mitochondrial localization of GSDMD

Environmental Pollution, Год журнала: 2024, Номер 349, С. 123874 - 123874

Опубликована: Март 27, 2024

Язык: Английский

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Degradation of Polymer Materials in the Environment and Its Impact on the Health of Experimental Animals: A Review

Polymers, Год журнала: 2024, Номер 16(19), С. 2807 - 2807

Опубликована: Окт. 3, 2024

The extensive use of polymeric materials has resulted in significant environmental pollution, prompting the need for a deeper understanding their degradation processes and impacts. This review provides comprehensive analysis environment impact on health experimental animals. It identifies common polymers, delineates pathways, describes resulting products under different conditions. covers physical, chemical, biological mechanisms, highlighting complex interplay factors influencing these processes. Furthermore, it examines implications products, using animals as proxies assessing potential risks to human health. By synthesizing current research, focuses studies related small organisms (primarily rodents invertebrates, supplemented by fish mollusks) explore effects polymer living underscores urgency developing implementing effective waste management strategies. These strategies are crucial mitigating adverse impacts degradation, thus promoting more sustainable interaction between activities natural environment.

Язык: Английский

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The boom era of emerging contaminants: A review of remediating agricultural soils by biochar

The Science of The Total Environment, Год журнала: 2024, Номер 931, С. 172899 - 172899

Опубликована: Апрель 30, 2024

Язык: Английский

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Micro-nanoplastics and cardiovascular diseases: evidence and perspectives

European Heart Journal, Год журнала: 2024, Номер 45(38), С. 4099 - 4110

Опубликована: Сен. 6, 2024

Abstract Emerging evidence indicates that chemical exposures in the environment are overlooked drivers of cardiovascular diseases (CVD). Recent suggests micro- and nanoplastic (MNP) particles derived largely from or mechanical degradation plastics might represent a novel CVD risk factor. Experimental data preclinical models suggest MNPs can foster oxidative stress, platelet aggregation, cell senescence, inflammatory responses endothelial immune cells while promoting range metabolic alterations lead to disease premature death. In humans, various plastics, including polyethylene polyvinylchloride, have been detected atherosclerotic plaques other tissues, pericardia, epicardial adipose pericardial myocardia, left atrial appendages. measurable levels within thrombi seem accumulate preferentially areas vascular lesions. Their presence carotid is associated with subsequent increased incidence events. To further investigate possible causal role CVD, future studies should focus on large, prospective cohorts assessing exposure individuals plastic-related pollution, routes absorption, existence putative safety limit, correspondence between accumulation timing development, pathophysiological mechanisms instigated by pertinent concentrations MNPs. Data such would allow design preventive, even therapeutic, strategies. Meanwhile, existing reducing plastic production use will produce benefits for human health. This goal could be achieved through UN Global Plastics Treaty currently negotiation.

Язык: Английский

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Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Май 13, 2024

Introduction Global microplastic (MP) pollution is now well recognized, with humans and animals consuming inhaling MPs on a daily basis, growing body of concern surrounding the potential impacts human health. Methods Using mouse model mild COVID-19, we describe herein effects azide-free 1 μm polystyrene MP beads, co-delivered into lungs SARS-CoV-2 omicron BA.5 inoculum. The effect host response to infection was analysed using histopathology RNA-Seq at 2 6 days post-infection (dpi). Results Although reduced clearance from lung, virus titres viral RNA levels were not significantly affected by MPs, overt MP-associated clinical or histopathological changes observed. However, infected revealed that exposure suppressed innate immune responses dpi increased pro-inflammatory signatures dpi. cytokine profile showed significant correlation ‘cytokine release syndrome’ signature observed in some COVID-19 patients. Discussion findings are consistent recent finding can inhibit phagocytosis apoptotic cells via binding Tim4. They also add literature suggesting dysregulate inflammatory processes specific disease settings.

Язык: Английский

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