Neuroscience, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Июль 22, 2024
Abstract Cytokines are critical in regulating immune responses and cellular behavior, playing dual roles both normal physiology the pathology of diseases such as cancer. These molecules, including interleukins, interferons, tumor necrosis factors, chemokines, growth factors like TGF-β, VEGF, EGF, can promote or inhibit growth, influence microenvironment, impact efficacy cancer treatments. Recent advances targeting these pathways have shown promising therapeutic potential, offering new strategies to modulate system, progression, overcome resistance conventional therapies. In this review, we summarized current understanding implications cytokine chemokine signaling By exploring molecules biology response, highlighted development novel agents aimed at modulating combat The review elaborated on nature cytokines promoters suppressors tumorigenesis, depending context, discussed challenges opportunities presents for intervention. We also examined latest advancements targeted therapies, monoclonal antibodies, bispecific receptor inhibitors, fusion proteins, engineered variants, their metastasis, microenvironment. Additionally, evaluated potential combining therapies with other treatment modalities improve patient outcomes. Besides, focused ongoing research clinical trials that pivotal advancing our application cytokine- chemokine-targeted patients.
Язык: Английский
Процитировано
67
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116783 - 116783
Опубликована: Май 25, 2024
During tumor development, the itself must continuously generate new blood vessels to meet their growth needs while also allowing for invasion and metastasis. One of most common features tumors is hypoxia, which drives process angiogenesis by regulating microenvironment, thus adversely affecting prognosis patients. In addition, overcome unsuitable environments growth, such as nutrient deficiency, hyperacidity, immunosuppression, microenvironment (TME) coordinates in several ways restore supply oxygen nutrients remove metabolic wastes. A growing body research suggests that hypoxia interact through a complex interplay crosstalk, inextricably linked TME. Here, we review TME's positive contribution from an angiogenesis-centric perspective considering objective impact hypoxic phenotypes status limitations current angiogenic therapies.
Язык: Английский
Процитировано
11
Current Treatment Options in Oncology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 22, 2025
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140382 - 140382
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101254 - 101254
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2763 - 2763
Опубликована: Март 19, 2025
Glioblastomas (GBMs), among the most aggressive and resilient brain tumors, characteristically exhibit high angiogenic potential, leading to formation of a dense yet aberrant vasculature, both morphologically functionally. With these premises, numerous expectations were initially placed on anti-angiogenic therapies, soon dashed by their limited efficacy in concretely improving patient outcomes. Neovascularization GBM emerged as complex, dynamic, heterogeneous process, hard manage with classical standard care. Growing evidence has revealed existence non-canonical strategies angiogenesis, variously exploited meet its ever-increasing metabolic demand differently involved tumor progression, recurrence, escape from treatments. In this review, we provide an accurate description each neovascularization mode encountered tumors date, highlighting molecular players signaling cascades primarily involved. We also detail key architectural functional aspects characteristic vascular compartment because intricate crosstalk between different networks. Additionally, explore repertoire emerging therapies against that are currently under study, concluding question: faced such challenging scenario, could combined tailored patient’s genetic signatures, represent effective game changer?
Язык: Английский
Процитировано
1
Cancers, Год журнала: 2023, Номер 16(1), С. 194 - 194
Опубликована: Дек. 30, 2023
The peritoneum is the most common metastatic site of advanced gastric cancer and associated with extremely poor prognosis. Endothelial-specific molecule 1 (ESM1) was found to be significantly peritoneal metastasis (GCPM); however, biological functions molecular mechanisms ESM1 in regulating GCPM remain unclear. Herein, we demonstrated that expression upregulated tissues positively correlated platelet endothelial cell adhesion molecule-1 (CD31) levels. Moreover, clinical validation, vitro vivo experiments, confirmed promoted angiogenesis, eventually promoting metastasis. Mechanistically, tumor angiogenesis by binding c-Met on vascular membrane. In addition, our results VEGFA, HIF1α, MMP9 induced activating MAPK/ERK pathway. conclusion, findings identified role GCPM, thus providing insights into diagnosis treatment cancer.
Язык: Английский
Процитировано
21
Food Science & Nutrition, Год журнала: 2024, Номер 12(10), С. 7088 - 7107
Опубликована: Авг. 29, 2024
Abstract Cancer remains a critical global health challenge, with limited progress in reducing mortality despite advancements diagnosis and treatment. The growing resistance of tumors to existing chemotherapy exacerbates this burden. In response, the search for new anticancer compounds from plants has intensified, given their historical success yielding effective treatments. This review focuses on α‐solanine, glycoalkaloid primarily derived potato tubers nightshade family plants, recognized its diverse biological activities, including anti‐allergic, antipyretic, anti‐inflammatory, anti‐diabetic, antibiotic properties. Recently, α‐solanine gained attention as potential agent. Utilizing resources like PubMed/MedLine, ScienceDirect, Web Science, Scopus, American Chemical Society, Google Scholar, Springer Link, Wiley, various commercial websites, consolidates two decades research α‐solanine's effects mechanisms against nine different cancers, highlighting role modulating signaling pathways. It also discusses lead compound cancer therapy. abundant availability peel, often discarded waste or sold cheaply, is suggested sustainable source large‐scale extraction. study concludes that holds promise standalone adjunctive However, further necessary optimize mitigate toxicity through strategies.
Язык: Английский
Процитировано
5
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2023, Номер 1878(6), С. 189020 - 189020
Опубликована: Ноя. 1, 2023
Язык: Английский
Процитировано
12
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Апрель 2, 2024
Abstract Lung cancer is a deeply malignant tumor with high incidence and mortality. Despite the rapid development of diagnosis treatment technology, abundant patients lung are still inevitably faced recurrence metastasis, contributing to death. Lymphatic metastasis first step distant an important prognostic indicator non-small cell cancer. Tumor-induced lymphangiogenesis involved in construction microenvironment, except promoting proliferation cells, it also plays crucial role individual response treatment, especially immunotherapy. Thus, this article reviews current research status lymphatic cancer, order provide some insights for basic clinical translational application field.
Язык: Английский
Процитировано
4