Targeting cytokine and chemokine signaling pathways for cancer therapy

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: July 22, 2024

Abstract Cytokines are critical in regulating immune responses and cellular behavior, playing dual roles both normal physiology the pathology of diseases such as cancer. These molecules, including interleukins, interferons, tumor necrosis factors, chemokines, growth factors like TGF-β, VEGF, EGF, can promote or inhibit growth, influence microenvironment, impact efficacy cancer treatments. Recent advances targeting these pathways have shown promising therapeutic potential, offering new strategies to modulate system, progression, overcome resistance conventional therapies. In this review, we summarized current understanding implications cytokine chemokine signaling By exploring molecules biology response, highlighted development novel agents aimed at modulating combat The review elaborated on nature cytokines promoters suppressors tumorigenesis, depending context, discussed challenges opportunities presents for intervention. We also examined latest advancements targeted therapies, monoclonal antibodies, bispecific receptor inhibitors, fusion proteins, engineered variants, their metastasis, microenvironment. Additionally, evaluated potential combining therapies with other treatment modalities improve patient outcomes. Besides, focused ongoing research clinical trials that pivotal advancing our application cytokine- chemokine-targeted patients.

Language: Английский

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Survival strategies: How tumor hypoxia microenvironment orchestrates angiogenesis

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116783 - 116783

Published: May 25, 2024

During tumor development, the itself must continuously generate new blood vessels to meet their growth needs while also allowing for invasion and metastasis. One of most common features tumors is hypoxia, which drives process angiogenesis by regulating microenvironment, thus adversely affecting prognosis patients. In addition, overcome unsuitable environments growth, such as nutrient deficiency, hyperacidity, immunosuppression, microenvironment (TME) coordinates in several ways restore supply oxygen nutrients remove metabolic wastes. A growing body research suggests that hypoxia interact through a complex interplay crosstalk, inextricably linked TME. Here, we review TME's positive contribution from an angiogenesis-centric perspective considering objective impact hypoxic phenotypes status limitations current angiogenic therapies.

Language: Английский

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A bioactive polysaccharide derived from Rosa laevigata fruits: Structural properties, antitumor efficacy, and potential mechanisms

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140382 - 140382

Published: Jan. 1, 2025

Language: Английский

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ESM1 Interacts with c-Met to Promote Gastric Cancer Peritoneal Metastasis by Inducing Angiogenesis

Cancers, Journal Year: 2023, Volume and Issue: 16(1), P. 194 - 194

Published: Dec. 30, 2023

The peritoneum is the most common metastatic site of advanced gastric cancer and associated with extremely poor prognosis. Endothelial-specific molecule 1 (ESM1) was found to be significantly peritoneal metastasis (GCPM); however, biological functions molecular mechanisms ESM1 in regulating GCPM remain unclear. Herein, we demonstrated that expression upregulated tissues positively correlated platelet endothelial cell adhesion molecule-1 (CD31) levels. Moreover, clinical validation, vitro vivo experiments, confirmed promoted angiogenesis, eventually promoting metastasis. Mechanistically, tumor angiogenesis by binding c-Met on vascular membrane. In addition, our results VEGFA, HIF1α, MMP9 induced activating MAPK/ERK pathway. conclusion, findings identified role GCPM, thus providing insights into diagnosis treatment cancer.

Language: Английский

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Changing landscape of anti-angiogenic therapy: Novel approaches and clinical perspectives

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(6), P. 189020 - 189020

Published: Nov. 1, 2023

Language: Английский

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Advances in lymphatic metastasis of non-small cell lung cancer

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 2, 2024

Abstract Lung cancer is a deeply malignant tumor with high incidence and mortality. Despite the rapid development of diagnosis treatment technology, abundant patients lung are still inevitably faced recurrence metastasis, contributing to death. Lymphatic metastasis first step distant an important prognostic indicator non-small cell cancer. Tumor-induced lymphangiogenesis involved in construction microenvironment, except promoting proliferation cells, it also plays crucial role individual response treatment, especially immunotherapy. Thus, this article reviews current research status lymphatic cancer, order provide some insights for basic clinical translational application field.

Language: Английский

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Candidate Biomarker of Response to Immunotherapy In Small Cell Lung Cancer

Current Treatment Options in Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

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Naringenin: a potential therapeutic agent for modulating angiogenesis and immune response in hepatocellular carcinoma

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101254 - 101254

Published: March 1, 2025

Language: Английский

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Exosomes containing miR-152-3p targeting FGFR3 mediate SLC7A7-induced angiogenesis in bladder cancer

npj Precision Oncology, Journal Year: 2025, Volume and Issue: 9(1)

Published: March 12, 2025

Abstract Bladder cancer (BCa) is a prevalent malignancy with poor prognosis. SLC7A7 has been linked to BCa progression and angiogenesis, but its specific role remains unclear. We established SLC7A7-knockdown cell line investigate effects on angiogenesis. In vivo experiments assessed tumor vascularization, while in vitro studies explored exosome involvement. MiRNA sequencing identified miR-152-3p as key regulator. Further investigation using dual-luciferase reporter assays, qRT-PCR, Western blot revealed that inhibits the expression of FGFR3 by binding 3’ UTR. Meanwhile, functional including angiogenesis Transwell wound healing were performed evaluate confirmed significant progression, specifically promoting through involvement exosomes regulatory axis miR-152-3p/ FGFR3. Targeting might be promising strategy reverse control for an improved

Language: Английский

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Angiogenesis and targeted therapy in the tumour microenvironment: From basic to clinical practice

Clinical and Translational Medicine, Journal Year: 2025, Volume and Issue: 15(4)

Published: April 1, 2025

Abstract Angiogenesis, as a core marker of cancer survival and growth, is integral to the processes tumour invasion metastasis. In recent years, targeted angiogenesis treatment strategies have gradually become an important direction in treatment. Single‐cell sequencing technology can provide new insights into by providing deeper understanding heterogeneity endothelial cells exploring interactions between surrounding microenvironment. Here, we systematically review research progress cell pathophysiology its endothelial‒mesenchymal transition illustrate from single‐cell perspective. Finally, examine contributions different types within microenvironment relation angiogenesis, well latest therapy, hoping useful clinical application antiangiogenic Furthermore, summary present development potential inhibitors ongoing trials for combination therapies provided. Key points Angiogenesis plays key role progression, metastasis, so targeting are becoming therapy. Interactions stromal immune significant angiogenesis. The immunotherapy nanotechnology therapy provides vital strategy prolonging patients.

Language: Английский

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