Advances in lymphatic metastasis of non-small cell lung cancer

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Апрель 2, 2024

Abstract Lung cancer is a deeply malignant tumor with high incidence and mortality. Despite the rapid development of diagnosis treatment technology, abundant patients lung are still inevitably faced recurrence metastasis, contributing to death. Lymphatic metastasis first step distant an important prognostic indicator non-small cell cancer. Tumor-induced lymphangiogenesis involved in construction microenvironment, except promoting proliferation cells, it also plays crucial role individual response treatment, especially immunotherapy. Thus, this article reviews current research status lymphatic cancer, order provide some insights for basic clinical translational application field.

Язык: Английский

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Angiogenesis and targeted therapy in the tumour microenvironment: From basic to clinical practice

Clinical and Translational Medicine, Год журнала: 2025, Номер 15(4)

Опубликована: Апрель 1, 2025

Abstract Angiogenesis, as a core marker of cancer survival and growth, is integral to the processes tumour invasion metastasis. In recent years, targeted angiogenesis treatment strategies have gradually become an important direction in treatment. Single‐cell sequencing technology can provide new insights into by providing deeper understanding heterogeneity endothelial cells exploring interactions between surrounding microenvironment. Here, we systematically review research progress cell pathophysiology its endothelial‒mesenchymal transition illustrate from single‐cell perspective. Finally, examine contributions different types within microenvironment relation angiogenesis, well latest therapy, hoping useful clinical application antiangiogenic Furthermore, summary present development potential inhibitors ongoing trials for combination therapies provided. Key points Angiogenesis plays key role progression, metastasis, so targeting are becoming therapy. Interactions stromal immune significant angiogenesis. The immunotherapy nanotechnology therapy provides vital strategy prolonging patients.

Язык: Английский

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Fucoxanthin: From chemical properties and sources to novel anticancer mechanistic insights and synergistic therapeutic opportunities

Current Research in Biotechnology, Год журнала: 2024, Номер 7, С. 100203 - 100203

Опубликована: Янв. 1, 2024

Fucoxanthin (FX) is a carotenoid of marine origin primarily distributed in brown seaweeds and has garnered interest for its antioxidative, anti-inflammatory, anticancer properties. Despite potential, comprehensive understanding effects mechanisms action remains elusive. The aim this review to present novel insights into the FX, shedding light on previously unexplored molecular synergistic potential with established chemotherapeutic agents. A search was conducted employing databases like PubMed/MedLine, Scopus, Web Science aggregate relevant pharmacological experimental studies. results studies showed that FX exhibits activity against various cancer types, including breast, colorectal, lung cancer, through multiple pathways: cell cycle arrest, apoptosis induction, inhibition angiogenesis. Additionally, potentiates existing agents, making it candidate combination therapies. evidence suggests possesses considerable properties, acting diverse mechanisms; heterogeneity study designs limited number clinical trials make hard conclude. Further in-depth studies, particularly randomized controlled trials, are essential validating FX's efficacy paving way integration standard treatment regimens; additional research needed explore pharmacokinetics, safety profile, chemotherapeutics.

Язык: Английский

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Pan-cancer dissection of vasculogenic mimicry characteristic to provide potential therapeutic targets

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Апрель 17, 2024

Introduction: Vasculogenic mimicry (VM) represents a novel form of tumor angiogenesis that is associated with invasiveness and drug resistance. However, the VM landscape across cancer types remains poorly understood. In this study, we elucidate characterizations cancers based on multi-omics data provide potential targeted therapeutic strategies. Methods: Multi-omics from The Cancer Genome Atlas was used to conduct comprehensive analyses characteristics related genes (VRGs) types. Pan-cancer vasculogenic score established depiction correlation between phenotypes conducted explore regulatory mechanisms VM. We further systematically examined relationship both immunity microenvironment (TME). addition, cell communication analysis single-cell transcriptome investigate interactions cells TME. Finally, transcriptional response Genomics Drug Sensitivity in database were utilized identify targets drugs. impact immunotherapy also clarified. Results: Our study revealed VRGs dysregulated regulated by multiple mechanisms. Then, level found be heterogeneous among different tumors correlated invasiveness, metastatic potential, malignancy, prognosis. strongly epithelial-mesenchymal transition (EMT). Further cancer-associated fibroblasts can promote EMT formation. Furthermore, immune-suppressive state characterized high levels as an indicator predict effect immunotherapy. seven drugs targeting identified. Conclusion: conclusion, key various types, underscoring pivotal role CAFs immunosuppressive clues for research provides initial overview reference point future VM, opening up new avenues intervention.

Язык: Английский

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Direct antitumor activity of bevacizumab: an overlooked mechanism?

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Апрель 23, 2024

Keywords: vascular endothelial growth factor A, bevacizumab, antiangiogenesis, direct antitumor activity, tumor cells

Язык: Английский

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Enhancing anti-angiogenic immunotherapy for melanoma through injectable metal–organic framework hydrogel co-delivery of combretastatin A4 and poly(I:C)

Nanoscale Advances, Год журнала: 2024, Номер 6(12), С. 3135 - 3145

Опубликована: Янв. 1, 2024

The interplay between vascularization and macrophage-induced immune suppression plays a crucial role in melanoma treatment. In this study, we propose novel combination approach to combat by simultaneously inhibiting tumor enhancing macrophage-mediated anti-tumor responses. We investigate the potential of combining combretastatin A4 (CA4), vascular-disrupting agent, with poly(I:C) (PIC), an immunostimulatory adjuvant. This effectively suppresses cell proliferation, disrupts vascularization, promotes macrophage polarization towards M1 phenotype for suppression. To facilitate efficient co-delivery CA4 PIC enhanced anti-angiogenic immunotherapy, develop injectable metal-organic framework hydrogel using Zeolitic Imidazolate Framework-8 (ZIF-8) hyaluronic acid (HA) (ZIF-8/HA). Our findings demonstrate that ZIF-8 enables loading enhances stability against RNAase degradation

Язык: Английский

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Exosomes containing miR-152-3p targeting FGFR3 mediate SLC7A7-induced angiogenesis in bladder cancer

npj Precision Oncology, Год журнала: 2025, Номер 9(1)

Опубликована: Март 12, 2025

Abstract Bladder cancer (BCa) is a prevalent malignancy with poor prognosis. SLC7A7 has been linked to BCa progression and angiogenesis, but its specific role remains unclear. We established SLC7A7-knockdown cell line investigate effects on angiogenesis. In vivo experiments assessed tumor vascularization, while in vitro studies explored exosome involvement. MiRNA sequencing identified miR-152-3p as key regulator. Further investigation using dual-luciferase reporter assays, qRT-PCR, Western blot revealed that inhibits the expression of FGFR3 by binding 3’ UTR. Meanwhile, functional including angiogenesis Transwell wound healing were performed evaluate confirmed significant progression, specifically promoting through involvement exosomes regulatory axis miR-152-3p/ FGFR3. Targeting might be promising strategy reverse control for an improved

Язык: Английский

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Inflammatory Microenvironment‐Responsive Nanomotors with NIR Photothermal Effect for Deep Inflammation Elimination and Infection Inhibition

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

Abstract The infected chronic wound area has a unique microenvironment featuring hypoxia, excessive reactive oxygen species (ROS), and inflammatory conditions. Bacteria‐formed biofilms limit the anti‐inflammation efficiency of most therapeutics by hindering their penetration into deep tissues increasing drug resistance. unitary modulation pro‐inflammatory M1 macrophage polarization cannot relieve inflammation immediately. Here, “all in one” folic acid‐modified small organic molecule‐based nanoparticles (2TT‐ m C6B@CeO 2 @FA, PCFs) are developed, which possess dual‐targeting to bacteria macrophages, double photothermal therapy (PTT), enzymatic‐like activities. Based on considerable catalase‐ superoxide dismutase‐like activities, PCFs can efficiently scavenge ROS produce (O ). generated O automatically drive movement as nanomotors further promote rescue hypoxia. scavenging promotes macrophages polarized anti‐inflammatory M2 macrophages. study also identifies that FA‐modified target selectively eliminate through PTT, relieves healing. Transcriptome analysis confirms inhibit expression inflammatory‐related genes while cytokines. In vivo experiments identify benefit neovascularization neonatal tissue generation at sites.

Язык: Английский

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An Overview of the Use of Anti-Angiogenic Agents in the Treatment of Thymic Epithelial Tumors

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(23), С. 17065 - 17065

Опубликована: Дек. 2, 2023

Angiogenesis significantly influences the carcinogenesis of thymic epithelial tumors (TET). Both thymomas and carcinoma (TC) overexpress VEGF-A VEGFR-1 -2. This review aims to provide an appraisal use anti-angiogenics in treatment TET. The literature research identified 16 studies that were deemed eligible for further analysis. Seven assessed clinical efficacy sunitinib five apatinib and/or anlotinib. multicenter Japanese phase II REMORA trial investigated lenvatinib, which is a multi-targeted inhibitor VEGFR, FGFR, RET, c-Kit, other kinases. objective response rate was 38% (25.6-52%), highest documented TET progressed after first-line chemotherapy. Anti-angiogenic agents may be useful TET, are not amenable curative treatment. Their toxicity profile seems acceptable. However, angiogenesis inhibitors do appear have major influence on either or TC, although multikinase some effect TC. current evidence suggests most active agent whereas could proposed as acceptable second-line therapy Further concerning combination immune checkpoint with anti-angiogenic drugs warranted.

Язык: Английский

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The MCIB Model: A Novel Theory for Describing the Spatial Heterogeneity of the Tumor Microenvironment

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10486 - 10486

Опубликована: Сен. 29, 2024

The tumor microenvironment (TME) can be regarded as a complex and dynamic microecosystem generated by the interactions of cells, interstitial extracellular matrix, their products plays an important role in occurrence, progression metastasis tumors. In previous study, we constructed IEO model (prI-, prE-, pOst-metastatic niche) according to chronological sequence TME development. this paper, fill theoretical gap spatial heterogeneity TME, defined MCIB (Metabolic, Circulatory, Immune, microBial microenvironment). divides into four subtypes that interact with each other terms mechanism, corresponding major links metabolic reprogramming, vascular remodeling, immune response, microbial action, providing new way assess TME. combination comprehensively depicts spatiotemporal evolution provide basis for clinical targeted therapy, immunotherapy, comprehensive treatment modalities tumors crosstalk different powerful research paradigm drug-resistance mechanisms biological behavior.

Язык: Английский

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