Deciphering the omicron variant: integrated omics analysis reveals critical biomarkers and pathophysiological pathways
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 29, 2024
The
rapid
emergence
and
global
dissemination
of
the
Omicron
variant
SARS-CoV-2
have
posed
formidable
challenges
in
public
health.
This
scenario
underscores
urgent
need
for
an
enhanced
understanding
Omicron's
pathophysiological
mechanisms
to
guide
clinical
management
shape
health
strategies.
Our
study
is
aimed
at
deciphering
intricate
molecular
underlying
infections,
particularly
focusing
on
identification
specific
biomarkers.
Язык: Английский
Morphology and Function of Red Blood Cells in COVID-19 Patients: Current Overview 2023
Life,
Год журнала:
2024,
Номер
14(4), С. 460 - 460
Опубликована: Апрель 1, 2024
In
severe
cases,
SARS-CoV-2
infection
leads
to
respiratory
failure.
Although
angiotensin-converting
enzyme
2
(ACE2)
receptors
are
not
expressed
in
red
blood
cells,
can
interact
with
cells
(RBCs)
via
several
or
auxiliary
membrane
proteins.
Recent
data
show
that
viral
causes
significant
damage
the
RBCs,
altering
their
morphology,
deformability,
and
aggregability.
Loss
of
RBC
deformability
and/or
increased
aggregability
favors
development
thrombotic
processes
microcirculation,
as
has
been
described
occur
COVID-19
patients.
addition,
many
patients
also
develop
systemic
endotheliitis
associated
generalized
coagulopathy.
This
manifests
itself
clinically
obstructive
microthrombi
area
medium
smallest
vessels,
which
affect
all
internal
organs.
It
is
thought
such
changes
RBCs
may
contribute
microangiopathy/microthrombosis
result
impaired
capillary
flow
tissue
oxygenation.
Язык: Английский
Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Immune
thrombocytopenia
(ITP)
is
an
autoimmune
disorder
characterized
by
reduced
platelet
levels
and
heightened
susceptibility
to
bleeding
resulting
from
augmented
autologous
destruction
diminished
thrombopoiesis.
Although
antibody‐mediated
reactions
are
widely
recognized
as
primary
factors,
the
precise
etiological
agents
that
trigger
ITP
remain
unidentified.
The
pathogenesis
of
remains
unclear
owing
absence
comprehensive
high‐throughput
data,
except
for
belated
emergence
autoreactive
antibodies.
In
this
study,
using
flow
cytometry
(FCM),
proteomics,
single‐cell
RNA
sequencing
samples
patients
with
ITP,
it
shown
exosome‐mediated
lectin
complement
pathway
involved
in
which
triggers
enlarges
activation
cascade
without
effective
regulation
because
downregulated
CD55.
activated
system
enhances
immune
response
resistin
further
Macrophage
Migration
Inhibitory
Factor
(MIF)
several
proinflammatory
signaling
pathways,
contribute
survival
hyperactivated
cells
dysfunctional
arachidonic
acid
(AA)
metabolism.
MIF
also
identified
potential
contributors
resistance
glucocorticoid
therapy.
Taken
together,
findings
indicate
system,
resistin,
MIF,
AA
metabolism
may
serve
promising
targets
treatment,
offering
novel
perspectives
on
therapeutic
interventions.
Язык: Английский
The dual role of toll-like receptors in COVID-19: Balancing protective immunity and immunopathogenesis
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
unknown, С. 137836 - 137836
Опубликована: Ноя. 1, 2024
Язык: Английский
Does SARS-CoV-2 infect platelets?
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 23, 2024
Citation:
Subramaniam
S,
Mohiuddin
N
and
Jose
A
(2024)
Does
SARS-CoV-2
infect
platelets?
Front.
Immunol.
15:1392000.
doi:
10.3389/fimmu.2024.1392000
Язык: Английский
1,25‐Dihydroxyvitamin D3 attenuates platelet aggregation potentiated by SARS‐CoV‐2 spike protein via inhibiting integrin αIIbβ3 outside‐in signaling
Cell Biochemistry and Function,
Год журнала:
2024,
Номер
42(4)
Опубликована: Май 15, 2024
Platelet
hyperreactivity
contributes
to
the
pathogenesis
of
COVID-19,
which
is
associated
with
a
hypercoagulability
state
and
thrombosis
disorder.
It
has
been
demonstrated
that
Vitamin
D
deficiency
severity
COVID-19
infection.
supplement
widely
used
as
dietary
due
its
safety
health
benefits.
In
this
study,
we
investigated
direct
effects
underlying
mechanisms
1,25(OH)
Язык: Английский
The influence of Omicron on vaccine efficacy and durability: a neurology perspective
Clinical and Experimental Vaccine Research,
Год журнала:
2024,
Номер
13(3), С. 175 - 175
Опубликована: Янв. 1, 2024
Omicron
variants
present
new
challenges
when
it
comes
to
understanding
their
impact
on
vaccines,
antiviral
strategies,
and
possible
neurological
consequences.
This
article
describes
the
characteristics
of
variant,
its
epidemiology,
efficacy
vaccines
monoclonal
antibodies,
association
with
lymphoid
depletion.
We
also
explore
implications
Omicron,
focusing
encephalopathy
encephalitis.
There
are
unique
associated
which
is
characterized
by
distinct
mutations
increased
transmissibility.
For
a
better
effects
this
disease
developing
strategies
combat
spread,
especially
concerning
complications,
ongoing
research
necessary.
Язык: Английский