The influence of Omicron on vaccine efficacy and durability: a neurology perspective DOI Creative Commons
Jethendra Kumar Muruganantham, Ramakrishnan Veerabathiran

Clinical and Experimental Vaccine Research, Journal Year: 2024, Volume and Issue: 13(3), P. 175 - 175

Published: Jan. 1, 2024

Omicron variants present new challenges when it comes to understanding their impact on vaccines, antiviral strategies, and possible neurological consequences. This article describes the characteristics of variant, its epidemiology, efficacy vaccines monoclonal antibodies, association with lymphoid depletion. We also explore implications Omicron, focusing encephalopathy encephalitis. There are unique associated which is characterized by distinct mutations increased transmissibility. For a better effects this disease developing strategies combat spread, especially concerning complications, ongoing research necessary.

Language: Английский

Deciphering the omicron variant: integrated omics analysis reveals critical biomarkers and pathophysiological pathways DOI Creative Commons

Qianyue Yang,

Zhiwei Lin, Mingshan Xue

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 29, 2024

The rapid emergence and global dissemination of the Omicron variant SARS-CoV-2 have posed formidable challenges in public health. This scenario underscores urgent need for an enhanced understanding Omicron's pathophysiological mechanisms to guide clinical management shape health strategies. Our study is aimed at deciphering intricate molecular underlying infections, particularly focusing on identification specific biomarkers.

Language: Английский

Citations

5
Morphology and Function of Red Blood Cells in COVID-19 Patients: Current Overview 2023 DOI Creative Commons
F. Jung, Philippe Connes

Life, Journal Year: 2024, Volume and Issue: 14(4), P. 460 - 460

Published: April 1, 2024

In severe cases, SARS-CoV-2 infection leads to respiratory failure. Although angiotensin-converting enzyme 2 (ACE2) receptors are not expressed in red blood cells, can interact with cells (RBCs) via several or auxiliary membrane proteins. Recent data show that viral causes significant damage the RBCs, altering their morphology, deformability, and aggregability. Loss of RBC deformability and/or increased aggregability favors development thrombotic processes microcirculation, as has been described occur COVID-19 patients. addition, many patients also develop systemic endotheliitis associated generalized coagulopathy. This manifests itself clinically obstructive microthrombi area medium smallest vessels, which affect all internal organs. It is thought such changes RBCs may contribute microangiopathy/microthrombosis result impaired capillary flow tissue oxygenation.

Language: Английский

Citations

4
Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia DOI Creative Commons

Jin Li,

Xiaoqian Wang,

Yaoyao Chen

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by reduced platelet levels and heightened susceptibility to bleeding resulting from augmented autologous destruction diminished thrombopoiesis. Although antibody‐mediated reactions are widely recognized as primary factors, the precise etiological agents that trigger ITP remain unidentified. The pathogenesis of remains unclear owing absence comprehensive high‐throughput data, except for belated emergence autoreactive antibodies. In this study, using flow cytometry (FCM), proteomics, single‐cell RNA sequencing samples patients with ITP, it shown exosome‐mediated lectin complement pathway involved in which triggers enlarges activation cascade without effective regulation because downregulated CD55. activated system enhances immune response resistin further Macrophage Migration Inhibitory Factor (MIF) several proinflammatory signaling pathways, contribute survival hyperactivated cells dysfunctional arachidonic acid (AA) metabolism. MIF also identified potential contributors resistance glucocorticoid therapy. Taken together, findings indicate system, resistin, MIF, AA metabolism may serve promising targets treatment, offering novel perspectives on therapeutic interventions.

Language: Английский

Citations

0
The dual role of toll-like receptors in COVID-19: Balancing protective immunity and immunopathogenesis DOI
Payam Behzadi, Deepak Chandran, Chiranjib Chakraborty

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137836 - 137836

Published: Nov. 1, 2024

Language: Английский

Citations

3
Does SARS-CoV-2 infect platelets? DOI Creative Commons
Saravanan Subramaniam,

Naila Mohiuddin,

Asha Jose

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 23, 2024

Citation: Subramaniam S, Mohiuddin N and Jose A (2024) Does SARS-CoV-2 infect platelets? Front. Immunol. 15:1392000. doi: 10.3389/fimmu.2024.1392000

Language: Английский

Citations

1
1,25‐Dihydroxyvitamin D3 attenuates platelet aggregation potentiated by SARS‐CoV‐2 spike protein via inhibiting integrin αIIbβ3 outside‐in signaling DOI
Ruijie Wang, Zezhong Tian, Caixia Wang

et al.

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(4)

Published: May 15, 2024

Platelet hyperreactivity contributes to the pathogenesis of COVID-19, which is associated with a hypercoagulability state and thrombosis disorder. It has been demonstrated that Vitamin D deficiency severity COVID-19 infection. supplement widely used as dietary due its safety health benefits. In this study, we investigated direct effects underlying mechanisms 1,25(OH)

Language: Английский

Citations

0
The influence of Omicron on vaccine efficacy and durability: a neurology perspective DOI Creative Commons
Jethendra Kumar Muruganantham, Ramakrishnan Veerabathiran

Clinical and Experimental Vaccine Research, Journal Year: 2024, Volume and Issue: 13(3), P. 175 - 175

Published: Jan. 1, 2024

Omicron variants present new challenges when it comes to understanding their impact on vaccines, antiviral strategies, and possible neurological consequences. This article describes the characteristics of variant, its epidemiology, efficacy vaccines monoclonal antibodies, association with lymphoid depletion. We also explore implications Omicron, focusing encephalopathy encephalitis. There are unique associated which is characterized by distinct mutations increased transmissibility. For a better effects this disease developing strategies combat spread, especially concerning complications, ongoing research necessary.

Language: Английский

Citations

0