Targeting sepsis through inflammation and oxidative metabolism DOI
Shery Jacob, Shery Jacob, Joby Thoppil

и другие.

World Journal of Critical Care Medicine, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 11, 2024

Infection is a public health problem and represents spectrum of disease that can result in sepsis septic shock. Sepsis characterized by dysregulated immune response to infection. Septic shock the most severe form which leads distributive high mortality rates. There have been significant advances management mainly focusing on early identification therapy. However, complicating matters lack reliable diagnostic tools poor specificity sensitivity existing scoring i.e., systemic inflammatory syndrome criteria, sequential organ failure assessment (SOFA), or quick SOFA. These limitations underscored modest progress reducing sepsis-related mortality. This review will focus novel therapeutics such as oxidative stress targets, cytokine modulation, endothelial cell etc., are being conceptualized for

Язык: Английский

Linking norepinephrine production and performance to diet-induced low-grade, chronic inflammation in the intestine of broilers DOI Creative Commons
Michael H. Kogut,

J. Allen Byrd,

Kenneth J. Genovese

и другие.

Poultry Science, Год журнала: 2024, Номер 103(10), С. 104061 - 104061

Опубликована: Июль 18, 2024

Maintenance of intestinal health is critical to successful poultry production and one the goals industry. For decades industry has relied upon inclusion antibiotic growth promoters (AGP) achieve this goal improve performance. With removal AGPs, emergence chronic, low-level gut inflammation come forefront concern in with diet being primary source inflammatory triggers. We have developed a dietary model low-grade, chronic broilers that employs feeding high nonstarch polysaccharides (NSP) composed 30% rice bran study effects on bird performance physiology. present studies, we hypothesize low-grade causes neurons enteric nervous system secrete neurochemicals activate immune cells drive negatively affect To test our hypothesis, 1-day-old broiler chickens were weighed divided into 2 regimes: control corn-soybean group fed NSP (30% bran). At 7-, 14-, 21-, 28-d posthatch (PH), birds weighed, fecal material collected, 5 sacrificed sections duodenal cecal tissues excised, contents collected for ultra-high liquid chromatography analyses (UHPLC). UHPLC revealed 1000s-fold increase concentration norepinephrine (NOR) compared birds. Further, concentrations NOR also found be significantly elevated throughout all time points. There no differences weight gain nor feed conversion from 1 14 d PH, but had reduced 28 PH. The results dietary-induced response increased which affected This suggests neuroimmune pathways may serve as mechanistic target development new interventions decrease incidence thereby benefit

Язык: Английский

Процитировано

1

Management of Sepsis in the First 24 Hours: Bundles of Care and Individualized Approach DOI
Irene Coloretti, M. Tosi, Emanuela Biagioni

и другие.

Seminars in Respiratory and Critical Care Medicine, Год журнала: 2024, Номер 45(04), С. 503 - 509

Опубликована: Авг. 1, 2024

Early diagnosis and prompt management are essential to enhance the outcomes of patients with sepsis septic shock. Over past two decades, evidence-based guidelines have guided appropriate treatment recommended implementation a bundle strategy deliver fundamental treatments within initial hours care. Shortly after its introduction, has led substantial decrease in mortality rates across various health care settings. The primary advantage these bundles is their universality, making them applicable all sepsis. However, this same quality also represents disadvantage as it fails account for significant heterogeneity patient population. Recently, individualization included been suggested potential further improving prognosis New strategies early identification microorganisms resistance patterns, advanced knowledge antibiotic kinetics critically ill patients, more conservative fluid therapy specific populations, use alternative vasopressors catecholamines, well tailored source control based on conditions site infection, approaches personalize subgroups patients. These innovative methodologies improve clinical practice should be by solid evidence. Therefore, imperative that future research evaluate safety, efficacy, cost-effectiveness strategies.

Язык: Английский

Процитировано

1

Elevated serum albumin-to-creatinine ratio as a protective factor on clinical outcomes among critically ill patients with sepsis: a retrospective study DOI Creative Commons

Zhenkui Hu,

Chao Song, Jinhui Zhang

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Сен. 19, 2024

Background The aim of this study was to examine the prognostic significance serum albumin-to-creatinine ratio (ACR) in critically ill patients with sepsis. Methods This retrospective analyzed sepsis cases admitted Affiliated Hospital Jiangsu University between January 2015 and November 2023. were divided into four groups based on their ACR upon admission intensive care unit (ICU). Laboratory data collected at time ICU admission, primary outcome measure in-hospital all-cause mortality. Kaplan–Meier survival curves generated illustrate differences 30−/60-day mortality among various groups. Multivariate Cox regression models restricted cubic splines (RCS) utilized explore association patients. Subgroup analyses conducted impact other covariates relationship Results A total 1,123 eligible included study, a median 0.169. rate 33.7%, 31.9%, 30-day 28.1%. analysis demonstrated that higher had significantly lower risk (log-rank p < 0.001). Multivariable proportional hazards revealed an independent predictor death (HR: 0.454, 95% CI 0.271–0.761, = 0.003), 0.498, 0.293–0.847, 0.010), 0.399, 0.218–0.730, 0.003). For each 1-unit increase ACR, there 1.203-fold decrease during hospital stay. RCS curve illustrated non-linear negative correlation (p for =0.018), ( =0.005), =0.006). Sensitivity indicated consistent effect sizes directions different subgroups, confirming stability results. Conclusion Low levels identified as factors associated increased in-hospital, ICU, can serve significant clinical

Язык: Английский

Процитировано

1

Metabolic biomarkers of neonatal sepsis: identification using metabolomics combined with machine learning DOI Creative Commons

Zhi Bian,

X. Q. Zha,

Yanru Chen

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Окт. 21, 2024

Background Sepsis is a common disease associated with neonatal and infant mortality, for diagnosis, blood culture currently the gold standard method, but it has low positivity rate requires more than 2 days to develop. Meanwhile, unfortunately, specific biomarkers early timely diagnosis of sepsis in infants determination severity this are lacking clinical practice. Methods Samples from 18 comorbidities, 25 without noninfectious diseases were evaluated using serum metabolomics approach based on liquid chromatography‒mass spectrometry (LC‒MS) technology. Differentially abundant metabolites screened via multivariate statistical analysis. In addition, least absolute shrinkage selection operator (LASSO) support vector machine recursive feature elimination (SVM-RFE) analyses conducted identify key infections. The random forest algorithm was applied determine differentially between comorbidities. Receiver operating characteristic (ROC) curves generated biomarker value testing. Finally, metabolic pathway analysis explore signaling pathways identified metabolites. Results A total 189 exhibited significant differences infectious infants, while 137 distinct septic After screening LASSO SVM-RFE analyses, hexylamine, psychosine sulfate, LysoPC (18:1 (9Z)/0:0), 2,4,6-tribromophenol, 25-cinnamoyl-vulgaroside retained sepsis. ROC curve revealed that area under (AUC) 0.9200 0.9749 0.9684 0.7405 0.8893 25-cinnamoyl-vulgaroside, 1.000 combination all When comorbidities compared those four endogenous greatest importance algorithm, namely, 12-oxo-20-trihydroxy-leukotriene B4, dihydrovaltrate, PA (8:0/12:0), 2-heptanethiol. these AUC 1 Pathway indicated phenylalanine, tyrosine, tryptophan biosynthesis, phenylalanine metabolism, porphyrin metabolism play important roles Conclusion Serum metabolite profiles identified, learning diseases. findings obtained expected facilitate disease.

Язык: Английский

Процитировано

1

Therapeutically Fine-Tuning Autonomic Nervous System to Treat Sepsis: A New Perspective on the Immunomodulatory Effects of Acupuncture DOI Creative Commons
Ziyi Zhang,

Dingdan Zhang,

Qing Lin

и другие.

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 4373 - 4387

Опубликована: Июль 1, 2024

Abstract: Recent studies have highlighted the immunomodulatory effects of acupuncture on sepsis and proposed novel non-pharmacological or bioelectronic approaches to managing inflammatory illnesses. Establishing rules for selectively activating sympathetic vagal nerve-mediated anti-inflammatory pathways using has valuable clinical applications. Over years, revealed segmental modulatory role in regulating visceral function by targeting autonomic nervous system (ANS). In this review, we aim summarize recent findings treating sepsis, focusing underlying ANS mechanism, as well acupoint specificity, intensity, frequency, other parameters utilized these studies. Mechanistically, properties been highlighted. Furthermore, explore immunotherapeutic benefits sepsis. A better understanding immunoregulatory mechanism may offer development therapeutics treat prevent a variety diseases. Keywords: inflammation, peripheral nerve stimulation, system, sympathoadrenal axis, macrophage, medicine

Язык: Английский

Процитировано

0

Immune system and its neurophysiology DOI
Aditi Banerjee

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 295 - 319

Опубликована: Окт. 1, 2024

Процитировано

0

Comparative metabolomic analysis reveals shared and unique features of COVID-19 cytokine storm and surgical sepsis DOI Creative Commons

Irina Russkih,

О. С. Попов, Tatiana G. Klochkova

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract The clinical manifestations of the cytokine storm (CS) associated with COVID-19 resemble acute phase sepsis. Metabolomics may contribute to understanding specific pathobiology these two syndromes. aim this study was compare serum metabolomic profiles in CS vs. septic surgery patients. In retrospective cross-sectional samples from patients COVID-19, and without comorbidity as well surgical sepsis were investigated. A targeted analysis carried out all using LC-MS/MS method. Analysis revealed that similar alterations metabolome amino acid metabolism, nitrogen inflammatory status, methionine cycle glycolysis. most significant difference identified for levels metabolites kynurenine synthesis, tricarboxylic cycle, gamma-aminobutyric niacinamide. metabolic pathway cysteine metabolism disturbed significantly For first time, similarities differences between investigated northwest Russian Federation.

Язык: Английский

Процитировано

0

Lipopolysaccharide Effects on Neurotransmission: Understanding Implications for Depression DOI Creative Commons
Lauren Batey,

Beatrice Baumberger,

Habibeh Khoshbouei

и другие.

ACS Chemical Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 27, 2024

Immune activation in the body is well studied; however, much less known about how peripheral inflammation changes brain chemistry. Because depression and are close comorbidities, investigating affects brain's chemicals will help us to better understand depression. The levels of monoamines dopamine, serotonin norepinephrine thought be affected by both In this Perspective, we review studies that find chemical after administration endotoxin LPS, which a robust method induce rapid inflammation. From these studies, interpreted LPS reduce dopamine increase various regions brain. These not sign "dysfunction" but serve an important evolutionary purpose encourages recover from immune insult altering mood.

Язык: Английский

Процитировано

0

Targeting sepsis through inflammation and oxidative metabolism DOI
Shery Jacob, Shery Jacob, Joby Thoppil

и другие.

World Journal of Critical Care Medicine, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 11, 2024

Infection is a public health problem and represents spectrum of disease that can result in sepsis septic shock. Sepsis characterized by dysregulated immune response to infection. Septic shock the most severe form which leads distributive high mortality rates. There have been significant advances management mainly focusing on early identification therapy. However, complicating matters lack reliable diagnostic tools poor specificity sensitivity existing scoring i.e., systemic inflammatory syndrome criteria, sequential organ failure assessment (SOFA), or quick SOFA. These limitations underscored modest progress reducing sepsis-related mortality. This review will focus novel therapeutics such as oxidative stress targets, cytokine modulation, endothelial cell etc., are being conceptualized for

Язык: Английский

Процитировано

0