World Journal of Critical Care Medicine,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 11, 2024
Infection
is
a
public
health
problem
and
represents
spectrum
of
disease
that
can
result
in
sepsis
septic
shock.
Sepsis
characterized
by
dysregulated
immune
response
to
infection.
Septic
shock
the
most
severe
form
which
leads
distributive
high
mortality
rates.
There
have
been
significant
advances
management
mainly
focusing
on
early
identification
therapy.
However,
complicating
matters
lack
reliable
diagnostic
tools
poor
specificity
sensitivity
existing
scoring
i.e.,
systemic
inflammatory
syndrome
criteria,
sequential
organ
failure
assessment
(SOFA),
or
quick
SOFA.
These
limitations
underscored
modest
progress
reducing
sepsis-related
mortality.
This
review
will
focus
novel
therapeutics
such
as
oxidative
stress
targets,
cytokine
modulation,
endothelial
cell
etc.,
are
being
conceptualized
for
Poultry Science,
Год журнала:
2024,
Номер
103(10), С. 104061 - 104061
Опубликована: Июль 18, 2024
Maintenance
of
intestinal
health
is
critical
to
successful
poultry
production
and
one
the
goals
industry.
For
decades
industry
has
relied
upon
inclusion
antibiotic
growth
promoters
(AGP)
achieve
this
goal
improve
performance.
With
removal
AGPs,
emergence
chronic,
low-level
gut
inflammation
come
forefront
concern
in
with
diet
being
primary
source
inflammatory
triggers.
We
have
developed
a
dietary
model
low-grade,
chronic
broilers
that
employs
feeding
high
nonstarch
polysaccharides
(NSP)
composed
30%
rice
bran
study
effects
on
bird
performance
physiology.
present
studies,
we
hypothesize
low-grade
causes
neurons
enteric
nervous
system
secrete
neurochemicals
activate
immune
cells
drive
negatively
affect
To
test
our
hypothesis,
1-day-old
broiler
chickens
were
weighed
divided
into
2
regimes:
control
corn-soybean
group
fed
NSP
(30%
bran).
At
7-,
14-,
21-,
28-d
posthatch
(PH),
birds
weighed,
fecal
material
collected,
5
sacrificed
sections
duodenal
cecal
tissues
excised,
contents
collected
for
ultra-high
liquid
chromatography
analyses
(UHPLC).
UHPLC
revealed
1000s-fold
increase
concentration
norepinephrine
(NOR)
compared
birds.
Further,
concentrations
NOR
also
found
be
significantly
elevated
throughout
all
time
points.
There
no
differences
weight
gain
nor
feed
conversion
from
1
14
d
PH,
but
had
reduced
28
PH.
The
results
dietary-induced
response
increased
which
affected
This
suggests
neuroimmune
pathways
may
serve
as
mechanistic
target
development
new
interventions
decrease
incidence
thereby
benefit
Seminars in Respiratory and Critical Care Medicine,
Год журнала:
2024,
Номер
45(04), С. 503 - 509
Опубликована: Авг. 1, 2024
Early
diagnosis
and
prompt
management
are
essential
to
enhance
the
outcomes
of
patients
with
sepsis
septic
shock.
Over
past
two
decades,
evidence-based
guidelines
have
guided
appropriate
treatment
recommended
implementation
a
bundle
strategy
deliver
fundamental
treatments
within
initial
hours
care.
Shortly
after
its
introduction,
has
led
substantial
decrease
in
mortality
rates
across
various
health
care
settings.
The
primary
advantage
these
bundles
is
their
universality,
making
them
applicable
all
sepsis.
However,
this
same
quality
also
represents
disadvantage
as
it
fails
account
for
significant
heterogeneity
patient
population.
Recently,
individualization
included
been
suggested
potential
further
improving
prognosis
New
strategies
early
identification
microorganisms
resistance
patterns,
advanced
knowledge
antibiotic
kinetics
critically
ill
patients,
more
conservative
fluid
therapy
specific
populations,
use
alternative
vasopressors
catecholamines,
well
tailored
source
control
based
on
conditions
site
infection,
approaches
personalize
subgroups
patients.
These
innovative
methodologies
improve
clinical
practice
should
be
by
solid
evidence.
Therefore,
imperative
that
future
research
evaluate
safety,
efficacy,
cost-effectiveness
strategies.
Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Сен. 19, 2024
Background
The
aim
of
this
study
was
to
examine
the
prognostic
significance
serum
albumin-to-creatinine
ratio
(ACR)
in
critically
ill
patients
with
sepsis.
Methods
This
retrospective
analyzed
sepsis
cases
admitted
Affiliated
Hospital
Jiangsu
University
between
January
2015
and
November
2023.
were
divided
into
four
groups
based
on
their
ACR
upon
admission
intensive
care
unit
(ICU).
Laboratory
data
collected
at
time
ICU
admission,
primary
outcome
measure
in-hospital
all-cause
mortality.
Kaplan–Meier
survival
curves
generated
illustrate
differences
30−/60-day
mortality
among
various
groups.
Multivariate
Cox
regression
models
restricted
cubic
splines
(RCS)
utilized
explore
association
patients.
Subgroup
analyses
conducted
impact
other
covariates
relationship
Results
A
total
1,123
eligible
included
study,
a
median
0.169.
rate
33.7%,
31.9%,
30-day
28.1%.
analysis
demonstrated
that
higher
had
significantly
lower
risk
(log-rank
p
<
0.001).
Multivariable
proportional
hazards
revealed
an
independent
predictor
death
(HR:
0.454,
95%
CI
0.271–0.761,
=
0.003),
0.498,
0.293–0.847,
0.010),
0.399,
0.218–0.730,
0.003).
For
each
1-unit
increase
ACR,
there
1.203-fold
decrease
during
hospital
stay.
RCS
curve
illustrated
non-linear
negative
correlation
(p
for
=0.018),
(
=0.005),
=0.006).
Sensitivity
indicated
consistent
effect
sizes
directions
different
subgroups,
confirming
stability
results.
Conclusion
Low
levels
identified
as
factors
associated
increased
in-hospital,
ICU,
can
serve
significant
clinical
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Окт. 21, 2024
Background
Sepsis
is
a
common
disease
associated
with
neonatal
and
infant
mortality,
for
diagnosis,
blood
culture
currently
the
gold
standard
method,
but
it
has
low
positivity
rate
requires
more
than
2
days
to
develop.
Meanwhile,
unfortunately,
specific
biomarkers
early
timely
diagnosis
of
sepsis
in
infants
determination
severity
this
are
lacking
clinical
practice.
Methods
Samples
from
18
comorbidities,
25
without
noninfectious
diseases
were
evaluated
using
serum
metabolomics
approach
based
on
liquid
chromatography‒mass
spectrometry
(LC‒MS)
technology.
Differentially
abundant
metabolites
screened
via
multivariate
statistical
analysis.
In
addition,
least
absolute
shrinkage
selection
operator
(LASSO)
support
vector
machine
recursive
feature
elimination
(SVM-RFE)
analyses
conducted
identify
key
infections.
The
random
forest
algorithm
was
applied
determine
differentially
between
comorbidities.
Receiver
operating
characteristic
(ROC)
curves
generated
biomarker
value
testing.
Finally,
metabolic
pathway
analysis
explore
signaling
pathways
identified
metabolites.
Results
A
total
189
exhibited
significant
differences
infectious
infants,
while
137
distinct
septic
After
screening
LASSO
SVM-RFE
analyses,
hexylamine,
psychosine
sulfate,
LysoPC
(18:1
(9Z)/0:0),
2,4,6-tribromophenol,
25-cinnamoyl-vulgaroside
retained
sepsis.
ROC
curve
revealed
that
area
under
(AUC)
0.9200
0.9749
0.9684
0.7405
0.8893
25-cinnamoyl-vulgaroside,
1.000
combination
all
When
comorbidities
compared
those
four
endogenous
greatest
importance
algorithm,
namely,
12-oxo-20-trihydroxy-leukotriene
B4,
dihydrovaltrate,
PA
(8:0/12:0),
2-heptanethiol.
these
AUC
1
Pathway
indicated
phenylalanine,
tyrosine,
tryptophan
biosynthesis,
phenylalanine
metabolism,
porphyrin
metabolism
play
important
roles
Conclusion
Serum
metabolite
profiles
identified,
learning
diseases.
findings
obtained
expected
facilitate
disease.
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 4373 - 4387
Опубликована: Июль 1, 2024
Abstract:
Recent
studies
have
highlighted
the
immunomodulatory
effects
of
acupuncture
on
sepsis
and
proposed
novel
non-pharmacological
or
bioelectronic
approaches
to
managing
inflammatory
illnesses.
Establishing
rules
for
selectively
activating
sympathetic
vagal
nerve-mediated
anti-inflammatory
pathways
using
has
valuable
clinical
applications.
Over
years,
revealed
segmental
modulatory
role
in
regulating
visceral
function
by
targeting
autonomic
nervous
system
(ANS).
In
this
review,
we
aim
summarize
recent
findings
treating
sepsis,
focusing
underlying
ANS
mechanism,
as
well
acupoint
specificity,
intensity,
frequency,
other
parameters
utilized
these
studies.
Mechanistically,
properties
been
highlighted.
Furthermore,
explore
immunotherapeutic
benefits
sepsis.
A
better
understanding
immunoregulatory
mechanism
may
offer
development
therapeutics
treat
prevent
a
variety
diseases.
Keywords:
inflammation,
peripheral
nerve
stimulation,
system,
sympathoadrenal
axis,
macrophage,
medicine
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 6, 2024
Abstract
The
clinical
manifestations
of
the
cytokine
storm
(CS)
associated
with
COVID-19
resemble
acute
phase
sepsis.
Metabolomics
may
contribute
to
understanding
specific
pathobiology
these
two
syndromes.
aim
this
study
was
compare
serum
metabolomic
profiles
in
CS
vs.
septic
surgery
patients.
In
retrospective
cross-sectional
samples
from
patients
COVID-19,
and
without
comorbidity
as
well
surgical
sepsis
were
investigated.
A
targeted
analysis
carried
out
all
using
LC-MS/MS
method.
Analysis
revealed
that
similar
alterations
metabolome
amino
acid
metabolism,
nitrogen
inflammatory
status,
methionine
cycle
glycolysis.
most
significant
difference
identified
for
levels
metabolites
kynurenine
synthesis,
tricarboxylic
cycle,
gamma-aminobutyric
niacinamide.
metabolic
pathway
cysteine
metabolism
disturbed
significantly
For
first
time,
similarities
differences
between
investigated
northwest
Russian
Federation.
ACS Chemical Neuroscience,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
Immune
activation
in
the
body
is
well
studied;
however,
much
less
known
about
how
peripheral
inflammation
changes
brain
chemistry.
Because
depression
and
are
close
comorbidities,
investigating
affects
brain's
chemicals
will
help
us
to
better
understand
depression.
The
levels
of
monoamines
dopamine,
serotonin
norepinephrine
thought
be
affected
by
both
In
this
Perspective,
we
review
studies
that
find
chemical
after
administration
endotoxin
LPS,
which
a
robust
method
induce
rapid
inflammation.
From
these
studies,
interpreted
LPS
reduce
dopamine
increase
various
regions
brain.
These
not
sign
"dysfunction"
but
serve
an
important
evolutionary
purpose
encourages
recover
from
immune
insult
altering
mood.
World Journal of Critical Care Medicine,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 11, 2024
Infection
is
a
public
health
problem
and
represents
spectrum
of
disease
that
can
result
in
sepsis
septic
shock.
Sepsis
characterized
by
dysregulated
immune
response
to
infection.
Septic
shock
the
most
severe
form
which
leads
distributive
high
mortality
rates.
There
have
been
significant
advances
management
mainly
focusing
on
early
identification
therapy.
However,
complicating
matters
lack
reliable
diagnostic
tools
poor
specificity
sensitivity
existing
scoring
i.e.,
systemic
inflammatory
syndrome
criteria,
sequential
organ
failure
assessment
(SOFA),
or
quick
SOFA.
These
limitations
underscored
modest
progress
reducing
sepsis-related
mortality.
This
review
will
focus
novel
therapeutics
such
as
oxidative
stress
targets,
cytokine
modulation,
endothelial
cell
etc.,
are
being
conceptualized
for
