LWT, Год журнала: 2024, Номер unknown, С. 116784 - 116784
Опубликована: Сен. 1, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Окт. 9, 2024
Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other metabolic pathways, impacts the phenotypes functions of immune cells. The regulation system is important in pathogenesis progression numerous diseases, such as cancers, autoimmune diseases diseases. concept immunometabolism was introduced over a decade ago to elucidate intricate interplay between metabolism immunity. definition has expanded from chronic low-grade inflammation reprogramming cells various With being proposed developed, can be gradually summarized becomes more clearer. In context many cancer, disease, occurs inducing proinflammatory or anti-inflammatory effects. phenotypic functional changes caused by further affect development Based on experimental results, targeting cellular promising therapy. this review, we focus introduce their pathways reprogramming, summarize how these effects We thoroughly explore targets treatments based existing studies. challenges translating results into clinical applications field are also summarized. believe that better understanding health will improve management most
Язык: Английский
Процитировано
40
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Окт. 28, 2024
Ulcerative colitis (UC) is a debilitating inflammatory bowel disease characterized by intestinal inflammation, barrier dysfunction, and dysbiosis, with limited treatment options available. This study systematically investigates the therapeutic potential of synbiotic composed galactooligosaccharides (GOS) Limosilactobacillus reuteri in murine model colitis, revealing that GOS L. synergistically protect against inflammation dysfunction promoting synthesis pentadecanoic acid, an odd-chain fatty from Bacteroides acidifaciens. Notably, synbiotic, B. acidifaciens, acid are each capable suppressing enhancing tight junction inhibiting NF-κB activation. Furthermore, similar reduction acidifaciens levels also observed feces both human UC patients lipopolysaccharide-induced pigs. Our findings elucidate protective mechanism highlight its potential, along for other disorders. Here, Yujun Wu colleagues report alleviates gut animals enriching showing treating ulcerative colitis.
Язык: Английский
Процитировано
21
Deleted Journal, Год журнала: 2025, Номер 2(1)
Опубликована: Фев. 25, 2025
Язык: Английский
Процитировано
4
Current Opinion in Clinical Nutrition & Metabolic Care, Год журнала: 2025, Номер unknown
Опубликована: Янв. 14, 2025
Purpose of review This aims to examine recent research on the role specialized pro-resolving mediators (SPMs) in regulation gut immunophysiology. Recent findings Inflammatory bowel disease (IBD) is characterized by chronic inflammation gastrointestinal tract, driven disruptions intestinal barrier and an imbalance between host immune system microbiota. Dietary polyunsaturated fatty acids (PUFAs), especially ω-3 ω-6, are key regulators responses help maintain integrity barrier. These PUFAs serve as precursors SPMs, lipid that play a critical resolving inflammation. SPMs actively reprogram cells, promoting clearance cellular debris, reducing cytokine production, restoring tissue homeostasis without suppressing response. Emerging evidence indicates gut, strengthen function, modulate colitis colon cancer, influence microbiota composition. Summary The strongly supports central maintaining health organ function following inflammatory challenges. highlights potential therapeutic approaches target these pathways for both prevention treatment gut-related conditions.
Язык: Английский
Процитировано
2
Poultry Science, Год журнала: 2025, Номер 104(2), С. 104773 - 104773
Опубликована: Янв. 4, 2025
Salmonella enterica serovar Enteritidis (S. Enteritidis) is a common zoonotic pathogen that not only causes gastroenteritis or death of livestock and poultry but also poses serious threat to human health, causing severe economic losses the industry society. Herein, RNA-sequencing (RNA-seq) was used analyze transcriptome variation chicken cecum at four different time points (1, 3, 7, 14 days) following S. infection. There were 529, 1477, 476, 432 differentially expressed genes (DEGs) in days post-infection (dpi), respectively. The DEGs significantly enriched various immune-related pathways on 3 dpi 7 dpi, such as cytokine-cytokine-receptor interaction Toll-like receptor signaling pathway. several metabolic dpi. Gene ontology (GO) enrichment showed up-regulated terms On mainly signaling-related terms, while down-regulated primarily metabolic-related terms. Based weighted gene co-expression network analysis (WGCNA), key modules related energy, non-coding processes, immunity, development-related functions identified 1, respectively, 5, 8, 6, 5 hub screened out, This study demonstrated cecal regulation responding infection time-dependent. chickens coordinated by multiple systems, involving metabolism, signal transduction. Both are for immune response. As progresses, metabolism-related increasingly identified. change reflects dynamic adjustment between response metabolism Jining Bairi These results suggested starting from gradually transition an triggered state where they adapt modulating their metabolism.
Язык: Английский
Процитировано
1
Nutrition Journal, Год журнала: 2025, Номер 24(1)
Опубликована: Янв. 23, 2025
Ulcerative colitis (UC) has experienced a steady increase in global incidence and prevalence recently. Current research into UC pathogenesis focuses on the complex interplay of genetic environmental factors with immune system gut microbiome, leading to disruption intestinal barrier. Normally, epithelium, interact maintain homeostasis. However, when this equilibrium is disturbed, harmful cycle dysbiosis, dysregulation, inflammation emerges, resulting barrier dysfunction progression. Among various risk factors, diet significantly influences epithelial integrity architectural stability through both direct indirect mechanisms, shaping entire continuum from pre-clinical prevention active phase treatment remission maintenance. This review provides insights impact dietary content eating behaviors UC, focusing specific food, food groups, nutrients, intermittent fasting, while providing detailed explanation why microbiota may mediate sustained effects across all stages UC. Additionally, it addresses limitations current studies, explores underexamined areas proposes potential directions for future expansion. Not applicable.
Язык: Английский
Процитировано
1
Current Nutrition Reports, Год журнала: 2025, Номер 14(1)
Опубликована: Янв. 31, 2025
Язык: Английский
Процитировано
1
The journal of nutrition health & aging, Год журнала: 2025, Номер 29(4), С. 100505 - 100505
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
1
Renal Failure, Год журнала: 2024, Номер 46(1)
Опубликована: Апрель 17, 2024
The mechanisms underlying the complex correlation between immunoglobulin A nephropathy (IgAN) and inflammatory bowel disease (IBD) remain unclear. This study aimed to identify optimal cross-talk genes, potential pathways, mutual immune-infiltrating microenvironments IBD IgAN elucidate linkage patients with IgAN. datasets were obtained from Gene Expression Omnibus (GEO). Three algorithms, CIBERSORTx, ssGSEA, xCell, used evaluate similarities in infiltrating microenvironment two diseases. Weighted gene co-expression network analysis (WGCNA) was implemented dataset major immune infiltration modules, Boruta algorithm, RFE LASSO regression applied filter genes. Next, multiple machine learning models confirm Finally, relevant findings validated using histology immunohistochemistry of mice. Immune showed no significant differences samples most cells. three algorithms identified 10 diagnostic MAPK3, NFKB1, FDX1, EPHX2, SYNPO, KDF1, METTL7A, RIDA, HSDL2, RIPK2; FDX1 NFKB1 enhanced kidney Kyoto Encyclopedia Genes Genomes 15 pathways diseases, lipid metabolism playing a vital role cross-talk. Our offer insights into shared IBD. These common cell-mediated abnormal immunity may inform further experimental studies.
Язык: Английский
Процитировано
5
Nutrients, Год журнала: 2024, Номер 16(17), С. 3031 - 3031
Опубликована: Сен. 8, 2024
Background/Objectives: Dietary fats have been linked to the increasing incidence of chronic diseases, including inflammatory bowel diseases (IBD), namely, Crohn’s disease (CD). Methods: This study investigated impact pentadecanoic acid (C15:0), a type an odd-numbered chain saturated fatty acid, for its potential anti-inflammatory properties in different mouse models experimental IBD using SAMP1/YitFc (SAMP) line (14- or 24-week-old), ileitis and DSS-induced colitis. To quantitively assess effect C:15, we tested two dosages C:15 selected experiments comparison control mice. Intestinal inflammation intestinal permeability were used as primary outcomes. Results: In ileitis, supplementation showed SAMP mice (e.g., reduction severity vs. p < 0.0043), which was reproducible when DSS model colitis reduced 0.0006). Of relevance, even short-term therapy prevented by maintaining body weight, decreasing inflammation, preserving gut integrity, alleviating signs. Conclusions: Collectively, findings from both indicate that may therapeutic effects treatment (colitis short term). promising has major translational alleviation humans.
Язык: Английский
Процитировано
4