Diet
habit
plays
a
vital
role
in
fecal
incontinence
(FI)
progression.
However,
it
remains
unknown
whether
dietary
quality
is
related
to
FI.
Our
study
sought
explore
the
relationship
between
healthy
eating
index-2015
(HEI-2015)
score
and
FI
among
US
adults.
An
analysis
of
data
from
2005–2010
National
Health
Nutrition
Examination
Survey
was
conducted
our
study.
The
Bowel
Questionnaire
defined
as
losing
liquid,
solid,
or
mucus
stool
at
least
monthly.
diet's
evaluated
using
HEI-2015
score.
odds
ratios
(ORs)
95%
confidence
interval
(95%CI)
were
calculated
multi-variable
logistic
regression
models.
There
11,452
participants,
with
9.3%
(1062/11452)
who
experienced
Compared
individuals
inadequate
group
(HEI
<
50),
adjusted
OR
values
for
HEI
average
(50
≤
70)
optimal
≥
0.89
(95%CI:
0.74–1.07,
p
=
0.214)
0.69
0.52–0.91,
0.011),
respectively.
Subsequent
stratified
analyses
did
not
reveal
any
interactions.
High-quality
diets
are
lower
risk
Therefore,
imperative
take
into
account
potential
impact
diet
on
when
devising
strategies
treatment
prevention.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Окт. 9, 2024
Metabolism,
including
glycolysis,
oxidative
phosphorylation,
fatty
acid
oxidation,
and
other
metabolic
pathways,
impacts
the
phenotypes
functions
of
immune
cells.
The
regulation
system
is
important
in
pathogenesis
progression
numerous
diseases,
such
as
cancers,
autoimmune
diseases
diseases.
concept
immunometabolism
was
introduced
over
a
decade
ago
to
elucidate
intricate
interplay
between
metabolism
immunity.
definition
has
expanded
from
chronic
low-grade
inflammation
reprogramming
cells
various
With
being
proposed
developed,
can
be
gradually
summarized
becomes
more
clearer.
In
context
many
cancer,
disease,
occurs
inducing
proinflammatory
or
anti-inflammatory
effects.
phenotypic
functional
changes
caused
by
further
affect
development
Based
on
experimental
results,
targeting
cellular
promising
therapy.
this
review,
we
focus
introduce
their
pathways
reprogramming,
summarize
how
these
effects
We
thoroughly
explore
targets
treatments
based
existing
studies.
challenges
translating
results
into
clinical
applications
field
are
also
summarized.
believe
that
better
understanding
health
will
improve
management
most
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Окт. 28, 2024
Ulcerative
colitis
(UC)
is
a
debilitating
inflammatory
bowel
disease
characterized
by
intestinal
inflammation,
barrier
dysfunction,
and
dysbiosis,
with
limited
treatment
options
available.
This
study
systematically
investigates
the
therapeutic
potential
of
synbiotic
composed
galactooligosaccharides
(GOS)
Limosilactobacillus
reuteri
in
murine
model
colitis,
revealing
that
GOS
L.
synergistically
protect
against
inflammation
dysfunction
promoting
synthesis
pentadecanoic
acid,
an
odd-chain
fatty
from
Bacteroides
acidifaciens.
Notably,
synbiotic,
B.
acidifaciens,
acid
are
each
capable
suppressing
enhancing
tight
junction
inhibiting
NF-κB
activation.
Furthermore,
similar
reduction
acidifaciens
levels
also
observed
feces
both
human
UC
patients
lipopolysaccharide-induced
pigs.
Our
findings
elucidate
protective
mechanism
highlight
its
potential,
along
for
other
disorders.
Here,
Yujun
Wu
colleagues
report
alleviates
gut
animals
enriching
showing
treating
ulcerative
colitis.
Current Opinion in Clinical Nutrition & Metabolic Care,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Purpose
of
review
This
aims
to
examine
recent
research
on
the
role
specialized
pro-resolving
mediators
(SPMs)
in
regulation
gut
immunophysiology.
Recent
findings
Inflammatory
bowel
disease
(IBD)
is
characterized
by
chronic
inflammation
gastrointestinal
tract,
driven
disruptions
intestinal
barrier
and
an
imbalance
between
host
immune
system
microbiota.
Dietary
polyunsaturated
fatty
acids
(PUFAs),
especially
ω-3
ω-6,
are
key
regulators
responses
help
maintain
integrity
barrier.
These
PUFAs
serve
as
precursors
SPMs,
lipid
that
play
a
critical
resolving
inflammation.
SPMs
actively
reprogram
cells,
promoting
clearance
cellular
debris,
reducing
cytokine
production,
restoring
tissue
homeostasis
without
suppressing
response.
Emerging
evidence
indicates
gut,
strengthen
function,
modulate
colitis
colon
cancer,
influence
microbiota
composition.
Summary
The
strongly
supports
central
maintaining
health
organ
function
following
inflammatory
challenges.
highlights
potential
therapeutic
approaches
target
these
pathways
for
both
prevention
treatment
gut-related
conditions.
Poultry Science,
Год журнала:
2025,
Номер
104(2), С. 104773 - 104773
Опубликована: Янв. 4, 2025
Salmonella
enterica
serovar
Enteritidis
(S.
Enteritidis)
is
a
common
zoonotic
pathogen
that
not
only
causes
gastroenteritis
or
death
of
livestock
and
poultry
but
also
poses
serious
threat
to
human
health,
causing
severe
economic
losses
the
industry
society.
Herein,
RNA-sequencing
(RNA-seq)
was
used
analyze
transcriptome
variation
chicken
cecum
at
four
different
time
points
(1,
3,
7,
14
days)
following
S.
infection.
There
were
529,
1477,
476,
432
differentially
expressed
genes
(DEGs)
in
days
post-infection
(dpi),
respectively.
The
DEGs
significantly
enriched
various
immune-related
pathways
on
3
dpi
7
dpi,
such
as
cytokine-cytokine-receptor
interaction
Toll-like
receptor
signaling
pathway.
several
metabolic
dpi.
Gene
ontology
(GO)
enrichment
showed
up-regulated
terms
On
mainly
signaling-related
terms,
while
down-regulated
primarily
metabolic-related
terms.
Based
weighted
gene
co-expression
network
analysis
(WGCNA),
key
modules
related
energy,
non-coding
processes,
immunity,
development-related
functions
identified
1,
respectively,
5,
8,
6,
5
hub
screened
out,
This
study
demonstrated
cecal
regulation
responding
infection
time-dependent.
chickens
coordinated
by
multiple
systems,
involving
metabolism,
signal
transduction.
Both
are
for
immune
response.
As
progresses,
metabolism-related
increasingly
identified.
change
reflects
dynamic
adjustment
between
response
metabolism
Jining
Bairi
These
results
suggested
starting
from
gradually
transition
an
triggered
state
where
they
adapt
modulating
their
metabolism.
Ulcerative
colitis
(UC)
has
experienced
a
steady
increase
in
global
incidence
and
prevalence
recently.
Current
research
into
UC
pathogenesis
focuses
on
the
complex
interplay
of
genetic
environmental
factors
with
immune
system
gut
microbiome,
leading
to
disruption
intestinal
barrier.
Normally,
epithelium,
interact
maintain
homeostasis.
However,
when
this
equilibrium
is
disturbed,
harmful
cycle
dysbiosis,
dysregulation,
inflammation
emerges,
resulting
barrier
dysfunction
progression.
Among
various
risk
factors,
diet
significantly
influences
epithelial
integrity
architectural
stability
through
both
direct
indirect
mechanisms,
shaping
entire
continuum
from
pre-clinical
prevention
active
phase
treatment
remission
maintenance.
This
review
provides
insights
impact
dietary
content
eating
behaviors
UC,
focusing
specific
food,
food
groups,
nutrients,
intermittent
fasting,
while
providing
detailed
explanation
why
microbiota
may
mediate
sustained
effects
across
all
stages
UC.
Additionally,
it
addresses
limitations
current
studies,
explores
underexamined
areas
proposes
potential
directions
for
future
expansion.
Not
applicable.
The
mechanisms
underlying
the
complex
correlation
between
immunoglobulin
A
nephropathy
(IgAN)
and
inflammatory
bowel
disease
(IBD)
remain
unclear.
This
study
aimed
to
identify
optimal
cross-talk
genes,
potential
pathways,
mutual
immune-infiltrating
microenvironments
IBD
IgAN
elucidate
linkage
patients
with
IgAN.
datasets
were
obtained
from
Gene
Expression
Omnibus
(GEO).
Three
algorithms,
CIBERSORTx,
ssGSEA,
xCell,
used
evaluate
similarities
in
infiltrating
microenvironment
two
diseases.
Weighted
gene
co-expression
network
analysis
(WGCNA)
was
implemented
dataset
major
immune
infiltration
modules,
Boruta
algorithm,
RFE
LASSO
regression
applied
filter
genes.
Next,
multiple
machine
learning
models
confirm
Finally,
relevant
findings
validated
using
histology
immunohistochemistry
of
mice.
Immune
showed
no
significant
differences
samples
most
cells.
three
algorithms
identified
10
diagnostic
MAPK3,
NFKB1,
FDX1,
EPHX2,
SYNPO,
KDF1,
METTL7A,
RIDA,
HSDL2,
RIPK2;
FDX1
NFKB1
enhanced
kidney
Kyoto
Encyclopedia
Genes
Genomes
15
pathways
diseases,
lipid
metabolism
playing
a
vital
role
cross-talk.
Our
offer
insights
into
shared
IBD.
These
common
cell-mediated
abnormal
immunity
may
inform
further
experimental
studies.
