Dissecting the mediating role of inflammatory factors in the interaction between metabolites and sepsis: insights from bidirectional Mendelian randomization DOI Creative Commons
Fangchen Gong,

Wenbin Liu,

Lei Pei

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 14, 2024

Sepsis, a life-threatening condition, involves complex interactions among metabolic alterations, inflammatory mediators, and host responses. This study utilized bidirectional Mendelian randomization approach to investigate the causal relationships between 1400 metabolites sepsis, mediating role of factors. We identified 36 significantly associated with sepsis (p < 0.05), AXIN1, FGF-19, FGF-23, IL-4, OSM showing an inverse association, suggesting protective role, while IL-2 exhibited positive correlation, indicating potential risk factor. Among these metabolites, Piperine 9-Hydroxystearate demonstrated particularly interesting effects against sepsis. Piperine’s effect was mediated through its interaction contributing 16.296% reduction in risk. suggests pathway where influences outcomes by modulating AXIN1 levels. also association FGF-19 negative IL-2, 9.436% 12.565%, respectively, effect. Experimental validation confirmed elevated levels reduced piperine, 9-hydroxyoctadecanoic acid patients compared healthy controls. positively correlated negatively supporting findings. Our findings provide insights into molecular mechanisms highlighting unique roles contributions specific their mediators. enhances our understanding pathophysiology opens avenues for targeted therapeutic interventions biomarker development management. However, further research is essential validate pathways across diverse populations fully explore

Language: Английский

Metabolic regulation of the immune system in health and diseases: mechanisms and interventions DOI Creative Commons
Tengyue Hu, Changhai Liu, Min Lei

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 9, 2024

Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other metabolic pathways, impacts the phenotypes functions of immune cells. The regulation system is important in pathogenesis progression numerous diseases, such as cancers, autoimmune diseases diseases. concept immunometabolism was introduced over a decade ago to elucidate intricate interplay between metabolism immunity. definition has expanded from chronic low-grade inflammation reprogramming cells various With being proposed developed, can be gradually summarized becomes more clearer. In context many cancer, disease, occurs inducing proinflammatory or anti-inflammatory effects. phenotypic functional changes caused by further affect development Based on experimental results, targeting cellular promising therapy. this review, we focus introduce their pathways reprogramming, summarize how these effects We thoroughly explore targets treatments based existing studies. challenges translating results into clinical applications field are also summarized. believe that better understanding health will improve management most

Language: Английский

Citations

33
Galactooligosaccharides and Limosilactobacillus reuteri synergistically alleviate gut inflammation and barrier dysfunction by enriching Bacteroides acidifaciens for pentadecanoic acid biosynthesis DOI Creative Commons
Yujun Wu, Xiangyu Zhang, Xiaoyi Liu

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 28, 2024

Ulcerative colitis (UC) is a debilitating inflammatory bowel disease characterized by intestinal inflammation, barrier dysfunction, and dysbiosis, with limited treatment options available. This study systematically investigates the therapeutic potential of synbiotic composed galactooligosaccharides (GOS) Limosilactobacillus reuteri in murine model colitis, revealing that GOS L. synergistically protect against inflammation dysfunction promoting synthesis pentadecanoic acid, an odd-chain fatty from Bacteroides acidifaciens. Notably, synbiotic, B. acidifaciens, acid are each capable suppressing enhancing tight junction inhibiting NF-κB activation. Furthermore, similar reduction acidifaciens levels also observed feces both human UC patients lipopolysaccharide-induced pigs. Our findings elucidate protective mechanism highlight its potential, along for other disorders. Here, Yujun Wu colleagues report alleviates gut animals enriching showing treating ulcerative colitis.

Language: Английский

Citations

19
Specialized pro-resolving lipid mediators in gut immunophysiology: from dietary precursors to inflammation resolution DOI
Emmanuel Albuquerque‐Souza, Jesmond Dalli

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Purpose of review This aims to examine recent research on the role specialized pro-resolving mediators (SPMs) in regulation gut immunophysiology. Recent findings Inflammatory bowel disease (IBD) is characterized by chronic inflammation gastrointestinal tract, driven disruptions intestinal barrier and an imbalance between host immune system microbiota. Dietary polyunsaturated fatty acids (PUFAs), especially ω-3 ω-6, are key regulators responses help maintain integrity barrier. These PUFAs serve as precursors SPMs, lipid that play a critical resolving inflammation. SPMs actively reprogram cells, promoting clearance cellular debris, reducing cytokine production, restoring tissue homeostasis without suppressing response. Emerging evidence indicates gut, strengthen function, modulate colitis colon cancer, influence microbiota composition. Summary The strongly supports central maintaining health organ function following inflammatory challenges. highlights potential therapeutic approaches target these pathways for both prevention treatment gut-related conditions.

Language: Английский

Citations

2
Omega-3 fatty acids and the gut microbiome: a new frontier in cardiovascular disease prevention DOI Creative Commons
Vikram Kumar,

Alka Rohilla,

Jayesh J. Ahire

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: Feb. 25, 2025

Language: Английский

Citations

2
Dietary content and eating behavior in ulcerative colitis: a narrative review and future perspective DOI Creative Commons
Lun‐Xiu Qin,

Wenliang Lv

Nutrition Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 23, 2025

Ulcerative colitis (UC) has experienced a steady increase in global incidence and prevalence recently. Current research into UC pathogenesis focuses on the complex interplay of genetic environmental factors with immune system gut microbiome, leading to disruption intestinal barrier. Normally, epithelium, interact maintain homeostasis. However, when this equilibrium is disturbed, harmful cycle dysbiosis, dysregulation, inflammation emerges, resulting barrier dysfunction progression. Among various risk factors, diet significantly influences epithelial integrity architectural stability through both direct indirect mechanisms, shaping entire continuum from pre-clinical prevention active phase treatment remission maintenance. This review provides insights impact dietary content eating behaviors UC, focusing specific food, food groups, nutrients, intermittent fasting, while providing detailed explanation why microbiota may mediate sustained effects across all stages UC. Additionally, it addresses limitations current studies, explores underexamined areas proposes potential directions for future expansion. Not applicable.

Language: Английский

Citations

1
Leaky Gut Syndrome: An Interplay Between Nutrients and Dysbiosis DOI

Ana Beatriz Marcari,

Aline Dias Paiva,

Claudio Roberto Simon

et al.

Current Nutrition Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 31, 2025

Language: Английский

Citations

1
Accelerated biological aging and risk of inflammatory bowel disease: A prospective study from 401,013 participants DOI Creative Commons

Baolong Cao,

Xiaoke Zhao,

Zhixi Lu

et al.

The journal of nutrition health & aging, Journal Year: 2025, Volume and Issue: 29(4), P. 100505 - 100505

Published: Feb. 13, 2025

Language: Английский

Citations

1
Novel immune cross-talk between inflammatory bowel disease and IgA nephropathy DOI Creative Commons

Qianqian Yan,

Zihao Zhao, Dongwei Liu

et al.

Renal Failure, Journal Year: 2024, Volume and Issue: 46(1)

Published: April 17, 2024

The mechanisms underlying the complex correlation between immunoglobulin A nephropathy (IgAN) and inflammatory bowel disease (IBD) remain unclear. This study aimed to identify optimal cross-talk genes, potential pathways, mutual immune-infiltrating microenvironments IBD IgAN elucidate linkage patients with IgAN. datasets were obtained from Gene Expression Omnibus (GEO). Three algorithms, CIBERSORTx, ssGSEA, xCell, used evaluate similarities in infiltrating microenvironment two diseases. Weighted gene co-expression network analysis (WGCNA) was implemented dataset major immune infiltration modules, Boruta algorithm, RFE LASSO regression applied filter genes. Next, multiple machine learning models confirm Finally, relevant findings validated using histology immunohistochemistry of mice. Immune showed no significant differences samples most cells. three algorithms identified 10 diagnostic MAPK3, NFKB1, FDX1, EPHX2, SYNPO, KDF1, METTL7A, RIDA, HSDL2, RIPK2; FDX1 NFKB1 enhanced kidney Kyoto Encyclopedia Genes Genomes 15 pathways diseases, lipid metabolism playing a vital role cross-talk. Our offer insights into shared IBD. These common cell-mediated abnormal immunity may inform further experimental studies.

Language: Английский

Citations

5
Temporal Transcriptome Profiling in the response to Salmonella enterica serovar Enteritidis Infection in Chicken Cecum DOI Creative Commons
Yanan Peng, Huilong Li,

Jingchao Yang

et al.

Poultry Science, Journal Year: 2025, Volume and Issue: 104(2), P. 104773 - 104773

Published: Jan. 4, 2025

Salmonella enterica serovar Enteritidis (S. Enteritidis) is a common zoonotic pathogen that not only causes gastroenteritis or death of livestock and poultry but also poses serious threat to human health, causing severe economic losses the industry society. Herein, RNA-sequencing (RNA-seq) was used analyze transcriptome variation chicken cecum at four different time points (1, 3, 7, 14 days) following S. infection. There were 529, 1477, 476, 432 differentially expressed genes (DEGs) in days post-infection (dpi), respectively. The DEGs significantly enriched various immune-related pathways on 3 dpi 7 dpi, such as cytokine-cytokine-receptor interaction Toll-like receptor signaling pathway. several metabolic dpi. Gene ontology (GO) enrichment showed up-regulated terms On mainly signaling-related terms, while down-regulated primarily metabolic-related terms. Based weighted gene co-expression network analysis (WGCNA), key modules related energy, non-coding processes, immunity, development-related functions identified 1, respectively, 5, 8, 6, 5 hub screened out, This study demonstrated cecal regulation responding infection time-dependent. chickens coordinated by multiple systems, involving metabolism, signal transduction. Both are for immune response. As progresses, metabolism-related increasingly identified. change reflects dynamic adjustment between response metabolism Jining Bairi These results suggested starting from gradually transition an triggered state where they adapt modulating their metabolism.

Language: Английский

Citations

0
Effect of probiotic extracellular vesicles and their applications on health and disease DOI Open Access
Guangzhao Wang, Yang Wang, Kangliang Sheng

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Probiotics have been established to exert a positive impact on the treatment of various diseases. Indeed, these active microorganisms garnered significant attention in recent years for their potential prevent and treat illnesses. Their beneficial effects hypothesized be linked released extracellular vesicles. These nanoscale structures, secreted during growth metabolism probiotics, possess favorable biocompatibility targeting properties, thereby promoting intercellular material transport signaling. This article aimed review bioactive components functions probiotics vesicles, highlighting role diseases discussing future applications. By exploring mechanisms probiotic vesicles disease development, this provide theoretical reference further research therapeutic potential. © 2025 Society Chemical Industry.

Language: Английский

Citations

0