Increased intracellular stress responses and decreased KLF2 in adult patients with atopic dermatitis
Cell Stress and Chaperones,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Atopic
dermatitis
(AD)
is
prone
to
exacerbations
in
response
various
triggering
factors
and
flare-ups
after
remission.
We
searched
for
molecules
associated
with
relapse/exacerbation
of
AD
among
altered
gene
expression
the
skin
patients
AD.
Microarray
analyses
were
performed
on
lesional
non-lesional
adolescent
or
adult
recalcitrant
healthy
controls.
Five
chaperones
involved
intracellular
stress
responses,
namely
heat
shock
protein
family
A
(Hsp70)
member
9
(HSPA9),
90
beta
1
(HSP90B1),
calnexin
(CANX),
malectin
(MLEC;
endoplasmic
reticulum-associated
degradation),
D
(Hsp60)
(HSPD1),
consistently
upregulated
uninvolved
Damage-associated
molecular
patterns
skin.
KLF
transcription
factor
2
(KLF2)
was
decreased
exhibited
a
decreasing
trend
CD4(+)/CD8(+)
double-positive
cells
(1.4%
T
cells)
detected
lesions
declined
KLF2
levels.
WNT
inhibitory
(WIF1)
downregulated
Prolactin-induced
only
found
increased
responses
Multifactorial
genetic
diseases,
such
as
asthma,
inflammatory
bowel
disease,
type
diabetes,
rheumatoid
arthritis,
are
stress.
Intracellular
abnormalities
may
also
be
responsible
Further
research
incorporate
enhanced
into
mechanism
underlying
Язык: Английский
The differential roles of heat shock protein 90 isoforms in skin inflammation: Anti-inflammatory potential of TRAP1 inhibition
Journal of Investigative Dermatology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
A tri-compound formula comprising ginsenoside Rg1, tetrandrine and icariin alleviates atopic dermatitis symptoms in a mouse model
Phytomedicine,
Год журнала:
2025,
Номер
unknown, С. 156737 - 156737
Опубликована: Апрель 1, 2025
Язык: Английский
HSP90 Complex From OLP Lesion Induces T‐Cell Polarization via Activation of Dendritic Cells
Oral Diseases,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 12, 2024
To
investigate
the
effects
of
heat
shock
protein
90
(HSP90)
complex
from
oral
lichen
planus
(OLP)
lesion
tissues
on
dendritic
cell
(DC)
activation
and
polarization
naïve
T
cells.
Язык: Английский
The heat shock protein 90 inhibitor RGRN-305 attenuates SARS-CoV-2 spike protein-induced inflammation in vitro but lacks effectiveness as COVID-19 treatment in mice
PLoS ONE,
Год журнала:
2024,
Номер
19(9), С. e0310915 - e0310915
Опубликована: Сен. 26, 2024
The
inhibition
of
heat
shock
protein
90
(HSP90),
a
molecular
chaperone,
has
been
proposed
to
be
potential
novel
treatment
strategy
for
Coronavirus
disease
2019
(COVID-19).
In
contrast
other
studies,
our
data
demonstrated
that
RGRN-305,
HSP90
inhibitor,
exacerbated
the
cytopathic
effect
and
did
not
reduce
viral
shedding
in
VeroE6-hTMPRSS2
cells
infected
with
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2).
Likewise
murine
model
SARS-CoV-2,
transgenic
mice
treated
orally
RGRN-305
exhibited
reduced
survival
by
end
experiment
(day
12)
as
14%
(1/7)
survived
compared
63%
(5/8)
those
drug-vehicle.
Animal
weight
was
treatment.
Interestingly,
we
significantly
dampened
inflammatory
response
induced
SARS-CoV-2
spike
human
macrophage-like
(U937)
lung
epithelial
(A549).
Measured
quantitative
real-time
PCR,
mRNA
expression
proinflammatory
cytokines
TNF
,
IL1B
IL6
were
reduced.
Together,
these
suggest
exacerbates
infection
vitro
reduces
but
exhibits
strong
anti-inflammatory
properties.
This
shows
while
may
helpful
‘cytokine
storm’,
it
no
beneficial
impact
on
replication
or
animals
monotherapy.
Further
animal
studies
inhibitors
combination
an
anti-viral
drug
provide
additional
insights
into
its
utility
infections
whether
continue
COVID-19
disease.
Язык: Английский
Association of inflammatory skin biomarkers with clinical response in RGRN‐305‐treated patients with hidradenitis suppurativa
Journal of the European Academy of Dermatology and Venereology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 2, 2024
Data
will
be
shared
upon
reasonable
request
to
the
corresponding
author.
Язык: Английский
Investigation of catechin’s anti-inflammatory activity: A bioinformatics and molecular docking study
Acta Biochimica Indonesiana,
Год журнала:
2024,
Номер
7(2), С. 199 - 199
Опубликована: Дек. 28, 2024
Background:
Inflammation
plays
a
key
role
in
the
progression
of
many
chronic
diseases.
As
country
with
rich
biodiversity,
Indonesia
offers
numerous
phytochemicals
potential
for
drug
development,
including
catechin,
natural
compound
anti-inflammatory
properties.
Objective:
This
study
aimed
to
identify
targets
catechin
and
evaluate
its
inhibitory
potency
through
molecular
docking
simulations.
Methods:
Data
acquisition
refinement
were
conducted
using
NCBI,
STRING,
STITCH
databases,
intersections
identified
Venn
diagrams.
Molecular
was
performed
AutoDockTools
1.5.6,
interactions
visualized
BIOVIA
Discovery
Studio.
Results:
Bioinformatics
analysis
predicted
that
inhibits
three
pro-inflammatory
proteins:
COX-2,
HSP90,
IL-2.
Catechin’s
indicated
by
negative
binding
energies
amino
acid
residues
critical
target
protein
activity.
Among
targets,
IL-2
exhibited
lowest
energy
(-5.12
kcal/mol),
suggesting
it
as
primary
target.
However,
catechin’s
affinity
lower
than
native
ligand
(-11.78
kcal/mol).
Conclusion:
is
be
Structural
modifications
are
recommended
enhance
therapeutic
potential.
Язык: Английский