Advances in molecular oncology,
Год журнала:
2024,
Номер
11(4), С. 8 - 22
Опубликована: Дек. 9, 2024
Recent
development
of
molecular
and
genetic
technologies
has
demonstrated
at
the
level
co-evolutionary
principles
interaction
between
microbiota,
virome
host
organism,
as
well
role
microorganisms
viruses
both
in
maintaining
physiological
homeostasis
various
diseases,
including
malignant
neoplasms.
The
presented
review
is
devoted
to
analysis
generalization
modern
data
on
inhabiting
human
body,
their
processes
initiation,
promotion
progression
carcinogenesis.
provides
information
known
oncogenic
according
classification
carcinogenic
agents
International
Agency
for
Research
Cancer.
Mechanistic
procarcinogenic
effect
microbiota
are
considered
accordance
with
concept
key
characteristics
a
agent.
Particular
attention
paid
influence
immunity
first
results
immunotherapy
Coley
toxin
soft
tissue
sarcomas
osteosarcomas,
individual
types
formation
immunocompetent
cell
profile
organism.
In
addition,
intratumor
intracellular
respectively,
microenvironment
tumor
cells
cellular
signaling,
solid
tumors
that
have
no
contact
external
environment
also
discussed.
important
terms
holobiota
concept,
showing
interdependent
existence
viruses,
improve
prevention
therapy
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 26, 2024
Glioblastoma
(GBM)
tumors
are
the
most
aggressive
primary
brain
in
adults
that,
despite
maximum
treatment,
carry
a
dismal
prognosis.
GBM
exhibit
tissue
hypoxia,
which
promotes
tumor
aggressiveness
and
maintenance
of
glioma
stem
cells
creates
an
overall
immunosuppressive
landscape.
This
article
reviews
how
hypoxic
conditions
overlap
with
inflammatory
responses,
favoring
proliferation
inhibiting
cytotoxic
T
cell
development.
Immunotherapies,
including
vaccines,
immune
checkpoint
inhibitors,
CAR-T
therapy,
represent
promising
avenues
for
treatment.
However,
challenges
such
as
heterogeneity,
TME,
BBB
restrictiveness
hinder
their
effectiveness.
Strategies
to
address
these
challenges,
combination
therapies
targeting
actively
being
explored
improve
outcomes
patients.
Targeting
hypoxia
immunotherapy
represents
potential
strategy
enhance
treatment
efficacy.
Advanced Materials,
Год журнала:
2024,
Номер
36(38)
Опубликована: Июль 26, 2024
Abstract
In
recent
years,
advancements
in
microbial
sequencing
technology
have
sparked
an
increasing
interest
the
bacteria
residing
within
solid
tumors
and
its
distribution
functions
various
tumors.
Intratumoral
critically
modulate
tumor
oncogenesis
development
through
DNA
damage
induction,
chronic
inflammation,
epigenetic
alterations,
metabolic
immune
regulation,
while
also
influencing
cancer
treatment
efficacy
by
affecting
drug
metabolism.
response
to
these
discoveries,
a
variety
of
anti‐cancer
therapies
targeting
microorganisms
emerged.
These
approaches
encompass
oncolytic
therapy
utilizing
tumor‐associated
bacteria,
design
biomaterials
based
on
intratumoral
use
bacterial
components
for
delivery
systems,
comprehensive
strategies
aimed
at
eradication
tumor‐promoting
bacteria.
Herein,
this
review
article
summarizes
patterns
different
tumors,
examines
their
impact
evaluates
current
therapeutic
centered
Furthermore,
challenges
prospects
developing
drugs
that
target
communities
are
explored,
promising
new
directions
treatment.
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Авг. 5, 2024
Atherosclerotic
cardiovascular
disease
(ASCVD)
is
the
most
important
cause
of
morbidity
and
mortality
worldwide.
While
it
traditionally
attributed
to
lipid
accumulation
in
vascular
endothelium,
recent
research
has
shown
that
plaque
inflammation
an
additional
driver
atherogenesis.
Though
clinical
outcome
trials
utilizing
anti-inflammatory
agents
have
proven
promising
terms
reducing
ASCVD
risk,
imperative
identify
novel
actionable
targets
are
more
specific
atherosclerosis
mitigate
adverse
effects
associated
with
systemic
immune
suppression.
To
end,
this
review
explores
contributions
various
cells
from
innate
adaptive
system
promoting
mitigating
by
integrating
findings
experimental
studies,
high-throughput
multi-omics
technologies,
epidemiological
research.
Cancers,
Год журнала:
2025,
Номер
17(6), С. 940 - 940
Опубликована: Март 10, 2025
Exosomes
have
emerged
as
pivotal
players
in
precision
oncology,
offering
innovative
solutions
to
longstanding
challenges
such
metastasis,
therapeutic
resistance,
and
immune
evasion.
These
nanoscale
extracellular
vesicles
facilitate
intercellular
communication
by
transferring
bioactive
molecules
that
mirror
the
biological
state
of
their
parent
cells,
positioning
them
transformative
tools
for
cancer
diagnostics
therapeutics.
Recent
advancements
exosome
engineering,
artificial
intelligence
(AI)-driven
analytics,
isolation
technologies
are
breaking
barriers
scalability,
reproducibility,
clinical
application.
Bioengineered
exosomes
being
leveraged
CRISPR-Cas9
delivery,
while
AI
models
enhancing
biomarker
discovery
liquid
biopsy
accuracy.
Despite
these
advancements,
key
obstacles
heterogeneity
populations
lack
standardized
protocols
persist.
This
review
synthesizes
pioneering
research
on
biology,
molecular
translation,
emphasizing
dual
roles
both
mediators
tumor
progression
intervention.
It
also
explores
emerging
areas,
including
microbiome–exosome
interactions
integration
machine
learning
exosome-based
medicine.
By
bridging
innovation
with
translational
strategies,
this
work
charts
a
forward-looking
path
integrating
into
next-generation
care,
setting
it
apart
comprehensive
guide
overcoming
technological
hurdles
rapidly
evolving
field.
Recent
studies
suggest
that
the
human
microbiome
influence
tumor
development.
Endometrial
carcinoma
(EC)
is
sixth
most
common
malignancy
in
women.
research
has
demonstrated
microbes
play
a
critical
role
development
and
metastasis
of
EC.
However,
it
remains
unclear
whether
intratumoral
are
associated
with
microenvironment
(TME)
prognosis
In
this
study,
we
collected
EC
data
from
cBioPortal
constructed
prognostic
model
based
on
Resident
Microbiome
Endometrium
(RME).
We
then
examined
relationship
between
RME
score,
immune
cell
infiltration,
immunotherapy-related
signature,
prognosis.
The
findings
independent
value
score
for
group
low
scores
had
higher
enrichment
cells.
Drug
sensitivity
analysis
revealed
may
serve
as
potential
predictor
chemotherapy
efficacy.
conclusion,
our
offers
new
perspectives
relationships
immunity
microbes.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7091 - 7091
Опубликована: Июнь 28, 2024
Breast
cancer
(BC)
continues
to
pose
a
significant
burden
on
global
cancer-related
morbidity
and
mortality,
primarily
driven
by
metastasis.
However,
the
combined
influence
of
microRNAs
(miRNAs)
intratumoral
microbiota
BC
metastasis
remains
largely
unexplored.
In
this
study,
we
aimed
elucidate
interplay
between
composition,
miRNA
expression
profiles,
their
collective
development
in
patients
employing
16S
rRNA
sequencing
qPCR
methodologies.
Our
findings
revealed
an
increase
miR-149-5p,
miR-20b-5p,
miR-342-5p
metastatic
breast
(Met-BC)
patients.
The
Met-BC
exhibited
heightened
microbial
richness
diversity,
attributed
diverse
pathogenic
bacteria.
Taxonomic
analysis
identified
several
pro-inflammatory
species
enriched
Met-BC,
contrasting
with
non-metastatic
(NonMet-BC)
patients,
which
displayed
enrichment
potential
probiotic
anti-inflammatory
species.
Notably,
verified
baseline
prognostic
signature
for
its
clinical
relevance
further
validated
impact
overall
survival.
conclusion,
observed
disparities
species-level
bacterial
abundance
suggest
involvement
progression.
holds
promise
risk
assessment,
paving
way
personalized
interventions
improved
outcomes
