Pancreatic
Ductal
Adenocarcinoma
(PDAC)
is
an
aggressive
cancer
characterized
by
immunosuppressive
microenvironment.
Patients
from
specific
ethnicities
and
population
groups
have
poorer
prognoses
than
others.
Therefore,
a
better
understanding
of
the
immune
landscape
in
such
necessary
for
disease
elucidation,
predicting
patient
outcomes
therapeutic
targeting.
This
study
investigated
expression
circulating
key
cell
markers
South
African
PDAC
patients
ancestry.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июль 9, 2024
Abstract
Multiple
myeloma
(MM)
is
a
hematologic
malignancy
characterized
by
uncontrolled
proliferation
of
plasma
cells
in
the
bone
marrow.
MM
patients
with
aggressive
progression
have
poor
survival,
emphasizing
urgent
need
for
identifying
new
therapeutic
targets.
Here,
we
show
that
leukocyte
immunoglobulin-like
receptor
B1
(LILRB1),
transmembrane
conducting
negative
immune
response,
top-ranked
gene
associated
prognosis
patients.
LILRB1
deficiency
inhibits
vivo
enhancing
ferroptosis
cells.
Mechanistic
studies
reveal
forms
complex
low-density
lipoprotein
(LDLR)
and
LDLR
adapter
protein
1
(LDLRAP1)
to
facilitate
LDL/cholesterol
uptake.
Loss
impairs
cholesterol
uptake
but
activates
de
novo
synthesis
pathway
maintain
cellular
homeostasis,
leading
decrease
anti-ferroptotic
metabolite
squalene.
Our
study
uncovers
function
regulating
metabolism
protecting
from
ferroptosis,
implicating
as
promising
target
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 15
Опубликована: Март 1, 2025
The
side
effects
of
chemotherapy
drugs
have
prompted
the
development
targeted
therapies.
Distinctive
abundance
lipid
peroxidation
(LPO)
in
tumor
cells
represents
a
potential
target
for
drug
delivery.
However,
LPO
-
based
ligands
remain
under
exploited.
In
this
work,
targeting
2,2,6,6-tetramethylpiperidin-1-oxyl
(TEMPO),
was
investigated
within
mesoporous
silica
nanocarrier
loaded
with
doxorubicin
(DOX)
and
connected
4-NH2-TEMPO
obtaining
DOX/MSN-TEMPO.
A
cellular
uptake
assay
showed
faster
DOX/MSN-TEMPO
than
blank
group
on
Hela,
L929
4T1
cells,
revealing
TEMPO's
active
ability
cells.
After
observing
phenomenon,
fabrication
basic
copolymer
module
carrying
cyanine5.5
(Cy5.5)
TEMPO
reported.
vivo
experiments
were
conducted
mouse
MCF-7
models,
displaying
selective
aggregation
nano
micelles
at
site
thereby
verifying
broad
applicability
TEMPO.
Based
large
amounts
leads
to
presence
numerous
free
radicals,
while
TEMPO,
as
radical
capture
agent,
further
targets
These
findings
verify
most
collectively
underscore
analogous
agents
innovative
Antioxidants,
Год журнала:
2025,
Номер
14(4), С. 469 - 469
Опубликована: Апрель 14, 2025
Breast
cancer
is
a
leading
diagnosis
for
women
around
the
world,
with
variable
degree
of
curability.
Conventional
chemotherapeutic
treatments
often
induce
toxicity
and
damage
to
healthy
tissues,
as
well
development
drug
resistance,
which
why
an
increasing
number
new
therapeutic
regimens
focus
on
use
natural
products
various
modifications
their
delivery
target
tissues.
Silver
nanoparticles
possess
unique
physicochemical
characteristics,
notably
increased
surface
area,
suggesting
that
they
hold
significant
potential
biomedical
applications.
This
research
evaluates
capacity
silver
green
synthesized
aqueous
extracts
Filipendula
ulmaria
(FUAgNPs)
Salvia
verticillata
(SVAgNPs)
alter
migration
redox
homeostasis
in
human
breast
cell
line
MDA-MB-231.
To
determine
values
parameters,
cells
were
treated
five
different
concentrations
(5,
10,
20,
50,
100
μg/mL)
24
h
72
h,
while
test
migratory
matrix
metalloproteinase-9
(MMP-9)
nuclear
factor
erythroid
2–related
2
(Nrf-2),
at
two
(5
50
µg/mL)
h.
The
obtained
results
indicate
production
superoxide
anion
radicals,
malondialdehyde
(MDA),
nitrites
after
investigated
treatment
MDA-MB-231
cells.
induced
only
slight
elevation
Nrf-2
levels,
correlates
weak
de
novo
synthesis
reduced
glutathione
(GSH),
tested
weaken
inherent
antioxidative
systems
was
significantly
reduced,
MMP-9
concentration
inhibited.
Based
demonstrated
antitumor
effect,
confirmed
by
examined
disrupted
balance,
these
have
additional
investigation
aim
improving
efficacy
therapy.
Also,
FUAgNPs
SVAgNPs
be
potentially
promising
novel
agents
against
progression
metastasis.
Cell Biology and Toxicology,
Год журнала:
2025,
Номер
41(1)
Опубликована: Апрель 26, 2025
Abstract
The
vulnerability
of
tumor
cells
to
lipid
peroxidation,
driven
by
redox
imbalance
and
overabundance
within
the
microenvironment
(TME),
has
become
a
focal
point
for
novel
antitumor
strategies.
Ferroptosis,
form
regulated
cell
death
predicated
on
is
emerging
as
promising
approach.
Beyond
their
role
in
directly
eliminating
cells,
peroxidation
its
products,
such
4-hydroxynonenal
(HNE),
exert
an
additional
influence
damaging
DNA
shaping
environment
conducive
growth
metastasis.
This
process
polarizes
macrophages
towards
pro-inflammatory
phenotype,
dampens
antigen-presenting
capacity
dendritic
(DCs),
undermines
cytotoxic
functions
T
NK
cells.
Furthermore,
it
transforms
neutrophils
into
pro-tumorigenic
polymorphonuclear
myeloid-derived
suppressor
(PMN-MDSCs).
stroma
also
contributes
progression.
Although
advanced
nanotherapies
have
shown
ability
target
precisely,
they
often
overlook
nuanced
effects
products.
In
this
review,
we
highlight
synergistic
mechanism
which
products
ferroptosis
contribute
immunosuppressive
state
that
temporally
distinct
from
death.
insight
broadens
our
understanding
ferroptosis-derived
immunosuppression,
encompassing
all
types
immune
TME.
review
aims
catalyze
further
research
underexplored
area,
emphasizing
potential
hinder
clinical
translation
ferroptosis-based
therapies.
Graphical
abstract
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 30, 2024
Despite
being
a
groundbreaking
approach
to
treating
colorectal
cancer
(CRC),
the
efficacy
of
immunotherapy
is
significantly
compromised
by
immunosuppressive
tumor
microenvironment
and
dysbiotic
intestinal
microbiota.
Here,
leveraging
superior
carrying
capacity
innate
immunity-stimulating
property
living
bacteria,
nanomedicine-engineered
bacterium,
LR-S-CD/CpG@LNP,
with
optical
responsiveness,
immune-stimulating
activity,
ability
regulate
microbiota
metabolome
developed.
Immunoadjuvant
(CpG)
carbon
dot
(CD)
co-loaded
plant
lipid
nanoparticles
(CD/CpG@LNPs)
are
constructed
conjugated
surface
Limosilactobacillus
reuteri
(LR)
via
reactive
oxygen
species
(ROS)-responsive
linkers.
The
inherent
photothermal
photodynamic
properties
oral
CD/CpG@LNPs
induce
in
situ
cytotoxic
ROS
generation
immunogenic
cell
death
cells.
generated
neoantigens
released
CpG
function
as
potent
vaccine
that
stimulates
maturation
immature
dendritic
mature
cells
metabolites
secreted
LR
subsequently
facilitated
infiltration
T
lymphocytes
eradicate
tumors.
further
vivo
results
demonstrate
photo-immunotherapy
microbial
metabolite
regulation
LR-S-CD/CpG@LNPs
collectively
suppressed
growth
orthotopic
tumors
their
liver
metastases,
presenting
promising
avenue
for
synergistic
treatment
CRC
route.
Ural Medical Journal,
Год журнала:
2024,
Номер
23(5), С. 89 - 103
Опубликована: Окт. 18, 2024
Purpose
—
to
investigate
the
dynamics
of
content
antioxidant
enzymes
superoxide
dismutase
1
(SOD1),
glutathione
peroxidase
(GPO1),
reductase
(GR)
and
lipid
peroxidation
products
diene
conjugates
(DC),
malondialdehyde
(MDA)
in
spleen
liver
during
latent
period
growth
metastasis
experimental
tumor.
Materials
methods
.
Using
28
white
male
rats,
a
model
hematogenous
was
created
by
transplanting
sarcoma
45
cells
(S45)
into
spleen,
previously
lead
out
under
skin
3
weeks
before.
Previously,
determined
that
tumor
visualized
at
5
weeks,
metastases
7
after
transplantation
S45.
Levels
SOD1,
GPO1,
GR
MDA
were
using
ELISA
DC
biochemical
method
homogenates
(1–2
post-transplantation).
Results
Significant
changes
(1.5–5.2
times,
р
<
0.050–0.001)
studied
factors
levels
observed
compared
intact
rats
with
out.
Activation
system
noted
(tumor-carrying
organ)
metastasis.
At
same
time,
(the
target
organ
metastasis)
also
increased
but
simultaneously
pronounced
decreased
(5
p
0.001)
without
affecting
SOD1
levels.
Conclusion
Liver
tissue
exhibited
inferiority
protection
formation
pro-oxidant
condition
growth,
which
may
prepare
soil
for
Research and Practical Medicine Journal,
Год журнала:
2024,
Номер
11(2), С. 22 - 35
Опубликована: Май 10, 2024
Purpose
of
the
study
.
To
intensity
lipid
peroxidation
(LPO)
and
activity
antioxidant
protection
components
in
tumor
tissues,
peritumoral
zone
conditionally
healthy
skin
tissue
basal
cell
carcinoma,
depending
on
type
growth,
gender
patients,
presence
concomitant
diseases.
Materials
methods.
Tissues
from
34
patients
with
carcinoma
(BCC)
were
studied,
including
17
women
(10
superficial
growth
7
solid
growth)
men
(5
12
respectively).
We
used
flaps
obtained
during
operations
10
without
malignant
pathology
(“norm”)
as
a
comparison
material.
The
content
malondialdehyde
(MDA),
diene
conjugates
(DC),
superoxide
dismutase
(SOD)
total
peroxidase
(TPA)
determined.
Statistical
processing
results
was
carried
out
using
Statistica
10.0
program.
Results.
In
women,
level
MDA
increased
all
tissues:
BCC
by
2.1–2.5
times
(
p
≤
0.05),
1.6–2.1
<
0.05)
relative
to
“norm”.
an
increase
3.2
3.1
observed
0.02),
no
detected
11
growth.
An
DC
(on
average
2–5
times)
hypertension
diabetes
mellitus
mainly
women.
Activation
SOD
tissue,
greater
extent
(2.4
1.7
0.05
tissue),
can
be
considered
mechanism
antiradical
tumor.
Conclusions.
nearby
tissues
both
types
only
Analysis
individual
characteristics
LPO
indicators
revealed
dependence
severity
especially
(hypertension,
mellitus).
Journal of Dental Research,
Год журнала:
2024,
Номер
103(10), С. 953 - 961
Опубликована: Авг. 26, 2024
The
average
age
and
obesity
prevalence
are
increasing
globally.
Both
aging
metabolic
disease
burden
increase
the
risk
of
oral
squamous
cell
carcinoma
(OSCC)
through
profound
effects
on
immunological
characteristics
within
OSCC
tumor
microenvironment.
While
mechanisms
that
link
to
remain
unclear,
there
is
evidence
antitumor
responses
diminished
in
both
conditions.
Remarkably,
however,
immune
checkpoint
blockade,
a
form
cancer
immunotherapy,
remains
intact
despite
enhanced
immunosuppressive
microenvironment
context
either
or
obesity.
Herein,
we
review
current
knowledge
how
systemic
changes
affect
immunity
with
an
emphasis
role
tumor-associated
macrophages
greatly
contribute
immunosuppression.
Key
aspects
discussed
include
angiogenesis,
cytokine
release,
phagocytosis
attenuation,
recruitment
during
create
immune-suppressive
by
repolarization
macrophages.
Through
deeper
appreciation
these
mechanisms,
development
novel
therapeutic
approaches
control
will
provide
more
refined
management
