Olfactory Receptors and Aortic Aneurysm: Review of Disease Pathways DOI Open Access
Theodora M. Stougiannou, Konstantinos Christodoulou, Dimos Karangelis

и другие.

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(24), С. 7778 - 7778

Опубликована: Дек. 19, 2024

Aortic aneurysm, the pathological dilatation of aorta at distinct locations, can be attributed to many different genetic and environmental factors. The resulting pathobiological disturbances generate a complex interplay processes affecting cells extracellular molecules tunica interna, media externa. In short, aortic aneurysm affect involving matrix, lipid trafficking/atherosclerosis, vascular smooth muscle cells, inflammation, platelets intraluminal thrombus formation, as well various endothelial functions. Many these are interconnected, potentiating one another. Newer discoveries, including involvement odorant olfactory receptors in processes, have further shed light on disease initiation pathology. Olfactory varied group G protein coupled-receptors responsible for recognition chemosensory information. Although they comprise subgroups, some which not well-characterized or identified humans, receptors, particular, most commonly associated with They also ectopically localized thus carry out additional functions relevant tissue identified. It is purpose this narrative review summarize present propagation while incorporating evidence associating functioning overall

Язык: Английский

Anthocyanins from a new hybrid sweet potato peel cultivated in Northern Thailand mitigate LPS-induced inflammation and RANKL-induced osteoporosis by regulating ROS-mediated pathways DOI Creative Commons
Chalermpong Saenjum, Arthid Thim-uam, Chakkraphong Khonthun

и другие.

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Maejo 341 Sweet potato (MSP) is a new purple sweet variety cultivated in Northern Thailand, but its health benefits are unknown. This study aimed to investigate antioxidant, anti-inflammatory, and anti-osteoporotic activities, as well anthocyanin content. The peel flesh of MSP were extracted with ethanol water. Compared the extracts, extracts presented greater antioxidant capacity rich phenolics, flavonoids, anthocyanins, namely, cyanidin-3-O-glucoside, peonidin-3-O-glucoside, pelargonidin-3-O-glucoside, cyanidin, peonidin. suppressed lipopolysaccharide-induced inflammation by inhibiting secretion proinflammatory cytokines enzymes, including TNF-α, IL-1β, IL-6, COX-2, iNOS, reducing nitric oxide matrix metalloproteinase-9 secretion. inhibited RANKL-induced NF-κB MAPK pathways downregulated osteoclastogenic marker expression. Under LPS RANKL treatment, notably reduced reactive oxygen species production while increasing gene Furthermore, they increased osteoblast viability slightly raise alkaline phosphatase activity. These findings suggest that could be used functional food alleviate oxidative stress inflammation-related osteoporosis.

Язык: Английский

Процитировано

2
Review on the role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway in diabetes: mechanistic insights and therapeutic implications DOI
Abhishek Satheesan, Janardanan Kumar,

K.V. Leela

и другие.

Inflammopharmacology, Год журнала: 2024, Номер 32(5), С. 2753 - 2779

Опубликована: Авг. 19, 2024

Язык: Английский

Процитировано

6
A new paradigm in intracellular immunology: Mitochondria emerging as leading immune organelles DOI Creative Commons
Keman Xu,

Fatma Saaoud,

Ying Shao

и другие.

Redox Biology, Год журнала: 2024, Номер 76, С. 103331 - 103331

Опубликована: Авг. 29, 2024

Mitochondria, traditionally recognized as cellular 'powerhouses' due to their pivotal role in energy production, have emerged multifunctional organelles at the intersection of bioenergetics, metabolic signaling, and immunity. However, understanding exact contributions immunity inflammation is still developing. This review first introduces innovative concept intracellular immunity, emphasizing how mitochondria serve critical immune signaling hubs. They are instrumental recognizing responding pathogen danger signals, modulating responses. We also propose leading organelles, drawing parallels with broader system functions antigen presentation, regulation, response. Our comprehensive explores mitochondrial pathways, therapeutic potential managing chronic diseases, discusses cutting-edge methodologies for research. Targeting a broad readership both experts newcomers field, this sets forth new directions that could transform our integrated organelles.

Язык: Английский

Процитировано

4
The potential link between the development of Alzheimer’s disease and osteoporosis DOI Creative Commons

Fariha Nasme,

Jyotirmaya Behera,

Prisha Tyagi

и другие.

Biogerontology, Год журнала: 2025, Номер 26(1)

Опубликована: Янв. 20, 2025

Язык: Английский

Процитировано

0
Network Pharmacology and Molecular Analysis of Mechanisms underlying the therapeutic effects of Rhubarb in treating Atherosclerosis and Abdominal Aortic Aneurysm DOI Creative Commons
Huilin Xu, Jun Huang, Youjie Zeng

и другие.

Heliyon, Год журнала: 2025, Номер 11(4), С. e41906 - e41906

Опубликована: Янв. 23, 2025

The aim of this study was to systematically investigate the effects and mechanisms Rhubarb in treatment Atherosclerosis (AS) Abdominal Aortic Aneurysm (AAA) by utilizing network pharmacology molecular docking techniques. TCMSP systematic database utilized search for active chemical components Rhubarb. Disease-related targets were retrieved from GEO dataset Disgenet database. Gene interactions identify common with AS/AAA, interaction networks constructed using Cytoscape 3.9.1. Protein-protein (PPI) core STRING GO KEGG pathway enrichment analysis performed DAVID. Molecular is used assess potential target-active compound interactions. In our study, 16 compounds screened Rhubarb, along 310 targets. Additionally, 110 AS/AAA target genes out. Topological PPI protein yielded 23 targets, biological functions signaling pathways further investigated. indicated that may be effective treating through processes such as lipids, atherosclerosis, extracellular matrix catabolism, collagenolytic metabolic processes, environment. Five pharmacological also identified: TNF, IL-1β MMP9, TP53, PPARG. showed a strong binding ability between This successfully predicted functions, associated AS/AAA. addition, identified ingredients can source drug screening.

Язык: Английский

Процитировано

0
Improving access to chimeric antigen receptor T-cells for refractory or relapsing diffuse large B cell lymphoma therapy in Asia DOI Creative Commons
Ya Hwee Tan,

Dok Hyun Yoon,

Andrew Davies

и другие.

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 14, 2025

Язык: Английский

Процитировано

0
Exploring the shared genetic mechanisms of atopic dermatitis and alopecia areata via bioinformatics approaches DOI
Qianqian Chen, Ting Yang,

Jiayi Cheng

и другие.

Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)

Опубликована: Фев. 20, 2025

Язык: Английский

Процитировано

0
SET7 lysine methyltransferase mediates the up-regulation of NADPH oxidase expression, oxidative stress, and NLRP3 inflammasome priming in atherosclerosis DOI Creative Commons
Simona‐Adriana Manea,

Mihaela-Loredana Vlad,

Alexandra-Gela Lazar

и другие.

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Март 17, 2025

Dysregulation of histone methylation-based epigenetic mechanisms leads to either transient or long-lasting transcriptomic alterations in vascular and immune cells with important consequences on atherosclerotic plaque development stability. We hypothesized that the enzyme SET7 lysine methyltransferase contributes up-regulation NADPH oxidase (Nox) NLRP3 inflammasome expression atherosclerosis. To test this hypothesis, we examined human non-atherosclerotic tissue samples, apolipoprotein E-deficient (ApoE-/-) mice, macrophages (Mac) employing real-time PCR, Western blot, immunofluorescence microscopy, histological techniques. Male ApoE-/- mice established atherosclerosis were randomized receive concomitant high-fat diet, 5 mg/kg (R)-PFI-2, a selective pharmacological inhibitor, its vehicle, every other day for 4 weeks. The results revealed mRNA protein, H3K4me1 levels significantly elevated carotid lesions, aorta cultured pro-inflammatory Mac. In blockade catalytic activity specific reduced development, decreased aortic protein Nox subunits, mitigated formation NT-/4HNE-protein adducts, attenuated gene expression, pro-caspase-1 pro-IL18 cleavage. polarized M1-Mac, SET7-oriented intervention transcriptional NLRP3, caspase-1, IL1β, IL18, secretion IL1β TNFα. Transient overexpression endothelial enhanced Nox1, Nox2, Nox4, Nox5, p22phox. novel show regulates leading reactive oxygen species cytokines release data recommend as promising target interventions supportive therapeutic strategy cardiovascular diseases.

Язык: Английский

Процитировано

0
Alzheimer's disease as an auto-innate immune pathology with potential cell trans-differentiation and enhanced trained immunity in 3xTg-AD mouse model DOI

Fatma Saaoud,

Lu Liu,

Keman Xu

и другие.

Journal of Alzheimer s Disease, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Background Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory impairment. Neuroinflammatory processes, mediated glial and immune cells, contribute to neuronal damage. Emerging evidence implicates innate mechanisms, including trained immunity cell trans-differentiation, in AD pathogenesis, though their roles remain unclear. Objective To investigate transcriptomic changes the 3xTg-AD mouse model, focusing on trans-differentiation mechanisms. Methods RNA-sequencing was performed brain tissue (cortex plus hippocampus) from 11-month-old female wild-type mice (n = 3/group). Differentially expressed genes (fold change > 1.5, p < 0.05) were identified followed bioinformatics knowledge-based profiling. Public datasets also analyzed. Results exhibited 316 upregulated 412 downregulated genes. Downregulated included those for blood-brain barrier protein, while related cerebrospinal fluid. Increased expression of proinflammatory markers, as well differentiation, proliferation, activation, adhesion. Upregulation associated with migration suggests potential role inflammation cellular plasticity. Additionally, involved inflammasome pathways, immunometabolism, upregulated. Mechanistically, these modulated knockdown promoter SET-7, overexpression inhibitor IL-37, knockout IL-1 receptor, caspase-1, pattern recognition receptor CD36. Conclusions The finding underscore AD, revealing mechanistic framework which danger-associated molecular patterns drive responses, plasticity offering therapeutic targets neuroinflammation reprograming.

Язык: Английский

Процитировано

0
Gasdermin D Inhibitor Necrosulfonamide Alleviates Angiotensin II-Induced Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Mice DOI Creative Commons
Jia Guo, Qing Zhang, Zhidong Li

и другие.

Biomolecules, Год журнала: 2024, Номер 14(6), С. 726 - 726

Опубликована: Июнь 19, 2024

Abdominal aortic aneurysm (AAA) is a chronic disease that lacks effective pharmacological therapies. This study was performed to determine the influence of treatment with gasdermin D inhibitor necrosulfonamide on experimental AAAs. AAAs were induced in male apolipoprotein E-deficient mice by subcutaneous angiotensin II infusion (1000 ng/kg body weight/min), daily administration (5 mg/kg weight) or vehicle starting 3 days prior for 30 days. Necrosulfonamide remarkably suppressed AAA enlargement, as indicated reduced suprarenal maximal external diameter and surface area, lowered incidence severity Histologically, attenuated medial elastin breaks, smooth muscle cell depletion, wall collagen deposition. Macrophages, CD4

Язык: Английский

Процитировано

1