Journal of Clinical Gastroenterology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 23, 2024
Objective:
Constipation
is
commonly
seen
among
patients
with
cardiovascular
diseases
and
linked
to
adverse
outcomes.
However,
the
association
between
constipation
risk
of
stroke
remains
conflicting.
Therefore,
we
aim
conduct
a
systematic
review
meta-analysis
summarize
available
data
on
this
topic.
Methods:
We
identified
potentially
eligible
studies
from
MEDLINE
EMBASE
databases,
searching
inception
May
2024,
investigate
stroke.
To
be
included,
needed
compare
incidence
groups
without
constipation.
Effect
size
95%
CIs
were
combined
using
generic
inverse
variance
method.
Results:
Our
included
8
that
met
eligibility
criteria.
There
5,360,573
participants,
mean
age
53.9
years
69%
are
males.
found
have
41%
increased
pooled
ratio
1.41
(95%
CI:
1.13-1.75;
P
<
0.01,
I
2
=
99%)
compared
those
Subgroup
analysis
revealed
50%
ischemic
1.50
1.15-1.96;
99%),
but
no
statistical
significance
was
for
mixed-type
outcome.
Conclusions:
study
associated
higher
These
findings
could
influence
future
strategies
disease
prevention
management
in
chronic
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3694 - 3694
Опубликована: Март 26, 2024
Metabolic-associated
fatty
liver
disease
(MAFLD)
includes
several
metabolic
dysfunctions
caused
by
dysregulation
in
the
brain–gut–liver
axis
and,
consequently,
increases
cardiovascular
risks
and
dysfunction.
In
MAFLD,
type
2
diabetes
mellitus,
obesity,
syndrome
are
frequently
present;
these
conditions
related
to
lipogenesis
systemic
inflammation.
This
study
aimed
review
connection
between
MAFLD.
The
inflammatory
process,
cellular
alterations
hepatocytes
stellate
cells,
hypercaloric
diet,
sedentarism
aggravate
prognosis
of
patients
with
Thus,
understand
modulation
physiopathology
it
is
necessary
include
organokines
involved
this
process
(adipokines,
myokines,
osteokines,
hepatokines)
their
clinical
relevance
project
future
perspectives
condition
bring
light
new
possibilities
therapeutic
approaches.
Adipokines
responsible
for
activation
distinct
signaling
different
tissues,
such
as
insulin
pro-inflammatory
cytokines,
which
important
balancing
substances
avoid
MAFLD
its
progression.
Myokines
improve
quantity
quality
adipose
contributing
avoiding
development
Finally,
hepatokines
decisive
improving
or
not
progression
through
regulation
anti-inflammatory
organokines.
Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 185 - 200
Опубликована: Янв. 1, 2025
Abstract:
Cerebral
ischemia-reperfusion
injury
(CIRI)
is
clinically
characterized
by
high
rates
of
morbidity,
disability,
mortality,
and
recurrence
as
well
economic
burden.
The
clinical
manifestations
CIRI
are
often
accompanied
gastrointestinal
symptoms
such
intestinal
bacterial
dysbiosis
bleeding.
Gut
microbiota
plays
an
important
role
in
the
pathogenesis
CIRI,
its
potential
biological
effects
have
received
extensive
attention.
gut
not
only
affects
barrier
function
but
also
regulates
immunity
host
homeostasis.
Traditional
Chinese
medicine
(TCM),
a
multi-component
multi-targeted
drug,
has
shown
remarkable
few
adverse
reactions
prevention
treatment
CIRI.
Notably,
effect
TCM
on
regulating
maintaining
homeostasis
gradually
become
hot
topic.
This
review
summarizes
functional
development
progression
therapeutic
improving
dysbiosis,
affecting
metabolism,
immunity.
active
ingredients
used
for
relevant
studies
were
saponins,
triterpenoids,
phenolics,
alkaloids.
In
addition,
to
treat
briefly
discussed.
established
significance
prospects
TCM-based
treatments
provided
necessary
theoretical
support
further
resources
Keywords:
cerebral
injury,
ischemic
stroke,
gut-brain
axis,
microbiota,
traditional
ACS Omega,
Год журнала:
2025,
Номер
10(6), С. 5148 - 5171
Опубликована: Фев. 3, 2025
Alzheimer's
disease
(AD)
is
an
aging-related
irreversible
neurodegenerative
affecting
mostly
the
elderly
population.
The
main
pathological
features
of
AD
are
extracellular
Aβ
plaques
generated
by
APP
cleavage
through
amyloidogenic
pathway,
intracellular
neurofibrillary
tangles
(NFT)
resulting
from
hyperphosphorylated
tau
proteins,
and
cholinergic
neurodegeneration.
However,
actual
causes
unknown,
but
several
studies
suggest
hereditary
mutations
in
PSEN1
-2,
APOE4,
APP,
TAU
genes
major
perpetrators.
In
order
to
understand
etiology
pathogenesis
AD,
various
hypotheses
proposed.
These
include
following
hypotheses:
amyloid
accumulation,
tauopathy,
inflammation,
oxidative
stress,
mitochondrial
dysfunction,
glutamate/excitotoxicity,
deficiency,
gut
dysbiosis.
Currently
approved
therapeutic
interventions
donepezil,
galantamine,
rivastigmine,
which
cholinesterase
inhibitors
(ChEIs),
memantine,
N-methyl-d-aspartate
(NMDA)
antagonist.
treatment
strategies
focus
on
only
symptomatic
management
attenuating
symptoms
not
regeneration
neurons
or
clearance
Tau.
This
review
focuses
pathophysiology,
novel
targets,
disease-altering
treatments
such
as
α-secretase
modulators,
active
immunotherapy,
passive
natural
antioxidant
products,
nanomaterials,
antiamyloid
therapy,
aggregation
inhibitors,
transplantation
fecal
microbiota
stem
cells,
microtubule
stabilizers
that
clinical
trials
still
under
investigation.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 24, 2025
Significant
changes
in
gut
microbial
composition
are
associated
with
chronic
liver
disease.
Using
preclinical
models,
it
has
been
demonstrated
that
ethanol/alcohol-induced
disease
is
transmissible
through
fecal
microbiota
transplantation
(FMT).
So,
the
survival
rate
of
people
severe
alcoholic
hepatitis
got
better,
which
suggests
makeup
and
function
play
a
role
metabolic
The
leaky
intestinal
barrier
plays
major
influencing
metabolic-related
development
microbiota.
As
result,
viable
bacteria
products
can
be
transported
to
liver,
causing
inflammation,
contributing
hepatocyte
death,
fibrotic
response.
starts
gets
worse,
dysbiosis
linked
immune
system,
bile
acid
composition,
gut.
Metabolic-related
disease,
as
well
its
self-perpetuation,
will
using
data
from
human
studies.
Further,
we
summarize
how
untargeted
treatment
approaches
affect
including
dietary
changes,
probiotics,
antibiotics,
FMT.
It
discusses
targeted
therapies
improve
various
areas.
These
may
options.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 3, 2025
Post-stroke
depression
(PSD)
is
one
of
the
most
common
and
devastating
neuropsychiatric
complications
in
stroke
patients,
affecting
more
than
one-third
survivors
ischemic
(IS).
Despite
its
high
incidence,
PSD
often
overlooked
or
undertreated
clinical
practice,
effective
preventive
measures
therapeutic
interventions
remain
limited.
Although
exact
mechanisms
are
not
fully
understood,
emerging
evidence
suggests
that
gut
microbiota
plays
a
key
role
regulating
gut-brain
communication.
This
has
sparked
great
interest
relationship
between
microbiota-gut-brain
axis
(MGBA)
PSD,
especially
context
cerebral
ischemia.
In
addition
to
microbiota,
another
important
factor
barrier,
which
acts
as
frontline
sensor
distinguishing
beneficial
harmful
microbes,
inflammatory
responses
immunomodulation.
Based
on
this,
this
paper
proposes
new
approach,
microbiota-immune-barrier
axis,
only
closely
related
pathophysiology
IS
but
may
also
play
critical
occurrence
progression
PSD.
review
aims
systematically
analyze
how
affects
integrity
function
barrier
after
through
immunomodulation,
leading
production
exacerbation
depressive
symptoms
addition,
we
will
explore
existing
technologies
can
assess
MGBA
potential
strategies
for
with
hope
providing
insights
future
research
interventions.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Март 4, 2025
Stroke
represents
a
predominant
cause
of
mortality
and
disability
on
global
scale,
impacting
millions
annually
exerting
considerable
strain
healthcare
systems.
The
incidence
stroke
exhibits
regional
variability,
with
ischemic
accounting
for
the
majority
occurrences.
Post-stroke
complications,
such
as
cognitive
impairment,
motor
dysfunction,
recurrent
stroke,
profoundly
affect
patients’
quality
life.
Recent
advancements
have
elucidated
microbiota-gut-brain
axis
(MGBA),
underscoring
complex
interplay
between
gut
health
brain
function.
Dysbiosis,
characterized
by
an
imbalance
in
microbiota,
is
significantly
linked
to
elevated
risk
unfavorable
outcomes.
MGBA
plays
crucial
role
modulating
immune
function,
neurotransmitter
levels,
metabolic
byproducts,
which
may
intensify
neuroinflammation
impair
cerebral
health.
This
review
elucidates
pathophysiology
explores
potential
gut-targeted
therapeutic
strategies
reduce
promote
recovery,
including
probiotics,
prebiotics,
pharmacological
interventions,
dietary
modifications.
However,
current
prevention
treatment
based
intestinal
flora
still
face
many
problems,
large
difference
individual
flora,
stability
efficacy,
long-term
safety
need
be
considered.
Further
research
needs
strengthened
its
better
application
clinical
practice.
Deleted Journal,
Год журнала:
2025,
Номер
2(2), С. 16 - 16
Опубликована: Апрель 15, 2025
Background:
In
veterinary
medicine,
fecal
microbiota
transplantation
(FMT)
shows
promise
for
treating
chronic
enteropathy
(CE)
in
dogs,
but
standardized
protocols
dosage,
preparation,
and
administration
are
lacking.
This
study
aimed
to
evaluate
the
efficacy
of
freeze-dried
FMT
capsules
(cFMT)
investigate
existence
a
possible
optimal
dosage
dogs
with
CE.
Methods:
A
multicenter
prospective
was
conducted
on
171
CE,
treated
(100
mg
≤
10
kg,
200
>
kg).
The
material
expressed
different
ways,
effect
putative
active
principles.
Clinical
outcomes
were
assessed
by
classifying
as
responders
(R)
or
non-responders
(NR)
based
evaluations
from
questionnaire,
along
changes
CIBDAI
score
variations
15
clinical
signs
(CE).
Data
collected
before
days
after
treatment.
Results:
Of
111
included
final
analysis,
82%
showed
positive
response,
no
significant
differences
response
between
capsule
sizes
irrespective
how
it
expressed.
Conclusion:
Effective
range
cFMT
affected
CE
defined.
oral
100
daily
month
shown
be
sufficient
achieve
an
80%
rate.
Further
studies
needed
explore
additional
factors
that
may
influence
overall
effectiveness
