Cerium oxide nanoparticles in wound care: a review of mechanisms and therapeutic applications

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: May 20, 2024

Skin wound healing is a complex and tightly regulated process. The frequent occurrence reoccurrence of acute chronic wounds cause significant skin damage to patients impose socioeconomic burdens. Therefore, there an urgent requirement promote interdisciplinary development in the fields material science medicine investigate novel mechanisms for healing. Cerium oxide nanoparticles (CeO 2 NPs) are type nanomaterials that possess distinct properties have broad application prospects. They recognized their capabilities enhancing closure, minimizing scarring, mitigating inflammation, exerting antibacterial effects, which has led prominence care research. In this paper, distinctive physicochemical CeO NPs most recent synthesis approaches discussed. It further investigates therapeutic process Following that, review critically examines previous studies focusing on effects Finally, it suggests potential cerium as innovative nanomaterial diverse discusses its prospects future advancements.

Language: Английский

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The regulatory mechanisms of cerium oxide nanoparticles in oxidative stress and emerging applications in refractory wound care

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 2, 2024

Cerium oxide nanoparticles (CeNPs) have emerged as a potent therapeutic agent in the realm of wound healing, attributing their efficacy predominantly to exceptional antioxidant properties. Mimicking activity endogenous enzymes, CeNPs alleviate oxidative stress and curtail generation inflammatory mediators, thus expediting healing process. Their application spans various disease models, showcasing potential treating responses infections, particularly stress-induced chronic wounds such diabetic ulcers, radiation-induced skin injuries, psoriasis. Despite promising advancements laboratory studies, clinical translation is challenged by several factors, including biocompatibility, toxicity, effective drug delivery, development multifunctional compounds. Addressing these challenges necessitates CeNP synthesis functionalization, novel nano delivery systems, comprehensive bio effectiveness safety evaluations. This paper reviews progress highlighting mechanisms, applications, challenges, future perspectives therapeutics.

Language: Английский

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New trends in supportive care of head and neck cancers

Current Opinion in Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Purpose of review Supportive care plays a vital role in the management head and neck cancer (HNC) patients, as disease often affects frail older population that is treated with multiple strategies associated severe symptoms. We will focus on mucositis, dermatitis, dysphagia, pain, cachexia, infections, they are among most common challenging symptoms encountered. Recent findings Efforts have focused multiomics approaches to decipher complex biological pathways drive symptom onset treatment-related toxicities, aim developing novel therapeutic strategies. A notable example ponsegromab, monoclonal antibody designed target cachexia. Other promising areas research, such machine-learning models oral gut microbiota cachexia actively being explored; however, their impact date remains limited. Summary In recent years, new knowledge has emerged regarding underlying causes predictive for supportive HNC patients. Unfortunately, this expanding body primarily adds complexity without translating into practical applications or substantial improvements Future efforts should prioritize standardization algorithms, generation robust evidence based existing preclinical models.

Language: Английский

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Radiation-Induced Fibrosis in Head and Neck Cancer: Challenges and Future Therapeutic Strategies for Vocal Fold Treatments

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1108 - 1108

Published: March 26, 2025

Head and neck cancer encompasses a diverse group of malignant neoplasms originating in regions such as the oral cavity, oropharynx, hypopharynx, larynx, sinonasal cavities, salivary glands. HNC represents significant public health challenge, recent reports indicate an increment incidence young adults. In 2020, approximately 377,700 new cases 177,800 HNC-related deaths were reported globally. Major risk factors include tobacco smoking, alcohol consumption, human papillomavirus (HPV) infections. impacts vital functions breathing, swallowing, speech. Treatments for this type within complex anatomy surgery, radiotherapy, chemotherapy combinations. Radiotherapy is often essential component both curative palliative treatment, balancing tumor control with preservation function appearance. However, its use can damage adjacent normal tissues, causing acute or chronic toxicity. One complication irradiation VF fibrosis, which leads to severe voice impairments, significantly affecting patients' quality life. Fibrosis involves excessive aberrant deposition extracellular matrix, driven by TGF-β1 inflammatory cytokines, ultimately impair flexibility VF. Current radiation-induced fibrosis treatments primarily focus on symptom management systemic therapies like corticosteroids, anti-inflammatory drugs, antioxidants. these have limited efficacy. Experimental approaches targeting molecular pathways involved are being explored. Given limitations treatments, advancing research crucial develop more effective therapeutic strategies that improve life patients, especially those vulnerable fibrosis.

Language: Английский

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Berberine in the treatment of radiation-induced skin injury: insights from proteomics and network pharmacology

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 12, 2025

Background Radiation-induced skin injury (RISI) is a notable complication of cancer radiotherapy, impacting patients’ quality life. Existing interventions mainly address symptoms, with limited success in targeting the fundamental mechanisms. Berberine (BBR), bioactive compound recognized for its anti-inflammatory, antioxidant, and anti-fibrotic characteristics, presents compelling option treating RISI. Methods The molecular targets BBR RISI were identified using Swiss Target Prediction GeneCards databases. A protein-protein interaction (PPI) network was then constructed, core screened Cytoscape plug-in. Molecular functions pathways analyzed through GO KEGG pathway enrichment analyses. Proteomic analysis differential protein expression following treatment. docking validated BBR’s binding to PRKACA PIK3CB. Finally, therapeutic efficacy confirmed irradiated cell animal models. Results pivotal modulating linked inflammation, oxidative stress, tissue repair. Protein histology indicates marked increase epithelial migration proliferation markers (KRT14, KRT16) decrease inflammatory (IL6ST, TNFRSF10B). Enrichment like MAPK cascade development highlights role regeneration. confirms stable key PIK3CB, essential inflammation control. Moreover, treatment promoted cells accelerated wound healing Conclusion demonstrates multi-target potential managing by cellular repair processes. These findings provide foundation future clinical studies optimize dosage delivery, aiming improve outcomes

Language: Английский

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Nets in fibrosis: Bridging innate immunity and tissue remodeling

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 137, P. 112516 - 112516

Published: June 20, 2024

Language: Английский

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Blockade of Sialylation with Decrease in Polysialic Acid Levels Counteracts Transforming Growth Factor β1-Induced Skin Fibroblast-to-Myofibroblast Transition

Cells, Journal Year: 2024, Volume and Issue: 13(12), P. 1067 - 1067

Published: June 19, 2024

Aberrant sialylation with overexpression of the homopolymeric glycan polysialic acid (polySia) was recently reported in fibroblasts from fibrotic skin lesions. Yet, whether such a rise polySia levels or general may be functionally implicated profibrotic activation and their transition to myofibroblasts remains unknown. Therefore, we herein explored inhibition could interfere process fibroblast-to-myofibroblast induced by master mediator transforming growth factor β1 (TGFβ1). Adult human were pretreated competitive pan-sialyltransferase inhibitor 3-Fax-peracetyl-Neu5Ac (3-Fax) before stimulation recombinant TGFβ1, then analyzed for expression, cell viability, proliferation, migratory ability, acquisition myofibroblast-like morphofunctional features. Skin fibroblast TGFβ1 resulted polySia, which effectively blunted 3-Fax pre-administration. Pretreatment efficiently lessened TGFβ1-induced migration, changes morphology, phenotypic functional differentiation into myofibroblasts, as testified significant reduction FAP, ACTA2, COL1A1, COL1A2, FN1 gene α-smooth muscle actin, N-cadherin, FN-EDA protein levels, well reduced contractile capability. Moreover, pre-administered displayed decrease Smad3-dependent canonical signaling. Collectively, our vitro findings demonstrate first time that aberrant increased has role suggest sialyltransferase might offer new therapeutic opportunities against fibrosis.

Language: Английский

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Quantitative assessment of the results of lymphovenous edema therapy in patients after combined treatment of breast cancer

Український радіологічний та онкологічний журнал, Journal Year: 2024, Volume and Issue: 32(2), P. 275 - 284

Published: July 2, 2024

Background. Secondary lymphovenous edema of the hand is one most common and serious complications specialized treatment breast cancer. Purpose – to quantify dynamics by measuring its volume using proposed device model. Materials methods. In 23 patients, type radiation injury was determined radionuclide method, degree secondary a number designed devices. Treatment performed irradiating areas fibrosis corresponding lymphatic collectors with ultra-low frequency electromagnetic (UHF EMR) compression drainage. Results discussion. The evaluated change in hand, which amount fluid displaced from model when distal part upper limb immersed it. Conclusions. This technique can be considered as an objective method for quantifying hand.

Language: Английский

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Global hotspots and research trends of radiation-induced skin injury: a bibliometric analysis from 2004 to 2023

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Aug. 26, 2024

Background Radiation therapy has become an important treatment for many malignant tumours after surgery and palliative tumour care. Although modern radiotherapy technology is constantly improving, radiation damage to normal tissues often difficult avoid, radiation-induced skin injury (RSI) a common complication, manifested as erythema, peeling, ulceration, even bone deep organ damage, seriously affect the quality of life patients. Basic research clinical trials related RSI have achieved certain results, while no researchers conducted comprehensive bibliometric studies. Objective A analysis publications on published between 2004 2023 was identify current hotspots future directions in this area study. Methods RSI-related January 1, 2004, December 31, 2023, were retrieved from Web Science Core Collection (WoSCC) database using VOSviewer CiteSpace analytics. Results total 1009 included WoSCC database. The United States had highest productivity with 299 papers, accounting 29.63% production, followed by China 193 papers (19.13%) Japan 111 (11.00%). In terms institutions journals, University Toronto Journal Supportive Care Cancer number papers. Professor Edward Chow most articles, Shuyu Zhang cited. top ten most-cited focused pathogenesis, prevention, management RSI. Keyword co-occurrence 25 keywords strongest citation bursts suggest that focuses Conclusion This study systematic 2023; identified trends publications, major countries, institutions, authors, keywords; revealed development direction field. provides valuable reference research.

Language: Английский

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The Histopathology of Chronic “Radiation Conjunctivitis” Shows Diagnostic Features Similar to Those Seen in Radiation Dermatitis, Including Radiation Fibroblasts

Head and Neck Pathology, Journal Year: 2024, Volume and Issue: 18(1)

Published: Oct. 14, 2024

Language: Английский

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