Viral Oncogenesis: Synergistic Role of Genome Integration and Persistence DOI Creative Commons
Simone La Frazia, Silvia Pauciullo, Verdiana Zulian

и другие.

Viruses, Год журнала: 2024, Номер 16(12), С. 1965 - 1965

Опубликована: Дек. 23, 2024

Persistence is a strategy used by many viruses to evade eradication the immune system, ensuring their permanence and transmission within host optimizing viral fitness. During persistence, can trigger various phenomena, including target organ damage, mainly due an inflammatory state induced infection, as well cell proliferation and/or immortalization. In addition evasion chronic inflammation, factors contributing persistence include low-level replication, accumulation of mutants, and, most importantly, maintenance genome reliance on oncoprotein production. This review focuses process integration, which may occur at different stages infection (e.g., HBV), during phase HPV, EBV), or essential part life cycle, seen in retroviruses (HIV, HTLV-1). It also explores close relationship between oncogenesis. Several models have been proposed describe integration process, non-homologous recombination, looping, microhomology models. Integration either randomly specific genomic sites, often leading destabilization. some cases, results loss regions impairs regulation oncogene oncosuppressor expression, tumor development.

Язык: Английский

Fibrin-associated large B-cell lymphoma arising in a cystic lymphangiomatous lesion of the adrenal gland: A case report and overview of the entity DOI Creative Commons
Stefan Kircher, Julia Böck, Katja Maurus

и другие.

Pathology - Research and Practice, Год журнала: 2025, Номер unknown, С. 155957 - 155957

Опубликована: Апрель 1, 2025

Fibrin-associated large B-cell lymphoma (FA-LBCL) has been recognized as a distinct entity in the 5th WHO classification of hematolymphoid tumors. It is rare Epstein-Barr virus-positive neoplasia that arises various sites chronic fibrin deposition associated with (pseudo-)cystic cavities, hematomas, cardiac myxomas, or prostheses. Cystic lymphangiomatous lesions adrenal gland are rare, benign vascular most commonly asymptomatic. However, they occasionally discovered incidentally and then often removed to rule out other, more serious diagnoses. The present case report documents highly unusual instance 45-year-old female patient who was diagnosed FA-LBCL arising from long-standing cystic lesion gland, representing co-occurence two We provide comprehensive morphological, immunohistochemical, molecular features this give brief overview emerging entity.

Язык: Английский

Процитировано

0
Understanding EBV Infection and EBV-Associated Lymphomas in children DOI
Paola Chabay

Virology, Год журнала: 2025, Номер unknown, С. 110544 - 110544

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Transcriptional regulation mechanism of PARP1 and its application in disease treatment DOI Creative Commons
Lu Yu,

Wenliang Fu,

Weiwei Xing

и другие.

Epigenetics & Chromatin, Год журнала: 2024, Номер 17(1)

Опубликована: Авг. 8, 2024

Poly (ADP-ribose) polymerase 1 (PARP1) is a multifunctional nuclear enzyme that catalyzes poly-ADP ribosylation in eukaryotic cells. In addition to maintaining genomic integrity, this also involved transcriptional regulation. PARP1 can trigger and maintain changes the chromatin structure directly recruit transcription factors. prevents DNA methylation. However, most previous reviews on have focused its involvement genome with less focus regulatory function. This article comprehensively function of application disease treatment, providing new ideas for targeting treatment diseases other than cancer.

Язык: Английский

Процитировано

3
From virus to cancer: Epstein–Barr virus miRNA connection in Burkitt's lymphoma DOI Creative Commons
Shahram Jalilian, Mohammad‐Navid Bastani

Infectious Agents and Cancer, Год журнала: 2024, Номер 19(1)

Опубликована: Окт. 18, 2024

In Burkitt's lymphoma (BL), Epstein–Barr virus-encoded microRNAs (EBV miRNAs) are emerging as crucial regulatory agents that impact cellular and viral gene regulation. This review investigates the multifaceted functions of EBV miRNAs in pathogenesis Burkitt lymphoma. regulate several processes essential for BL development, such apoptosis, immune evasion, proliferation. These small, non-coding RNAs target both host mRNAs, finely adjusting environment to favor oncogenesis. Prominent miRNAs, BART (BamHI-A rightward transcript) BHRF1 (BamHI fragment H open reading frame 1), emphasized their roles tumor growth For example, prevent apoptosis by suppressing pro-apoptotic proteins, whereas promote latency immunological evasion. Understanding intricate connections among targets illuminates suggests novel treatment approaches. Targeting or specific pathways offers a feasible option developing innovative therapies aim disrupt carcinogenic initiated these components. future studies should focus on precisely mapping miRNA‒target networks miRNA-based diagnostic therapeutic tools. comprehensive article highlights importance lymphoma, indicating potential biomarkers strategies.

Язык: Английский

Процитировано

1
Epstein Barr virus: A cellular hijacker in cancer DOI

Moyed Abd Alhussain Hamza Al-Saadawe,

Bakeel A Radman,

Jingyi Long

и другие.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер unknown, С. 189218 - 189218

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

1
Investigating of the serum level of VCA-IgG antibody in gastric cancer patients in Ardebil city DOI Creative Commons

Faraz Malek Bagali,

Hamidreza Hanifezade,

Peyman Azgani

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Окт. 18, 2024

Abstract Background Gastric cancer (GC) is known as the fourth most common and second leading cause of death in world. Many environmental factors, such age, sex, blood group, heredity, Epstein-Barr virus (EBV), Helicobacter pylori (H. pylori), unhealthy diet, geographical region, are possible risk factors for gastric cancer. Moreover, one important causes GC (EBV). Due to a lack information about etiologic role EBV cancer, this study, we investigated serum level viral capsid antigen IgG antibodies (VCA-IgG) patients Ardebil city. Methods This cross-sectional study included 92 healthy individuals control group. Demographic pathological were recorded, samples collected measure antibody (VCA IgG) levels. Data analyzed using SPSS software statistical tests, including chi-square, independent t-test, one-way ANOVA, Pearson correlation. Results Among 184 participants, 58.7% male 41.3% female. The group was type A (44.0%), while lowest B (7.6%). VCA (IgG) tests showed that 42.4% participants positive. Additionally, 57.1% tested positive H. pylori. Statistical analysis no significant association between gender, pylori, infection. associated with (p-value > 0.05). However, found positivity = 0.02). Conclusion suggests may be an factor determining Future research larger more diverse recommended obtain robust results.

Язык: Английский

Процитировано

0
The novel immune landscape of immune‐checkpoint blockade in EBV‐associated malignancies DOI
Feng Zhang, Wenjing Li, Xinglong Zheng

и другие.

The FASEB Journal, Год журнала: 2024, Номер 38(21)

Опубликована: Ноя. 9, 2024

Abstract The Epstein–Barr virus (EBV) is a ubiquitous gamma‐herpesvirus and class 1 carcinogen that closely associated with series of malignant lymphomas epithelial cell carcinomas. Although these EBV‐related cancers may exhibit different features in clinical symptoms anatomical sites, they all have characteristic immune‐suppressed tumor immune microenvironment (TIME) tightly correlated an abundance tumor‐infiltrating lymphocytes (TILs) primarily result from the EBV infection. Overwhelming evidence indicates upregulation immune‐checkpoint molecules powerful strategy employed by to escape surveillance. While previous studies mainly focused on therapeutic effects PD‐1 CTLA‐4 blockades treating EBV‐associated tumors, several novel inhibitory receptors (e.g., CD47, LAG‐3, TIM‐3, VISTA, DDR1) recently been identified as potential targets for malignancies (EBVaMs). This review retrospectively summarizes biological mechanisms used checkpoint evasion tumors. Its purpose update our current knowledge concerning underlying which blockade triggers host antitumor immunity against EBVaMs. Additionally, this help investigators more fully understand correlation between infection development subsequently develop strategies.

Язык: Английский

Процитировано

0
Bromodomain proteins as potential therapeutic targets for B-cell non-Hodgkin lymphoma DOI Creative Commons

Dan Zou,

Sitong Feng, Bowen Hu

и другие.

Cell & Bioscience, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 23, 2024

Abstract Background B-cell non-Hodgkin lymphoma (B-NHL) is the most common type of and significantly heterogeneous among various subtypes. Despite considerable advancements in treatment strategies for B-NHL, prognosis relapsed/refractory patients remains poor. Main text It has been indicated that epigenetic dysregulation critically associated with pathogenesis hematological malignancies, resulting clinical targeting modifications. Bromodomain (BRD) proteins are essential regulators which contain eight subfamilies, including BRD extra-terminal domain (BET) family, histone acetyltransferases (HATs) HAT-related proteins, transcriptional coactivators, mediators, methyltransferases, helicases, ATP-dependent chromatin-remodeling complexes, nuclear-scaffolding proteins. Most pre-clinical studies on B-NHL have focused predominantly BET family use inhibitors as mono-treatment or co-treatment other anti-tumor drugs. Furthermore, preclinical models revealed degraders more active than inhibitors. Moreover, development degraders, non-BET protein also designed shown antitumor activities models. This review summarized mechanism recent progress protein-related drugs B-NHL. study aimed to collect evidences summarize possibility whether can serve therapeutic targets Conclusion In summary, critical regulatory factors may be potential

Язык: Английский

Процитировано

0
Viral Oncogenesis: Synergistic Role of Genome Integration and Persistence DOI Creative Commons
Simone La Frazia, Silvia Pauciullo, Verdiana Zulian

и другие.

Viruses, Год журнала: 2024, Номер 16(12), С. 1965 - 1965

Опубликована: Дек. 23, 2024

Persistence is a strategy used by many viruses to evade eradication the immune system, ensuring their permanence and transmission within host optimizing viral fitness. During persistence, can trigger various phenomena, including target organ damage, mainly due an inflammatory state induced infection, as well cell proliferation and/or immortalization. In addition evasion chronic inflammation, factors contributing persistence include low-level replication, accumulation of mutants, and, most importantly, maintenance genome reliance on oncoprotein production. This review focuses process integration, which may occur at different stages infection (e.g., HBV), during phase HPV, EBV), or essential part life cycle, seen in retroviruses (HIV, HTLV-1). It also explores close relationship between oncogenesis. Several models have been proposed describe integration process, non-homologous recombination, looping, microhomology models. Integration either randomly specific genomic sites, often leading destabilization. some cases, results loss regions impairs regulation oncogene oncosuppressor expression, tumor development.

Язык: Английский

Процитировано

0